Mrgprd (MAS-related GPR, member D) - Rat Genome Database

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Gene: Mrgprd (MAS-related GPR, member D) Mus musculus
Analyze
Symbol: Mrgprd
Name: MAS-related GPR, member D
RGD ID: 1553636
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in genitourinary system; nervous system; and skin. Used to study dilated cardiomyopathy. Orthologous to human MRGPRD (MAS related GPR family member D).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-alanine receptor; G protein-coupled receptor MrgD; G-protein coupled receptor TGR7; Gm499; Mas-related G protein-coupled receptor d; mas-related G-protein coupled receptor member D; Mgrd; Mrg; MrgD; TGR7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,868,572 - 144,877,796 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,868,572 - 144,877,823 (+)EnsemblGRCm39 Ensembl
GRCm387145,314,835 - 145,324,059 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7145,314,835 - 145,324,086 (+)EnsemblGRCm38mm10GRCm38
MGSCv377152,500,740 - 152,509,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367145,124,225 - 145,133,449 (+)NCBIMGSCv36mm8
Celera7145,083,196 - 145,092,547 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map789.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.
Additional References at PubMed
PMID:11551509   PMID:12397184   PMID:12477932   PMID:15037633   PMID:15629699   PMID:16446141   PMID:16602821   PMID:17553423   PMID:17618277   PMID:18171930   PMID:18234974   PMID:18498732  
PMID:18498735   PMID:19451647   PMID:19564617   PMID:19571152   PMID:19846708   PMID:20064391   PMID:20096094   PMID:20147550   PMID:21267068   PMID:21543603   PMID:21873635   PMID:22787056  
PMID:23077038   PMID:23266932   PMID:23364746   PMID:23536068   PMID:24194600   PMID:24316076   PMID:24549959   PMID:24583022   PMID:24583173   PMID:25111710   PMID:25369838   PMID:25834056  
PMID:27217404   PMID:28476948   PMID:29022879   PMID:29045838   PMID:29066740   PMID:29864146   PMID:29988128   PMID:30148678   PMID:30225912   PMID:30339496   PMID:30408082   PMID:30532001  
PMID:30563864   PMID:30826183   PMID:30917309   PMID:30919047   PMID:31248728   PMID:31390574   PMID:31392515   PMID:31801063   PMID:32084332   PMID:32769979   PMID:32810432   PMID:33080316  
PMID:33091423   PMID:33116307   PMID:33692491   PMID:33765440   PMID:33789102   PMID:33876765   PMID:34130311   PMID:34346721   PMID:34580157   PMID:34980925   PMID:35258714   PMID:35561677  
PMID:35732741   PMID:35875660   PMID:35979816   PMID:36278870   PMID:36334588   PMID:36641071   PMID:36693373   PMID:36961815   PMID:37250305   PMID:37464016   PMID:37541195   PMID:37851573  
PMID:37889748   PMID:38147415   PMID:38335058   PMID:38355793   PMID:38810919   PMID:38915692  


Genomics

Comparative Map Data
Mrgprd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,868,572 - 144,877,796 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,868,572 - 144,877,823 (+)EnsemblGRCm39 Ensembl
GRCm387145,314,835 - 145,324,059 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7145,314,835 - 145,324,086 (+)EnsemblGRCm38mm10GRCm38
MGSCv377152,500,740 - 152,509,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367145,124,225 - 145,133,449 (+)NCBIMGSCv36mm8
Celera7145,083,196 - 145,092,547 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map789.06NCBI
MRGPRD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,980,021 - 68,980,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,980,021 - 68,980,986 (-)EnsemblGRCh38hg38GRCh38
GRCh371168,747,490 - 68,748,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361168,504,066 - 68,505,031 (-)NCBINCBI36Build 36hg18NCBI36
Build 341168,504,065 - 68,505,031NCBI
Celera1166,087,241 - 66,088,206 (-)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1165,086,709 - 65,087,666 (-)NCBIHuRef
CHM1_11168,630,734 - 68,631,699 (-)NCBICHM1_1
T2T-CHM13v2.01168,990,212 - 68,991,177 (-)NCBIT2T-CHM13v2.0
Mrgprd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,908,487 - 209,917,183 (+)NCBIGRCr8
mRatBN7.21200,479,204 - 200,487,902 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,485,189 - 200,486,148 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,860,568 - 208,861,527 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,947,137 - 215,948,096 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,621,341 - 208,622,300 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,481,146 - 218,491,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,487,824 - 218,488,783 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,348,996 - 225,358,326 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,771,612 - 205,772,571 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,925,064 - 205,926,024 (+)NCBI
Celera1198,039,696 - 198,040,655 (+)NCBICelera
Cytogenetic Map1q42NCBI
Mrgprd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,980,932 - 16,981,903 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,980,896 - 16,981,906 (+)NCBIChiLan1.0ChiLan1.0
MRGPRD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2969,937,571 - 69,940,015 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,977,299 - 70,983,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01164,069,508 - 64,070,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11167,370,432 - 67,371,399 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1167,370,432 - 67,371,397 (-)Ensemblpanpan1.1panPan2
MRGPRD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,028,149 - 49,029,198 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,028,149 - 49,029,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,635,397 - 47,636,446 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,702,851 - 49,703,900 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1849,702,851 - 49,703,900 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,148,742 - 49,149,703 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,735,109 - 48,736,158 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01849,481,779 - 49,482,828 (+)NCBIUU_Cfam_GSD_1.0
Mrgprd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,941,988 - 4,942,947 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365991,384,216 - 1,385,296 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRGPRD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115,591,179 - 5,593,796 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038102,872,023 - 102,873,328 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrgprd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476717,999,897 - 18,000,932 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrgprd
228 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:925
Count of miRNA genes:521
Interacting mature miRNAs:591
Transcripts:ENSMUST00000062163
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000062163   ⟹   ENSMUSP00000063021
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7144,868,572 - 144,877,823 (+)Ensembl
GRCm38.p6 Ensembl7145,314,835 - 145,324,086 (+)Ensembl
RefSeq Acc Id: NM_203490   ⟹   NP_987075
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397144,868,572 - 144,877,796 (+)NCBI
GRCm387145,314,835 - 145,324,059 (+)ENTREZGENE
MGSCv377152,500,740 - 152,509,964 (+)RGD
Celera7145,083,196 - 145,092,547 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_987075   ⟸   NM_203490
- UniProtKB: Q91ZB8 (UniProtKB/Swiss-Prot),   Q5UCB4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000063021   ⟸   ENSMUST00000062163
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
MRGD I-TASSER model Q91ZB8 1-321 view protein structure
AF-Q91ZB8-F1-model_v2 AlphaFold Q91ZB8 1-321 view protein structure

Promoters
RGD ID:8666307
Promoter ID:EPDNEW_M11185
Type:single initiation site
Name:Mrgprd_1
Description:Mus musculus MAS-related GPR, member D , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387145,314,749 - 145,314,809EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3033142 AgrOrtholog
Ensembl Genes ENSMUSG00000051207 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000062163 ENTREZGENE
  ENSMUST00000062163.8 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:211578 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3033142 ENTREZGENE
NCBI Gene 211578 ENTREZGENE
PANTHER MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mrgprd PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MRGRD_MOUSE UniProtKB/Swiss-Prot
  Q5UCB4 ENTREZGENE, UniProtKB/TrEMBL
  Q91ZB8 ENTREZGENE