Cd74 (CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)) - Rat Genome Database

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Gene: Cd74 (CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)) Mus musculus
Analyze
Symbol: Cd74
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
RGD ID: 1553657
MGI Page MGI
Description: Enables MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including macrophage migration inhibitory factor signaling pathway; positive regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of T cell differentiation; and thymic T cell selection. Located in several cellular components, including external side of plasma membrane; lysosome; and multivesicular body. Part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Is expressed in lower jaw; lower jaw incisor; lower jaw molar; and thymus primordium. Orthologous to human CD74 (CD74 molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C; class II-associated invariant chain peptide; CLIP; DHLAG; dinucleotide microsatellite; H-2 class II histocompatibility antigen gamma chain; histocompatibility: class II antigens, gamma chain of; HLA-DR-GAMMA; HLADG; ia antigen-associated invariant chain; Ia-associated invariant chain; Ia-GAMMA; Ii; ii chain; invariant polypeptide of major histocompatibility complex, class II antigen-associated; MHC class II-associated invariant chain
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391860,936,921 - 60,945,724 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1860,936,920 - 60,945,724 (+)EnsemblGRCm39 Ensembl
GRCm381860,803,849 - 60,812,652 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,803,848 - 60,812,652 (+)EnsemblGRCm38mm10GRCm38
MGSCv371860,963,503 - 60,972,306 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361860,929,247 - 60,938,021 (+)NCBIMGSCv36mm8
Celera1862,088,874 - 62,098,436 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
amitriptyline  (ISO)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
bergomottin  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bupropion  (ISO)
buspirone  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
clofibrate  (EXP)
clothianidin  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
diquat  (EXP)
diuron  (ISO)
doramapimod  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenthion  (EXP)
ferric oxide  (EXP)
folpet  (EXP)
fructose  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glucose  (EXP)
glycidol  (ISO)
glyphosate  (EXP)
hexachlorobenzene  (ISO)
hydroxychloroquine  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
losartan  (ISO)
luteolin  (ISO)
manganese(II) chloride  (ISO)
menadione  (EXP)
metformin  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP)
N-(6-acetamidohexyl)acetamide  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
n-propyl gallate  (ISO)
nefazodone  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
nobiletin  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
pevonedistat  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium tungstate  (ISO)
sotorasib  (ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimethoprim  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antigen processing and presentation  (IBA,IDA,IMP)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (IMP)
blocking of symbiont entry into host cell  (ISO)
canonical NF-kappaB signal transduction  (ISO)
chaperone cofactor-dependent protein refolding  (IDA,IMP)
defense response  (IMP)
immunoglobulin mediated immune response  (IMP)
intracellular protein transport  (IDA,IMP)
macrophage migration inhibitory factor signaling pathway  (IDA)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of cell migration  (IEA,ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IBA,IMP,ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IBA,IMP,ISO)
negative regulation of mature B cell apoptotic process  (IMP)
negative regulation of peptide secretion  (IEA,ISO)
negative regulation of T cell differentiation  (IMP)
negative thymic T cell selection  (IMP)
positive regulation of adaptive immune response  (NAS)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IDA)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of cytokine-mediated signaling pathway  (IBA,IMP,ISO)
positive regulation of dendritic cell antigen processing and presentation  (IDA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IMP,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of innate immune response  (IC)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of kinase activity  (ISO)
positive regulation of macrophage cytokine production  (IBA,IDA)
positive regulation of macrophage migration inhibitory factor signaling pathway  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of monocyte differentiation  (IEA,ISO)
positive regulation of neutrophil chemotaxis  (IDA)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of prostaglandin biosynthetic process  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of T cell differentiation  (IMP)
positive regulation of type 2 immune response  (IBA,IMP)
positive regulation of viral entry into host cell  (IEA,ISO)
positive thymic T cell selection  (IMP)
prostaglandin biosynthetic process  (ISO,ISS)
protein stabilization  (IMP)
protein trimerization  (IEA)
protein-containing complex assembly  (IDA)
response to type II interferon  (IDA,ISO)
signal transduction involved in regulation of gene expression  (ISO)
T cell activation involved in immune response  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal antigen presentation  (IAGP)
abnormal antigen presentation via MHC class II  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal blood cell morphology  (IAGP)
abnormal bone marrow cell number  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal dendritic cell antigen presentation  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal level of surface class II molecules  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal mast cell morphology  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal megakaryocyte progenitor cell morphology  (IAGP)
abnormal positive T cell selection  (IAGP)
abnormal professional antigen presenting cell physiology  (IAGP)
abnormal T cell number  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
arrested B cell differentiation  (IAGP)
cachexia  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased body size  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased follicular B cell number  (IAGP)
decreased granulocyte monocyte progenitor cell number  (IAGP)
decreased granulocyte number  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased IgM level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased lymphocyte cell number  (IEA)
decreased megakaryocyte-erythroid progenitor cell number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased Peyer's patch number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased T cell proliferation  (IAGP)
defective assembly of class II molecules  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased eosinophil cell number  (IEA)
increased immature B cell number  (IAGP)
increased mean corpuscular volume  (IAGP)
increased monocyte cell number  (IEA)
increased myocardial infarct size  (IAGP)
increased neutrophil cell number  (IEA)
increased red blood cell distribution width  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to myocardial ischemic injury  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased T cell proliferation  (IAGP)
macrocytic anemia  (IAGP)
macrocytosis  (IAGP)
premature death  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1354644   PMID:1358813   PMID:1457043   PMID:1531041   PMID:1686018   PMID:1794058   PMID:2111346   PMID:2492095   PMID:2981770   PMID:2993162   PMID:3038530   PMID:3422739  
PMID:3864916   PMID:3920321   PMID:6327293   PMID:6402712   PMID:7510069   PMID:7553001   PMID:7553002   PMID:7558022   PMID:7679955   PMID:7697546   PMID:7985028   PMID:8064228  
PMID:8098731   PMID:8288218   PMID:8294875   PMID:8548834   PMID:8589516   PMID:8598039   PMID:8598040   PMID:8643655   PMID:8690902   PMID:8706013   PMID:8747928   PMID:8765017  
PMID:8810244   PMID:8889548   PMID:8921421   PMID:8977190   PMID:8996239   PMID:9079649   PMID:9096350   PMID:9158147   PMID:9237107   PMID:9256469   PMID:9285405   PMID:9299440  
PMID:9432982   PMID:9531264   PMID:9551884   PMID:9551894   PMID:9723702   PMID:9743527   PMID:9824491   PMID:9872742   PMID:10349636   PMID:10384121   PMID:10706709   PMID:10727467  
PMID:10748235   PMID:10843678   PMID:10925256   PMID:11042159   PMID:11067886   PMID:11076861   PMID:11087837   PMID:11160278   PMID:11160279   PMID:11290790   PMID:11483509   PMID:11602620  
PMID:11754812   PMID:11777953   PMID:11796577   PMID:11823488   PMID:11854359   PMID:11867743   PMID:11937578   PMID:12011451   PMID:12021314   PMID:12023345   PMID:12126629   PMID:12165499  
PMID:12417635   PMID:12466851   PMID:12477932   PMID:12538710   PMID:12629221   PMID:12634786   PMID:12646641   PMID:12782713   PMID:12855551   PMID:14556985   PMID:14557411   PMID:14568937  
PMID:14707062   PMID:14764672   PMID:15034026   PMID:15048712   PMID:15096489   PMID:15126315   PMID:15259020   PMID:15294975   PMID:15322158   PMID:15322189   PMID:15489334   PMID:15534371  
PMID:15814741   PMID:15998789   PMID:16051149   PMID:16081819   PMID:16094690   PMID:16141072   PMID:16141073   PMID:16210606   PMID:16484589   PMID:16602821   PMID:17045821   PMID:17105964  
PMID:17114422   PMID:17114428   PMID:17182551   PMID:17296316   PMID:17492940   PMID:17557376   PMID:17634957   PMID:17846227   PMID:17869133   PMID:17901247   PMID:17947664   PMID:18003616  
PMID:18056708   PMID:18322197   PMID:18362148   PMID:18684922   PMID:18684948   PMID:18952077   PMID:18993085   PMID:19074353   PMID:19188446   PMID:19269807   PMID:19278296   PMID:19342667  
PMID:19413900   PMID:19587020   PMID:19723499   PMID:19966810   PMID:20416035   PMID:20547545   PMID:20614481   PMID:20639480   PMID:20697023   PMID:20816669   PMID:21157037   PMID:21183789  
PMID:21267068   PMID:21411731   PMID:21555577   PMID:21565221   PMID:21576321   PMID:21677750   PMID:21873635   PMID:21969590   PMID:22140262   PMID:22306692   PMID:22355577   PMID:22454509  
PMID:22689013   PMID:22966065   PMID:23026773   PMID:23044992   PMID:23172918   PMID:23267013   PMID:23267015   PMID:23267016   PMID:23753877   PMID:23776208   PMID:23896945   PMID:24205828  
PMID:24244014   PMID:24424413   PMID:24441872   PMID:24683185   PMID:24760155   PMID:24974304   PMID:24983315   PMID:25172501   PMID:25329434   PMID:25425146   PMID:25609432   PMID:26157172  
PMID:26195549   PMID:26358505   PMID:26410627   PMID:26413780   PMID:26511587   PMID:26524590   PMID:26524976   PMID:26883190   PMID:26952977   PMID:27157615   PMID:27181906   PMID:27199465  
PMID:27371158   PMID:27463800   PMID:27478940   PMID:27506953   PMID:27825106   PMID:28219888   PMID:28539339   PMID:28550201   PMID:28642294   PMID:28904129   PMID:29467473   PMID:29924850  
PMID:30587340   PMID:30760929   PMID:31167126   PMID:31421080   PMID:31484822   PMID:31653839   PMID:31669150   PMID:32004754   PMID:32220631   PMID:32493987   PMID:32667245   PMID:32810588  
PMID:32855215   PMID:32962825   PMID:32970988   PMID:33239420   PMID:33661886   PMID:33932339   PMID:34183650   PMID:34709416   PMID:36414616   PMID:36736545   PMID:36925198   PMID:37057892  
PMID:37718683   PMID:37796743   PMID:38117649   PMID:38355793   PMID:38565329   PMID:38685050   PMID:38702311   PMID:38760574  


Genomics

Comparative Map Data
Cd74
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391860,936,921 - 60,945,724 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1860,936,920 - 60,945,724 (+)EnsemblGRCm39 Ensembl
GRCm381860,803,849 - 60,812,652 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,803,848 - 60,812,652 (+)EnsemblGRCm38mm10GRCm38
MGSCv371860,963,503 - 60,972,306 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361860,929,247 - 60,938,021 (+)NCBIMGSCv36mm8
Celera1862,088,874 - 62,098,436 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
CD74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,401,639 - 150,412,910 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,401,637 - 150,412,969 (-)EnsemblGRCh38hg38GRCh38
GRCh375149,781,202 - 149,792,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,761,393 - 149,772,525 (-)NCBINCBI36Build 36hg18NCBI36
Build 345149,761,396 - 149,772,511NCBI
Celera5145,862,277 - 145,873,409 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5144,928,781 - 144,940,080 (-)NCBIHuRef
CHM1_15149,213,619 - 149,224,915 (-)NCBICHM1_1
T2T-CHM13v2.05150,938,180 - 150,949,451 (-)NCBIT2T-CHM13v2.0
Cd74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,527,071 - 56,536,406 (+)NCBIGRCr8
mRatBN7.21854,256,757 - 54,266,003 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,256,778 - 54,266,003 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,345,511 - 56,354,694 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,060,123 - 57,069,310 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01854,880,697 - 54,889,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,071,420 - 56,080,851 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,071,478 - 56,080,849 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,305,827 - 55,315,246 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,756,511 - 56,765,711 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11856,828,786 - 56,837,940 (+)NCBI
Celera1852,411,586 - 52,420,786 (+)NCBICelera
RH 3.4 Map18525.0RGD
Cytogenetic Map18q12.1NCBI
Cd74
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,129,254 - 4,137,826 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,129,151 - 4,138,336 (+)NCBIChiLan1.0ChiLan1.0
CD74
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,629,969 - 145,641,243 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,769,515 - 143,780,789 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,825,635 - 145,836,916 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,830,311 - 151,841,334 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,830,311 - 151,841,334 (-)Ensemblpanpan1.1panPan2
CD74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,689,745 - 58,698,421 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,689,752 - 58,698,151 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,456,154 - 58,464,833 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,170,613 - 59,179,292 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,170,623 - 59,198,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,959,149 - 58,967,827 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,073,563 - 59,082,236 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,604,607 - 59,613,287 (+)NCBIUU_Cfam_GSD_1.0
Cd74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,948,591 - 142,958,314 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,522,751 - 4,531,750 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,522,576 - 4,532,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD74
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,402,211 - 151,409,833 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,402,210 - 151,409,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CD74
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,008,802 - 53,022,953 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2353,009,394 - 53,022,923 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603424,695,767 - 24,707,325 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd74
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,700,393 - 9,709,514 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,699,876 - 9,708,871 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd74
327 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:683
Count of miRNA genes:193
Interacting mature miRNAs:216
Transcripts:ENSMUST00000050487, ENSMUST00000097563, ENSMUST00000167610
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
12910791Pwgrq8_mpre-weaning growth rate QTL 8 (mouse)185802139969349142Mouse
4141431Msmr2_mMSM lymphoma resistance 2 (mouse)Not determined5497587361238870Mouse
10412183Sstapa2_mSuseptibility to Staphylococus aureus infection 2 (mouse)Not determined185679463066952485Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184513060468778777Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
1302050Radpf4_mradiation pulmonary fibrosis 4 (mouse)Not determined185296615668778777Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse
27226720Tibw5_mtibia width 5, proximal, 10 week (mouse)185043306762633071Mouse

Markers in Region
D18Mit77  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381860,803,958 - 60,804,241UniSTSGRCm38
MGSCv371860,963,612 - 60,963,895UniSTSGRCm37
Celera1862,088,983 - 62,089,266UniSTS
Cytogenetic Map18E1UniSTS
cM Map1836.0UniSTS
Whitehead Genetic1824.0UniSTS
D18Mit78  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381860,808,675 - 60,808,809UniSTSGRCm38
MGSCv371860,968,329 - 60,968,463UniSTSGRCm37
Celera1862,094,459 - 62,094,593UniSTS
Cytogenetic Map18E1UniSTS
cM Map1836.0UniSTS
Whitehead Genetic1824.0UniSTS
PMC154349P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381860,807,908 - 60,808,309UniSTSGRCm38
MGSCv371860,967,562 - 60,967,963UniSTSGRCm37
Celera1862,093,691 - 62,094,093UniSTS
Celera1862,092,936 - 62,094,093UniSTS
Cytogenetic Map18E1UniSTS
cM Map1832.0UniSTS
Ii  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381860,808,637 - 60,808,791UniSTSGRCm38
MGSCv371860,968,291 - 60,968,445UniSTSGRCm37
Celera1862,094,421 - 62,094,575UniSTS
Cytogenetic Map18E1UniSTS
cM Map1832.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001042605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC139759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW123644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG148172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM669145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M35872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000050487   ⟹   ENSMUSP00000057836
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1860,936,920 - 60,945,724 (+)Ensembl
GRCm38.p6 Ensembl1860,803,848 - 60,812,652 (+)Ensembl
Ensembl Acc Id: ENSMUST00000097563   ⟹   ENSMUSP00000095171
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1860,936,920 - 60,945,718 (+)Ensembl
GRCm38.p6 Ensembl1860,803,848 - 60,812,646 (+)Ensembl
Ensembl Acc Id: ENSMUST00000167610   ⟹   ENSMUSP00000126688
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1860,936,928 - 60,945,718 (+)Ensembl
GRCm38.p6 Ensembl1860,803,856 - 60,812,646 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237097
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1860,936,920 - 60,942,325 (+)Ensembl
GRCm38.p6 Ensembl1860,803,848 - 60,809,253 (+)Ensembl
Ensembl Acc Id: ENSMUST00000238179
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1860,936,977 - 60,943,590 (+)Ensembl
GRCm38.p6 Ensembl1860,803,905 - 60,810,518 (+)Ensembl
RefSeq Acc Id: NM_001042605   ⟹   NP_001036070
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391860,936,921 - 60,945,724 (+)NCBI
GRCm381860,803,849 - 60,812,652 (+)ENTREZGENE
MGSCv371860,963,503 - 60,972,306 (+)RGD
Celera1862,088,874 - 62,098,436 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010545   ⟹   NP_034675
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391860,936,921 - 60,945,724 (+)NCBI
GRCm381860,803,849 - 60,812,652 (+)ENTREZGENE
MGSCv371860,963,503 - 60,972,306 (+)RGD
Celera1862,088,874 - 62,098,436 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001036070   ⟸   NM_001042605
- Peptide Label: isoform 1
- UniProtKB: O19452 (UniProtKB/Swiss-Prot),   P04441 (UniProtKB/Swiss-Prot),   Q3U4Q8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_034675   ⟸   NM_010545
- Peptide Label: isoform 2
- UniProtKB: Q545Y5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000126688   ⟸   ENSMUST00000167610
Ensembl Acc Id: ENSMUSP00000057836   ⟸   ENSMUST00000050487
Ensembl Acc Id: ENSMUSP00000095171   ⟸   ENSMUST00000097563
Protein Domains
MHC class II-associated invariant chain   MHC class II-associated invariant chain/CLIP MHC II-   Thyroglobulin type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04441-F1-model_v2 AlphaFold P04441 1-279 view protein structure

Promoters
RGD ID:13677918
Promoter ID:EPDNEW_M23108
Type:initiation region
Name:Cd74_1
Description:Mus musculus CD74 antigen (invariant polypeptide of major histocompatibilitycomplex, class II antigen-associated) , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381860,803,849 - 60,803,909EPDNEW
RGD ID:6829137
Promoter ID:MM_KWN:25406
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:ENSMUST00000050487,   ENSMUST00000097563,   NM_010545
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361860,963,329 - 60,963,829 (+)MPROMDB
RGD ID:6850390
Promoter ID:EP16069
Type:single initiation site
Name:MM_HG2A
Description:Ia-Associated gamma (class II invariant gamma-chain gene),CD74 or II gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 82; Mammalian class II histocomp. antigen gamma
Experiment Methods:Sequencing of a full-length cDNA; experiments performed with; closely related gene; Primer extension; experiments performed with closely related; gene
Regulation:lymphoid cells; (induced by or strongly expressed in) antigen
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371860,963,499 - 60,963,559EPD
MGSCv361860,963,499 - 60,963,559EPD
RGD ID:6847488
Promoter ID:MM_ACW:25089
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:CD74.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361860,967,256 - 60,967,756 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96534 AgrOrtholog
Ensembl Genes ENSMUSG00000024610 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000050487 ENTREZGENE
  ENSMUST00000050487.16 UniProtKB/Swiss-Prot
  ENSMUST00000097563 ENTREZGENE
  ENSMUST00000097563.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.870.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD74_antigen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC-II_Gamma/Thyroglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II-assoc_invar/CLIP_MHC-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II-assoc_invar_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II-assoc_invariant_trimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHCII_invariant_trimer_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16149 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96534 ENTREZGENE
NCBI Gene 16149 ENTREZGENE
PANTHER HLA CLASS II GAMMA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MHC2-interact UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHCassoc_trimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd74 PhenoGen
PIRSF CD74_antigen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CD74ANTIGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48305 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HG2A_MOUSE UniProtKB/Swiss-Prot
  O19452 ENTREZGENE
  P04441 ENTREZGENE
  Q3U4Q8 ENTREZGENE, UniProtKB/TrEMBL
  Q545Y5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O19452 UniProtKB/Swiss-Prot