Nr3c2 (nuclear receptor subfamily 3, group C, member 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Nr3c2 (nuclear receptor subfamily 3, group C, member 2) Mus musculus
Analyze
Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
RGD ID: 1553569
MGI Page MGI
Description: Enables steroid binding activity. Involved in several processes, including angiotensin-activated signaling pathway; potassium ion homeostasis; and regulation of blood volume by renal aldosterone. Acts upstream of or within intracellular sodium ion homeostasis and renal sodium excretion. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; intestine; and trophectoderm. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldosterone receptor; M; mineralocorticoid receptor; Mlr; MR; nuclear receptor subfamily 3 group C member 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39877,626,422 - 77,971,641 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl877,626,070 - 77,971,641 (+)EnsemblGRCm39 Ensembl
GRCm38876,898,083 - 77,245,012 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl876,899,442 - 77,245,012 (+)EnsemblGRCm38mm10GRCm38
MGSCv37879,426,407 - 79,767,538 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36879,765,155 - 80,141,081 (+)NCBIMGSCv36mm8
Celera881,194,433 - 81,532,459 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
11-deoxycorticosterone  (ISO)
11-deoxycortisol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3-phenoxybenzoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acephate  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
alachlor  (ISO)
aldosterone  (EXP,ISO)
allethrin  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
beclomethasone  (ISO)
Benoxacor  (EXP)
benzo[a]pyrene  (ISO)
betamethasone  (ISO)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bleomycin A2  (ISO)
budesonide  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (ISO)
caffeine  (ISO)
candesartan  (ISO)
canrenoic acid  (ISO)
carbamazepine  (ISO)
chlormequat chloride  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
cortisone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (ISO)
diethyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
dimethoate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drospirenone  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
enalapril  (ISO)
enzacamene  (ISO)
eplerenone  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP,ISO)
fipronil  (ISO)
flavonoids  (ISO)
fludrocortisone  (ISO)
flumethasone  (ISO)
fluoxetine  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
gentamycin  (ISO)
gypenoside LXXV  (EXP)
hydrochlorothiazide  (ISO)
irinotecan  (ISO)
L-methionine  (EXP)
lycopene  (EXP)
medroxyprogesterone acetate  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
mometasone furoate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP)
permethrin  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
prednisolone  (ISO)
prednylidene  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrethrins  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
spironolactone  (ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (ISO)
terbutylazine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
torasemide  (ISO)
torcetrapib  (ISO)
trametinib  (ISO)
triamcinolone  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
zineb  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Spironolactone reversed hepato-ovarian triglyceride accumulation caused by letrozole-induced polycystic ovarian syndrome: tissue uric acid-a familiar foe. Adeyanju OA, etal., Naunyn Schmiedebergs Arch Pharmacol. 2020 Jun;393(6):1055-1066. doi: 10.1007/s00210-020-01809-1. Epub 2020 Jan 10.
2. A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans. Aoun EG, etal., Mol Psychiatry. 2018 Jun;23(6):1466-1473. doi: 10.1038/mp.2017.97. Epub 2017 May 2.
3. Blocking the Mineralocorticoid Receptor Improves Cognitive Impairment after Anesthesia/Splenectomy in Rats. Feng X, etal., Int J Med Sci. 2021 Jan 1;18(2):387-397. doi: 10.7150/ijms.48767. eCollection 2021.
4. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Geller DS, etal., Nat Genet. 1998 Jul;19(3):279-81.
5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
6. Marinobufagenin in Urine: A Potential Marker of Predisposition to Ethanol and a Target for Spironolactone. Kashkin VA, etal., Curr Hypertens Rev. 2018;14(1):35-38. doi: 10.2174/1573402114666180212115518.
7. Chronic intermittent stress does not differentially alter brain corticosteroid receptor densities in rats prenatally exposed to ethanol. Kim CK, etal., Psychoneuroendocrinology. 1999 Aug;24(6):585-611. doi: 10.1016/s0306-4530(99)00015-3.
8. Interactive effects of prenatal alcohol exposure and chronic stress in adulthood on anxiety-like behavior and central stress-related receptor mRNA expression: Sex- and time-dependent effects. Lam VYY, etal., Psychoneuroendocrinology. 2018 Nov;97:8-19. doi: 10.1016/j.psyneuen.2018.06.018. Epub 2018 Jun 23.
9. Prenatal alcohol exposure and prenatal stress differentially alter glucocorticoid signaling in the placenta and fetal brain. Lan N, etal., Neuroscience. 2017 Feb 7;342:167-179. doi: 10.1016/j.neuroscience.2015.08.058. Epub 2015 Sep 2.
10. Central amygdala mineralocorticoid receptors modulate alcohol self-administration. Makhijani VH, etal., Neuropharmacology. 2020 Dec 15;181:108337. doi: 10.1016/j.neuropharm.2020.108337. Epub 2020 Sep 29.
11. The mineralocorticoid receptor antagonist spironolactone reduces alcohol self-administration in female and male rats. Makhijani VH, etal., Pharmacol Biochem Behav. 2018 Dec;175:10-18. doi: 10.1016/j.pbb.2018.07.011. Epub 2018 Aug 29.
12. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, etal., Mamm Genome 1996 Jun;7(6):413-6.
13. Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats. Mesripour A, etal., Basic Clin Pharmacol Toxicol. 2012 Aug;111(2):75-80. doi: 10.1111/j.1742-7843.2012.00860.x. Epub 2012 Feb 28.
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. Nakamura M, etal., J Toxicol Sci. 2018;43(10):611-621. doi: 10.2131/jts.43.611.
17. Spironolactone decreases the somatic signs of opiate withdrawal by blocking the mineralocorticoid receptors (MR). Navarro-Zaragoza J, etal., Toxicology. 2014 Dec 4;326:36-43. doi: 10.1016/j.tox.2014.10.002. Epub 2014 Oct 11.
18. Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain. Ngai YF, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R613-22. doi: 10.1152/ajpregu.00075.2015. Epub 2015 Jul 15.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism. Pujo L, etal., Hum Mutat. 2007 Jan;28(1):33-40.
23. Impact of adolescent stress on the expression of stress-related receptors in the hippocampus of animals exposed to alcohol prenatally. Raineki C, etal., Hippocampus. 2018 Mar;28(3):201-216. doi: 10.1002/hipo.22823. Epub 2018 Jan 8.
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Structural organization of the mouse glycophorin A gene. Terajima M, etal., J Biochem (Tokyo) 1994 Nov;116(5):1105-10.
28. Basal regulation of HPA and dopamine systems is altered differentially in males and females by prenatal alcohol exposure and chronic variable stress. Uban KA, etal., Psychoneuroendocrinology. 2013 Oct;38(10):1953-66. doi: 10.1016/j.psyneuen.2013.02.017. Epub 2013 Apr 8.
29. Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats. Van Waes V, etal., Eur J Neurosci. 2006 Aug;24(4):1193-200. doi: 10.1111/j.1460-9568.2006.04973.x. Epub 2006 Aug 21.
30. Crystal structure of the carbohydrate recognition domain of p58/ERGIC-53, a protein involved in glycoprotein export from the endoplasmic reticulum. Velloso LM, etal., J Biol Chem 2002 May 3;277(18):15979-84.
31. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:7713493   PMID:7759105   PMID:8668199   PMID:8733008   PMID:8761296   PMID:8884266   PMID:8889548   PMID:8972488   PMID:9143490   PMID:9457687   PMID:9689096   PMID:9973259  
PMID:10349636   PMID:10398852   PMID:10458909   PMID:10581199   PMID:10645956   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11258486   PMID:11338179   PMID:11495902   PMID:11591489  
PMID:11713657   PMID:11809749   PMID:11997477   PMID:12198239   PMID:12447992   PMID:12466851   PMID:12477932   PMID:15123520   PMID:15251441   PMID:15569353   PMID:15743993   PMID:15860252  
PMID:16118390   PMID:16141072   PMID:16141073   PMID:16361444   PMID:16368758   PMID:16554481   PMID:16602821   PMID:16971476   PMID:16973757   PMID:17360585   PMID:17384139   PMID:17432969  
PMID:17475815   PMID:17596887   PMID:18001136   PMID:18287559   PMID:18547242   PMID:19029984   PMID:19447109   PMID:19477942   PMID:19620512   PMID:19635986   PMID:19635989   PMID:19846540  
PMID:20059953   PMID:20207834   PMID:20363891   PMID:20434520   PMID:20663957   PMID:20697155   PMID:20843830   PMID:20849967   PMID:20861078   PMID:20932939   PMID:21242479   PMID:21267068  
PMID:21270097   PMID:21321305   PMID:21383102   PMID:21440617   PMID:21467193   PMID:21677750   PMID:21788604   PMID:21814189   PMID:21860595   PMID:21873635   PMID:22135314   PMID:22212769  
PMID:22234470   PMID:22326264   PMID:22543192   PMID:22653557   PMID:22798426   PMID:22831399   PMID:22919064   PMID:22922412   PMID:22940619   PMID:22962254   PMID:22962255   PMID:22988430  
PMID:23296296   PMID:23382219   PMID:23548632   PMID:23595884   PMID:23661677   PMID:23684652   PMID:23754993   PMID:24026182   PMID:24206662   PMID:24222670   PMID:24311380   PMID:24451386  
PMID:24465979   PMID:24490674   PMID:24491541   PMID:24566081   PMID:24567706   PMID:24603367   PMID:24664319   PMID:24713303   PMID:24806198   PMID:24952961   PMID:25057793   PMID:25317829  
PMID:25354087   PMID:25602134   PMID:25662276   PMID:25966493   PMID:26066075   PMID:26183312   PMID:26268211   PMID:26351032   PMID:26351033   PMID:26441470   PMID:26459855   PMID:26600250  
PMID:26605921   PMID:26712527   PMID:26879229   PMID:26966277   PMID:27253999   PMID:27422824   PMID:27464843   PMID:27683672   PMID:27881672   PMID:28087726   PMID:28298295   PMID:28325853  
PMID:28454724   PMID:28637706   PMID:28684740   PMID:28713285   PMID:28974571   PMID:29391190   PMID:29453308   PMID:29463624   PMID:29466427   PMID:29789551   PMID:29929989   PMID:29981797  
PMID:30021155   PMID:30038907   PMID:30595118   PMID:30664640   PMID:30759207   PMID:30900255   PMID:30934833   PMID:30946837   PMID:30953639   PMID:30992401   PMID:31294624   PMID:31440147  
PMID:31665900   PMID:31736768   PMID:31745235   PMID:31817997   PMID:32036385   PMID:32652691   PMID:33095647   PMID:33144612   PMID:33391254   PMID:33517669   PMID:33934622   PMID:34058848  
PMID:34077736   PMID:34325504   PMID:34615372   PMID:35020830   PMID:35044859   PMID:35281733   PMID:35314145   PMID:35563683   PMID:36109497   PMID:36834731   PMID:36873102   PMID:37018396  
PMID:37195271   PMID:37289042   PMID:37734559   PMID:37832761   PMID:38307407   PMID:38446896  


Genomics

Comparative Map Data
Nr3c2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39877,626,422 - 77,971,641 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl877,626,070 - 77,971,641 (+)EnsemblGRCm39 Ensembl
GRCm38876,898,083 - 77,245,012 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl876,899,442 - 77,245,012 (+)EnsemblGRCm38mm10GRCm38
MGSCv37879,426,407 - 79,767,538 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36879,765,155 - 80,141,081 (+)NCBIMGSCv36mm8
Celera881,194,433 - 81,532,459 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.34NCBI
NR3C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384148,078,764 - 148,445,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4148,078,762 - 148,444,698 (-)EnsemblGRCh38hg38GRCh38
GRCh374148,999,915 - 149,365,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364149,219,370 - 149,582,973 (-)NCBINCBI36Build 36hg18NCBI36
Build 344149,357,524 - 149,721,128NCBI
Celera4146,321,236 - 146,684,999 (-)NCBICelera
Cytogenetic Map4q31.23NCBI
HuRef4144,727,062 - 145,090,717 (-)NCBIHuRef
CHM1_14148,978,561 - 149,342,342 (-)NCBICHM1_1
T2T-CHM13v2.04151,402,689 - 151,769,605 (-)NCBIT2T-CHM13v2.0
Nr3c2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81947,619,853 - 47,964,089 (-)NCBIGRCr8
mRatBN7.21930,715,634 - 31,059,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,715,648 - 31,059,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1937,554,315 - 37,898,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01938,208,168 - 38,552,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01940,460,411 - 40,809,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01934,408,275 - 34,761,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1934,448,289 - 34,752,695 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01945,287,442 - 45,639,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,527,752 - 32,875,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11932,532,632 - 32,880,250 (-)NCBI
Celera1930,192,512 - 30,534,995 (-)NCBICelera
Cytogenetic Map19q11NCBI
Nr3c2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554713,061,735 - 3,395,520 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554713,059,210 - 3,397,894 (-)NCBIChiLan1.0ChiLan1.0
NR3C2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23145,955,891 - 146,322,035 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14146,318,234 - 146,684,514 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04140,418,624 - 140,785,180 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14152,072,962 - 152,435,965 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4152,108,508 - 152,430,298 (-)Ensemblpanpan1.1panPan2
NR3C2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11546,390,030 - 46,718,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1546,390,023 - 46,710,131 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1546,783,147 - 47,111,076 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01547,065,842 - 47,394,398 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1547,065,445 - 47,392,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11546,332,314 - 46,660,048 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01546,430,796 - 46,758,507 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01546,738,917 - 47,073,793 (-)NCBIUU_Cfam_GSD_1.0
Nr3c2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530143,702,929 - 44,030,134 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365351,140,178 - 1,467,471 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365351,139,687 - 1,467,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR3C2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl880,312,234 - 80,668,412 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1880,303,172 - 80,669,050 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2885,308,914 - 85,644,752 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR3C2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1794,574,010 - 94,935,348 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603774,281,853 - 74,644,245 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Nr3c2
12830 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2289
Count of miRNA genes:684
Interacting mature miRNAs:846
Transcripts:ENSMUST00000034031, ENSMUST00000109911, ENSMUST00000109912, ENSMUST00000109913, ENSMUST00000126697, ENSMUST00000128862, ENSMUST00000143284, ENSMUST00000148106
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
11039503Ccc4_mcolitis susceptibility in the Collaborative Cross 4 (mouse)86517423778002730Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86872247983326976Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7158942790929226Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse

Markers in Region
UniSTS:235932  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,011,261 - 77,011,606UniSTSGRCm38
MGSCv37879,535,160 - 79,535,505UniSTSGRCm37
Celera881,300,799 - 81,301,144UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS
PMC124545P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38876,908,815 - 76,909,134UniSTSGRCm38
MGSCv37879,432,714 - 79,433,033UniSTSGRCm37
Celera881,200,727 - 81,201,046UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS
G42952  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,244,860 - 77,244,991UniSTSGRCm38
MGSCv37879,768,759 - 79,768,890UniSTSGRCm37
Celera881,533,680 - 81,533,811UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001083906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001426575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001426576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001426577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001426578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC119248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02006570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ311855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ311856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC133713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ174990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ104355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000034031   ⟹   ENSMUSP00000034031
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl877,634,901 - 77,969,159 (+)Ensembl
GRCm38.p6 Ensembl876,908,272 - 77,242,530 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109911   ⟹   ENSMUSP00000105537
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl877,629,104 - 77,970,292 (+)Ensembl
GRCm38.p6 Ensembl876,902,476 - 77,243,663 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109912   ⟹   ENSMUSP00000105538
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl877,628,916 - 77,971,636 (+)Ensembl
GRCm38.p6 Ensembl876,902,288 - 77,245,007 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109913   ⟹   ENSMUSP00000105539
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl877,626,400 - 77,971,641 (+)Ensembl
GRCm38.p6 Ensembl876,899,772 - 77,245,012 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126697
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl877,854,642 - 77,912,501 (+)Ensembl
GRCm38.p6 Ensembl877,128,013 - 77,185,872 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128862   ⟹   ENSMUSP00000116008
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl877,628,975 - 77,635,285 (+)Ensembl
GRCm38.p6 Ensembl876,902,347 - 76,908,656 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143284   ⟹   ENSMUSP00000122959
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl877,626,070 - 77,635,042 (+)Ensembl
GRCm38.p6 Ensembl876,899,442 - 76,908,413 (+)Ensembl
RefSeq Acc Id: ENSMUST00000148106   ⟹   ENSMUSP00000118222
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl877,628,916 - 77,969,625 (+)Ensembl
GRCm38.p6 Ensembl876,902,288 - 77,242,996 (+)Ensembl
RefSeq Acc Id: NM_001083906   ⟹   NP_001077375
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39877,628,961 - 77,971,641 (+)NCBI
GRCm38876,902,330 - 77,245,012 (+)NCBI
MGSCv37879,426,407 - 79,767,538 (+)RGD
Celera881,194,433 - 81,532,459 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001426575   ⟹   NP_001413504
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39877,628,961 - 77,971,641 (+)NCBI
RefSeq Acc Id: NM_001426576   ⟹   NP_001413505
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39877,628,179 - 77,971,641 (+)NCBI
RefSeq Acc Id: NM_001426577   ⟹   NP_001413506
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39877,626,422 - 77,971,641 (+)NCBI
RefSeq Acc Id: NM_001426578   ⟹   NP_001413507
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39877,626,422 - 77,971,641 (+)NCBI
RefSeq Acc Id: XM_036153720   ⟹   XP_036009613
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39877,628,807 - 77,883,052 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001077375   ⟸   NM_001083906
- UniProtKB: Q8VII9 (UniProtKB/Swiss-Prot),   Q8VII8 (UniProtKB/Swiss-Prot),   A3KN90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000122959   ⟸   ENSMUST00000143284
RefSeq Acc Id: ENSMUSP00000034031   ⟸   ENSMUST00000034031
RefSeq Acc Id: ENSMUSP00000105539   ⟸   ENSMUST00000109913
RefSeq Acc Id: ENSMUSP00000105537   ⟸   ENSMUST00000109911
RefSeq Acc Id: ENSMUSP00000105538   ⟸   ENSMUST00000109912
RefSeq Acc Id: ENSMUSP00000118222   ⟸   ENSMUST00000148106
RefSeq Acc Id: ENSMUSP00000116008   ⟸   ENSMUST00000128862
RefSeq Acc Id: XP_036009613   ⟸   XM_036153720
- Peptide Label: isoform X2
- UniProtKB: D6RIL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001413506   ⟸   NM_001426577
- UniProtKB: Q8VII9 (UniProtKB/Swiss-Prot),   Q8VII8 (UniProtKB/Swiss-Prot),   A3KN90 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001413507   ⟸   NM_001426578
- UniProtKB: Q8VII9 (UniProtKB/Swiss-Prot),   Q8VII8 (UniProtKB/Swiss-Prot),   A3KN90 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001413505   ⟸   NM_001426576
- UniProtKB: Q8VII8 (UniProtKB/Swiss-Prot),   Q8VII9 (UniProtKB/Swiss-Prot),   A3KN90 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001413504   ⟸   NM_001426575
- UniProtKB: Q8VII9 (UniProtKB/Swiss-Prot),   Q8VII8 (UniProtKB/Swiss-Prot),   A3KN90 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VII8-F1-model_v2 AlphaFold Q8VII8 1-978 view protein structure

Promoters
RGD ID:6843560
Promoter ID:MM_KWN:54912
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000055199,   OTTMUST00000055204
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36879,422,886 - 79,423,386 (+)MPROMDB
RGD ID:6843562
Promoter ID:MM_KWN:54914
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000109911,   ENSMUST00000109912,   ENSMUST00000109915,   OTTMUST00000055201,   OTTMUST00000083577
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36879,425,809 - 79,426,309 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99459 AgrOrtholog
Ensembl Genes ENSMUSG00000031618 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034031.6 UniProtKB/TrEMBL
  ENSMUST00000109911.8 UniProtKB/TrEMBL
  ENSMUST00000109912 ENTREZGENE
  ENSMUST00000109912.8 UniProtKB/TrEMBL
  ENSMUST00000109913.9 UniProtKB/TrEMBL
  ENSMUST00000128862.2 UniProtKB/TrEMBL
  ENSMUST00000143284.2 UniProtKB/TrEMBL
  ENSMUST00000148106 ENTREZGENE
  ENSMUST00000148106.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Str_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110784 UniProtKB/TrEMBL
MGD MGI:99459 ENTREZGENE
NCBI Gene 110784 ENTREZGENE
PANTHER KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MINERALOCORTICOID RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NR3C2 RGD
PhenoGen Nr3c2 PhenoGen
PRINTS STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A3KN90 ENTREZGENE, UniProtKB/TrEMBL
  D3Z473_MOUSE UniProtKB/TrEMBL
  D3Z7F2_MOUSE UniProtKB/TrEMBL
  D3Z7J4_MOUSE UniProtKB/TrEMBL
  D6RIL1 ENTREZGENE, UniProtKB/TrEMBL
  E9Q8M8_MOUSE UniProtKB/TrEMBL
  MCR_MOUSE UniProtKB/Swiss-Prot
  Q3UW58_MOUSE UniProtKB/TrEMBL
  Q8VII8 ENTREZGENE
  Q8VII9 ENTREZGENE
UniProt Secondary Q8VII9 UniProtKB/Swiss-Prot