Spi1 (Spi-1 proto-oncogene) - Rat Genome Database

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Gene: Spi1 (Spi-1 proto-oncogene) Mus musculus
Analyze
Symbol: Spi1
Name: Spi-1 proto-oncogene (Ensembl:spleen focus forming virus (SFFV) proviral integration oncogene)
RGD ID: 1553307
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and histone deacetylase binding activity. Involved in several processes, including lymphocyte differentiation; regulation of macromolecule biosynthetic process; and regulation of myeloid leukocyte mediated immunity. Acts upstream of or within several processes, including apoptotic process involved in blood vessel morphogenesis; hemopoiesis; and regulation of DNA-templated transcription. Located in nucleus. Part of chromatin. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study acute myeloid leukemia. Human ortholog(s) of this gene implicated in agammaglobulinemia 10. Orthologous to human SPI1 (Spi-1 proto-oncogene).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 31 kDa-transforming protein; Dis; Dis-1; Dis1; hematopoietic transcription factor PU.1; PU.; PU.1; Sf; SFFV proviral integration 1 protein; Sfp; Sfpi-1; Sfpi1; Sp; Spi-1; spleen focus forming virus (SFFV) proviral integration oncogene; Tcfpu; Tcfpu1; Tfpu.; Tfpu.1; transcription factor PU.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,912,750 - 90,946,104 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,912,735 - 90,946,101 (+)EnsemblGRCm39 Ensembl
GRCm38291,082,374 - 91,115,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,082,390 - 91,115,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,936,954 - 90,955,913 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,897,636 - 90,916,595 (+)NCBIMGSCv36mm8
Celera292,481,297 - 92,500,928 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure regression  (IMP)
apoptotic process involved in blood vessel morphogenesis  (IMP)
cell differentiation  (IBA)
cellular response to ethanol  (ISO)
defense response to tumor cell  (ISO)
endothelial to hematopoietic transition  (IEP)
erythrocyte differentiation  (IMP)
follicular B cell differentiation  (IGI)
germinal center B cell differentiation  (IGI)
granulocyte differentiation  (IDA)
immature B cell differentiation  (IGI)
interleukin-6-mediated signaling pathway  (ISO)
lipopolysaccharide-mediated signaling pathway  (IMP)
lymphocyte differentiation  (IDA)
lymphoid progenitor cell differentiation  (IMP)
macrophage differentiation  (IDA)
myeloid dendritic cell differentiation  (IMP)
myeloid leukocyte differentiation  (IMP,ISO)
negative regulation of adipose tissue development  (IMP)
negative regulation of DNA-templated transcription  (IMP,ISO)
negative regulation of gene expression  (IMP,ISO)
negative regulation of MHC class II biosynthetic process  (IDA)
negative regulation of neutrophil degranulation  (IMP)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of non-canonical NF-kappaB signal transduction  (ISO)
negative regulation of protein localization to chromatin  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
oncogene-induced cell senescence  (IDA)
osteoclast differentiation  (ISO)
pericyte cell differentiation  (IMP)
positive regulation of antifungal innate immune response  (IMP)
positive regulation of B cell differentiation  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of microglial cell mediated cytotoxicity  (IMP)
positive regulation of miRNA transcription  (IDA,ISO)
positive regulation of myeloid dendritic cell chemotaxis  (IMP)
positive regulation of p38MAPK cascade  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
pro-T cell differentiation  (IMP)
regulation of DNA-binding transcription factor activity  (IMP)
regulation of DNA-templated transcription  (IDA,ISO)
regulation of erythrocyte differentiation  (ISO)
regulation of myeloid progenitor cell differentiation  (IMP)
regulation of transcription by RNA polymerase II  (IBA,IDA)
response to ethanol  (ISO)
somatic stem cell population maintenance  (IDA)
TRAIL-activated apoptotic signaling pathway  (ISO)
transcription initiation-coupled chromatin remodeling  (IDA,ISO)
transforming growth factor beta receptor signaling pathway  (IMP)
vasculature development  (IMP)

Cellular Component
chromatin  (IDA,ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA,ISO)
transcription regulator complex  (IC,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell number  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal chromosome number  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal double-negative T cell morphology  (IAGP)
abnormal erythrocyte cell number  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal eye development  (IAGP)
abnormal fetal derived definitive erythrocyte cell number  (IAGP)
abnormal granulocyte differentiation  (IAGP)
abnormal granulocyte morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal immature B cell morphology  (IAGP)
abnormal leukopoiesis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal macrophage differentiation  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal monocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal neutrophil differentiation  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal spleen germinal center morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell number  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
absent B cells  (IAGP)
absent common myeloid progenitor cells  (IAGP)
absent erythrocytes  (IAGP)
absent mature B cells  (IAGP)
absent spleen germinal center  (IAGP)
anemia  (IAGP)
arrested B cell differentiation  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1a cell number  (IAGP)
decreased body size  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased erythrocyte cell number  (IEA)
decreased granulocyte number  (IAGP)
decreased hematocrit  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased motor neuron number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased spleen red pulp amount  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
decreased thymus weight  (IAGP)
enlarged liver  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
failure of myelopoiesis  (IAGP)
failure of tooth eruption  (IAGP)
hemorrhage  (IEA)
impaired myelopoiesis  (IAGP)
increased B cell apoptosis  (IAGP)
increased B-1 B cell number  (IAGP)
increased B-1b cell number  (IAGP)
increased bone marrow cell number  (IAGP)
increased double-negative T cell number  (IAGP)
increased granulocyte number  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hematopoietic stem cell proliferation  (IAGP)
increased IgM level  (IAGP)
increased leukemia incidence  (IAGP)
increased liver weight  (IAGP)
increased lymphocyte cell number  (IAGP)
increased mean corpuscular volume  (IEA)
increased neutrophil cell number  (IAGP)
increased spleen weight  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IAGP)
increased tumor incidence  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver hyperplasia  (IAGP)
motor neuron degeneration  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteopetrosis  (IAGP)
persistence of hyaloid vascular system  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
sepsis  (IAGP)
small thymus  (IAGP)
spleen hyperplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Attaya M, etal., Nature 1992 Feb 13;355(6361):647-9.
2. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
3. Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Galson DL, etal., Mol Cell Biol 1993 May;13(5):2929-41.
4. Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage. Joshi PC, etal., J Immunol. 2005 Nov 15;175(10):6837-45.
5. Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1. Lichanska AM, etal., Blood 1999 Jul 1;94(1):127-38.
6. Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats. Mehta AJ, etal., Alcohol Clin Exp Res. 2011 Aug;35(8):1519-28. doi: 10.1111/j.1530-0277.2011.01488.x. Epub 2011 Mar 29.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Jak2 is essential for signaling through a variety of cytokine receptors. Parganas E, etal., Cell 1998 May 1;93(3):385-95.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. PU.1 expression in microglia. Walton MR, etal., J Neuroimmunol. 2000 May 1;104(2):109-15.
16. PU.1-silenced dendritic cells prolong allograft survival in rats receiving intestinal transplantation. Xu XW, etal., World J Gastroenterol. 2013 Nov 21;19(43):7766-71. doi: 10.3748/wjg.v19.i43.7766.
Additional References at PubMed
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Genomics

Comparative Map Data
Spi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,912,750 - 90,946,104 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,912,735 - 90,946,101 (+)EnsemblGRCm39 Ensembl
GRCm38291,082,374 - 91,115,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,082,390 - 91,115,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,936,954 - 90,955,913 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,897,636 - 90,916,595 (+)NCBIMGSCv36mm8
Celera292,481,297 - 92,500,928 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
SPI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,354,860 - 47,378,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,354,860 - 47,409,369 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,376,411 - 47,400,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,332,985 - 47,356,703 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,332,987 - 47,356,674NCBI
Celera1147,515,686 - 47,541,505 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,075,532 - 47,099,721 (-)NCBIHuRef
CHM1_11147,375,652 - 47,399,367 (-)NCBICHM1_1
T2T-CHM13v2.01147,511,687 - 47,538,667 (-)NCBIT2T-CHM13v2.0
Spi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,529,509 - 97,548,204 (+)NCBIGRCr8
mRatBN7.2377,059,744 - 77,093,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,073,012 - 77,092,393 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,552,207 - 80,570,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,151,217 - 89,169,847 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,002,389 - 87,021,093 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,918,127 - 79,937,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,627,684 - 86,646,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,456,353 - 75,475,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,352,724 - 75,372,093 (+)NCBI
Celera376,282,068 - 76,300,680 (+)NCBICelera
Cytogenetic Map3q24NCBI
Spi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422873,735 - 886,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422873,735 - 886,560 (+)NCBIChiLan1.0ChiLan1.0
SPI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,555,991 - 49,581,635 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,575,785 - 49,601,430 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,301,245 - 47,326,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,853,991 - 47,880,259 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,853,991 - 47,880,259 (-)Ensemblpanpan1.1panPan2
SPI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,253,849 - 42,269,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,253,811 - 42,269,727 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,983,530 - 40,999,141 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,908,919 - 42,924,536 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,908,267 - 42,924,759 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,395,271 - 42,410,877 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,950,490 - 41,966,095 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,679,725 - 42,695,395 (+)NCBIUU_Cfam_GSD_1.0
Spi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,741,101 - 19,757,903 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,852,740 - 1,870,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,852,759 - 1,870,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,227,881 - 15,245,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,227,850 - 15,245,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,434,712 - 16,452,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,935,037 - 17,961,638 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,935,922 - 17,961,717 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,237,583 - 115,263,142 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,394,704 - 1,404,406 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,376,649 - 1,404,382 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spi1
961 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:731
Count of miRNA genes:459
Interacting mature miRNAs:527
Transcripts:ENSMUST00000002180, ENSMUST00000131400, ENSMUST00000132741, ENSMUST00000169852
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276678758103095823Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse

Markers in Region
X17463  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38291,115,608 - 91,115,705UniSTSGRCm38
MGSCv37290,955,765 - 90,955,862UniSTSGRCm37
Celera292,500,780 - 92,500,877UniSTS
Cytogenetic Map2E3UniSTS
cM Map247.5UniSTS
Whitehead/MRC_RH21270.89UniSTS
PMC186377P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38291,115,547 - 91,115,626UniSTSGRCm38
MGSCv37290,955,704 - 90,955,783UniSTSGRCm37
Celera292,500,719 - 92,500,798UniSTS
Cytogenetic Map2E3UniSTS
cM Map247.5UniSTS
Sfpi1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E3UniSTS
cM Map247.5UniSTS
Sfpi1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001378898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA239990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA789819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL691450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ187167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L03215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X17463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000002180   ⟹   ENSMUSP00000002180
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl290,926,441 - 90,946,101 (+)Ensembl
GRCm38.p6 Ensembl291,096,096 - 91,115,756 (+)Ensembl
Ensembl Acc Id: ENSMUST00000131400
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl290,912,753 - 90,920,655 (+)Ensembl
GRCm38.p6 Ensembl291,082,408 - 91,090,310 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132741   ⟹   ENSMUSP00000128457
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl290,927,125 - 90,943,660 (+)Ensembl
GRCm38.p6 Ensembl291,096,780 - 91,113,315 (+)Ensembl
Ensembl Acc Id: ENSMUST00000169852   ⟹   ENSMUSP00000130368
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl290,912,735 - 90,944,711 (+)Ensembl
GRCm38.p6 Ensembl291,082,390 - 91,114,366 (+)Ensembl
Ensembl Acc Id: ENSMUST00000249728   ⟹   ENSMUSP00000159896
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl290,912,735 - 90,946,101 (+)Ensembl
Ensembl Acc Id: ENSMUST00000249729   ⟹   ENSMUSP00000159897
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl290,926,441 - 90,946,101 (+)Ensembl
RefSeq Acc Id: NM_001378898   ⟹   NP_001365827
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39290,927,045 - 90,946,102 (+)NCBI
GRCm38291,096,700 - 91,115,757 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001378899   ⟹   NP_001365828
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39290,912,750 - 90,946,102 (+)NCBI
GRCm38291,082,405 - 91,115,757 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011355   ⟹   NP_035485
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39290,927,023 - 90,946,104 (+)NCBI
GRCm38291,096,678 - 91,115,759 (+)NCBI
MGSCv37290,936,954 - 90,955,913 (+)RGD
Celera292,481,297 - 92,500,928 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035485   ⟸   NM_011355
- Peptide Label: isoform 2
- UniProtKB: Q99L57 (UniProtKB/Swiss-Prot),   P17433 (UniProtKB/Swiss-Prot),   Q3U5L4 (UniProtKB/TrEMBL),   A0AAA9WUS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001365828   ⟸   NM_001378899
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001365827   ⟸   NM_001378898
- Peptide Label: isoform 1
- UniProtKB: A0AAA9WUS1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000128457   ⟸   ENSMUST00000132741
Ensembl Acc Id: ENSMUSP00000002180   ⟸   ENSMUST00000002180
Ensembl Acc Id: ENSMUSP00000130368   ⟸   ENSMUST00000169852
Ensembl Acc Id: ENSMUSP00000159897   ⟸   ENSMUST00000249729
Ensembl Acc Id: ENSMUSP00000159896   ⟸   ENSMUST00000249728
Protein Domains
ETS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17433-F1-model_v2 AlphaFold P17433 1-272 view protein structure

Promoters
RGD ID:6832687
Promoter ID:MM_KWN:30445
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:OTTMUST00000033994,   OTTMUST00000033995
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36290,935,286 - 90,937,147 (+)MPROMDB
RGD ID:6877884
Promoter ID:EPDNEW_M2393
Type:initiation region
Name:Spi1_1
Description:Mus musculus spleen focus forming virus proviral integrationoncogene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38291,096,760 - 91,096,820EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98282 AgrOrtholog
Ensembl Genes ENSMUSG00000002111 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002180 ENTREZGENE
  ENSMUST00000002180.8 UniProtKB/Swiss-Prot
  ENSMUST00000132741.3 UniProtKB/TrEMBL
  ENSMUST00000169852.2 UniProtKB/TrEMBL
  ENSMUST00000249728.1 UniProtKB/TrEMBL
  ENSMUST00000249729.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ets_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETS_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98282 ENTREZGENE
NCBI Gene 20375 ENTREZGENE
PANTHER PTHR11849 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR PU.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ets UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spi1 PhenoGen
PRINTS ETSDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ETS_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETS_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETS_DOMAIN_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ETS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AAA9WUS1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAA9WW00_MOUSE UniProtKB/TrEMBL
  E9Q6W1_MOUSE UniProtKB/TrEMBL
  E9QAI9_MOUSE UniProtKB/TrEMBL
  P17433 ENTREZGENE
  Q3U5L4 ENTREZGENE, UniProtKB/TrEMBL
  Q99L57 ENTREZGENE
  SPI1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q99L57 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-05 Spi1  Spi-1 proto-oncogene  Spi1  spleen focus forming virus (SFFV) proviral integration oncogene  Symbol and/or name change 5135510 APPROVED
2013-08-06 Spi1  spleen focus forming virus (SFFV) proviral integration oncogene  Sfpi1  SFFV proviral integration 1  Symbol and/or name change 5135510 APPROVED