Slc24a5 (solute carrier family 24, member 5)

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Gene: Slc24a5 (solute carrier family 24, member 5) Mus musculus

Analyze

Symbol:

Slc24a5

Name:

solute carrier family 24, member 5

RGD ID:

1553523

MGI Page

MGI

Description:

Enables calcium ion transmembrane transporter activity. Involved in calcium ion import. Acts upstream of or within negative regulation of melanin biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in trans-Golgi network. Is expressed in several structures, including brain; gonad; sensory organ; spleen; and submandibular gland. Used to study ocular albinism. Human ortholog(s) of this gene implicated in oculocutaneous albinism type VI. Orthologous to human SLC24A5 (solute carrier family 24 member 5).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

F630045L20Rik; JSX; K-independent Na+/Ca2+ exchanger JSX; Na(+)/K(+)/Ca(2+)-exchange protein 5; Na-Ca exchanger 5; NCKX; NCKX5; NCX; NCX5; Oc; Oca6; sodium/potassion/calcium exchanger 5; sodium/potassium/calcium exchanger 5; solute carrier family 24 member 5

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC24A5 (solute carrier family 24 member 5)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Slc24a5 (solute carrier family 24 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc24a5 (solute carrier family 24 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC24A5 (solute carrier family 24 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC24A5 (solute carrier family 24 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc24a5 (solute carrier family 24 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC24A5 (solute carrier family 24 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC24A5 (solute carrier family 24 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc24a5 (solute carrier family 24 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Slc24a5 (solute carrier family 24 member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SLC24A5 (solute carrier family 24 member 5)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc24a5 (solute carrier family 24 member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	CG1090	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG12061	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	slc24a5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	124,910,076 - 124,930,316 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	124,910,044 - 124,930,597 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	125,068,127 - 125,088,677 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	125,068,124 - 125,088,677 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	124,893,863 - 124,914,413 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	124,759,568 - 124,780,118 (+)	NCBI		MGSCv36	mm8
Celera	2	126,319,377 - 126,339,281 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

Marfan syndrome (ISO)

ocular albinism (IAGP)

oculocutaneous albinism (ISO)

oculocutaneous albinism type VI (ISO)

Skin/Hair/Eye Pigmentation, Variation In, 4 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

amphetamine (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

copper atom (ISO)

copper(0) (ISO)

doxorubicin (ISO)

ethanol (EXP)

Monobutylphthalate (ISO)

N-nitrosodiethylamine (EXP)

paracetamol (ISO)

piperonyl butoxide (EXP)

silicon dioxide (EXP)

sodium arsenite (ISO)

thioacetamide (ISO)

trichloroethene (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion import (IDA,ISO)

calcium ion transmembrane transport (IBA)

calcium ion transport (IEA)

intracellular calcium ion homeostasis (IBA)

melanin biosynthetic process (IMP)

melanocyte differentiation (IBA)

monoatomic ion transmembrane transport (ISO)

monoatomic ion transport (IEA)

negative regulation of melanin biosynthetic process (IMP)

potassium ion transport (IEA)

sodium ion transport (IEA)

transmembrane transport (IEA)

Cellular Component

Golgi apparatus (IEA)

membrane (IEA)

trans-Golgi network (IBA,ISO)

Molecular Function

antiporter activity (IEA)

calcium channel activity (IBA)

calcium ion transmembrane transporter activity (IDA)

calcium, potassium:sodium antiporter activity (IBA,ISO)

protein binding (ISO)

symporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium transport pathway (ISO)

calcium/calcium-mediated signaling pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal ciliary body pigmentation (IAGP)

abnormal dermal pigmentation (IAGP)

abnormal ear pigmentation (IAGP)

abnormal epidermal pigmentation (IAGP)

abnormal hair shaft melanin granule morphology (IAGP)

abnormal hair shaft melanin granule shape (IAGP)

abnormal iris pigmentation (IAGP)

abnormal iris transillumination (IEA)

abnormal melanosome morphology (IAGP)

abnormal ocular fundus morphology (IAGP)

abnormal retina morphology (IEA)

abnormal retina pigment epithelium morphology (IAGP)

abnormal retina pigmentation (IAGP)

decreased fasting circulating glucose level (IEA)

decreased prepulse inhibition (IEA)

hypopigmentation (IAGP)

increased circulating sodium level (IEA)

increased grip strength (IEA)

iris hypoplasia (IAGP)

ocular albinism (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport.	Lytton J Biochem J. 2007 Sep 15;406(3):365-82.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12477932	PMID:14681479	PMID:15489334	PMID:16141072	PMID:16141073	PMID:16357253	PMID:18166528	PMID:18424845
PMID:21267068	PMID:21873635	PMID:24194600	PMID:27093457	PMID:27626380	PMID:29128492	PMID:31201282

Genomics

Comparative Map Data

Slc24a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	124,910,076 - 124,930,316 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	124,910,044 - 124,930,597 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	125,068,127 - 125,088,677 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	125,068,124 - 125,088,677 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	124,893,863 - 124,914,413 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	124,759,568 - 124,780,118 (+)	NCBI		MGSCv36	mm8
Celera	2	126,319,377 - 126,339,281 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI

SLC24A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	48,120,990 - 48,142,672 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	15	48,120,990 - 48,142,672 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	48,413,187 - 48,434,869 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	46,200,461 - 46,221,881 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	46,200,460 - 46,221,881	NCBI
Celera	15	25,305,700 - 25,327,109 (+)	NCBI		Celera
Cytogenetic Map	15	q21.1	NCBI
HuRef	15	25,246,372 - 25,267,781 (+)	NCBI		HuRef
CHM1_1	15	48,531,372 - 48,552,781 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	45,929,094 - 45,950,765 (+)	NCBI		T2T-CHM13v2.0

Slc24a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	112,319,305 - 112,339,231 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	112,319,308 - 112,339,231 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	116,180,534 - 116,199,802 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	124,776,063 - 124,795,331 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	122,436,426 - 122,455,694 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	117,335,212 - 117,354,480 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	117,335,212 - 117,354,480 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	123,859,070 - 123,878,338 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	112,368,177 - 112,387,444 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	112,228,292 - 112,292,568 (+)	NCBI
Celera	3	111,178,214 - 111,197,484 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Slc24a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	5,747,624 - 5,768,122 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	5,747,624 - 5,768,122 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC24A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	15	41,556,643 - 41,564,274 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	27,069,937 - 27,091,619 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	45,394,090 - 45,415,550 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	45,394,090 - 45,415,823 (+)	Ensembl	panpan1.1		panPan2

SLC24A5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	14,372,019 - 14,400,262 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	14,371,778 - 14,400,152 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	14,293,747 - 14,321,766 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	14,505,907 - 14,533,924 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	14,505,892 - 14,537,914 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	14,428,709 - 14,456,722 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	14,544,152 - 14,572,176 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	14,655,945 - 14,684,011 (+)	NCBI		UU_Cfam_GSD_1.0

Slc24a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	92,621,921 - 92,644,271 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	10,470,046 - 10,493,104 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936471	10,470,078 - 10,492,334 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC24A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	123,635,043 - 123,656,736 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	123,635,077 - 123,657,205 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	137,663,480 - 137,685,118 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC24A5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	35,143,004 - 35,164,134 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	35,143,097 - 35,163,718 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	105,948,002 - 105,968,929 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc24a5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	11,552,969 - 11,574,044 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	11,552,865 - 11,573,987 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc24a5
616 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	318
Count of miRNA genes:	250
Interacting mature miRNAs:	284
Transcripts:	ENSMUST00000070353, ENSMUST00000139615, ENSMUST00000149963
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1302174	Dssc2_m	dextran sodium sulfate induced colitis QTL2 (mouse)			Not determined		2	24224632	148700377	Mouse
4141854	T2dm2sa_m	type 2 diabetes mellitus 2 in SMXA RI mice (mouse)			Not determined		2	29307947	148374934	Mouse
1301344	Lith1_m	lithogenic gene 1 (mouse)			Not determined		2	45347635	145312647	Mouse
13824983	Vclq1_m	curvilinear velocity QTL 1 (mouse)					2	61830344	136841920	Mouse
5491197	Mobq5_m	multigenic obesity QTL 5 (mouse)			Not determined		2	65269746	162518926	Mouse
11528549	Sluc31_m	susceptibility to lung cancer 31 (mouse)					2	74524117	129213005	Mouse
4141155	Plast2b_m	plasma plant sterol 2b (mouse)			Not determined		2	84013198	148522175	Mouse
10412082	Hylaq1_m	Hyperlocomotor activity related QTL 1 (mouse)			Not determined		2	84013198	148667470	Mouse
5491196	Mobq6_m	multigenic obesity QTL 6 (mouse)			Not determined		2	85724269	180896594	Mouse
1301098	Cd8mts3_m	CD8 memory T cell subset 3 (mouse)			Not determined		2	91089974	125090104	Mouse
1301909	Smdq2_m	segregation of mitochondrial DNA QTL 2 (mouse)			Not determined		2	92778465	126778607	Mouse
27226761	Feml18_m	femur length 18, 16 week (mouse)					2	94230345	154241920	Mouse
11049569	Lmr28d_m	leishmaniasis resistance 28d (mouse)					2	97123370	131123532	Mouse
11049568	Lmr28c_m	leishmaniasis resistance 28c (mouse)					2	97123370	131123532	Mouse
12904935	Edlmmq2_m	extensor digitorum longus muscle mass QTL 2 (mouse)					2	97210364	131210364	Mouse
12904954	Gmmq2_m	gastrocnemius muscle mass QTL 2 (mouse)					2	97210364	131210364	Mouse
4141802	Ignpq1_m	IgA nephropathy QTL 1 (mouse)			Not determined		2	100824060	134824269	Mouse
1302203	Gvhd3_m	graft-versus host disease 3 (mouse)			Not determined		2	100942930	134943090	Mouse
1301330	Tbbmd2_m	total body bone mineral density 2 (mouse)			Not determined		2	100942930	134943090	Mouse
1302071	Fembrs1_m	femur breaking strength 1 (mouse)			Not determined		2	100942930	134943090	Mouse
27226788	Feml13_m	femur length 13, 10 week (mouse)					2	102630345	159941920	Mouse
11041906	Lmr28a_m	leishmaniasis resistance 28a (mouse)					2	103095716	129213005	Mouse
11038702	Ltpr2_m	Leishmania tropica response 2 (mouse)					2	103095716	167212356	Mouse
1301825	Pbrgcsf1_m	peripheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)			Not determined		2	106233580	140233729	Mouse
10043875	Bw25_m	body weight QTL 25 (mouse)			Not determined		2	107255676	141255676	Mouse
1301087	Bbaa15_m	B.burgdorferi-associated arthritis 15 (mouse)			Not determined		2	110489658	144489807	Mouse
10045885	Cplaq15_m	circadian period of locomotor activity 15 (mouse)			Not determined		2	110916118	154354667	Mouse
1558990	Skmw9_m	skeletal muscle weight 9 (mouse)			Not determined		2	111173704	145173821	Mouse
1300793	Pcfm2_m	periosteal circumference and femur length 2 (mouse)			Not determined		2	111173704	145173821	Mouse
1301905	Lgth2_m	body length 2 (mouse)			Not determined		2	111173704	145173821	Mouse
1301755	Hrq1_m	heart rate quantitative locus 1 (mouse)			Not determined		2	111173704	145173821	Mouse
1301201	Chab1_m	cholesterol absorption 1 (mouse)			Not determined		2	111551028	145551163	Mouse
1302033	Nsv1_m	Neuroadapted Sindbis viral RNA level 1 (mouse)			Not determined		2	111623386	145623526	Mouse
1300798	Actre3_m	activity response to ethanol 3 (mouse)			Not determined		2	112024987	128173821	Mouse
1301415	Actre4_m	activity response to ethanol 4 (mouse)			Not determined		2	112024987	128173821	Mouse
11039520	Ltpr2h_m	Leishmania tropica response 2h (mouse)					2	112212746	146213005	Mouse
11038699	Ltpr2b_m	Leishmania tropica response 2b (mouse)					2	112212746	146213005	Mouse
11038700	Ltpr2a_m	Leishmania tropica response 2a (mouse)					2	112212746	146213005	Mouse
1301029	T2dm3_m	type 2 diabetes mellitus 3 (mouse)			Not determined		2	114288075	132714157	Mouse
11039521	Ltpr2g_m	Leishmania tropica response 2g (mouse)					2	115212857	149212994	Mouse
11038696	Ltpr2f_m	Leishmania tropica response 2f (mouse)					2	115212857	149212994	Mouse
1301295	Prdt1_m	prion disease incubation time 1 (mouse)			Not determined		2	116077623	150077741	Mouse
1558881	Ses7_m	salmonella enteritidis susceptibility 7 (mouse)			Not determined		2	116306330	150306474	Mouse
1301618	Bglu1_m	blood glucose level 1 (mouse)			Not determined		2	117942930	174324863	Mouse
12904007	Cfq7_m	conditioned fear QTL 7 (mouse)					2	118356772	125048872	Mouse
12910795	Pwbwq5_m	post-weaning body weight QTL 5 (mouse)					2	118589253	160611165	Mouse
12910799	Pwgrq2_m	pre-weaning growth rate QTL 2 (mouse)					2	118589253	160611165	Mouse
12910812	Pwgrq1_m	pre-weaning growth rate QTL 1 (mouse)					2	118589253	160611165	Mouse
12910814	Pwbwq1_m	pre-weaning body weight QTL 1 (mouse)					2	118589253	160611165	Mouse
1300712	El2_m	epilepsy 2 (mouse)			Not determined		2	122207146	142532135	Mouse
1301294	Hrtfm5_m	heart failure modifier 5 (mouse)			Not determined		2	122883015	156883131	Mouse
1301066	Otx2m2_m	orthodenticle homolog 2 (Drosophila) modifier 2 (mouse)			Not determined		2	123231973	148700377	Mouse
1301822	Pgia2_m	proteoglycan induced arthritis 2 (mouse)			Not determined		2	123937311	157937424	Mouse
27226749	Femd10_m	femur midshaft diameter 10, 16 week (mouse)					2	124441920	168241920	Mouse

Markers in Region

Slc24a5

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	2	F1	UniSTS
cM Map	2	61.14	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_175034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB085629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK089225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL928902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY236527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC094232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC144866	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC145643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000070353 ⟹ ENSMUSP00000063887

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	124,910,044 - 124,930,597 (+)	Ensembl
GRCm38.p6 Ensembl	2	125,068,124 - 125,088,677 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000139615

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	124,911,164 - 124,925,146 (+)	Ensembl
GRCm38.p6 Ensembl	2	125,069,244 - 125,083,226 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000149963

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	124,922,275 - 124,924,999 (+)	Ensembl
GRCm38.p6 Ensembl	2	125,080,355 - 125,083,079 (+)	Ensembl

RefSeq Acc Id:

NM_175034 ⟹ NP_778199

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	124,910,076 - 124,930,316 (+)	NCBI
GRCm38	2	125,068,127 - 125,088,677 (+)	ENTREZGENE
MGSCv37	2	124,893,863 - 124,914,413 (+)	RGD
Celera	2	126,319,377 - 126,339,281 (+)	RGD
cM Map	2		ENTREZGENE

Sequence:

show sequence

ATAAGTCTCCCTTGCTCCCTTCCTGAACCACACACTGCAAAGAGCACGCTGGAAATGCGGACAA
AATGGGGCCCAACTTGGACAAGGAGGGTCCTGCTGCTGGGGATCTTTTGGGTCTCTGCATACCT
GCCTGTCCGTGGTGTCTCCCTGCCCCCGCGCCTCCCAAGGGCCACAGGAAACAGCACGCAATGT
GCTGTCTCTCCAGCATCGGAGTTTCCCGAAGGGTTCTTCACCAAGCAGGAGAGCACGGATGGAG
GTATCGTAATCTACTTCCTCATTATCCTCTACATGTGCATGGCCATCTCCATCGTCTGCGACAA
GTACTTCTTGCCCTCCCTGGAAATCATCAGTGACTCCCTTGGACTGTCGCAGGATGTTGCAGGT
GCAACTTTCATGGCAGCTGGTAGCTCCGCCCCTGAACTAGTTACCGCCTTCTTGGGTGTATTTA
TCACAAAGGGAGATATTGGTATCAGCACCATACTAGGATCTGCAATTTATAATCTCCTCGGCAT
CTGTGCTGCCTGCGGCCTCCTGTCCAACATGGTTTCAACACTCTCCTGCTGGCCCCTCTTCCGA
GACTGTGCAGTGTATGCAGTTAGTGTAGGAGCAGTTTTTGGCATAATATTTGACAACCGAATTT
ACTGGTACGAAGGAGCAGGGCTGCTACTGATATATGGGCTCTATGTTCTGCTGCTGTGTTTTGA
CACCACGATCAGCCGGCATGTCATGAAAACATGCAGTCCCTGTTGTCCCTGCCTTGCCAGAGCT
ATGGAGGAGAGAATTGAACAGCAGACACTGTTGGGATGGGAGGATGAGAGCCAGCTCTTCATTC
GTCGCCAGTCAAGGACAGACAGTGGAATATTTCAGGAAGATTCCGGTTACTCCCAACTTTCTCT
AAGCTTGCATGGTCTTAGTCAGGTTTCTGAAGATCCACCAAGTGTTTTCAGCATGCCAGAAGCA
GACTTAAGAAGAATTTTTTGGGTTCTCTCTCTTCCTATTATTACATTACTTGCTCTGACAACAC
CAGACTGCAGGAGAAAGTTTTGGAAAAATTACTTTGTGATAACCTTTTTCATGTCTGCACTATG
GATATCTGCATTCACATACATCCTAGTTTGGATGGTCACAGTAACAGGGGAAACACTAGGGATC
CCAGACACAGTGATGGGCCTTACTTTGTTGGCAGCAGGGACAAGCATACCAGATACAGTCACAA
GTGTGTTAGTTGCAAGAAAAGGTAAAGGAGACATGGCTATATCTAACATCGTGGGATCCAATGT
GTTTGATATGCTATGCCTAGGTCTTCCCTGGTTTATTAAGACTGCATTTACGAATGCATCTGCT
CCTATAGAAGTGAATAGCAAGGGACTCACATATATAACAATCTCTCTCAACATTTCAATTTTAT
TTCTGTTCTTAGCAGTTCATTTTAATGGCTGGAAACTAGACCGAAAGTTGGGGGTGGTCTGCCT
AGTGTTATACTTAGGACTTGCTACTTTATCAGTTCTATATGAAATTGGAATTATTGGAAATAAT
AGAATAAGGGGTTGTGGAGTTTGATATTTTTTAATAGTGTTATGTGGAAAGATGGAATGGTAGA
GGGGCAAAAAGAAGAAAATTCATGTCTTCATTTAGGTCAAATAAAAAGCATCTTCAACTTTAGA
GTCTAACACTTAATTACTATTCTTTATAAGCAGAGAAAAGTAATTTAAACCAAACCAAAATCCA
TCCTAATTTGTCTGAGCCCTTTCTTTCCTTTAACTCACATACAAAGCAAAGATTTTAAAAGAAA
ACAAAGTATCTGTGAGCTTACACCAAGGTCGGGAAAACTGGAACAGACAAACTCTGCTACTGAA
AATAACAAAATGGCTTATTTCATTAAAAATGGTATGTCCATCCACTGAAACTGAATGATCAGAT
GTGCTGTCTTTAGAAACTCAAACTTGAGAAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_778199	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH94232	(Get FASTA)	NCBI Sequence Viewer
	AAI44867	(Get FASTA)	NCBI Sequence Viewer
	AAI45644	(Get FASTA)	NCBI Sequence Viewer
	AAP57526	(Get FASTA)	NCBI Sequence Viewer
	BAC24122	(Get FASTA)	NCBI Sequence Viewer
	BAC40800	(Get FASTA)	NCBI Sequence Viewer
	EDL28124	(Get FASTA)	NCBI Sequence Viewer
	EDL28125	(Get FASTA)	NCBI Sequence Viewer
	Q8C261	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_778199 ⟸ NM_175034
- Peptide Label:	precursor
- UniProtKB:	Q8CJF1 (UniProtKB/Swiss-Prot), Q8C261 (UniProtKB/Swiss-Prot), A2ATP8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRTKWGPTWTRRVLLLGIFWVSAYLPVRGVSLPPRLPRATGNSTQCAVSPASEFPEGFFTKQES TDGGIVIYFLIILYMCMAISIVCDKYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFL GVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLSCWPLFRDCAVYAVSVGAVFGIIFD NRIYWYEGAGLLLIYGLYVLLLCFDTTISRHVMKTCSPCCPCLARAMEERIEQQTLLGWEDESQ LFIRRQSRTDSGIFQEDSGYSQLSLSLHGLSQVSEDPPSVFSMPEADLRRIFWVLSLPIITLLA LTTPDCRRKFWKNYFVITFFMSALWISAFTYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPD TVTSVLVARKGKGDMAISNIVGSNVFDMLCLGLPWFIKTAFTNASAPIEVNSKGLTYITISLNI SILFLFLAVHFNGWKLDRKLGVVCLVLYLGLATLSVLYEIGIIGNNRIRGCGV hide sequence

RefSeq Acc Id:

ENSMUSP00000063887 ⟸ ENSMUST00000070353

Protein Domains

Sodium/calcium exchanger membrane region

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8C261-F1-model_v2	AlphaFold	Q8C261	1-501	view protein structure

Promoters

RGD ID:

6832733

Promoter ID:

MM_KWN:31505

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Brain, Lung, MEF_B6

Transcripts:

OTTMUST00000036371

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	124,905,764 - 124,906,264 (+)	MPROMDB

RGD ID:

6878556

Promoter ID:

EPDNEW_M2729

Type:

initiation region

Name:

Slc24a5_1

Description:

Mus musculus solute carrier family 24, member 5 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	2	125,068,156 - 125,068,216	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2677271	AgrOrtholog
Ensembl Genes	ENSMUSG00000035183	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSMUSP00000063887	ENTREZGENE
	ENSMUSP00000063887.4	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000070353	ENTREZGENE
	ENSMUST00000070353.4	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1420.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	K/Na/Ca-exchanger	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NaCa_Exmemb	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NCX_ion-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:317750	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:2677271	ENTREZGENE
NCBI Gene	317750	ENTREZGENE
PANTHER	PTHR10846	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10846:SF61	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Na_Ca_ex	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc24a5	PhenoGen
TIGRFAMs	TIGR00367	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A2ATP8	ENTREZGENE, UniProtKB/TrEMBL
	NCKX5_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q8CJF1	ENTREZGENE
UniProt Secondary	Q6XE39	UniProtKB/Swiss-Prot
	Q8CJF1	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

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