Ptpn22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) - Rat Genome Database

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Gene: Ptpn22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) Mus musculus
Analyze
Symbol: Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RGD ID: 1552858
MGI Page MGI
Description: Enables SH3 domain binding activity; kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including dephosphorylation; regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within T cell differentiation and T cell receptor signaling pathway. Located in cytoplasm; cytoplasmic side of plasma membrane; and nucleus. Is expressed in dorsal root ganglion; peripheral nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); pulmonary tuberculosis; and systemic scleroderma. Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 70zp; 70zpep; hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; PEP; PEST domain-enriched tyrosine phosphatase; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 8; Pt; Ptpn8; tyrosine-protein phosphatase non-receptor type 22
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393103,763,891 - 103,819,568 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3103,767,111 - 103,819,563 (+)EnsemblGRCm39 Ensembl
GRCm383103,856,575 - 103,912,252 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,859,795 - 103,912,247 (+)EnsemblGRCm38mm10GRCm38
MGSCv373103,664,215 - 103,716,170 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363103,989,353 - 104,041,308 (+)NCBIMGSCv36mm8
Celera3106,063,559 - 106,114,657 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
cellular response to muramyl dipeptide  (IDA,ISO)
dephosphorylation  (IEA)
immune system process  (IEA)
lipid metabolic process  (IEA)
lipopolysaccharide-mediated signaling pathway  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of gene expression  (IMP,ISO)
negative regulation of interleukin-6 production  (IMP,ISO)
negative regulation of interleukin-8 production  (IMP,ISO)
negative regulation of JUN kinase activity  (ISO)
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IBA,IMP,ISO)
negative regulation of p38MAPK cascade  (IBA,IMP,ISO)
negative regulation of T cell activation  (IBA,IMP,ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (IBA,IMP,ISO)
peptidyl-tyrosine dephosphorylation  (IBA)
phosphoanandamide dephosphorylation  (IDA)
positive regulation of CD8-positive, alpha-beta T cell proliferation  (IBA,IMP)
positive regulation of defense response to virus by host  (IBA,IMP)
positive regulation of ERK1 and ERK2 cascade  (IBA,IMP,ISO)
positive regulation of gene expression  (IMP,ISO)
positive regulation of granzyme B production  (IBA,IMP)
positive regulation of interferon-alpha production  (IMP)
positive regulation of interferon-beta production  (IMP)
positive regulation of NLRP3 inflammasome complex assembly  (IDA,ISO)
positive regulation of protein import into nucleus  (IMP)
positive regulation of protein K63-linked ubiquitination  (IBA,IMP,ISO)
positive regulation of toll-like receptor 3 signaling pathway  (IBA,IMP,ISO)
positive regulation of toll-like receptor 4 signaling pathway  (IBA,IMP,ISO)
positive regulation of toll-like receptor 7 signaling pathway  (IBA,IMP)
positive regulation of toll-like receptor 9 signaling pathway  (IBA,IMP)
positive regulation of type I interferon production  (ISO)
positive regulation of type II interferon production  (ISO)
protein dephosphorylation  (IMP,ISO)
regulation of antigen processing and presentation  (IMP)
regulation of calcium ion transmembrane transport  (ISO)
regulation of leukocyte migration  (IMP)
regulation of natural killer cell proliferation  (ISO)
regulation of NIK/NF-kappaB signaling  (IBA,IMP,ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of T cell receptor signaling pathway  (IEA)
response to lipopolysaccharide  (ISO)
T cell differentiation  (IBA,IMP)
T cell receptor signaling pathway  (IBA,IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell morphology  (IAGP)
abnormal B cell number  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal double-positive T cell morphology  (IAGP)
abnormal follicular B cell physiology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lymphocyte cell number  (IAGP)
abnormal Peyer's patch germinal center morphology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell number  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal thymocyte activation  (IAGP)
abnormal thymus morphology  (IAGP)
autoimmune response  (IAGP)
decreased B cell apoptosis  (IAGP)
decreased body weight  (IAGP)
decreased follicular B cell number  (IAGP)
decreased mature B cell number  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
glomerulonephritis  (IAGP)
glomerulosclerosis  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-insulin autoantibody level  (IAGP)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased B cell proliferation  (IAGP)
increased CD4-positive, alpha-beta memory T cell number  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased dendritic cell number  (IAGP)
increased double-positive T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IAGP)
increased effector memory CD8-positive, alpha-beta T cell number  (IAGP)
increased follicular B cell number  (IAGP)
increased germinal center B cell number  (IAGP)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased inflammatory response  (IAGP)
increased interleukin-12 secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased memory T cell number  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased plasma cell number  (IAGP)
increased regulatory T cell number  (IAGP)
increased spleen germinal center number  (IAGP)
increased spleen germinal center size  (IAGP)
increased T cell number  (IAGP)
increased T cell proliferation  (IAGP)
increased transitional stage B cell number  (IAGP)
increased transitional stage T1 B cell number  (IAGP)
increased urine protein level  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
pale kidney  (IAGP)
premature death  (IAGP)
spleen hyperplasia  (IAGP)
thymus hyperplasia  (IAGP)
vascular inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The role of PTPN22 gene polymorphism in childhood immune thrombocytopenic purpura. Anis SK, etal., Blood Coagul Fibrinolysis. 2011 Sep;22(6):521-5.
2. Multiplex family-based study in systemic lupus erythematosus: association between the R620W polymorphism of PTPN22 and the FcgammaRIIa (CD32A) R131 allele. Balada E, etal., Tissue Antigens. 2006 Nov;68(5):432-8.
3. The association of the PTPN22 620W polymorphism with Behcet's disease. Baranathan V, etal., Ann Rheum Dis. 2007 Nov;66(11):1531-3. Epub 2007 Jul 27.
4. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Barrett JC, etal., Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
5. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Begovich AB, etal., Am J Hum Genet. 2004 Aug;75(2):330-7. Epub 2004 Jun 18.
6. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Bottini N, etal., Nat Genet. 2004 Apr;36(4):337-8. Epub 2004 Mar 7.
7. PTPN22 polymorphism presumably plays a role in the genetic background of chronic spontaneous autoreactive urticaria. Brzoza Z, etal., Dermatology. 2012;224(4):340-5. doi: 10.1159/000339332. Epub 2012 Jun 19.
8. A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo. Canton I, etal., Genes Immun. 2005 Oct;6(7):584-7.
9. High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. Cao Y, etal., PLoS One. 2012;7(8):e42783. doi: 10.1371/journal.pone.0042783. Epub 2012 Aug 3.
10. The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients. Chinoy H, etal., Arthritis Rheum. 2008 Oct;58(10):3247-54. doi: 10.1002/art.23900.
11. The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis. Chuang WY, etal., Genes Immun. 2009 Dec;10(8):667-72. Epub 2009 Aug 20.
12. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Criswell LA, etal., Am J Hum Genet. 2005 Apr;76(4):561-71. Epub 2005 Feb 17.
13. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. Dai X, etal., J Clin Invest. 2013 May 1;123(5):2024-36. doi: 10.1172/JCI66963. Epub 2013 Apr 24.
14. Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis. Diaz-Gallo LM, etal., Ann Rheum Dis. 2011 Mar;70(3):454-62. Epub 2010 Dec 3.
15. Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population. Douroudis K, etal., Tissue Antigens. 2008 Nov;72(5):425-30. Epub 2008 Aug 26.
16. Novel associations for hypothyroidism include known autoimmune risk loci. Eriksson N, etal., PLoS One. 2012;7(4):e34442. Epub 2012 Apr 6.
17. Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies. Espinoza JL, etal., Biol Blood Marrow Transplant. 2013 Feb;19(2):240-6. doi: 10.1016/j.bbmt.2012.09.014. Epub 2012 Sep 28.
18. PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. Fousteri G, etal., Clin Immunol. 2015 Feb;156(2):98-108. doi: 10.1016/j.clim.2014.12.002. Epub 2014 Dec 13.
19. PTPN22 C1858T polymorphism in women with endometriosis. Gomes FM, etal., Am J Reprod Immunol. 2010 Mar 1;63(3):227-32. Epub 2010 Jan 12.
20. PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases. Gomez LM, etal., Genes Immun. 2005 Oct;6(7):628-31.
21. Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to biopsy-proven giant cell arteritis. Gonzalez-Gay MA, etal., J Rheumatol. 2005 Aug;32(8):1510-2.
22. Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia. Hebbring SJ, etal., Blood. 2013 Jan 3;121(1):237-8. doi: 10.1182/blood-2012-08-450221.
23. Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. Hinks A, etal., Arthritis Rheum. 2005 Jun;52(6):1694-9.
24. Genetic analysis of adult-onset autoimmune diabetes. Howson JM, etal., Diabetes. 2011 Oct;60(10):2645-53. Epub 2011 Aug 26.
25. No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjogren's syndrome. Ittah M, etal., Genes Immun. 2005 Aug;6(5):457-8.
26. Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis. Juneblad K, etal., Arthritis Res Ther. 2011 Mar 16;13(2):R45.
27. The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata. Kemp EH, etal., Hum Immunol. 2006 Jul;67(7):535-9. Epub 2006 May 4.
28. The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population. Laberge GS, etal., Pigment Cell Melanoma Res. 2008 Apr;21(2):206-8. doi: 10.1111/j.1755-148X.2008.00443.x.
29. Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population. Lamsyah H, etal., Tissue Antigens. 2009 Sep;74(3):228-32. Epub 2009 Jun 25.
30. Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. Li Y, etal., J Invest Dermatol. 2009 Mar;129(3):629-34. doi: 10.1038/jid.2008.297. Epub 2008 Oct 16.
31. No impact of PTPN22, PTPRJ and ACP1 genes polymorphisms on the risk of immune thrombocytopenia in French adult patients. Lioger B, etal., Thromb Res. 2016 Aug;144:76-8. doi: 10.1016/j.thromres.2016.04.013. Epub 2016 Apr 25.
32. Association of a functional polymorphism of PTPN22 encoding a lymphoid protein phosphatase in bilateral Meniere's disease. Lopez-Escamez JA, etal., Laryngoscope. 2010 Jan;120(1):103-7. doi: 10.1002/lary.20650.
33. Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis. Luo L, etal., Endocr J. 2012 Feb 25.
34. MGDs mouse GO annotations MGD data from the GO Consortium
35. MGD IEA MGD IEA
36. PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. Namjou B, etal., PLoS One. 2013 Aug 7;8(8):e69404. doi: 10.1371/journal.pone.0069404. eCollection 2013.
37. Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Negro R, etal., Blood. 2012 Jun 28;119(26):6278-87. doi: 10.1182/blood-2012-01-403162. Epub 2012 May 8.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Orru V, etal., Hum Mol Genet. 2009 Feb 1;18(3):569-79. doi: 10.1093/hmg/ddn363. Epub 2008 Nov 3.
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Rodriguez-Rodriguez L, etal., Arthritis Rheum. 2011 Feb;63(2):365-72. doi: 10.1002/art.30145.
43. Atherosclerosis and PTPN22: a study in coronary artery disease. Saccucci P, etal., Cardiology. 2011;119(1):54-6. Epub 2011 Aug 12.
44. A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat. Sarmiento J, etal., J Immunol. 2015 Jan 15;194(2):615-29. doi: 10.4049/jimmunol.1302689. Epub 2014 Dec 12.
45. Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis. Serrano A, etal., Ann Rheum Dis. 2013 Nov 1;72(11):1882-6. doi: 10.1136/annrheumdis-2013-203641. Epub 2013 Aug 14.
46. Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease. Skinningsrud B, etal., Eur J Hum Genet. 2008 Aug;16(8):977-82. Epub 2008 Feb 27.
47. Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. Smith RL, etal., Br J Dermatol. 2008 May;158(5):962-8. doi: 10.1111/j.1365-2133.2008.08482.x. Epub 2008 Mar 13.
48. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Smyth D, etal., Diabetes. 2004 Nov;53(11):3020-3.
49. Preliminary evidence for interaction of PTPN12 polymorphism with TSHR genotype and association with Graves' ophthalmopathy. Syed AA, etal., Clin Endocrinol (Oxf). 2007 Nov;67(5):663-7. Epub 2007 Jul 3.
50. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Wang K, etal., Hum Mol Genet. 2010 May 15;19(10):2059-67. doi: 10.1093/hmg/ddq078. Epub 2010 Feb 22.
51. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
52. Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population. Wipff J, etal., Ann Rheum Dis. 2006 Sep;65(9):1230-2. Epub 2006 Feb 7.
53. Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats. Xu YB, etal., Chin Med Sci J. 2014 Jun;29(2):85-90.
54. [Association of polymorphism of protein tyrosine phosphatase nonreceptor-22 gene with AITD]. Yu ZY, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Aug;24(8):804-7.
55. The protein tyrosine phosphatase, non-receptor type 22 R620W polymorphism does not confer susceptibility to psoriasis in the genetic homogeneous population of Crete. Zervou MI, etal., Genet Test Mol Biomarkers. 2010 Feb;14(1):107-11. doi: 10.1089/gtmb.2009.0130.
56. No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations. Zhang Q, etal., PLoS One. 2012;7(3):e31230. doi: 10.1371/journal.pone.0031230. Epub 2012 Mar 2.
57. Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population. Zhebrun D, etal., Aging (Albany NY). 2011 Apr;3(4):368-73.
58. Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue. Zheng J, etal., Genes Immun. 2012 Dec;13(8):641-52. doi: 10.1038/gene.2012.46. Epub 2012 Oct 18.
Additional References at PubMed
PMID:1373816   PMID:8890164   PMID:9582365   PMID:10349636   PMID:10940933   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11423996   PMID:11685249   PMID:12466851   PMID:12477932  
PMID:12612075   PMID:14610273   PMID:14752163   PMID:15489334   PMID:15786712   PMID:16015370   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16938887   PMID:17631919   PMID:19299707  
PMID:20822712   PMID:21044313   PMID:21267068   PMID:21677750   PMID:21841778   PMID:21873635   PMID:22539785   PMID:23193160   PMID:23193190   PMID:23752610   PMID:23871208   PMID:23913970  
PMID:23991106   PMID:24453256   PMID:24498279   PMID:25108421   PMID:25715232   PMID:25748328   PMID:25993510   PMID:26019128   PMID:26077719   PMID:26329582   PMID:26438525   PMID:26810223  
PMID:27043286   PMID:27207523   PMID:27288531   PMID:27653681   PMID:27703032   PMID:27725666   PMID:27799548   PMID:27807193   PMID:27926878   PMID:28237724   PMID:28553952   PMID:28786745  
PMID:28801357   PMID:28948613   PMID:29040339   PMID:29116089   PMID:29666305   PMID:30054208   PMID:30139951   PMID:31107248   PMID:31194881   PMID:31335326   PMID:31501515   PMID:31591574  
PMID:31732921   PMID:32047502   PMID:32194571   PMID:32469452   PMID:33766222   PMID:34417261   PMID:35041491   PMID:35095903   PMID:35587260   PMID:35767715  


Genomics

Comparative Map Data
Ptpn22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393103,763,891 - 103,819,568 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3103,767,111 - 103,819,563 (+)EnsemblGRCm39 Ensembl
GRCm383103,856,575 - 103,912,252 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,859,795 - 103,912,247 (+)EnsemblGRCm38mm10GRCm38
MGSCv373103,664,215 - 103,716,170 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363103,989,353 - 104,041,308 (+)NCBIMGSCv36mm8
Celera3106,063,559 - 106,114,657 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
PTPN22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381113,813,811 - 113,871,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1113,813,811 - 113,871,753 (-)EnsemblGRCh38hg38GRCh38
GRCh371114,356,433 - 114,414,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,157,960 - 114,215,857 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,068,480 - 114,126,376NCBI
Celera1112,585,654 - 112,643,598 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1112,214,556 - 112,272,493 (-)NCBIHuRef
CHM1_11114,471,278 - 114,529,225 (-)NCBICHM1_1
T2T-CHM13v2.01113,825,481 - 113,883,420 (-)NCBIT2T-CHM13v2.0
Ptpn22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22191,366,761 - 191,414,782 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2191,366,808 - 191,414,779 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2198,963,704 - 199,011,553 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02196,836,441 - 196,884,289 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02191,653,405 - 191,701,246 (+)NCBIRnor_WKY
Rnor_6.02206,342,066 - 206,390,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,342,066 - 206,390,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02225,765,744 - 225,814,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42199,083,186 - 199,144,309 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12199,045,987 - 199,095,515 (+)NCBI
Celera2183,836,919 - 183,884,957 (+)NCBICelera
Cytogenetic Map2q34NCBI
Ptpn22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543517,082,762 - 17,139,067 (-)NCBIChiLan1.0ChiLan1.0
PTPN22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11106,067,591 - 106,123,889 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0188,685,736 - 88,743,164 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11123,734,511 - 123,790,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1123,734,511 - 123,790,830 (+)Ensemblpanpan1.1panPan2
PTPN22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11751,623,628 - 51,683,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1751,623,623 - 51,682,858 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1751,274,140 - 51,334,343 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01752,501,113 - 52,561,235 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1752,501,116 - 52,561,182 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11751,508,535 - 51,568,572 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01751,576,143 - 51,636,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01752,148,984 - 52,209,317 (-)NCBIUU_Cfam_GSD_1.0
Ptpn22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505815,244,798 - 15,296,846 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366902,181,047 - 2,232,958 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366902,180,804 - 2,232,869 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4106,686,604 - 106,758,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14106,692,102 - 106,758,101 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,897,216 - 116,927,483 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12019,792,807 - 19,855,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2019,793,083 - 19,855,827 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603822,562,918 - 22,626,522 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247729,472,913 - 9,550,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247729,472,869 - 9,552,751 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptpn22
243 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:290
Count of miRNA genes:226
Interacting mature miRNAs:239
Transcripts:ENSMUST00000029433, ENSMUST00000126548, ENSMUST00000134373, ENSMUST00000146071
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse

Markers in Region
M90388  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383103,912,141 - 103,912,241UniSTSGRCm38
MGSCv373103,716,064 - 103,716,164UniSTSGRCm37
Celera3106,114,551 - 106,114,651UniSTS
Cytogenetic Map3F3UniSTS
Cytogenetic Map3F2.2UniSTS
Whitehead_YAC3 UniSTS
D3Mit266  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383103,887,450 - 103,887,635UniSTSGRCm38
MGSCv373103,691,373 - 103,691,558UniSTSGRCm37
Celera3106,089,918 - 106,090,103UniSTS
Cytogenetic Map3F3UniSTS
cM Map351.1UniSTS
Whitehead Genetic338.3UniSTS
Whitehead_YAC3 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001409794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_104070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI327325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY092932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU210953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M90388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000029433   ⟹   ENSMUSP00000029433
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3103,767,593 - 103,819,563 (+)Ensembl
GRCm38.p6 Ensembl3103,860,277 - 103,912,247 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126548
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3103,809,355 - 103,819,562 (+)Ensembl
GRCm38.p6 Ensembl3103,902,039 - 103,912,246 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134373
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3103,795,938 - 103,816,774 (+)Ensembl
GRCm38.p6 Ensembl3103,888,622 - 103,909,458 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146071   ⟹   ENSMUSP00000122307
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3103,767,111 - 103,819,560 (+)Ensembl
GRCm38.p6 Ensembl3103,859,795 - 103,912,244 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196385
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3103,793,298 - 103,795,469 (+)Ensembl
GRCm38.p6 Ensembl3103,885,982 - 103,888,153 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197997
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3103,785,373 - 103,787,205 (+)Ensembl
GRCm38.p6 Ensembl3103,878,057 - 103,879,889 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198530
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3103,767,871 - 103,784,071 (+)Ensembl
GRCm38.p6 Ensembl3103,860,555 - 103,876,755 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198701
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3103,793,388 - 103,810,701 (+)Ensembl
GRCm38.p6 Ensembl3103,886,072 - 103,903,385 (+)Ensembl
RefSeq Acc Id: NM_001409794   ⟹   NP_001396723
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393103,766,754 - 103,819,568 (+)NCBI
RefSeq Acc Id: NM_001409795   ⟹   NP_001396724
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393103,767,596 - 103,819,568 (+)NCBI
RefSeq Acc Id: NM_008979   ⟹   NP_033005
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393103,767,596 - 103,819,568 (+)NCBI
GRCm383103,860,277 - 103,912,252 (+)NCBI
MGSCv373103,664,215 - 103,716,170 (+)RGD
Celera3106,063,062 - 106,114,662 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_104070
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393103,766,754 - 103,819,568 (+)NCBI
GRCm383103,859,795 - 103,912,252 (+)NCBI
Celera3106,063,062 - 106,114,662 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501148   ⟹   XP_006501211
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393103,763,891 - 103,819,568 (+)NCBI
GRCm383103,856,575 - 103,912,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501149   ⟹   XP_006501212
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393103,763,891 - 103,819,568 (+)NCBI
GRCm383103,856,575 - 103,912,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501150   ⟹   XP_006501213
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393103,763,891 - 103,819,568 (+)NCBI
GRCm383103,856,575 - 103,912,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011240041   ⟹   XP_011238343
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393103,763,891 - 103,819,568 (+)NCBI
GRCm383103,856,575 - 103,912,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011240042   ⟹   XP_011238344
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393103,763,891 - 103,819,568 (+)NCBI
GRCm383103,856,575 - 103,912,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017319504   ⟹   XP_017174993
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393103,767,743 - 103,819,568 (+)NCBI
GRCm383103,860,424 - 103,912,252 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033005   ⟸   NM_008979
- Peptide Label: isoform 1
- UniProtKB: Q7TMP9 (UniProtKB/Swiss-Prot),   P29352 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501213   ⟸   XM_006501150
- Peptide Label: isoform X1
- UniProtKB: Q7TMP9 (UniProtKB/Swiss-Prot),   P29352 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501211   ⟸   XM_006501148
- Peptide Label: isoform X1
- UniProtKB: Q7TMP9 (UniProtKB/Swiss-Prot),   P29352 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501212   ⟸   XM_006501149
- Peptide Label: isoform X1
- UniProtKB: Q7TMP9 (UniProtKB/Swiss-Prot),   P29352 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011238343   ⟸   XM_011240041
- Peptide Label: isoform X1
- UniProtKB: Q7TMP9 (UniProtKB/Swiss-Prot),   P29352 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011238344   ⟸   XM_011240042
- Peptide Label: isoform X1
- UniProtKB: Q7TMP9 (UniProtKB/Swiss-Prot),   P29352 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017174993   ⟸   XM_017319504
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000029433   ⟸   ENSMUST00000029433
RefSeq Acc Id: ENSMUSP00000122307   ⟸   ENSMUST00000146071
RefSeq Acc Id: NP_001396723   ⟸   NM_001409794
- Peptide Label: isoform 1
- UniProtKB: Q7TMP9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001396724   ⟸   NM_001409795
- Peptide Label: isoform 2
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29352-F1-model_v2 AlphaFold P29352 1-802 view protein structure

Promoters
RGD ID:6834330
Promoter ID:MM_KWN:35612
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:OTTMUST00000053696,   UC008QTU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363103,663,551 - 103,664,242 (+)MPROMDB
RGD ID:6881884
Promoter ID:EPDNEW_M4393
Type:initiation region
Name:Ptpn22_2
Description:Mus musculus protein tyrosine phosphatase, non-receptor type22 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4394  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383103,859,746 - 103,859,806EPDNEW
RGD ID:6881886
Promoter ID:EPDNEW_M4394
Type:initiation region
Name:Ptpn22_1
Description:Mus musculus protein tyrosine phosphatase, non-receptor type22 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4393  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383103,860,321 - 103,860,381EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107170 AgrOrtholog
Ensembl Genes ENSMUSG00000027843 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000029433 ENTREZGENE
  ENSMUSP00000029433.8 UniProtKB/Swiss-Prot
  ENSMUSP00000122307.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029433 ENTREZGENE
  ENSMUST00000029433.9 UniProtKB/Swiss-Prot
  ENSMUST00000146071 ENTREZGENE
  ENSMUST00000146071.8 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTN12/18/22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTN22_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPN22 UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19260 UniProtKB/Swiss-Prot
MGD MGI:107170 ENTREZGENE
NCBI Gene 19260 ENTREZGENE
PANTHER TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptpn22 PhenoGen
PIRSF PTPN8_PTPN22 UniProtKB/Swiss-Prot
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9QAS3_MOUSE UniProtKB/TrEMBL
  P29352 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3TEL9_MOUSE UniProtKB/TrEMBL
  Q7TMP9 ENTREZGENE
UniProt Secondary Q7TMP9 UniProtKB/Swiss-Prot