Nfkbiz (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nfkbiz (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta) Mus musculus
Analyze
Symbol: Nfkbiz
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
RGD ID: 1553089
MGI Page MGI
Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coregulator activity. Involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune response; and response to bacterium. Acts upstream of or within inflammatory response. Is active in nucleus. Is expressed in central nervous system; early conceptus; eye; and genitourinary system. Used to study Stevens-Johnson syndrome and atopic dermatitis. Orthologous to human NFKBIZ (NFKB inhibitor zeta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA408868; I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta; ikB-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; M; Mail; molecule possessing ankyrin repeats induced by lipopolysaccharide; molecule possessing ankyrin-repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391655,631,740 - 55,659,018 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1655,631,738 - 55,659,262 (-)EnsemblGRCm39 Ensembl
GRCm381655,811,375 - 55,838,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1655,811,375 - 55,838,899 (-)EnsemblGRCm38mm10GRCm38
MGSCv371655,811,490 - 55,838,754 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361655,736,329 - 55,763,805 (-)NCBIMGSCv36mm8
Celera1656,126,905 - 56,154,128 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1633.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
C.I. Natural Red 20  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP)
calciol  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
cefaloridine  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
fenoldopam  (ISO)
fipronil  (ISO)
fluoranthene  (EXP)
flurbiprofen  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glycidol  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
GSK-J4  (ISO)
isoprenaline  (EXP)
L-methionine  (EXP)
leflunomide  (ISO)
levofloxacin  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodimethylamine  (ISO)
oroxylin A  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
Shikonin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sulforaphane  (ISO)
tamoxifen  (EXP)
tebufenpyrad  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
tunicamycin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
yohimbine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IDA)
B cell proliferation  (IMP)
B cell receptor apoptotic signaling pathway  (IDA)
B cell receptor signaling pathway  (IDA)
cellular response to cytokine stimulus  (IDA,IMP)
cellular response to interleukin-17  (IDA,IMP)
cellular response to lipopolysaccharide  (IMP)
cellular response to transforming growth factor beta stimulus  (IMP)
chromatin organization  (IMP)
chromatin remodeling  (IDA,IMP)
chronic inflammatory response  (IMP)
cytokine-mediated signaling pathway  (IMP)
defense response to Gram-negative bacterium  (IMP)
epithelial cell apoptotic process  (IMP)
establishment of skin barrier  (IMP)
execution phase of apoptosis  (IMP)
gene expression  (IDA,IMP)
homeostasis of number of cells within a tissue  (IMP)
immunoglobulin mediated immune response  (IMP)
inflammatory response  (IDA,IMP)
inflammatory response to wounding  (IDA)
isotype switching  (IMP)
keratinocyte activation  (IMP)
keratinocyte differentiation  (IMP)
keratinocyte proliferation  (IMP)
lymphocyte activation involved in immune response  (IMP)
mRNA transcription by RNA polymerase II  (IDA,IMP)
plasma cell differentiation  (IMP)
positive regulation of defense response  (IEA)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of T-helper 17 cell differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA)
regulation of gene expression  (IBA)
regulation of immune response  (IMP)
response to cisplatin  (IDA)
response to cytokine  (IMP)
response to folic acid  (IDA)
response to Gram-positive bacterium  (IMP)
response to lipopolysaccharide  (IMP)
response to xenobiotic stimulus  (IMP)
skin development  (IMP)
skin epidermis development  (IMP)
spleen development  (IMP)
T cell differentiation  (IMP)
T cell mediated immunity  (IMP)
T cell receptor signaling pathway  (IMP)
T-helper 1 cell differentiation  (IMP)
T-helper 17 cell differentiation  (IMP)
toll-like receptor signaling pathway  (IDA,IMP)
transcription by RNA polymerase II  (IMP)
transcription preinitiation complex assembly  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal conjunctiva goblet cell morphology  (IAGP)
abnormal conjunctival epithelium morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin morphology  (IAGP)
abnormal T-helper 1 cell morphology  (IAGP)
abnormal tumor necrosis factor secretion  (IAGP)
acanthosis  (IAGP)
alopecia  (IAGP)
blepharitis  (IAGP)
conjunctivitis  (IAGP)
corneal limbitis  (IAGP)
decreased conjunctiva goblet cell number  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased tear production  (IAGP)
dermatitis  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
excessive scratching  (IAGP)
eye inflammation  (IAGP)
eyelid edema  (IAGP)
hyperkeratosis  (IAGP)
increased IgE level  (IAGP)
increased immunoglobulin level  (IAGP)
increased lacrimal gland apoptosis  (IAGP)
interstitial pneumonia  (IAGP)
lacrimal gland inflammation  (IAGP)
parakeratosis  (IAGP)
periocular dermatitis  (IAGP)
perioral dermatitis  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
reddish skin  (IAGP)
scaly skin  (IAGP)
skin edema  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
spontaneous skin ulceration  (IAGP)
thick skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11086164   PMID:11217851   PMID:11278262   PMID:11356851   PMID:11544199   PMID:11797098   PMID:12069074   PMID:12477932  
PMID:12565889   PMID:12703554   PMID:15241416   PMID:15491998   PMID:15522867   PMID:15527973   PMID:15618216   PMID:15671285   PMID:16141072   PMID:16141073   PMID:16322095   PMID:17367755  
PMID:17409644   PMID:18287559   PMID:18319258   PMID:18441309   PMID:18824552   PMID:20059953   PMID:20211142   PMID:20383124   PMID:20412781   PMID:20876105   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:22131231   PMID:23453632   PMID:23547114   PMID:23728777   PMID:24948478   PMID:25107474   PMID:25124037   PMID:25282160   PMID:25876660   PMID:26019294   PMID:26460049  
PMID:26563030   PMID:26776679   PMID:27129283   PMID:28391993   PMID:28740238   PMID:29670287   PMID:29934320   PMID:30224457   PMID:31164412   PMID:31182790   PMID:31622280   PMID:31853061  
PMID:31918161   PMID:32144162   PMID:32325033   PMID:32647171   PMID:33127905   PMID:33328388   PMID:33431705   PMID:33542719   PMID:35145063   PMID:35193410   PMID:35804007   PMID:35999460  
PMID:36306369   PMID:37725983   PMID:38162658   PMID:38918046   PMID:39279148  


Genomics

Comparative Map Data
Nfkbiz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391655,631,740 - 55,659,018 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1655,631,738 - 55,659,262 (-)EnsemblGRCm39 Ensembl
GRCm381655,811,375 - 55,838,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1655,811,375 - 55,838,899 (-)EnsemblGRCm38mm10GRCm38
MGSCv371655,811,490 - 55,838,754 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361655,736,329 - 55,763,805 (-)NCBIMGSCv36mm8
Celera1656,126,905 - 56,154,128 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1633.65NCBI
NFKBIZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383101,827,990 - 101,861,022 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3101,827,991 - 101,861,022 (+)EnsemblGRCh38hg38GRCh38
GRCh373101,546,834 - 101,579,866 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363103,029,547 - 103,062,556 (+)NCBINCBI36Build 36hg18NCBI36
Build 343103,051,047 - 103,062,555NCBI
Celera399,940,218 - 99,973,254 (+)NCBICelera
Cytogenetic Map3q12.3NCBI
HuRef398,915,528 - 98,948,489 (+)NCBIHuRef
CHM1_13101,510,104 - 101,543,165 (+)NCBICHM1_1
T2T-CHM13v2.03104,540,783 - 104,573,840 (+)NCBIT2T-CHM13v2.0
Nfkbiz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81158,251,720 - 58,279,767 (+)NCBIGRCr8
GRCr8 Ensembl1158,251,721 - 58,279,767 (+)EnsemblGRCr8 Ensembl
mRatBN7.21144,782,676 - 44,810,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,782,676 - 44,810,723 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1153,559,179 - 53,587,222 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01146,220,825 - 46,248,868 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01145,344,968 - 45,373,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01147,243,342 - 47,271,487 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1147,243,342 - 47,271,487 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,420,563 - 50,447,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,776,027 - 45,811,515 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1144,534,358 - 44,562,504 (+)NCBICelera
RGSC_v3.11145,851,817 - 45,867,783 (+)NCBI
Cytogenetic Map11q12NCBI
Nfkbiz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554273,350,174 - 3,360,379 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554273,350,174 - 3,358,609 (+)NCBIChiLan1.0ChiLan1.0
NFKBIZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2299,765,320 - 99,798,852 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1399,770,109 - 99,803,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0398,914,957 - 98,948,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13105,616,645 - 105,628,300 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3105,616,645 - 105,628,300 (+)Ensemblpanpan1.1panPan2
NFKBIZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1338,147,160 - 8,154,401 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl338,073,840 - 8,154,561 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha338,299,319 - 8,308,950 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0338,263,750 - 8,294,332 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl338,283,254 - 8,294,324 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1338,171,804 - 8,181,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0338,218,093 - 8,227,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0338,558,667 - 8,568,280 (+)NCBIUU_Cfam_GSD_1.0
Nfkbiz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602148,703,296 - 148,734,803 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366301,601,010 - 1,632,745 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366301,601,006 - 1,633,844 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKBIZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13157,261,419 - 157,272,688 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113157,261,419 - 157,273,119 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213166,743,487 - 166,777,576 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFKBIZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12279,044,624 - 79,077,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2279,044,619 - 79,055,776 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604187,478,007 - 87,510,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkbiz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478915,612,335 - 15,624,152 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478915,612,311 - 15,623,878 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfkbiz
652 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1664
Count of miRNA genes:399
Interacting mature miRNAs:520
Transcripts:ENSMUST00000036273, ENSMUST00000096026, ENSMUST00000114457, ENSMUST00000114458, ENSMUST00000139373
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164059392374594076Mouse
1301394Eae11_msusceptibility to experimental allergic encephalomyelitis 11 (mouse)Not determined165356189187562035Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
1301719Remslp3_mrapid eye movement sleep 3 (mouse)Not determined164438335078383506Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164219781782331174Mouse
14696806Smcl1_msmoke-mediated chord length 1 (mouse)165401530958330871Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
11522747Eae41_mexperimental allergic encephalomyelitis susceptibility 41 (mouse)164039913478015472Mouse
14928310Manh80_mmandible shape 80 (mouse)164821984182219841Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163732036284696888Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
4142112Skts-fp3_mskin tumor susceptibility in FVB and PWK 3 (mouse)Not determined164005388172924385Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
4141212Imraq3_mimmune response to AAV2 QTL 3 (mouse)Not determined164438335078383506Mouse
1558836Dice1b_mdetermination of interleukin 4 commitment 1b (mouse)Not determined164551100072274485Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
RH124783  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381655,811,444 - 55,811,679UniSTSGRCm38
MGSCv371655,811,557 - 55,811,792UniSTSGRCm37
Celera1656,126,972 - 56,127,207UniSTS
Cytogenetic Map16C1.2-C1.3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001159394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001159395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB020974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB026551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB040458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB047549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB196497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC156020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC165151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000036273   ⟹   ENSMUSP00000041173
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1655,631,738 - 55,659,262 (-)Ensembl
GRCm38.p6 Ensembl1655,811,375 - 55,838,899 (-)Ensembl
Ensembl Acc Id: ENSMUST00000096026   ⟹   ENSMUSP00000093726
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1655,631,741 - 55,659,217 (-)Ensembl
GRCm38.p6 Ensembl1655,811,378 - 55,838,854 (-)Ensembl
Ensembl Acc Id: ENSMUST00000114457   ⟹   ENSMUSP00000110101
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1655,631,738 - 55,659,262 (-)Ensembl
GRCm38.p6 Ensembl1655,811,375 - 55,838,899 (-)Ensembl
Ensembl Acc Id: ENSMUST00000114458   ⟹   ENSMUSP00000110102
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1655,631,738 - 55,642,501 (-)Ensembl
GRCm38.p6 Ensembl1655,811,375 - 55,822,138 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139373
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1655,645,029 - 55,659,262 (-)Ensembl
GRCm38.p6 Ensembl1655,824,666 - 55,838,899 (-)Ensembl
Ensembl Acc Id: ENSMUST00000231463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1655,638,109 - 55,638,878 (-)Ensembl
GRCm38.p6 Ensembl1655,817,746 - 55,818,515 (-)Ensembl
RefSeq Acc Id: NM_001159394   ⟹   NP_001152866
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391655,631,740 - 55,642,501 (-)NCBI
GRCm381655,811,377 - 55,822,138 (-)NCBI
MGSCv371655,811,490 - 55,838,754 (-)RGD
Celera1656,126,905 - 56,154,128 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001159395   ⟹   NP_001152867
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391655,631,740 - 55,659,018 (-)NCBI
GRCm381655,811,377 - 55,838,641 (-)ENTREZGENE
MGSCv371655,811,490 - 55,838,754 (-)RGD
Celera1656,126,905 - 56,154,128 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_030612   ⟹   NP_085115
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391655,631,740 - 55,659,018 (-)NCBI
GRCm381655,811,377 - 55,838,641 (-)ENTREZGENE
MGSCv371655,811,490 - 55,838,754 (-)RGD
Celera1656,126,905 - 56,154,128 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_085115   ⟸   NM_030612
- Peptide Label: isoform a
- UniProtKB: Q5NT97 (UniProtKB/Swiss-Prot),   Q3UW99 (UniProtKB/Swiss-Prot),   Q3URP0 (UniProtKB/Swiss-Prot),   Q3UCI2 (UniProtKB/Swiss-Prot),   Q3U8Y9 (UniProtKB/Swiss-Prot),   Q3TWK9 (UniProtKB/Swiss-Prot),   Q3TVL7 (UniProtKB/Swiss-Prot),   Q99NA4 (UniProtKB/Swiss-Prot),   Q9EST8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001152867   ⟸   NM_001159395
- Peptide Label: isoform b
- UniProtKB: Q9EST8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001152866   ⟸   NM_001159394
- Peptide Label: isoform a
- UniProtKB: Q5NT97 (UniProtKB/Swiss-Prot),   Q3UW99 (UniProtKB/Swiss-Prot),   Q3URP0 (UniProtKB/Swiss-Prot),   Q3UCI2 (UniProtKB/Swiss-Prot),   Q3U8Y9 (UniProtKB/Swiss-Prot),   Q3TWK9 (UniProtKB/Swiss-Prot),   Q3TVL7 (UniProtKB/Swiss-Prot),   Q99NA4 (UniProtKB/Swiss-Prot),   Q9EST8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000093726   ⟸   ENSMUST00000096026
Ensembl Acc Id: ENSMUSP00000041173   ⟸   ENSMUST00000036273
Ensembl Acc Id: ENSMUSP00000110101   ⟸   ENSMUST00000114457
Ensembl Acc Id: ENSMUSP00000110102   ⟸   ENSMUST00000114458
Protein Domains
OCA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EST8-F1-model_v2 AlphaFold Q9EST8 1-728 view protein structure

Promoters
RGD ID:6827296
Promoter ID:MM_KWN:21234
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000096026
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361655,818,146 - 55,819,602 (-)MPROMDB
RGD ID:6847319
Promoter ID:MM_ACW:20791
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B4,   MEF_B6
Transcripts:NFKBIZ.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361655,819,696 - 55,821,047 (-)MPROMDB
RGD ID:6827299
Promoter ID:MM_KWN:21235
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000114458
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361655,821,841 - 55,822,672 (-)MPROMDB
RGD ID:8686364
Promoter ID:EPDNEW_M21212
Type:multiple initiation site
Name:Nfkbiz_1
Description:Mus musculus nuclear factor of kappa light polypeptide gene enhancerin B cells inhibitor, zeta , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21213  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381655,822,138 - 55,822,198EPDNEW
RGD ID:8686366
Promoter ID:EPDNEW_M21213
Type:multiple initiation site
Name:Nfkbiz_2
Description:Mus musculus nuclear factor of kappa light polypeptide gene enhancerin B cells inhibitor, zeta , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21212  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381655,838,655 - 55,838,715EPDNEW
RGD ID:6827298
Promoter ID:MM_KWN:21236
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000114457,   OTTMUST00000047636,   OTTMUST00000047638
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361655,838,716 - 55,839,537 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1931595 AgrOrtholog
Ensembl Genes ENSMUSG00000035356 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000036273 ENTREZGENE
  ENSMUST00000036273.13 UniProtKB/Swiss-Prot
  ENSMUST00000096026.9 UniProtKB/Swiss-Prot
  ENSMUST00000114457 ENTREZGENE
  ENSMUST00000114457.8 UniProtKB/Swiss-Prot
  ENSMUST00000114458 ENTREZGENE
  ENSMUST00000114458.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  OCA UniProtKB/Swiss-Prot
KEGG Report mmu:80859 UniProtKB/Swiss-Prot
MGD MGI:1931595 ENTREZGENE
NCBI Gene 80859 ENTREZGENE
PANTHER ANKYRIN REPEAT FAMILY A UniProtKB/Swiss-Prot
  NF-KAPPA-B INHIBITOR ZETA UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
PhenoGen Nfkbiz PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  OCA UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt IKBZ_MOUSE UniProtKB/Swiss-Prot
  Q3TVL7 ENTREZGENE
  Q3TWK9 ENTREZGENE
  Q3U8Y9 ENTREZGENE
  Q3UCI2 ENTREZGENE
  Q3URP0 ENTREZGENE
  Q3UW99 ENTREZGENE
  Q5NT97 ENTREZGENE
  Q99NA4 ENTREZGENE
  Q9EST8 ENTREZGENE
UniProt Secondary Q3TVL7 UniProtKB/Swiss-Prot
  Q3TWK9 UniProtKB/Swiss-Prot
  Q3U8Y9 UniProtKB/Swiss-Prot
  Q3UCI2 UniProtKB/Swiss-Prot
  Q3URP0 UniProtKB/Swiss-Prot
  Q3UW99 UniProtKB/Swiss-Prot
  Q5NT97 UniProtKB/Swiss-Prot
  Q99NA4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Nfkbiz  nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta  Nfkbiz  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta  Symbol and/or name change 5135510 APPROVED