Vwf (Von Willebrand factor) - Rat Genome Database

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Gene: Vwf (Von Willebrand factor) Mus musculus
Analyze
Symbol: Vwf
Name: Von Willebrand factor
RGD ID: 1553644
MGI Page MGI
Description: Predicted to enable several functions, including identical protein binding activity; integrin binding activity; and protein-folding chaperone binding activity. Acts upstream of or within several processes, including activation of blood coagulation via clotting cascade; liver development; and platelet activation. Located in Weibel-Palade body; external side of plasma membrane; and extracellular space. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; immune system; and pancreas vasculature. Used to study von Willebrand's disease and von Willebrand's disease 2. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6820430P06Rik; AI551257; B130011O06Rik; C630030D09; F8VWF; Von Willebrand factor homolog; VWD
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,529,911 - 125,663,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,523,737 - 125,663,642 (+)EnsemblGRCm39 Ensembl
GRCm386125,552,948 - 125,686,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,546,774 - 125,686,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,502,981 - 125,636,695 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,520,072 - 125,652,161 (+)NCBIMGSCv36mm8
Celera6127,212,807 - 127,346,911 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
Aortic Injuries  (ISO)
atrial fibrillation  (ISO)
autism spectrum disorder  (ISO)
Behcet's disease  (ISO)
Bernard-Soulier syndrome  (ISO)
bipolar disorder  (ISO)
blood coagulation disease  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
Cytomegalovirus Infections  (ISO)
diabetes mellitus  (IDA)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Drug Hypersensitivity Syndrome  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
episodic ataxia type 1  (ISO)
essential thrombocythemia  (ISO)
exanthem  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor VIII deficiency  (IMP,ISO)
familial combined hyperlipidemia  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gastrointestinal Hemorrhage  (ISO)
genetic disease  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Hemorrhagic Shock  (ISO)
Hyperphosphatemic Familial Tumoral Calcinosis 1  (ISO)
hypertension  (ISO)
Hypothermia  (IEP)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
intracranial thrombosis  (ISO)
Kidney Reperfusion Injury  (ISO)
lymphoproliferative syndrome 2  (ISO)
mesangial proliferative glomerulonephritis  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
obesity  (ISO)
osteonecrosis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
severe acute respiratory syndrome  (IEP)
Spinal Cord Injuries  (ISO)
Stevens-Johnson syndrome  (ISO)
Stroke  (ISO)
systemic scleroderma  (ISO)
thrombocytopenia  (ISO)
Thrombocytopenic Purpura  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (IGI,ISO)
Thrombotic Thrombocytopenic Purpura, Acquired  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
Venous Thromboembolism  (ISO)
Von Willebrand Factor, Deficiency  (ISO)
von Willebrand's disease  (IAGP,ISO)
von Willebrand's disease 1  (ISO)
von Willebrand's disease 2  (IAGP,IMP,ISO)
von Willebrand's disease 3  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(S)-nicotine  (EXP,ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
cantharidin  (EXP)
carbon atom  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
cholesterol  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
cumene  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
Curcumol  (EXP)
D-glucose  (ISO)
desmopressin  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental carbon  (ISO)
enalapril  (EXP)
ergosterol  (ISO)
ethanol  (EXP)
fenoldopam  (ISO)
fenvalerate  (ISO)
folic acid  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (ISO)
gestodene  (ISO)
glucose  (ISO)
graphite  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP)
isoprenaline  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (EXP)
luteolin  (ISO)
maneb  (EXP)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (ISO)
nicotine  (EXP,ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
paricalcitol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perindopril  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sophoraflavanone B  (ISO)
succimer  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
toluene  (ISO)
tremolite asbestos  (EXP)
triadimefon  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
xanthohumol  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Small bowel ischaemia-reperfusion increases plasma concentrations of oxidised proteins in rats. Abu-Zidan FM, etal., Eur J Surg. 1999 Apr;165(4):383-9.
2. Baseline vWF factor predicts the development of elevated pulmonary artery pressure in systemic sclerosis. Barnes T, etal., Rheumatology (Oxford). 2012 Sep;51(9):1606-9. Epub 2012 May 16.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPIb-dependent process, defective in Bernard-Soulier syndrome. Beguin S, etal., J Thromb Haemost. 2004 Jan;2(1):170-6.
5. The vascular biology of the glycoprotein Ib-IX-V complex. Berndt MC, etal., Thromb Haemost. 2001 Jul;86(1):178-88.
6. Von Willebrand factor antigen levels in Behcet disease. Beyan E, etal., Am J Hematol. 2005 May;79(1):70-2.
7. Hypoxia and altered platelet behavior influence von Willebrand factor multimeric composition in secondary pulmonary hypertension. Caramuru LH, etal., Clin Appl Thromb Hemost. 2003 Jul;9(3):251-8.
8. Rosiglitazone does not improve vascular function in subjects with chronic kidney disease. Chan DT, etal., Nephrol Dial Transplant. 2011 Nov;26(11):3543-9. doi: 10.1093/ndt/gfr049. Epub 2011 Mar 4.
9. Variable content of von Willebrand factor mutant monomer drives the phenotypic variability in a family with von Willebrand disease. Chen J, etal., Blood. 2015 Jul 9;126(2):262-9. doi: 10.1182/blood-2014-11-613935. Epub 2015 May 27.
10. Effect of abdominal obesity on prothrombotic tendency in type 2 diabetes. Behavior of clotting factors VII and VIII, fibrinogen and von Willebrand Factor. Coca M, etal., Rom J Intern Med. 2005;43(1-2):115-26.
11. Oxidation of Met1606 in von Willebrand factor is a risk factor for thrombotic and septic complications in chronic renal failure. De Filippis V, etal., Biochem J. 2012 Mar 1;442(2):423-32. doi: 10.1042/BJ20111798.
12. Dominant type 1 von Willebrand disease caused by mutated cysteine residues in the D3 domain of von Willebrand factor. Eikenboom JC, etal., Blood. 1996 Oct 1;88(7):2433-41.
13. Small intestinal production of nitric oxide is decreased following resuscitated hemorrhage. Fruchterman TM, etal., J Surg Res. 1998 Nov;80(1):102-9.
14. Circulating thrombomodulin and hematological alterations in type 2 diabetic patients with retinopathy. Fujiwara Y, etal., J Atheroscler Thromb. 1998;5(1):21-8.
15. Long Non-coding RNA MALAT1/microRNA-143/VEGFA Signal Axis Modulates Vascular Endothelial Injury-Induced Intracranial Aneurysm. Gao G, etal., Nanoscale Res Lett. 2020 Jun 29;15(1):139. doi: 10.1186/s11671-020-03357-2.
16. Effects of Radix et Rhizoma Rhodiolae Kirilowii on expressions of von Willebrand factor, hypoxia-inducible factor 1 and vascular endothelial growth factor in myocardium of rats with acute myocardial infarction. Gao XF, etal., Zhong Xi Yi Jie He Xue Bao. 2009 May;7(5):434-40. doi: 10.3736/jcim20090507.
17. Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease. Gill JC, etal., Blood. 2015 Oct 22;126(17):2038-46. doi: 10.1182/blood-2015-02-629873. Epub 2015 Aug 3.
18. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. Gralinski LE, etal., mBio. 2013 Aug 6;4(4). pii: mBio.00271-13. doi: 10.1128/mBio.00271-13.
19. Impact of alpha-tocopherol and vitamin C on endothelial markers in rats with streptozotocin-induced diabetes. Haidara MA, etal., Med Sci Monit. 2004 Feb;10(2):BR41-6.
20. Neurovascular protection conferred by 2-BFI treatment during rat cerebral ischemia. Han Z, etal., Biochem Biophys Res Commun. 2012 Aug 3;424(3):544-8. doi: 10.1016/j.bbrc.2012.06.152. Epub 2012 Jul 6.
21. Type 2M vWD resulting from a lysine deletion within a four lysine residue repeat in the A1 loop of von Willebrand factor. Hilbert L, etal., Thromb Haemost. 2000 Aug;84(2):188-94.
22. Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor. Hope S, etal., Bipolar Disord. 2009 Nov;11(7):726-34. doi: 10.1111/j.1399-5618.2009.00757.x.
23. Hypothermia-induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model. Horioka K, etal., J Thromb Haemost. 2019 Oct;17(10):1762-1771. doi: 10.1111/jth.14555. Epub 2019 Jul 17.
24. Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome. Ito-Habe N, etal., Int J Hematol. 2011 Jan;93(1):47-52. doi: 10.1007/s12185-010-0732-4. Epub 2010 Dec 9.
25. A randomised pilot trial of the anti-von Willebrand factor aptamer ARC1779 in patients with type 2b von Willebrand disease. Jilma B, etal., Thromb Haemost. 2010 Sep;104(3):563-70. doi: 10.1160/TH10-01-0027. Epub 2010 Jun 29.
26. Endothelial haemostatic markers in members of families with familial combined hyperlipidemia. Karásek D, etal., Thromb Res. 2009;123(3):466-75. doi: 10.1016/j.thromres.2008.02.011. Epub 2008 Apr 16.
27. Distribution of von Willebrand factor in capillary endothelial cells of rat lungs with pulmonary fibrosis. Kasper M, etal., Exp Toxicol Pathol. 1996 Jun;48(4):283-8.
28. Expression of von Willebrand factor in normal and diseased rat livers and in cultivated liver cells. Knittel T, etal., Hepatology. 1995 Feb;21(2):470-6.
29. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees. Kunicki TJ, etal., Blood. 2004 Oct 15;104(8):2359-67. Epub 2004 Jun 29.
30. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
31. Qualitative and quantitative modifications of von Willebrand factor in patients with essential thrombocythemia and controlled platelet count. Lancellotti S, etal., J Thromb Haemost. 2015 Jul;13(7):1226-37. doi: 10.1111/jth.12967. Epub 2015 May 22.
32. Anticoagulatory, antiinflammatory, and antioxidative effects of protocatechuic acid in diabetic mice. Lin CY, etal., J Agric Food Chem. 2009 Aug 12;57(15):6661-7. doi: 10.1021/jf9015202.
33. Total plasmatic homocysteine and von Willebrand factor in experimental diabetes mellitus. Lopes RD, etal., Arq Bras Cardiol. 2007 Apr;88(4):424-9.
34. Type 2M:Milwaukee-1 von Willebrand disease: an in-frame deletion in the Cys509-Cys695 loop of the von Willebrand factor A1 domain causes deficient binding of von Willebrand factor to platelets. Mancuso DJ, etal., Blood. 1996 Oct 1;88(7):2559-68.
35. Characterization of partial gene deletions in type III von Willebrand disease with alloantibody inhibitors. Mancuso DJ, etal., Thromb Haemost. 1994 Aug;72(2):180-5.
36. Diffuse and persistent blood-spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells. Matsushita T, etal., Exp Neurol. 2015 May;267:152-64. doi: 10.1016/j.expneurol.2015.03.001. Epub 2015 Mar 12.
37. Is visceral adipose tissue a determinant of von Willebrand factor in overweight and obese premenopausal women? Mertens I, etal., Metabolism. 2006 May;55(5):650-5.
38. MGDs mouse GO annotations MGD data from the GO Consortium
39. MGD IEA MGD IEA
40. von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura. Moake JL Semin Hematol. 2004 Jan;41(1):4-14.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. Early embryonic expression of murine coagulation system components. Ong K, etal., Thromb Haemost 2000 Dec;84(6):1023-30.
43. Kynurenine pathway - a new link between endothelial dysfunction and carotid atherosclerosis in chronic kidney disease patients. Pawlak K, etal., Adv Med Sci. 2010;55(2):196-203. doi: 10.2478/v10039-010-0015-6.
44. Plasma concentration of von Willebrand factor predicts mortality in patients on chronic renal replacement therapy. Pequeriaux NC, etal., Nephrol Dial Transplant. 2012 Jun;27(6):2452-7. doi: 10.1093/ndt/gfr735. Epub 2011 Dec 20.
45. Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura. Peyvandi F, etal., N Engl J Med. 2016 Feb 11;374(6):511-22. doi: 10.1056/NEJMoa1505533.
46. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
47. Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B. Rayes J, etal., Blood. 2010 Jun 10;115(23):4870-7. doi: 10.1182/blood-2009-11-254193. Epub 2010 Mar 3.
48. Injury induces increase of von Willebrand factor in rat endothelial cells. Reidy MA, etal., Am J Pathol. 1989 Apr;134(4):857-64.
49. Mouse MP Annotation Import Pipeline RGD automated import pipeline
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Aortic endothelial cell von Willebrand factor content, and circulating plasminogen activator inhibitor-1 are increased, but expression of endothelial leukocyte adhesion molecules is unchanged in insulin-dependent diabetic BB rats. Ribau JC, etal., Atherosclerosis. 2000 Apr;149(2):331-42.
53. Plasma von Willebrand factor levels are an independent risk factor for adverse events including mortality and major bleeding in anticoagulated atrial fibrillation patients. Roldan V, etal., J Am Coll Cardiol. 2011 Jun 21;57(25):2496-504. doi: 10.1016/j.jacc.2010.12.033. Epub 2011 Apr 14.
54. Characterization of cytomegalovirus disease in solid organ transplant recipients by markers of inflammation in plasma. Rollag H, etal., PLoS One. 2013 Apr 8;8(4):e60767. doi: 10.1371/journal.pone.0060767. Print 2013.
55. Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Rosen ED, etal., Nature 1997 Nov 20;390(6657):290-4.
56. Increased levels of endothelial haemostatic markers in patients with coronary heart disease. Schumacher A, etal., Thromb Res. 2002 Jan 1;105(1):25-31.
57. [Effect of the recombinant staphylokinase on pancreatic ischemia in severe acute pancreatitis of rats]. Sha JP, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 Aug;19(8):467-70.
58. The important role of von Willebrand factor in platelet-derived FVIII gene therapy for murine hemophilia A in the presence of inhibitory antibodies. Shi Q, etal., J Thromb Haemost. 2015 Jul;13(7):1301-9. doi: 10.1111/jth.13001. Epub 2015 Jun 11.
59. Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population. Sun W, etal., Int Orthop. 2006 Jun;30(3):143-6. doi: 10.1007/s00264-005-0067-6. Epub 2006 Mar 18.
60. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences Sun YX, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 May;35(3):315-8.
61. Injury of the renal microvascular endothelium alters barrier function after ischemia. Sutton TA, etal., Am J Physiol Renal Physiol. 2003 Aug;285(2):F191-8. Epub 2003 Apr 8.
62. Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer. van der Veldt AA, etal., Int J Cancer. 2012 Aug 15;131(4):E484-93. doi: 10.1002/ijc.26456. Epub 2011 Nov 8.
63. Expression of the molecule detectable by anti-propolypeptide of von Willebrand factor antibody in rat mesangial cells in anti-Thy 1.1 mAb 1-22-3 induced glomerulonephritis: A marker of injured mesangial cells. Wakasugi M, etal., Nephron. 1999;82(4):338-47.
64. Biomarkers of endothelial dysfunction in patients with primary focal segmental glomerulosclerosis. Zhang Q, etal., Nephrology (Carlton). 2012 May;17(4):338-45. doi: 10.1111/j.1440-1797.2012.01575.x.
65. [Study on changes of blood coagulation factors in rats with hemorrhagic shock]. Zhang YJ, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Feb;13(1):110-3.
66. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
Additional References at PubMed
PMID:1317267   PMID:1384789   PMID:1630810   PMID:1936575   PMID:7490564   PMID:7502236   PMID:7526952   PMID:7662996   PMID:7681362   PMID:7683699   PMID:7854452   PMID:7896277  
PMID:7987303   PMID:8118024   PMID:8179996   PMID:8193357   PMID:8201022   PMID:8318738   PMID:8562500   PMID:8678996   PMID:8782436   PMID:8817457   PMID:8889548   PMID:8918453  
PMID:8950511   PMID:8986815   PMID:9686317   PMID:9689083   PMID:9689113   PMID:9806594   PMID:10349636   PMID:10359181   PMID:10441735   PMID:10552950   PMID:10625534   PMID:10688827  
PMID:10706142   PMID:10722222   PMID:10926765   PMID:10930441   PMID:10976050   PMID:10981960   PMID:11015584   PMID:11042159   PMID:11071623   PMID:11076861   PMID:11154224   PMID:11159184  
PMID:11212329   PMID:11217851   PMID:11389024   PMID:11493531   PMID:11520791   PMID:11691837   PMID:11807041   PMID:11891199   PMID:12122015   PMID:12160745   PMID:12217325   PMID:12393668  
PMID:12466851   PMID:12477932   PMID:12526796   PMID:12556486   PMID:12606288   PMID:12871266   PMID:14604963   PMID:14610273   PMID:14613933   PMID:14981081   PMID:15239958   PMID:15322537  
PMID:15327970   PMID:15572153   PMID:15591414   PMID:15616565   PMID:15731176   PMID:15875024   PMID:15956287   PMID:15967814   PMID:16141072   PMID:16141073   PMID:16505993   PMID:16638935  
PMID:16788103   PMID:16823491   PMID:16824188   PMID:16873672   PMID:16895970   PMID:16956626   PMID:16980969   PMID:17003372   PMID:17013884   PMID:17119108   PMID:17148587   PMID:17155961  
PMID:17376515   PMID:17380206   PMID:17438136   PMID:17656671   PMID:17699753   PMID:17996853   PMID:18048367   PMID:18058911   PMID:18059000   PMID:18083848   PMID:18084279   PMID:18187670  
PMID:18245384   PMID:18256319   PMID:18263586   PMID:18281502   PMID:18287559   PMID:18395835   PMID:18469803   PMID:18485763   PMID:18487513   PMID:18550847   PMID:18556568   PMID:18559674  
PMID:18627106   PMID:18688020   PMID:18695007   PMID:18752568   PMID:18758859   PMID:18802014   PMID:18992737   PMID:19036705   PMID:19088380   PMID:19182208   PMID:19332769   PMID:19377048  
PMID:19619540   PMID:19644667   PMID:19687510   PMID:19705428   PMID:19737616   PMID:19769963   PMID:19789385   PMID:19808696   PMID:19864314   PMID:19910638   PMID:19965676   PMID:20164094  
PMID:20194895   PMID:20360471   PMID:20363914   PMID:20371742   PMID:20457761   PMID:20530543   PMID:20551517   PMID:20558824   PMID:20606161   PMID:20616311   PMID:20624989   PMID:20684947  
PMID:20695979   PMID:20704649   PMID:20713964   PMID:20716766   PMID:20959603   PMID:21037087   PMID:21048155   PMID:21148427   PMID:21172336   PMID:21220740   PMID:21266777   PMID:21267068  
PMID:21300875   PMID:21346256   PMID:21570975   PMID:21693521   PMID:21708977   PMID:21873635   PMID:22001909   PMID:22012621   PMID:22134168   PMID:22159717   PMID:22267483   PMID:22372972  
PMID:22374700   PMID:22437503   PMID:22539596   PMID:22616016   PMID:22622036   PMID:22642380   PMID:22712744   PMID:22720736   PMID:22855607   PMID:22915646   PMID:22962592   PMID:22972987  
PMID:22983446   PMID:23139760   PMID:23178125   PMID:23335368   PMID:23335371   PMID:23343833   PMID:23426945   PMID:23529929   PMID:23580145   PMID:23720451   PMID:23737952   PMID:23742235  
PMID:23797810   PMID:23812299   PMID:23823180   PMID:23825365   PMID:23840065   PMID:23863621   PMID:23945153   PMID:24006456   PMID:24081657   PMID:24200682   PMID:24261607   PMID:24270421  
PMID:24357063   PMID:24477232   PMID:24504734   PMID:24553180   PMID:24553181   PMID:24642750   PMID:24700724   PMID:24713928   PMID:24733925   PMID:24755984   PMID:24805242   PMID:24850761  
PMID:24951431   PMID:24982209   PMID:25051961   PMID:25091710   PMID:25147341   PMID:25180602   PMID:25293780   PMID:25343959   PMID:25401279   PMID:25650553   PMID:25681586   PMID:25690668  
PMID:25728415   PMID:25905473   PMID:25931511   PMID:25977583   PMID:26047609   PMID:26156014   PMID:26209660   PMID:26266817   PMID:26329599   PMID:26494840   PMID:26511133   PMID:26517044  
PMID:26527618   PMID:26565707   PMID:26743845   PMID:26744078   PMID:26878215   PMID:26952749   PMID:26953188   PMID:27125875   PMID:27207787   PMID:27212476   PMID:27444201   PMID:27507004  
PMID:27554083   PMID:27602496   PMID:27782211   PMID:27889498   PMID:27943541   PMID:28071719   PMID:28216153   PMID:28428179   PMID:28487393   PMID:28495930   PMID:28527913   PMID:28572286  
PMID:28581694   PMID:28642239   PMID:28643773   PMID:28684544   PMID:28868583   PMID:28924218   PMID:29097365   PMID:29106382   PMID:29114040   PMID:29251627   PMID:29282218   PMID:29298288  
PMID:29348121   PMID:29392565   PMID:29456137   PMID:29618155   PMID:29729651   PMID:29925524   PMID:29941674   PMID:30026593   PMID:30033122   PMID:30124466   PMID:30287479   PMID:30565388  
PMID:30566624   PMID:30573509   PMID:30665023   PMID:30898865   PMID:30936179   PMID:30936549   PMID:30975637   PMID:31099973   PMID:31112136   PMID:31315435   PMID:31351040   PMID:31501155  
PMID:31594977   PMID:31594992   PMID:31606553   PMID:31758944   PMID:31902309   PMID:31974202   PMID:32059772   PMID:32135568   PMID:32870970   PMID:32967458   PMID:32998468   PMID:33057196  
PMID:33372189   PMID:33507292   PMID:33576766   PMID:33939120   PMID:34321999   PMID:34478462   PMID:34619301   PMID:34816104   PMID:34850819   PMID:35014213   PMID:35929448   PMID:35969769  
PMID:36239312   PMID:36347239   PMID:36928925   PMID:37185919   PMID:37720212   PMID:37756521   PMID:37759076   PMID:38355315   PMID:38374152   PMID:38461614  


Genomics

Comparative Map Data
Vwf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,529,911 - 125,663,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,523,737 - 125,663,642 (+)EnsemblGRCm39 Ensembl
GRCm386125,552,948 - 125,686,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,546,774 - 125,686,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,502,981 - 125,636,695 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,520,072 - 125,652,161 (+)NCBIMGSCv36mm8
Celera6127,212,807 - 127,346,911 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
VWF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38125,948,877 - 6,124,670 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl125,948,877 - 6,124,770 (-)EnsemblGRCh38hg38GRCh38
GRCh37126,058,043 - 6,233,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,928,301 - 6,104,097 (-)NCBINCBI36Build 36hg18NCBI36
Build 34125,928,307 - 6,104,097NCBI
Celera127,677,686 - 7,853,476 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef125,910,003 - 6,085,514 (-)NCBIHuRef
CHM1_1126,057,433 - 6,233,298 (-)NCBICHM1_1
T2T-CHM13v2.0125,956,421 - 6,132,275 (-)NCBIT2T-CHM13v2.0
Vwf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84160,042,900 - 160,177,757 (+)NCBIGRCr8
mRatBN7.24158,360,152 - 158,491,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,360,152 - 158,491,539 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4164,595,998 - 164,727,404 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04160,378,929 - 160,510,343 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04159,012,985 - 159,144,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04158,085,059 - 158,219,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4158,088,505 - 158,219,523 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04225,098,521 - 225,229,257 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,723,415 - 161,854,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14162,053,065 - 162,055,090 (+)NCBI
Celera4147,092,791 - 147,223,711 (+)NCBICelera
Cytogenetic Map4q42NCBI
Vwf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554133,672,470 - 3,819,571 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554133,672,470 - 3,825,588 (-)NCBIChiLan1.0ChiLan1.0
VWF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21011,504,401 - 11,680,404 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11211,501,159 - 11,677,162 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,073,836 - 6,249,806 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1125,990,612 - 6,166,632 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl125,990,612 - 6,165,153 (-)Ensemblpanpan1.1panPan2
VWF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,834,812 - 38,972,614 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,833,837 - 39,320,142 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,641,828 - 7,779,174 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02739,191,850 - 39,329,540 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2739,193,140 - 39,329,536 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12739,062,625 - 39,200,071 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02739,104,190 - 39,241,989 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,119,622 - 7,257,688 (-)NCBIUU_Cfam_GSD_1.0
Vwf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,910,587 - 103,074,328 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367091,579,096 - 1,741,754 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367091,578,137 - 1,741,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VWF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl564,519,186 - 65,002,452 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,516,627 - 64,655,938 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,999,793 - 67,078,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q21NCBI
VWF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,994,499 - 6,176,949 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,994,039 - 6,162,260 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660632,072,116 - 2,236,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vwf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248602,858,088 - 2,973,052 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248602,843,268 - 2,973,888 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vwf
5095 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2279
Count of miRNA genes:770
Interacting mature miRNAs:988
Transcripts:ENSMUST00000001995, ENSMUST00000100941, ENSMUST00000112253, ENSMUST00000112254, ENSMUST00000126709, ENSMUST00000129436, ENSMUST00000134073, ENSMUST00000139678, ENSMUST00000141521, ENSMUST00000146264, ENSMUST00000147101, ENSMUST00000150548
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
4141611Btts_mbitterness tasting (mouse)Not determined6125333609134096586Mouse

Markers in Region
AI551257  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386125,686,479 - 125,686,615UniSTSGRCm38
MGSCv376125,636,497 - 125,636,633UniSTSGRCm37
Celera6127,346,713 - 127,346,849UniSTS
Cytogenetic Map6F3UniSTS
cM Map660.8UniSTS
Whitehead/MRC_RH61269.99UniSTS
D6Mit334  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386125,618,124 - 125,618,224UniSTSGRCm38
MGSCv376125,568,142 - 125,568,242UniSTSGRCm37
Celera6127,278,060 - 127,278,160UniSTS
Cytogenetic Map6F3UniSTS
cM Map660.75UniSTS
Whitehead Genetic649.2UniSTS
Whitehead/MRC_RH61270.52UniSTS
Whitehead_YAC6 UniSTS
PMC15073P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386125,642,319 - 125,643,013UniSTSGRCm38
MGSCv376125,592,337 - 125,593,031UniSTSGRCm37
Celera6127,302,197 - 127,302,891UniSTS
Cytogenetic Map6F3UniSTS
cM Map660.8UniSTS
Vwf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386125,642,930 - 125,643,130UniSTSGRCm38
MGSCv376125,592,948 - 125,593,148UniSTSGRCm37
Celera6127,302,808 - 127,303,008UniSTS
Cytogenetic Map6F3UniSTS
cM Map660.8UniSTS
PMC26753P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386125,642,258 - 125,642,742UniSTSGRCm38
MGSCv376125,592,276 - 125,592,760UniSTSGRCm37
Celera6127,302,136 - 127,302,620UniSTS
Cytogenetic Map6F3UniSTS
cM Map660.8UniSTS
Vwf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386125,642,269 - 125,642,470UniSTSGRCm38
MGSCv376125,592,287 - 125,592,488UniSTSGRCm37
Celera6127,302,147 - 127,302,348UniSTS
Cytogenetic Map6F3UniSTS
cM Map660.8UniSTS
Vwf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F3UniSTS
cM Map660.8UniSTS
Vwf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F3UniSTS
cM Map660.8UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC153580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF152417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF539800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY162409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY208897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY515508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB653375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF662502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI133662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ355287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ355288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U27810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000100941   ⟹   ENSMUSP00000098502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,523,737 - 125,569,137 (+)Ensembl
GRCm38.p6 Ensembl6125,546,774 - 125,592,174 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112253   ⟹   ENSMUSP00000107872
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,529,926 - 125,569,434 (+)Ensembl
GRCm38.p6 Ensembl6125,552,963 - 125,592,471 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112254   ⟹   ENSMUSP00000107873
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,529,911 - 125,663,642 (+)Ensembl
GRCm38.p6 Ensembl6125,552,948 - 125,686,679 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126709
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,543,214 - 125,555,541 (+)Ensembl
GRCm38.p6 Ensembl6125,566,251 - 125,578,578 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129436
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,631,894 - 125,633,590 (+)Ensembl
GRCm38.p6 Ensembl6125,654,931 - 125,656,627 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134073
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,580,513 - 125,619,887 (+)Ensembl
GRCm38.p6 Ensembl6125,603,550 - 125,642,924 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139678
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,611,311 - 125,613,625 (+)Ensembl
GRCm38.p6 Ensembl6125,634,348 - 125,636,662 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,623,302 - 125,638,930 (+)Ensembl
GRCm38.p6 Ensembl6125,646,339 - 125,661,967 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146264
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,662,700 - 125,663,598 (+)Ensembl
GRCm38.p6 Ensembl6125,685,737 - 125,686,635 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147101   ⟹   ENSMUSP00000138132
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,626,232 - 125,663,635 (+)Ensembl
GRCm38.p6 Ensembl6125,649,269 - 125,686,672 (+)Ensembl
RefSeq Acc Id: ENSMUST00000150548
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,529,926 - 125,581,739 (+)Ensembl
GRCm38.p6 Ensembl6125,552,963 - 125,604,776 (+)Ensembl
RefSeq Acc Id: NM_011708   ⟹   NP_035838
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396125,529,911 - 125,663,642 (+)NCBI
GRCm386125,552,948 - 125,686,679 (+)NCBI
MGSCv376125,502,981 - 125,636,695 (+)RGD
Celera6127,212,792 - 127,346,913 (+)NCBI
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505918   ⟹   XP_006505981
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396125,542,492 - 125,663,638 (+)NCBI
GRCm386125,565,406 - 125,686,675 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035838   ⟸   NM_011708
- Peptide Label: precursor
- UniProtKB: E9QPU1 (UniProtKB/TrEMBL),   Q2I0J8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505981   ⟸   XM_006505918
- Peptide Label: isoform X1
- UniProtKB: Q2I0J8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000138132   ⟸   ENSMUST00000147101
RefSeq Acc Id: ENSMUSP00000107873   ⟸   ENSMUST00000112254
RefSeq Acc Id: ENSMUSP00000107872   ⟸   ENSMUST00000112253
RefSeq Acc Id: ENSMUSP00000098502   ⟸   ENSMUST00000100941
Protein Domains
CTCK   TIL   VWFA   VWFC   VWFD

Promoters
RGD ID:6891072
Promoter ID:EPDNEW_M8987
Type:multiple initiation site
Name:Vwf_1
Description:Mus musculus Von Willebrand factor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8988  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386125,552,963 - 125,553,023EPDNEW
RGD ID:6840152
Promoter ID:MM_KWN:47655
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:UC009DUT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366125,553,366 - 125,553,866 (+)MPROMDB
RGD ID:6891090
Promoter ID:EPDNEW_M8988
Type:multiple initiation site
Name:Vwf_2
Description:Mus musculus Von Willebrand factor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8987  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386125,649,906 - 125,649,966EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98941 AgrOrtholog
Ensembl Genes ENSMUSG00000001930 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000100941.9 UniProtKB/TrEMBL
  ENSMUST00000112253.6 UniProtKB/TrEMBL
  ENSMUST00000112254 ENTREZGENE
  ENSMUST00000112254.8 UniProtKB/TrEMBL
  ENSMUST00000147101.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys_knot UniProtKB/TrEMBL
  Cys_knot_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Unchr_dom_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Von_Willebrand_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_type-D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98941 ENTREZGENE
NCBI Gene 22371 ENTREZGENE
PANTHER EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MUCIN-2-LIKE-RELATED UniProtKB/TrEMBL
  PTHR11339:SF361 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/TrEMBL
  PF08742 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Vwf PhenoGen
PIRSF VWF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS VWFADOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CTCK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTCK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00832 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC_out UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57567 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2VCN5_MOUSE UniProtKB/TrEMBL
  E9QPU1 ENTREZGENE, UniProtKB/TrEMBL
  Q2I0J7_MOUSE UniProtKB/TrEMBL
  Q2I0J8 ENTREZGENE, UniProtKB/TrEMBL
  Q3TD35_MOUSE UniProtKB/TrEMBL
  Q3TPE1_MOUSE UniProtKB/TrEMBL
  Q3U017_MOUSE UniProtKB/TrEMBL
  Q8CIZ8 ENTREZGENE
  S4R195_MOUSE UniProtKB/TrEMBL
  VWF_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q60863 UniProtKB/Swiss-Prot
  Q6XUV6 UniProtKB/Swiss-Prot
  Q8BIU9 UniProtKB/Swiss-Prot
  Q8CGN0 UniProtKB/Swiss-Prot
  Q9JK16 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 Vwf  Von Willebrand factor    Von Willebrand factor homolog  Symbol and/or name change 5135510 APPROVED