Casr (calcium-sensing receptor) - Rat Genome Database

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Gene: Casr (calcium-sensing receptor) Mus musculus
Analyze
Symbol: Casr
Name: calcium-sensing receptor
RGD ID: 1553551
MGI Page MGI
Description: Predicted to enable several functions, including integrin binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Involved in regulation of presynaptic membrane potential. Acts upstream of or within positive regulation of gene expression and regulation of calcium ion transport. Is active in glutamatergic synapse. Is expressed in several structures, including branchial pouch; central nervous system; lung; metanephros; and superior cervical ganglion. Used to study autosomal dominant hypocalcemia 1; familial hypocalciuric hypercalcemia 1; and hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C; CaR; cation sensing receptor; extracellular calcium-sensing receptor; G protein coupled receptor, family C, group 2, member A; G protein-coupled receptor, family C, group 2, member A; Gpr; Gprc2a; parathyroid cell calcium-sensing receptor; PCaR1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391636,310,947 - 36,382,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1636,314,058 - 36,382,503 (-)EnsemblGRCm39 Ensembl
GRCm381636,490,585 - 36,562,141 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1636,493,696 - 36,562,141 (-)EnsemblGRCm38mm10GRCm38
MGSCv371636,493,782 - 36,562,220 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361636,412,935 - 36,481,373 (-)NCBIMGSCv36mm8
Celera1636,909,014 - 36,977,753 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
bile acid secretion  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
calcium ion import  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to peptide  (ISO)
cellular response to vitamin D  (ISO)
chloride transmembrane transport  (ISO)
detection of calcium ion  (IBA,ISO)
fat pad development  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
intracellular calcium ion homeostasis  (IBA,ISO)
JNK cascade  (ISO)
ossification  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of ATP-dependent activity  (IDA,IMP)
positive regulation of calcium ion import  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of insulin secretion  (ISO)
positive regulation of positive chemotaxis  (ISO)
positive regulation of vasoconstriction  (ISO)
regulation of calcium ion transport  (IBA,IDA)
regulation of presynaptic membrane potential  (EXP,IDA,IMP)
response to calcium ion  (ISO)
response to fibroblast growth factor  (ISO)
response to ischemia  (ISO)
response to metal ion  (ISO)
response to organic cyclic compound  (ISO)
signal transduction  (IEA)
vasodilation  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone mineralization  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal pancreas morphology  (IEA)
abnormal parathyroid gland chief cell morphology  (IAGP)
abnormal postural reflex  (IAGP)
abnormal posture  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
aphagia  (IAGP)
calcified muscle  (IAGP)
calcinosis  (IAGP)
cataract  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone trabecula number  (IAGP)
decreased circulating calcium level  (IAGP)
decreased circulating parathyroid hormone level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased compact bone volume  (IAGP)
decreased prepulse inhibition  (IEA)
decreased trabecular bone connectivity density  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased urine calcium level  (IAGP)
decreased urine phosphate level  (IAGP)
dehydration  (IAGP)
delayed bone ossification  (IAGP)
edema  (IEA)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged parathyroid gland  (IAGP)
enlarged uterus  (IEA)
fragile skeleton  (IAGP)
increased circulating calcium level  (IAGP)
increased circulating magnesium level  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased circulating phosphate level  (IAGP)
increased hematocrit  (IAGP)
increased urine calcium level  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
kyphoscoliosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethargy  (IAGP)
nephrocalcinosis  (IAGP)
parathyroid gland hyperplasia  (IAGP)
pigmented parathyroid gland  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
rickets  (IAGP)
small superior vagus ganglion  (IEA)
tongue inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. Alam MU, etal., Cardiovasc Res. 2009 Feb 1;81(2):260-8. doi: 10.1093/cvr/cvn279. Epub 2008 Oct 13.
2. Decrease in calcium-sensing receptor in the progress of diabetic cardiomyopathy. Bai SZ, etal., Diabetes Res Clin Pract. 2012 Mar;95(3):378-85. doi: 10.1016/j.diabres.2011.11.007. Epub 2011 Dec 3.
3. Mutations in the human Ca(2+)-sensing-receptor gene that cause familial hypocalciuric hypercalcemia. Chou YH, etal., Am J Hum Genet. 1995 May;56(5):1075-9.
4. A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis. Chou YH, etal., PLoS One. 2011;6(9):e25227. doi: 10.1371/journal.pone.0025227. Epub 2011 Sep 22.
5. A novel mutation in the calcium-sensing receptor gene in an Irish pedigree showing familial hypocalciuric hypercalcemia: a case report. Elamin WF and de Buyl O, J Med Case Rep. 2010 Oct 29;4:349. doi: 10.1186/1752-1947-4-349.
6. The clinical significance of parathyroid tissue calcium sensing receptor gene polymorphisms and expression levels in end-stage renal disease patients. Eren PA, etal., Clin Nephrol. 2009 Aug;72(2):114-21.
7. Vitamin D receptor and calcium-sensing receptor gene polymorphisms in hypercalciuric stone-forming patients. Ferreira LG, etal., Nephron Clin Pract. 2010;114(2):c135-44. doi: 10.1159/000254386. Epub 2009 Nov 3.
8. Increased expression of calcium-sensing receptors in atherosclerosis confers hypersensitivity to acute myocardial infarction in rats. Guo J, etal., Mol Cell Biochem. 2012 Jul;366(1-2):345-54. doi: 10.1007/s11010-012-1312-0. Epub 2012 Apr 17.
9. Early degenerative effects of diabetes mellitus on pancreas, liver, and kidney in rats: an immunohistochemical study. Haligur M, etal., Exp Diabetes Res. 2012;2012:120645. doi: 10.1155/2012/120645. Epub 2012 Jul 11.
10. A homozygous inactivating calcium-sensing receptor mutation, Pro339Thr, is associated with isolated primary hyperparathyroidism: correlation between location of mutations and severity of hypercalcaemia. Hannan FM, etal., Clin Endocrinol (Oxf). 2010 Dec;73(6):715-22. doi: 10.1111/j.1365-2265.2010.03870.x.
11. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Ho C, etal., Nat Genet. 1995 Dec;11(4):389-94.
12. Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification. Hough TA, etal., Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13566-71. Epub 2004 Sep 3.
13. Two novel missense mutations in calcium-sensing receptor gene associated with neonatal severe hyperparathyroidism. Kobayashi M, etal., J Clin Endocrinol Metab. 1997 Aug;82(8):2716-9.
14. Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic. Koleganova N, etal., Lab Invest. 2009 May;89(5):520-30. doi: 10.1038/labinvest.2009.7. Epub 2009 Feb 2.
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. Extracellular calcium-sensing receptor is functionally expressed in human artery. Molostvov G, etal., Am J Physiol Renal Physiol. 2007 Sep;293(3):F946-55. Epub 2007 May 30.
18. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. O'Seaghdha CM, etal., Hum Mol Genet. 2010 Nov 1;19(21):4296-303. doi: 10.1093/hmg/ddq342. Epub 2010 Aug 12.
19. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor. Pearce SH, etal., N Engl J Med. 1996 Oct 10;335(15):1115-22.
22. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
23. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Pollak MR, etal., Cell. 1993 Dec 31;75(7):1297-303.
26. Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation. Pollak MR, etal., Nat Genet. 1994 Nov;8(3):303-7.
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Primary hyperparathyroidism and the presence of kidney stones are associated with different haplotypes of the calcium-sensing receptor. Scillitani A, etal., J Clin Endocrinol Metab. 2007 Jan;92(1):277-83. doi: 10.1210/jc.2006-0857. Epub 2006 Oct 3.
30. A novel CASR mutation in a Tunisian FHH/NSHPT family associated with a mental retardation. Sfar S, etal., Mol Biol Rep. 2012 Mar;39(3):2395-400. doi: 10.1007/s11033-011-0990-0. Epub 2011 Jun 12.
31. Association between calcium-sensing receptor gene polymorphisms and recurrent calcium kidney stone disease: a comprehensive gene analysis. Shakhssalim N, etal., Scand J Urol Nephrol. 2010 Dec;44(6):406-12. doi: 10.3109/00365599.2010.497770. Epub 2010 Jul 5.
32. Phenotypic variation in a large family with autosomal dominant hypocalcaemia. Sorheim JI, etal., Horm Res Paediatr. 2010;74(6):399-405. doi: 10.1159/000303188. Epub 2010 May 26.
33. Biased agonism of the calcium-sensing receptor. Thomsen AR, etal., Cell Calcium. 2012 Feb;51(2):107-16. doi: 10.1016/j.ceca.2011.11.009. Epub 2011 Dec 20.
34. Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background. Tu Q, etal., J Clin Invest 2003 Apr;111(7):1029-37.
35. Polymorphisms at the regulatory regions of the CASR gene influence stone risk in primary hyperparathyroidism. Vezzoli G, etal., Eur J Endocrinol. 2011 Mar;164(3):421-7. doi: 10.1530/EJE-10-0915. Epub 2010 Dec 23.
36. Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients. Vezzoli G, etal., J Am Soc Nephrol. 2002 Oct;13(10):2517-23.
37. Calcium kidney stones are associated with a haplotype of the calcium-sensing receptor gene regulatory region. Vezzoli G, etal., Nephrol Dial Transplant. 2010 Jul;25(7):2245-52. doi: 10.1093/ndt/gfp760. Epub 2010 Jan 12.
38. Effect of silencing VDR gene in kidney on renal epithelial calcium transporter proteins and urinary calcium excretion in genetic hypercalciuric stone-forming rats. Xi QL, etal., Urology. 2011 Dec;78(6):1442.e1-7. doi: 10.1016/j.urology.2011.08.051.
39. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Yamamura A, etal., Circ Res. 2012 Aug 3;111(4):469-81. doi: 10.1161/CIRCRESAHA.112.266361. Epub 2012 Jun 22.
40. Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism. Yano S, etal., Kidney Int. 2000 Nov;58(5):1980-6.
41. Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstriction. Zhang J, etal., Antioxid Redox Signal. 2012 Aug 1;17(3):471-84. doi: 10.1089/ars.2011.4168. Epub 2012 Jan 25.
42. Calcium-sensing receptor activating phosphorylation of PKCdelta translocation on mitochondria to induce cardiomyocyte apoptosis during ischemia/reperfusion. Zheng H, etal., Mol Cell Biochem. 2011 Dec;358(1-2):335-43. doi: 10.1007/s11010-011-0984-1. Epub 2011 Jul 16.
Additional References at PubMed
PMID:8597637   PMID:9076582   PMID:9172145   PMID:9288833   PMID:9344650   PMID:9421228   PMID:9606417   PMID:9637715   PMID:9681508   PMID:9750190   PMID:10349636   PMID:10579354  
PMID:10625662   PMID:10652312   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11306604   PMID:11517179   PMID:11832378   PMID:12115735   PMID:12167589   PMID:12671040   PMID:12671051  
PMID:12727216   PMID:12834872   PMID:14966569   PMID:15099400   PMID:15547142   PMID:15962313   PMID:16141072   PMID:16141073   PMID:16166224   PMID:16167084   PMID:16264270   PMID:16377269  
PMID:16382241   PMID:16602821   PMID:16760252   PMID:17003237   PMID:17077282   PMID:17146194   PMID:17156446   PMID:17182288   PMID:17382312   PMID:17615148   PMID:17785631   PMID:17823248  
PMID:18065418   PMID:18223649   PMID:18621740   PMID:18719333   PMID:18765830   PMID:18794335   PMID:18813283   PMID:18955379   PMID:19005071   PMID:19056349   PMID:19088438   PMID:19162173  
PMID:19164599   PMID:19474191   PMID:19521566   PMID:19797241   PMID:20032198   PMID:20149906   PMID:20150282   PMID:20179105   PMID:20200973   PMID:20484821   PMID:20833954   PMID:20876097  
PMID:21183662   PMID:21252045   PMID:21352089   PMID:21430159   PMID:21542007   PMID:21873635   PMID:21956637   PMID:21966280   PMID:22094462   PMID:22275754   PMID:22276210   PMID:22373575  
PMID:22403735   PMID:22527485   PMID:22622426   PMID:22997254   PMID:23143333   PMID:23220722   PMID:23233539   PMID:23271661   PMID:23283989   PMID:23314289   PMID:23360235   PMID:23360827  
PMID:23528155   PMID:23545937   PMID:23564401   PMID:23615500   PMID:23639802   PMID:23782944   PMID:23886943   PMID:23895994   PMID:24842610   PMID:25071082   PMID:25331955   PMID:25500736  
PMID:25558818   PMID:25645361   PMID:25701758   PMID:25758239   PMID:25787141   PMID:25792563   PMID:25904744   PMID:25972512   PMID:25977473   PMID:26052899   PMID:26261299   PMID:26538090  
PMID:26579618   PMID:26661650   PMID:26911344   PMID:26968768   PMID:27402918   PMID:27441644   PMID:27450451   PMID:27879271   PMID:28120456   PMID:28281186   PMID:28368538   PMID:28575322  
PMID:28727763   PMID:29212817   PMID:29348484   PMID:29561186   PMID:29618612   PMID:29847805   PMID:29848507   PMID:30404020   PMID:30496623   PMID:30677043   PMID:30979723   PMID:31498905  
PMID:31527082   PMID:31603369   PMID:31619668   PMID:31709833   PMID:31960592   PMID:32325033   PMID:32394484   PMID:32768195   PMID:33001312   PMID:33259138   PMID:33729479   PMID:33958714  
PMID:33973519   PMID:34001955   PMID:34204449   PMID:35271934   PMID:35313217   PMID:36606511   PMID:37098022   PMID:37245986   PMID:37440279   PMID:38193195   PMID:38314127   PMID:38355793  
PMID:38386045  


Genomics

Comparative Map Data
Casr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391636,310,947 - 36,382,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1636,314,058 - 36,382,503 (-)EnsemblGRCm39 Ensembl
GRCm381636,490,585 - 36,562,141 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1636,493,696 - 36,562,141 (-)EnsemblGRCm38mm10GRCm38
MGSCv371636,493,782 - 36,562,220 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361636,412,935 - 36,481,373 (-)NCBIMGSCv36mm8
Celera1636,909,014 - 36,977,753 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.57NCBI
CASR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,183,668 - 122,291,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,183,668 - 122,291,629 (+)EnsemblGRCh38hg38GRCh38
GRCh373121,902,515 - 122,010,476 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,385,220 - 123,488,032 (+)NCBINCBI36Build 36hg18NCBI36
Build 343123,385,219 - 123,488,032NCBI
Celera3120,312,793 - 120,414,980 (+)NCBICelera
Cytogenetic Map3q13.33-q21.1NCBI
HuRef3119,276,062 - 119,378,878 (+)NCBIHuRef
CHM1_13121,866,087 - 121,968,904 (+)NCBICHM1_1
T2T-CHM13v2.03124,903,258 - 125,011,238 (+)NCBIT2T-CHM13v2.0
Casr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81177,738,398 - 77,813,639 (+)NCBIGRCr8
mRatBN7.21164,235,251 - 64,304,811 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,235,251 - 64,304,811 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,047,649 - 73,119,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01165,709,872 - 65,781,465 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,740,787 - 64,812,771 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,188,204 - 67,262,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,188,630 - 67,258,771 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,278,784 - 70,352,137 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,084,169 - 66,153,292 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,141,757 - 66,210,881 (-)NCBI
Celera1163,705,377 - 63,774,888 (+)NCBICelera
Cytogenetic Map11q22NCBI
Casr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542721,486,427 - 21,575,210 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542721,486,608 - 21,574,017 (+)NCBIChiLan1.0ChiLan1.0
CASR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,132,419 - 120,238,779 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13120,137,198 - 120,243,558 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,278,071 - 119,383,901 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,252,765 - 126,285,268 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,252,765 - 126,285,268 (+)Ensemblpanpan1.1panPan2
CASR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,340,822 - 25,432,814 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,405,846 - 25,432,559 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,430,838 - 25,457,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,575,807 - 25,668,548 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,592,410 - 25,668,339 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,439,049 - 25,465,515 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,481,863 - 25,508,587 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03326,039,992 - 26,066,527 (+)NCBIUU_Cfam_GSD_1.0
Casr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602128,921,650 - 128,996,645 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365368,574,064 - 8,599,454 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365368,574,064 - 8,599,446 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13138,280,364 - 138,364,252 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113138,279,785 - 138,364,934 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213147,907,312 - 147,991,214 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,579,640 - 58,612,142 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,578,396 - 58,604,756 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041107,618,566 - 107,763,120 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624912485,258 - 614,656 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624912485,252 - 613,572 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Casr
1550 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:977
Count of miRNA genes:463
Interacting mature miRNAs:530
Transcripts:ENSMUST00000063597, ENSMUST00000114847, ENSMUST00000172826, ENSMUST00000174750
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
25671380Hrsq2_mhost response to SARS QTL 2, titer (mouse)163140250136540273Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
10412263Gvhd6_mgraft-versus host disease 6 (mouse)Not determined163606085745511148Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
AF110178  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381636,493,788 - 36,493,934UniSTSGRCm38
MGSCv371636,493,874 - 36,494,020UniSTSGRCm37
Celera1636,909,106 - 36,909,252UniSTS
Cytogenetic Map16B3UniSTS
cM Map1626.3UniSTS
Whitehead/MRC_RH16357.97UniSTS
Casr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371636,490,839 - 36,491,120UniSTSGRCm37
Celera1636,906,071 - 36,906,352UniSTS
Cytogenetic Map16B3UniSTS
cM Map1626.3UniSTS
Casr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B3UniSTS
Casr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B3UniSTS
Casr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381636,490,753 - 36,491,034UniSTSGRCm38
MGSCv371636,490,839 - 36,491,120UniSTSGRCm37
Celera1636,906,071 - 36,906,352UniSTS
Cytogenetic Map16B3UniSTS
Casr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB027140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC074229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF002015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF068900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF092941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF110178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF110179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF128842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF159565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000063597   ⟹   ENSMUSP00000069080
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1636,314,058 - 36,382,496 (-)Ensembl
GRCm38.p6 Ensembl1636,493,696 - 36,562,134 (-)Ensembl
Ensembl Acc Id: ENSMUST00000114847   ⟹   ENSMUSP00000110496
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1636,314,058 - 36,382,496 (-)Ensembl
GRCm38.p6 Ensembl1636,493,696 - 36,562,134 (-)Ensembl
Ensembl Acc Id: ENSMUST00000172826   ⟹   ENSMUSP00000133500
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1636,314,829 - 36,381,968 (-)Ensembl
GRCm38.p6 Ensembl1636,494,467 - 36,561,606 (-)Ensembl
Ensembl Acc Id: ENSMUST00000174750
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1636,338,200 - 36,382,503 (-)Ensembl
GRCm38.p6 Ensembl1636,517,838 - 36,562,141 (-)Ensembl
RefSeq Acc Id: NM_013803   ⟹   NP_038831
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,310,947 - 36,382,496 (-)NCBI
GRCm381636,490,585 - 36,562,134 (-)NCBI
MGSCv371636,493,782 - 36,562,220 (-)RGD
Celera1636,909,014 - 36,977,753 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521729   ⟹   XP_006521792
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,310,947 - 36,352,632 (-)NCBI
GRCm381636,490,585 - 36,532,280 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006521730   ⟹   XP_006521793
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,310,947 - 36,382,605 (-)NCBI
GRCm381636,490,585 - 36,562,141 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006521731   ⟹   XP_006521794
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,310,947 - 36,382,184 (-)NCBI
GRCm381636,490,585 - 36,561,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006521732   ⟹   XP_006521795
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,310,947 - 36,353,506 (-)NCBI
GRCm381636,490,585 - 36,533,130 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159757   ⟹   XP_036015650
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,310,947 - 36,382,605 (-)NCBI
Sequence:
RefSeq Acc Id: NP_038831   ⟸   NM_013803
- Peptide Label: precursor
- UniProtKB: Q9R1D6 (UniProtKB/Swiss-Prot),   Q9QZU8 (UniProtKB/Swiss-Prot),   Q9QY95 (UniProtKB/Swiss-Prot),   O88519 (UniProtKB/Swiss-Prot),   O08968 (UniProtKB/Swiss-Prot),   G3UX06 (UniProtKB/Swiss-Prot),   Q9R1Y2 (UniProtKB/Swiss-Prot),   Q9QY96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521793   ⟸   XM_006521730
- Peptide Label: isoform X1
- UniProtKB: Q9R1D6 (UniProtKB/Swiss-Prot),   Q9QZU8 (UniProtKB/Swiss-Prot),   Q9QY95 (UniProtKB/Swiss-Prot),   O88519 (UniProtKB/Swiss-Prot),   O08968 (UniProtKB/Swiss-Prot),   G3UX06 (UniProtKB/Swiss-Prot),   Q9R1Y2 (UniProtKB/Swiss-Prot),   Q9QY96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521794   ⟸   XM_006521731
- Peptide Label: isoform X1
- UniProtKB: Q9R1D6 (UniProtKB/Swiss-Prot),   Q9QZU8 (UniProtKB/Swiss-Prot),   Q9QY95 (UniProtKB/Swiss-Prot),   O88519 (UniProtKB/Swiss-Prot),   O08968 (UniProtKB/Swiss-Prot),   G3UX06 (UniProtKB/Swiss-Prot),   Q9R1Y2 (UniProtKB/Swiss-Prot),   Q9QY96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521795   ⟸   XM_006521732
- Peptide Label: isoform X1
- UniProtKB: Q9R1D6 (UniProtKB/Swiss-Prot),   Q9QZU8 (UniProtKB/Swiss-Prot),   Q9QY95 (UniProtKB/Swiss-Prot),   O88519 (UniProtKB/Swiss-Prot),   O08968 (UniProtKB/Swiss-Prot),   G3UX06 (UniProtKB/Swiss-Prot),   Q9R1Y2 (UniProtKB/Swiss-Prot),   Q9QY96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521792   ⟸   XM_006521729
- Peptide Label: isoform X1
- UniProtKB: Q9R1D6 (UniProtKB/Swiss-Prot),   Q9QZU8 (UniProtKB/Swiss-Prot),   Q9QY95 (UniProtKB/Swiss-Prot),   O88519 (UniProtKB/Swiss-Prot),   O08968 (UniProtKB/Swiss-Prot),   G3UX06 (UniProtKB/Swiss-Prot),   Q9R1Y2 (UniProtKB/Swiss-Prot),   Q9QY96 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000133500   ⟸   ENSMUST00000172826
Ensembl Acc Id: ENSMUSP00000110496   ⟸   ENSMUST00000114847
Ensembl Acc Id: ENSMUSP00000069080   ⟸   ENSMUST00000063597
RefSeq Acc Id: XP_036015650   ⟸   XM_036159757
- Peptide Label: isoform X1
- UniProtKB: Q9R1D6 (UniProtKB/Swiss-Prot),   Q9QZU8 (UniProtKB/Swiss-Prot),   Q9QY96 (UniProtKB/Swiss-Prot),   Q9QY95 (UniProtKB/Swiss-Prot),   O88519 (UniProtKB/Swiss-Prot),   O08968 (UniProtKB/Swiss-Prot),   G3UX06 (UniProtKB/Swiss-Prot),   Q9R1Y2 (UniProtKB/Swiss-Prot)
Protein Domains
G-protein coupled receptors family 3 profile   Receptor ligand binding region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QY96-F1-model_v2 AlphaFold Q9QY96 1-1079 view protein structure

Promoters
RGD ID:8686128
Promoter ID:EPDNEW_M21095
Type:multiple initiation site
Name:Casr_1
Description:Mus musculus calcium-sensing receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381636,546,078 - 36,546,138EPDNEW
RGD ID:6826877
Promoter ID:MM_KWN:20910
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000114847,   NM_013803
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361636,561,891 - 36,562,391 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351351 AgrOrtholog
Ensembl Genes ENSMUSG00000051980 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000063597 ENTREZGENE
  ENSMUST00000063597.14 UniProtKB/Swiss-Prot
  ENSMUST00000114847.9 UniProtKB/Swiss-Prot
  ENSMUST00000172826 ENTREZGENE
  ENSMUST00000172826.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12374 UniProtKB/Swiss-Prot
MGD MGI:1351351 ENTREZGENE
NCBI Gene 12374 ENTREZGENE
PANTHER EXTRACELLULAR CALCIUM-SENSING RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24061 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCD3G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Casr PhenoGen
PRINTS CASENSINGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CASR_MOUSE UniProtKB/Swiss-Prot
  G3UX06 ENTREZGENE
  O08968 ENTREZGENE
  O88519 ENTREZGENE
  O88982_MOUSE UniProtKB/TrEMBL
  Q8CDP3_MOUSE UniProtKB/TrEMBL
  Q9QY95 ENTREZGENE
  Q9QY96 ENTREZGENE
  Q9QZU8 ENTREZGENE
  Q9R1D6 ENTREZGENE
  Q9R1Y2 ENTREZGENE
UniProt Secondary G3UX06 UniProtKB/Swiss-Prot
  O08968 UniProtKB/Swiss-Prot
  O88519 UniProtKB/Swiss-Prot
  Q9QY95 UniProtKB/Swiss-Prot
  Q9QZU8 UniProtKB/Swiss-Prot
  Q9R1D6 UniProtKB/Swiss-Prot
  Q9R1Y2 UniProtKB/Swiss-Prot