Thbd (thrombomodulin) - Rat Genome Database

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Gene: Thbd (thrombomodulin) Mus musculus
Symbol: Thbd
Name: thrombomodulin
RGD ID: 1553030
Description: Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Acts upstream of or within female pregnancy. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; lung; and skeleton. Used to study thrombophilia. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI385582; CD141; fetomodulin; snoRNA MBII-339; TM
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392148,246,391 - 148,250,108 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2148,246,386 - 148,250,108 (-)EnsemblGRCm39 Ensembl
GRCm382148,404,471 - 148,408,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,404,466 - 148,408,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv372148,230,207 - 148,233,924 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362148,095,912 - 148,099,544 (-)NCBIMGSCv36mm8
Celera2149,679,568 - 149,683,285 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (IDA,ISO)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
asthma  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Brain Injuries  (ISO)
brain small vessel disease  (ISO)
carotid artery thrombosis  (ISO)
cerebral infarction  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
dermatomyositis  (ISO)
disseminated intravascular coagulation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
end stage renal disease  (IDA,ISO)
Endotoxemia  (IEP,ISO)
Endotoxin-Induced Uveitis  (ISO)
Experimental Arthritis  (IMP)
Experimental Liver Cirrhosis  (ISO)
familial combined hyperlipidemia  (ISO)
familial Mediterranean fever  (ISO)
genetic disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Habitual Abortions  (ISO)
Heat Stroke  (ISO)
hemolytic-uremic syndrome  (IMP)
hemorrhagic disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
idiopathic pulmonary fibrosis  (ISO)
impotence  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
liver disease  (ISO)
lung non-small cell carcinoma  (ISO)
Metabolic Syndrome  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
obesity  (ISO)
Painful Neuropathy  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (IDA)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia  (ISO)
Thromboembolism  (ISO)
thrombophilia  (IAGP,ISO)
thrombophilia due to thrombomodulin defect  (ISO)
thrombosis  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
aconitine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
candesartan  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
carmustine  (ISO)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
fenvalerate  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gestodene  (ISO)
glucose  (ISO)
hydralazine  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (EXP)
LY294002  (ISO)
methotrexate  (EXP,ISO)
methyl methacrylate  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
mevalonic acid  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nitric oxide  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
triclosan  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
Tungsten carbide  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute phase protein level  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endocardium morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal leukocyte adhesion  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lung thrombosis  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal placenta development  (IAGP)
abnormal placental thrombosis  (IAGP)
abnormal response to injury  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal thrombosis  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent vitelline blood vessels  (IAGP)
cardiac fibrosis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased trophoblast giant cell number  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality prior to organogenesis  (IEA)
embryonic lethality, complete penetrance  (IAGP)
enlarged heart  (IAGP)
gastrointestinal hemorrhage  (IAGP)
hematuria  (IAGP)
hemothorax  (IAGP)
increased circulating D-dimer level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased heart right ventricle weight  (IAGP)
increased heart weight  (IAGP)
increased lung weight  (IEA)
increased megakaryocyte cell number  (IAGP)
increased myocardial infarct size  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to induced thrombosis  (IAGP)
intracerebral hemorrhage  (IAGP)
lethality during fetal growth through weaning, incomplete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hemorrhage  (IAGP)
lung hemorrhage  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IAGP)
placenta hemorrhage  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
priapism  (IAGP)
pulmonary hypertension  (IAGP)
skin hemorrhage  (IAGP)
slow postnatal weight gain  (IAGP)
small ectoplacental cone  (IAGP)
thrombocytopenia  (IAGP)

References - curated
# Reference Title Reference Citation
1. Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor and thrombomodulin levels in children with hypothyroidism. Alioglu B, etal., J Clin Res Pediatr Endocrinol. 2012 Sep;4(3):146-50. doi: 10.4274/Jcrpe.652.
2. Relationship between plasma soluble thrombomodulin levels and insulin resistance syndrome in type 2 diabetes: a comparison with von Willebrand factor. Aso Y, etal., Exp Clin Endocrinol Diabetes. 2001;109(4):210-6.
3. Inflammation, TNFalpha and endothelial dysfunction link lenalidomide to venous thrombosis in chronic lymphocytic leukemia. Aue G, etal., Am J Hematol. 2011 Oct;86(10):835-40. doi: 10.1002/ajh.22114. Epub 2011 Aug 2.
4. Decrease in circulating endothelial cell adhesion molecule and thrombomodulin levels during oral iloprost treatment in rheumatoid arthritis patients: preliminary results. Boehme MW, etal., Rheumatol Int. 2006 Feb;26(4):340-7. Epub 2005 Feb 8.
5. Cholinesterase inhibitors exert a protective effect on endothelial damage in Alzheimer disease patients. Borroni B, etal., J Neurol Sci. 2005 Mar 15;229-230:211-3. Epub 2004 Dec 8.
6. Increased immunohistochemical expression of thrombomodulin at placental perivascular myofibroblast in severe preeclampsia (PE). Bosco C, etal., Histol Histopathol. 2005 Oct;20(4):1045-55.
7. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
8. Expression patterns of adhesion receptors in the developing mouse lung: functional implications. Buck CA, etal., Cell Adhes Commun 1996 Aug;4(2):69-87.
9. The association of idiopathic recurrent pregnancy loss with polymorphisms in hemostasis-related genes. Cao Y, etal., Gene. 2013 Nov 10;530(2):248-52. doi: 10.1016/j.gene.2013.07.080. Epub 2013 Aug 14.
10. Thrombomodulin Ala455Val Polymorphism and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study. Cole JW, etal., BMC Neurol. 2004 Dec 1;4(1):21.
11. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Collard HR, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Jul;299(1):L3-7. Epub 2010 Apr 23.
12. Alterations in endothelial thrombomodulin expression in zymosan-induced lung injury. Cone JB, etal., J Trauma. 2003 Apr;54(4):731-6; discussion 736.
13. Upregulation of Inflammatory Mediators in End-Stage Renal Disease as Measured Using Biochip Array Technology. Davis R, etal., Clin Appl Thromb Hemost. 2011 Aug 25.
14. Erectile and endothelial dysfunction in Type II diabetes: a possible link. De Angelis L, etal., Diabetologia. 2001 Sep;44(9):1155-60.
15. Thrombomodulin mutations in atypical hemolytic-uremic syndrome. Delvaeye M, etal., N Engl J Med. 2009 Jul 23;361(4):345-57. doi: 10.1056/NEJMoa0810739.
16. Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation. Ding BS, etal., Am J Respir Crit Care Med. 2009 Aug 1;180(3):247-56. Epub 2009 Apr 2.
17. Serum thrombomodulin in systemic lupus erythematosus and juvenile idiopathic arthritis. el-Gamal YM, etal., Pediatr Allergy Immunol. 2004 Jun;15(3):270-7.
18. Neuroprotective effects of recombinant thrombomodulin in controlled contusion spinal cord injury implicates thrombin signaling. Festoff BW, etal., J Neurotrauma. 2004 Jul;21(7):907-22.
19. Prothrombotic markers in familial combined hyperlipidemia: evidence of endothelial cell activation and relation to metabolic syndrome. Georgieva AM, etal., Atherosclerosis. 2004 Aug;175(2):345-51.
20. Neuropathologic evidence of endothelial changes in cerebral small vessel disease. Giwa MO, etal., Neurology. 2011 Dec 14.
21. Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver. Gracia-Sancho J, etal., Gut. 2011 Apr;60(4):517-24. Epub 2010 Nov 26.
22. In vivo and in vitro effects of the anticoagulant, thrombomodulin, on the inflammatory response in rodent models. Hagiwara S, etal., Shock. 2010 Mar;33(3):282-8.
23. Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats. Hagiwara S, etal., Shock. 2010 Oct;34(4):402-6.
24. Impact of alpha-tocopherol and vitamin C on endothelial markers in rats with streptozotocin-induced diabetes. Haidara MA, etal., Med Sci Monit. 2004 Feb;10(2):BR41-6.
25. The effects of recombinant human thrombomodulin on endotoxin-induced multiple-system organ failure in rats. Hasegawa N, etal., Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1831-7.
26. Markers of endothelial cell activation in elderly men at high risk for coronary heart disease. Hjerkinn EM, etal., Scand J Clin Lab Invest. 2005;65(3):201-9.
27. Effect of recombinant human soluble thrombomodulin on clinical outcomes of patients with coagulopathy after hematopoietic stem cell transplantation. Ikezoe T, etal., Eur J Haematol. 2013 Nov;91(5):442-7. doi: 10.1111/ejh.12188. Epub 2013 Oct 1.
28. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Isermann B, etal., Nat Med 2003 Mar;9(3):331-7.
29. Effects of a novel peptide derived from human thrombomodulin on endotoxin-induced uveitis in vitro and in vivo. Jin H, etal., FEBS Lett. 2011 Nov 4;585(21):3457-64. doi: 10.1016/j.febslet.2011.10.002. Epub 2011 Oct 10.
30. Low soluble thrombomodulin activity and antigen is associated with a family history of heart disease while a high level is associated with a personal history of heart disease in type 2 diabetes. Konstantoulas CJ, etal., Thromb Haemost. 2007 Jan;97(1):161-4.
31. Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats -- a possible mechanism of intrasinusoidal microthrombus formation and liver dysfunction. Kume M, etal., J Hepatol. 2003 Jan;38(1):9-17.
32. Clinical significance of selected endothelial activation markers in patients with systemic lupus erythematosus. Kuryliszyn-Moskal A, etal., J Rheumatol. 2008 Jul;35(7):1307-13. Epub 2008 May 15.
33. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Li YP, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 Jun;19(6):365-8.
34. Decreased expression of thrombomodulin is correlated with tumor cell invasiveness and poor prognosis in nonsmall cell lung cancer. Liu PL, etal., Mol Carcinog. 2010 Oct;49(10):874-81.
35. Elevated plasma tissue-type plasminogen activator (t-PA) and soluble thrombomodulin in patients suffering from severe acute respiratory syndrome (SARS) as a possible index for prognosis and treatment strategy. Liu ZH, etal., Biomed Environ Sci. 2005 Aug;18(4):260-4.
36. [Expression of thrombomodulin, endothelial protein C receptor in lung tissue of acute paraquat poisoned rats and intervention of sodium dimercaptopropane sulfonate]. Lu ZQ, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Aug;27(8):453-6.
37. Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors. Meyer AA, etal., Pediatrics. 2006 May;117(5):1560-7.
38. MGDs mouse GO annotations MGD data from the GO Consortium
40. Hepatic expression and serum levels of thrombomodulin reflect the extent of liver injury in rats with fulminant hepatic failure and extensive hepatectomy. Miyamoto S, etal., Hepatol Res. 2002 Mar;22(3):206-213.
41. Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia. Nagato M, etal., Crit Care Med. 2009 Jul;37(7):2181-6.
42. Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism. Nakahara M, etal., PLoS One. 2013 Sep 30;8(9):e75961. doi: 10.1371/journal.pone.0075961. eCollection 2013.
43. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Noris M, etal., Clin J Am Soc Nephrol. 2010 Oct;5(10):1844-59. doi: 10.2215/CJN.02210310. Epub 2010 Jul 1.
44. Enhanced production of endothelial microparticles with increased binding to leukocytes in patients with severe systemic inflammatory response syndrome. Ogura H, etal., J Trauma. 2004 Apr;56(4):823-30; discussion 830-1.
45. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
46. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
47. Early embryonic expression of murine coagulation system components. Ong K, etal., Thromb Haemost 2000 Dec;84(6):1023-30.
48. Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure. Ozaki T, etal., Nephrol Dial Transplant. 2008 Jan;23(1):110-9. Epub 2007 Sep 5.
49. Circulating thrombomodulin levels in familial Mediterranean fever. Ozbalkan Z, etal., Clin Exp Rheumatol. 2006 Sep-Oct;24(5 Suppl 42):S95-8.
50. Thrombomodulin and antibeta2-glycoprotein I in stroke in children. Pilarska E, etal., Med Sci Monit. 2010 Jul;16(7):CR348-51.
51. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
52. Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis. Raife TJ, etal., Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2509-17.
53. Soluble Thrombomodulin Reduces Inflammation and Prevents Microalbuminuria Induced by Chronic Endothelial Activation in Transgenic Mice. Rajashekhar G, etal., Am J Physiol Renal Physiol. 2011 Nov 30.
54. Mouse MP Annotation Import Pipeline RGD automated import pipeline
55. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
57. Markers for endothelial dysfunction, but not markers for oxidative stress correlate with classical risk factors and the severity of coronary artery disease. (A subgroup analysis from the Ludwigshafen Risk and Cardiovascular Health Study). Ruef J, etal., Scand Cardiovasc J. 2006 Oct;40(5):274-9.
58. Hypertension associated with reduced plasma thrombomodulin levels and a hypercoagulable state in rats. Sawada K, etal., Clin Exp Hypertens. 2003 Feb;25(2):73-84.
59. Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. Scaldaferri F, etal., J Clin Invest. 2007 Jul;117(7):1951-60.
60. Soluble thrombomodulin protects ischemic kidneys. Sharfuddin AA, etal., J Am Soc Nephrol. 2009 Mar;20(3):524-34. Epub 2009 Jan 28.
61. Reduction expression of thrombomodulin and endothelial cell nitric oxide synthase in dermatomyositis. Shen GL, etal., Neuropathology. 2007 Aug;27(4):309-13.
62. Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. Starr ME, etal., Blood. 2010 Jun 10;115(23):4886-93. Epub 2010 Mar 26.
63. The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model. Su EJ, etal., J Thromb Haemost. 2011 Jun;9(6):1174-82. doi: 10.1111/j.1538-7836.2011.04269.x.
64. Elevation of intracellular cAMP up-regulated thrombomodulin mRNA in cultured vascular endothelial cells derived from spontaneous type-II diabetes mellitus model rat. Sunagawa M, etal., Endothelium. 2006 Sep-Oct;13(5):325-33.
65. Non-viral in vivo thrombomodulin gene transfer prevents early loss of thromboresistance of grafted veins. Tabuchi N, etal., Eur J Cardiothorac Surg. 2004 Nov;26(5):995-1001.
66. Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells. Takagi T, etal., Am J Respir Crit Care Med. 2011 Jan 1;183(1):31-42. Epub 2010 Aug 13.
67. Recombinant human soluble thrombomodulin prevents peripheral HMGB1-dependent hyperalgesia in rats. Tanaka J, etal., Br J Pharmacol. 2013 Nov;170(6):1233-41. doi: 10.1111/bph.12396.
68. Evaluation of various endothelial biomarkers in ankylosing spondylitis. Taylan A, etal., Clin Rheumatol. 2012 Jan;31(1):23-8. Epub 2011 May 10.
69. Soluble thrombomodulin as a predictor of type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-1998. Thorand B, etal., Diabetologia. 2007 Mar;50(3):545-8. Epub 2006 Dec 29.
70. Separation and characterization of the molecular species of thrombomodulin in the plasma of diabetic patients. Uehara S, etal., Thromb Res. 2001 Dec 1;104(5):325-32.
71. Expression of the endothelial thrombomodulin (TM) on the ischemic rat flap model: preliminary study. Uygur F, etal., Ann Plast Surg. 2009 Jun;62(6):693-8.
72. The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis. Van de Wouwer M, etal., J Thromb Haemost. 2006 Aug;4(8):1813-24.
73. Clinical and immunoserological characteristics of mixed connective tissue disease associated with pulmonary arterial hypertension. Vegh J, etal., Scand J Immunol. 2006 Jul;64(1):69-76.
74. cDNA cloning and sequencing, gene expression, and immunolocalization of thrombomodulin in the Sprague-Dawley rat. Wang J, etal., DNA Res 1999 Feb 26;6(1):57-62.
75. [Is soluble thrombomodulin a molecular marker of endothelial cell injury in children and adolescents with arterial hypertension?] Wojtkielewicz K, etal., Med Wieku Rozwoj. 2006 Jul-Sep;10(3 Pt 2):893-902.
76. Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study. Yamakawa K, etal., Crit Care. 2011;15(3):R123. Epub 2011 May 11.
77. Synergistic association of metabolic syndrome and overt nephropathy with elevated asymmetric dimethylarginine in serum and impaired cutaneous microvasodilation in patients with type 2 diabetes. Yamamoto R and Aso Y, Diabetes Care. 2006 Apr;29(4):928-30.
78. Cerebral endothelial injury in elderly patients with severe head injury measured by serum thrombomodulin and von Willebrand factor. Yokota H, etal., Neurol Med Chir (Tokyo). 2007 Sep;47(9):383-8; discussion 388.
79. Lack of the lectin-like domain of thrombomodulin worsens Shiga toxin-associated hemolytic uremic syndrome in mice. Zoja C, etal., J Immunol. 2012 Oct 1;189(7):3661-8. Epub 2012 Aug 31.
80. Clinical implications of serum thrombomodulin in PR3-ANCA-associated vasculitis. Zycinska K, etal., Eur J Med Res. 2009 Dec 7;14 Suppl 4:268-70.
Additional References at PubMed
PMID:1372003   PMID:2162790   PMID:2536925   PMID:2844823   PMID:3036632   PMID:7846065   PMID:8207015   PMID:8388220   PMID:8389207   PMID:8395401   PMID:8575060   PMID:8578517  
PMID:8681807   PMID:8918245   PMID:9063732   PMID:9073507   PMID:9144489   PMID:9198243   PMID:9548583   PMID:9576763   PMID:9834223   PMID:10233896   PMID:10349636   PMID:10487767  
PMID:10550314   PMID:10565546   PMID:11015584   PMID:11042159   PMID:11066091   PMID:11076861   PMID:11217851   PMID:11222138   PMID:11387227   PMID:11518727   PMID:11557684   PMID:12053176  
PMID:12195698   PMID:12208873   PMID:12477932   PMID:12539040   PMID:12761846   PMID:14556079   PMID:14592828   PMID:14615369   PMID:15448005   PMID:15489334   PMID:15769825   PMID:16014564  
PMID:16141072   PMID:16141073   PMID:16537572   PMID:16602821   PMID:16844427   PMID:17068293   PMID:17299096   PMID:17438064   PMID:17848551   PMID:17973652   PMID:17982464   PMID:18287559  
PMID:18490515   PMID:18508817   PMID:18599803   PMID:19091791   PMID:19299737   PMID:19334288   PMID:19687358   PMID:20442369   PMID:21111988   PMID:21267068   PMID:21308776   PMID:21423464  
PMID:21685324   PMID:21788337   PMID:21833011   PMID:21840881   PMID:22323363   PMID:22573811   PMID:22729286   PMID:22903729   PMID:23014597   PMID:23267072   PMID:23321922   PMID:23325830  
PMID:23409043   PMID:23823180   PMID:24136651   PMID:24194600   PMID:24261709   PMID:24323314   PMID:24368584   PMID:25497974   PMID:25609841   PMID:25816372   PMID:25860286   PMID:26338301  
PMID:26457757   PMID:26573396   PMID:26634653   PMID:27427915   PMID:27590316   PMID:27808085   PMID:28306049   PMID:28687614   PMID:28737512   PMID:28920104   PMID:30341568   PMID:30442679  
PMID:30550785   PMID:31628891   PMID:31676784   PMID:32220631   PMID:32735640   PMID:32870264   PMID:33028093   PMID:33617784   PMID:33836597   PMID:35277184   PMID:35364055   PMID:35700057  
PMID:36030260   PMID:36162255  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392148,246,391 - 148,250,108 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2148,246,386 - 148,250,108 (-)EnsemblGRCm39 Ensembl
GRCm382148,404,471 - 148,408,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,404,466 - 148,408,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv372148,230,207 - 148,233,924 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362148,095,912 - 148,099,544 (-)NCBIMGSCv36mm8
Celera2149,679,568 - 149,683,285 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.45NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382023,045,633 - 23,049,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,045,633 - 23,049,672 (-)EnsemblGRCh38hg38GRCh38
GRCh372023,026,270 - 23,030,309 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362022,974,270 - 22,978,301 (-)NCBINCBI36Build 36hg18NCBI36
Build 342022,974,270 - 22,978,301NCBI
Celera2023,099,650 - 23,103,681 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2022,987,792 - 22,991,823 (-)NCBIHuRef
CHM1_12023,026,970 - 23,031,001 (-)NCBICHM1_1
T2T-CHM13v2.02023,105,114 - 23,109,153 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23135,863,366 - 135,867,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3135,862,835 - 135,867,193 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3139,806,359 - 139,810,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,390,492 - 148,394,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,088,993 - 146,092,645 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03142,748,673 - 142,752,325 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3142,748,674 - 142,752,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,159,895 - 149,163,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,158,955 - 137,162,607 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,064,528 - 137,068,180 (-)NCBI
Celera3134,707,185 - 134,710,838 (-)NCBICelera
Cytogenetic Map3q41NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495541530,222,830 - 30,226,406 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12023,920,631 - 23,932,503 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02022,992,341 - 22,996,415 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12023,343,758 - 23,347,966 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2023,345,917 - 23,347,812 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.124599,773 - 601,649 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl24599,773 - 601,649 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha24624,590 - 626,466 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.024996,254 - 998,130 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl24996,254 - 998,130 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.124595,131 - 597,007 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.024697,184 - 699,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.024978,557 - 980,433 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640149,143,805 - 149,147,659 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366202,563,900 - 2,568,117 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1730,217,303 - 30,224,099 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11730,219,870 - 30,223,499 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,274,132 - 34,277,761 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1252,041,950 - 52,045,946 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl252,043,746 - 52,045,626 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660786,853,490 - 6,857,509 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462474122,880,481 - 22,883,962 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Thbd
75 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:529
Count of miRNA genes:382
Interacting mature miRNAs:423
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,404,686 - 148,404,811UniSTSGRCm38
MGSCv372148,230,422 - 148,230,547UniSTSGRCm37
Celera2149,679,783 - 149,679,908UniSTS
Cytogenetic Map2G3UniSTS
cM Map284.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv372148,232,550 - 148,232,779UniSTSGRCm37
MGSCv372148,232,208 - 148,232,811UniSTSGRCm37
Celera2149,685,200 - 149,685,855UniSTS
Cytogenetic Map2G3UniSTS
cM Map284.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,405,139 - 148,405,275UniSTSGRCm38
MGSCv372148,230,875 - 148,231,011UniSTSGRCm37
Celera2149,680,236 - 149,680,372UniSTS
Cytogenetic Map2G3UniSTS
cM Map284.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,407,696 - 148,408,070UniSTSGRCm38
MGSCv372148,233,432 - 148,233,806UniSTSGRCm37
Celera2149,682,793 - 149,683,167UniSTS
Cytogenetic Map2G3UniSTS
cM Map284.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,409,245 - 148,409,452UniSTSGRCm38
MGSCv372148,234,981 - 148,235,188UniSTSGRCm37
Celera2149,684,342 - 149,684,546UniSTS
Cytogenetic Map2G3UniSTS
cM Map1916.4UniSTS
cM Map2 UniSTS
Whitehead Genetic1916.4UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,410,125 - 148,410,815UniSTSGRCm38
MGSCv372148,235,861 - 148,236,551UniSTSGRCm37
Cytogenetic Map2G3UniSTS
cM Map284.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,406,814 - 148,407,043UniSTSGRCm38
MGSCv372148,232,550 - 148,232,779UniSTSGRCm37
Celera2149,681,911 - 149,682,140UniSTS
Cytogenetic Map2G3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,406,472 - 148,407,075UniSTSGRCm38
MGSCv372148,232,208 - 148,232,811UniSTSGRCm37
Celera2149,681,569 - 149,682,172UniSTS
Cytogenetic Map2G3UniSTS



RefSeq Acc Id: ENSMUST00000099270   ⟹   ENSMUSP00000096877
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2148,246,386 - 148,250,108 (-)Ensembl
GRCm38.p6 Ensembl2148,404,466 - 148,408,188 (-)Ensembl
RefSeq Acc Id: NM_009378   ⟹   NP_033404
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm392148,246,391 - 148,250,108 (-)NCBI
GRCm382148,404,471 - 148,408,188 (-)ENTREZGENE
MGSCv372148,230,207 - 148,233,924 (-)RGD
Celera2149,679,568 - 149,683,285 (-)RGD
RefSeq Acc Id: NP_033404   ⟸   NM_009378
- Peptide Label: precursor
- UniProtKB: P15306 (UniProtKB/Swiss-Prot),   Q543W3 (UniProtKB/TrEMBL),   Q8BJB5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000096877   ⟸   ENSMUST00000099270
Protein Domains
C-type lectin   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15306-F1-model_v2 AlphaFold P15306 1-577 view protein structure

RGD ID:6832934
Promoter ID:MM_KWN:32138
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Mouse AssemblyChrPosition (strand)Source
MGSCv362148,230,946 - 148,234,797 (-)MPROMDB
RGD ID:6879050
Promoter ID:EPDNEW_M2976
Type:multiple initiation site
Description:Mus musculus thrombomodulin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm382148,408,119 - 148,408,179EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98736 AgrOrtholog
Ensembl Genes ENSMUSG00000074743 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000099270 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tme5_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21824 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR24036:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tme5_EGF_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Thbd PhenoGen
PIRSF CD93/CD141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRBM_MOUSE UniProtKB/Swiss-Prot