Npc2 (NPC intracellular cholesterol transporter 2) - Rat Genome Database

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Gene: Npc2 (NPC intracellular cholesterol transporter 2) Mus musculus
Analyze
Symbol: Npc2
Name: NPC intracellular cholesterol transporter 2
RGD ID: 1553506
MGI Page MGI
Description: Enables cholesterol binding activity. Involved in cholesterol efflux and intracellular cholesterol transport. Acts upstream of or within several processes, including cholesterol storage; sterol metabolic process; and sterol transport. Located in extracellular space. Is active in lysosome. Is expressed in brain; paravertebral ganglion; respiratory system; stomach; and ventral grey horn. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease and Niemann-Pick disease type C2. Orthologous to human NPC2 (NPC intracellular cholesterol transporter 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2700012J19Rik; AA408070; AU045843; epididymal secretory protein E1; HE1; mE1; niemann Pick type C2 protein homolog; Niemann-Pick type C2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,801,333 - 84,819,886 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,801,336 - 84,819,926 (-)EnsemblGRCm39 Ensembl
GRCm381284,754,559 - 84,773,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,754,562 - 84,773,152 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,095,509 - 86,114,062 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361285,644,307 - 85,662,860 (-)NCBIMGSCv36mm8
Celera1286,210,583 - 86,229,366 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
Archazolid B  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
metronidazole  (ISO)
miconazole  (EXP)
neomycin  (ISO)
nimesulide  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
tamibarotene  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
endoplasmic reticulum  (IEA)
extracellular space  (HDA,ISO)
lysosome  (IDA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Niemann-Pick disease type C: spectrum of HE1 mutations and genotype/phenotype correlations in the NPC2 group. Millat G, etal., Am J Hum Genet. 2001 Nov;69(5):1013-21. Epub 2001 Sep 20.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10863096   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125141   PMID:12477932   PMID:12520002   PMID:12591949   PMID:12591954   PMID:12719428  
PMID:14610273   PMID:15071184   PMID:15355983   PMID:15381285   PMID:15489334   PMID:15582152   PMID:15782199   PMID:15896196   PMID:16141072   PMID:16141073   PMID:16177447   PMID:16374838  
PMID:16484344   PMID:17018531   PMID:17389239   PMID:17492806   PMID:17880278   PMID:18799693   PMID:19723497   PMID:19883728   PMID:20007703   PMID:20650896   PMID:21267068   PMID:21289032  
PMID:21315718   PMID:21320502   PMID:21550990   PMID:21677750   PMID:21708114   PMID:21873635   PMID:21887293   PMID:22065762   PMID:22073306   PMID:22179027   PMID:22183894   PMID:23666609  
PMID:23843985   PMID:24006456   PMID:24076310   PMID:24154525   PMID:24438076   PMID:25131634   PMID:26183450   PMID:27336679   PMID:27626380   PMID:28031458   PMID:28053186   PMID:28082351  
PMID:28658628   PMID:29514215   PMID:29655638   PMID:30550785   PMID:32325033   PMID:34050187   PMID:34290407   PMID:34857757   PMID:37454976   PMID:38355793  


Genomics

Comparative Map Data
Npc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,801,333 - 84,819,886 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,801,336 - 84,819,926 (-)EnsemblGRCm39 Ensembl
GRCm381284,754,559 - 84,773,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,754,562 - 84,773,152 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,095,509 - 86,114,062 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361285,644,307 - 85,662,860 (-)NCBIMGSCv36mm8
Celera1286,210,583 - 86,229,366 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.37NCBI
NPC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,479,935 - 74,493,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,476,192 - 74,494,177 (-)EnsemblGRCh38hg38GRCh38
GRCh371474,946,638 - 74,960,215 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,016,396 - 74,029,837 (-)NCBINCBI36Build 36hg18NCBI36
Build 341474,016,396 - 74,029,837NCBI
Celera1454,985,030 - 54,998,469 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,115,095 - 55,128,528 (-)NCBIHuRef
CHM1_11474,886,183 - 74,899,622 (-)NCBICHM1_1
T2T-CHM13v2.01468,688,905 - 68,702,483 (-)NCBIT2T-CHM13v2.0
Npc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,128,325 - 110,149,245 (-)NCBIGRCr8
mRatBN7.26104,397,239 - 104,418,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,378,644 - 104,418,155 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,566,714 - 104,587,594 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,865,873 - 104,886,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,235,225 - 104,256,103 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,467,410 - 108,488,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,467,410 - 108,488,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,060,860 - 117,081,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,793,935 - 108,814,703 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16108,797,391 - 108,818,159 (-)NCBI
Celera6102,222,115 - 102,243,035 (-)NCBICelera
Cytogenetic Map6q31NCBI
Npc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555231,010,976 - 1,021,144 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555231,010,976 - 1,021,048 (+)NCBIChiLan1.0ChiLan1.0
NPC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21575,563,794 - 75,577,953 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11474,780,300 - 74,794,459 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,033,129 - 55,046,564 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11473,875,856 - 73,894,628 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,875,889 - 73,894,628 (-)Ensemblpanpan1.1panPan2
NPC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1847,641,185 - 47,650,543 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl847,628,077 - 47,650,576 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,325,075 - 47,334,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0847,868,101 - 47,877,468 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl847,866,650 - 47,877,427 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,539,316 - 47,548,676 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,560,539 - 47,569,881 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,958,527 - 47,967,885 (-)NCBIUU_Cfam_GSD_1.0
Npc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864028,392,518 - 28,404,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364883,663,655 - 3,676,505 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364883,664,171 - 3,676,438 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,730,516 - 97,740,331 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1797,730,532 - 97,740,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,573,100 - 103,582,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12451,685,699 - 51,700,557 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2451,685,609 - 51,700,557 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605339,920,625 - 39,935,553 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473427,166,880 - 27,177,229 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473427,166,867 - 27,177,229 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npc2
660 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1006
Count of miRNA genes:562
Interacting mature miRNAs:662
Transcripts:ENSMUST00000021668
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
RH126518  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381284,756,429 - 84,756,677UniSTSGRCm38
MGSCv371286,097,379 - 86,097,627UniSTSGRCm37
Celera1286,212,453 - 86,212,701UniSTS
Cytogenetic Map12D1UniSTS
Whitehead/MRC_RH12796.69UniSTS
D12Mit238  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381284,754,429 - 84,754,552UniSTSGRCm38
MGSCv371286,095,379 - 86,095,502UniSTSGRCm37
Cytogenetic Map12D1UniSTS
cM Map1241.0UniSTS
Whitehead Genetic1236.1UniSTS
Whitehead/MRC_RH12794.68UniSTS
Whitehead_YAC12 UniSTS
AU045843  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381284,754,868 - 84,755,002UniSTSGRCm38
MGSCv371286,095,818 - 86,095,952UniSTSGRCm37
Celera1286,210,892 - 86,211,026UniSTS
Cytogenetic Map12D1UniSTS
Whitehead/MRC_RH12794.68UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_023409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB021289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI391386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE952809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000021668   ⟹   ENSMUSP00000021668
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1284,801,336 - 84,819,926 (-)Ensembl
GRCm38.p6 Ensembl1284,754,562 - 84,773,152 (-)Ensembl
Ensembl Acc Id: ENSMUST00000221056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1284,811,560 - 84,819,688 (-)Ensembl
GRCm38.p6 Ensembl1284,764,786 - 84,772,914 (-)Ensembl
Ensembl Acc Id: ENSMUST00000223200
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1284,803,266 - 84,809,314 (-)Ensembl
GRCm38.p6 Ensembl1284,756,492 - 84,762,540 (-)Ensembl
RefSeq Acc Id: NM_023409   ⟹   NP_075898
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391284,801,333 - 84,819,886 (-)NCBI
GRCm381284,754,559 - 84,773,112 (-)ENTREZGENE
MGSCv371286,095,509 - 86,114,062 (-)RGD
Celera1286,210,583 - 86,229,366 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_075898   ⟸   NM_023409
- Peptide Label: precursor
- UniProtKB: Q3UB23 (UniProtKB/Swiss-Prot),   Q9Z0J0 (UniProtKB/Swiss-Prot),   Q3TXQ4 (UniProtKB/TrEMBL),   Q3U3C2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000021668   ⟸   ENSMUST00000021668
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0J0-F1-model_v2 AlphaFold Q9Z0J0 1-149 view protein structure

Promoters
RGD ID:8678798
Promoter ID:EPDNEW_M17430
Type:initiation region
Name:Npc2_1
Description:Mus musculus NPC intracellular cholesterol transporter 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381284,772,898 - 84,772,958EPDNEW
RGD ID:6846992
Promoter ID:MM_ACW:11468
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NPC2.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361286,101,499 - 86,101,999 (-)MPROMDB
RGD ID:6823252
Promoter ID:MM_KWN:12179
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_023409,   NM_028863,   UC007OFV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361286,112,756 - 86,114,812 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915213 AgrOrtholog
Ensembl Genes ENSMUSG00000021242 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021668 ENTREZGENE
  ENSMUST00000021668.10 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.770 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ML_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ML_Npc2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPC2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67963 UniProtKB/Swiss-Prot
MGD MGI:1915213 ENTREZGENE
NCBI Gene 67963 ENTREZGENE
PANTHER NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11306 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E1_DerP2_DerF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npc2 PhenoGen
SMART SM00737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NPC2_MOUSE UniProtKB/Swiss-Prot
  Q3TXQ4 ENTREZGENE, UniProtKB/TrEMBL
  Q3U3C2 ENTREZGENE, UniProtKB/TrEMBL
  Q3U8F7_MOUSE UniProtKB/TrEMBL
  Q3UB23 ENTREZGENE
  Q9Z0J0 ENTREZGENE
UniProt Secondary Q3UB23 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-05 Npc2  NPC intracellular cholesterol transporter 2    Niemann-Pick type C2  Symbol and/or name change 5135510 APPROVED
2014-04-09 Npc2  Niemann-Pick type C2    Niemann Pick type C2  Symbol and/or name change 5135510 APPROVED