Advanced Search (OLGA)

Gene: Ces2a (carboxylesterase 2A) Mus musculus

Analyze

No known orthologs.

Symbol:

Ces2a

Name:

carboxylesterase 2A

RGD ID:

1552829

MGI Page

MGI

Description:

Enables carboxylesterase activity. Acts upstream of or within protein glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver. Orthologous to human CES2 (carboxylesterase 2).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

9130231C15Rik; AI266984; carboxylesterase 6; carboxylic ester hydrolase 2A; Ces; Ces6; pyrethroid hydrolase Ces2a

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	CES2 (carboxylesterase 2)	HGNC	Ensembl, HGNC, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Ces2a (carboxylesterase 2A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CES2 (carboxylesterase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OrthoFinder\|PANTHER\|PhylomeDB)
Rattus norvegicus (Norway rat):	Ces2i (carboxylesterase 2I)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Ces2j (carboxylesterase 2J)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	ces3 (carboxylesterase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZC376.3	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	B0238.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Caenorhabditis elegans (roundworm):	C52A10.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Drosophila melanogaster (fruit fly):	Est-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	Est-P	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	Jhe	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	clt	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6414	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG3841	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid)
Drosophila melanogaster (fruit fly):	CG4382	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Caenorhabditis elegans (roundworm):	ges-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG4757	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ces3.1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ces3.4	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Related Pseudogenes:

Gm7208

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	105,460,635 - 105,468,266 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	105,460,635 - 105,468,266 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	104,734,003 - 104,741,634 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	104,734,003 - 104,741,634 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	107,257,903 - 107,265,534 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	107,623,137 - 107,630,761 (+)	NCBI		MGSCv36	mm8
Celera	8	108,964,463 - 108,972,010 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.04	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (EXP)

1,2-dichloroethane (EXP)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

4-nitrophenyl acetate (EXP)

aflatoxin B1 (EXP)

Aroclor 1254 (EXP)

Azoxymethane (EXP)

Benzo[k]fluoranthene (EXP)

beta-hexachlorocyclohexane (EXP)

bifenthrin (EXP)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP)

buta-1,3-diene (EXP)

captan (EXP)

choline (EXP)

cyclosporin A (EXP)

cyfluthrin (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

dextran sulfate (EXP)

Diallyl sulfide (EXP)

dichloroacetic acid (EXP)

diethyl maleate (EXP)

epoxiconazole (EXP)

ethoxyquin (EXP)

etoposide (EXP)

fipronil (EXP)

folpet (EXP)

genistein (EXP)

Heptachlor epoxide (EXP)

inulin (EXP)

lithocholic acid (EXP)

methidathion (EXP)

N-nitrosodiethylamine (EXP)

Octicizer (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (EXP)

phenobarbital (EXP)

pirinixic acid (EXP)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (EXP)

resveratrol (EXP)

rifampicin (EXP)

sodium arsenite (EXP)

sodium dichromate (EXP)

spironolactone (EXP)

tamoxifen (EXP)

tetrachloromethane (EXP)

titanium dioxide (EXP)

trichloroethene (EXP)

triphenyl phosphate (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

prostaglandin metabolic process (ISO)

protein glycosylation (IDA)

retinol metabolic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

intracellular membrane-bounded organelle (IBA)

Molecular Function

all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity (IEA)

carboxylesterase activity (IDA,ISO)

carboxylic ester hydrolase activity (IBA)

retinyl-palmitate esterase activity (ISO)

trans-permethrin hydrolase activity (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal adipose tissue distribution (IAGP)

decreased circulating triglyceride level (IAGP)

impaired glucose tolerance (IAGP)

increased body fat mass (IAGP)

increased body weight (IAGP)

increased brown adipose tissue mass (IAGP)

increased ceramide level (IAGP)

increased cholesterol level (IAGP)

increased circulating alanine transaminase level (IAGP)

increased circulating aspartate transaminase level (IAGP)

increased circulating insulin level (IAGP)

increased liver cholesterol level (IAGP)

increased liver triglyceride level (IAGP)

increased liver weight (IAGP)

increased susceptibility to diet-induced hepatic steatosis (IAGP)

insulin resistance (IAGP)

liver fibrosis (IAGP)

liver inflammation (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	MGDs mouse GO annotations	MGD data from the GO Consortium
2.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12477932	PMID:15123619	PMID:15208658	PMID:16141072	PMID:16141073	PMID:20931200	PMID:21677750	PMID:21873635
PMID:30733279	PMID:37059417

Genomics

Variants

Variants in Ces2a
675 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	507
Count of miRNA genes:	341
Interacting mature miRNAs:	378
Transcripts:	ENSMUST00000034346, ENSMUST00000159303, ENSMUST00000161824, ENSMUST00000164182
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300560	Tgl1_m	triglyceride level 1 (mouse)			Not determined		8	102486208	111650036	Mouse
4141435	Fbtq3_m	femoral bone trait QTL 3 (mouse)			Not determined		8	100965309	130127694	Mouse
11252141	Fdr2_m	fat response to dietary restriction 2 (mouse)					8	98390634	130127694	Mouse
1302105	Im1_m	Immunoregulatory 1 (mouse)			Not determined		8	99828531	130127694	Mouse
1357470	Obq16_m	obesity QTL 16 (mouse)			Not determined		8	76411976	110412125	Mouse
1301080	Sluc9_m	susceptibility to lung cancer 9 (mouse)			Not determined		8	99828531	130127694	Mouse
1558875	Eae31_m	experimental allergic encephalomyelitis susceptibility 31 (mouse)			Not determined		8	35109930	115563747	Mouse
10412234	Nhdlq14_m	non-HDL QTL 14 (mouse)			Not determined		8	76411976	110412125	Mouse
1301766	Desp1_m	despair 1 (mouse)			Not determined		8	85486208	119486373	Mouse
1301253	Skmw2_m	skeletal muscle weight 2 (mouse)			Not determined		8	86443553	120443701	Mouse
1301316	Dntcs1_m	dental caries susceptibility 1 (mouse)			Not determined		8	103443553	127781786	Mouse
1357708	Orq1_m	ovulation rate QTL 1 (mouse)			Not determined		8	71740461	124622354	Mouse
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32506572	117965439	Mouse
1300681	Pgia22_m	proteoglycan induced arthritis 22 (mouse)			Not determined		8	102486208	116025457	Mouse
10755519	Wbc1_m	white blood cell count 1 (mouse)					8	82345783	116345783	Mouse
27226754	Femd6_m	femur midshaft diameter 6, 10 week (mouse)					8	37867154	110326632	Mouse
1301581	Char2_m	P. chabaudi malaria resistance QTL 2 (mouse)			Not determined		8	79808806	113809031	Mouse
1301874	Hdlq16_m	HDL QTL 16 (mouse)			Not determined		8	76411976	110412125	Mouse
1357494	Obsty2_m	obesity 2 (mouse)			Not determined		8	96245241	129745061	Mouse
1301872	Cd4ts3_m	CD4 T cell subset 3 (mouse)			Not determined		8	72122809	106123021	Mouse
10045619	Heal14_m	wound healing/regeneration 14 (mouse)			Not determined		8	86443553	120443701	Mouse
1558780	Idd22_m	insulin dependent diabetes susceptibility 22 (mouse)			Not determined		8	71829531	105829637	Mouse
1300920	Pitm3_m	prion incubation time 3 (mouse)			Not determined		8	73929123	107929226	Mouse
12880431	Fgf23lq2_m	FGF23 serum level QTL 2 (mouse)					8	97626632	130127694	Mouse
10755530	Wbc2_m	white blood cell count 2 (mouse)					8	81819296	115819296	Mouse
1302049	Heal1_m	wound healing/regeneration 1 (mouse)			Not determined		8	86443553	120443701	Mouse
27226796	Scvln16_m	sacral vertebrae length 2, 16 week (mouse)					8	89726628	130027694	Mouse
27095912	Pglq14_m	pelvic girdle length QTL 14, 16 week (mouse)					8	74126628	126826739	Mouse
1301099	Cbm2_m	cerebellum weight 2 (mouse)			Not determined		8	79245241	113245331	Mouse
4142023	W3q5_m	weight 3 weeks QTL 5 (mouse)			Not determined			71740461	124622354	Mouse
1301481	Lith11_m	lithogenic gene 11 (mouse)			Not determined		8	98563635	130127694	Mouse
11532692	Sluc38a_m	susceptibility to lung cancer 38a (mouse)					8	105033977	130127694	Mouse
11532691	Sluc38_m	susceptibility to lung cancer 38 (mouse)					8	105033977	130127694	Mouse
1558890	Lith18_m	lithogenic gene 18 (mouse)			Not determined		8	76402145	110402251	Mouse

Markers in Region

AI266984

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	104,740,172 - 104,740,272	UniSTS	GRCm38
MGSCv37	8	107,264,072 - 107,264,172	UniSTS	GRCm37
Celera	8	108,970,548 - 108,970,648	UniSTS
Cytogenetic Map	8	D3	UniSTS
Whitehead/MRC_RH	8	1214.53	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001190330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_133960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC156564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK078953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK165784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC021609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC024082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC024491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC024517	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC025537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC025812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC026643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC031295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY088529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY458169	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000034346 ⟹ ENSMUSP00000034346

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	105,460,635 - 105,468,262 (+)	Ensembl
GRCm38.p6 Ensembl	8	104,734,003 - 104,741,630 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000159303 ⟹ ENSMUSP00000148459

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	105,466,240 - 105,467,909 (+)	Ensembl
GRCm38.p6 Ensembl	8	104,739,608 - 104,741,277 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000161824 ⟹ ENSMUSP00000148699

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	105,460,660 - 105,464,156 (+)	Ensembl
GRCm38.p6 Ensembl	8	104,734,028 - 104,737,524 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000164182 ⟹ ENSMUSP00000127346

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	105,460,650 - 105,468,266 (+)	Ensembl
GRCm38.p6 Ensembl	8	104,734,018 - 104,741,634 (+)	Ensembl

RefSeq Acc Id:

NM_001190330 ⟹ NP_001177259

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	105,460,635 - 105,468,266 (+)	NCBI
GRCm38	8	104,734,003 - 104,741,634 (+)	ENTREZGENE
MGSCv37	8	107,257,903 - 107,265,534 (+)	RGD
Celera	8	108,964,463 - 108,972,010 (+)	RGD
cM Map	8		ENTREZGENE

Sequence:

show sequence

GATCTGTTTTTGTTTCCTGCTGTGACACTCTCATGTGCAGCAGCACAGGTTTAGGCCTGAGATT
CAACCATGCCATTGGCTAGACTTCCTGGTTGGCTGTGTGTTGTTGCCTGTGGGCTCCTGCTTCT
CCTCCAGCATGTGCATGGCCAGGACTCAGCCAGCCCCATCAGGAACACCCACAGGGGTCAGGTG
AGAGGCAGCTTTGTCCACGTGAAGGACACTAAATCTGGTGTCCATGCCTTCCTGGGAATCCCCT
TTGCCAAGCCTCCTGTAGGACTACTGCGCTTTGCACCTCCTGAGGACCCTGAGCCATGGAGTGG
TGTGAGAGATGGGACCTCACAGCCGGCCATGTGTCTGCAGCCTGATATAATGAATTTAGAGGAT
GCGAAGGAAATGAATCTGATCCTGCCTCCCATCTCTATGTCCGAGGACTGCCTGTATCTCAACA
TCTACACACCAACCCACGCCCAGGAGGGCTCTAACCTGCCTGTGATGGTATGGATCCACGGTGG
TGGACTGGTTGTAGGATCAGCTTCCATGAATGATGTATCTAAACTGGCAGCCACTGAGGAAATA
GTAATTGTCGCCATCCAGTATCGCTTGGGGGTCCTTGGCTTCTTCAGCACTGGAGACCAGCATG
CCAGAGGCAACTGGGGATACCTGGACCAAGTGGCTGCCTTACGCTGGGTGCAGAAGAATATTGC
TTACTTTGGAGGCAACCGTGACAGGGTCACTATATTTGGAGTCTCAGCAGGAGGTACAAGTGTG
TCTTCTCATATTCTGTCCCCAATGTCCAAAGGACTCTTTCATGGAGCCATTATGCAGAGTGGAG
TGGCCCTGCTGCCTGACCTCATCTCTGACACTTCTGAGGTGGTCTACAAGGTCTTCAAGATGAT
CCCTGCTGTGGTGGATGGGGAGTTCCTACCCAAGCATCCTCAGGAGCTGCTGACCTCTATGGAT
TTTCACCCTGTCCCCAGCATCATTGGTGTCAACACAGATGAATGTGGCTGGGGAGTCCCCATGT
TCATGGGCCTTGACCATATCATAAAGAACATAACCAGAGAGACCCTGCCAGCTGTTCTGAAGAA
CACAGCAGCACGGATGATGTTGCCTCCAGAATGTAGTCACCTGCTAGTGGAGGAGTATATGGGG
GACACTGAGGACCCAGAGACCCTGCAAGCACAGTTCAGAGAGATGCTGGGGGACTTCATGTTTG
TGATCCCTGCTCTCCAAGTGGCACATTTCCAGCGTTCCCAGGCTCCTGTCTACTTCTATGAGTT
CCAGCATCTGTCCAGCTTCATCAAGCATGTCAGGCCATCACATGTGAAGGCAGACCATGGTGAT
GACGTTGCCTTTGTCTTTGGCTCCTATTTGTGGGACATGAATTTGGACCTCACTGAGGAGGAGG
AGCTGCTAAAGAGGATGATGATGAAGTACTGGGCCAATTTCGCAAGAAATGGGAACCCCAACAG
TGAGGGTCTACCCTCCTGGCCTGTGTTGGACCATGATGAGCAGTACCTGCAGCTGGACACCCAG
CCTGCTGTGGGTCGAGCCCTGAAGGCCAGAAGGCTGCAGTTCTGGACCAAGACTCTGCCCCAGA
AGATCCAGGAGCTCAAGGGTTCTCAGGACAAGCATGCAGAGCTGTAGCGTCCTGTGTCAGGGAA
GGTGTGTGAGATTAAAAGCAGATGGTGTAATTCTGAGGTTACAAAGTCCATTTATTCATTTTTA
TTTGTTCTAATACTTATGGAAGCATTTCTAATATCAGCATTTGCCCTTCCAGACATGTATGAAG
AGCAGTCAGTGTTATTTCTTATCATTCTGGGCAAACATTCATTAGAATCAATAAAAGCTCTCAT
AACAGTGTG

hide sequence

RefSeq Acc Id:

NM_133960 ⟹ NP_598721

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	105,460,635 - 105,468,266 (+)	NCBI
GRCm38	8	104,734,003 - 104,741,634 (+)	ENTREZGENE
MGSCv37	8	107,257,903 - 107,265,534 (+)	RGD
Celera	8	108,964,463 - 108,972,010 (+)	RGD
cM Map	8		ENTREZGENE

Sequence:

show sequence

GATCTGTTTTTGTTTCCTGCTGTGACACTCTCATGTGCAGCAGCACAGGTTTAGGCCTGAGATT
CAACCATGCCATTGGCTAGACTTCCTGGTTGGCTGTGTGTTGTTGCCTGTGGGCTCCTGCTTCT
CCTCCAGCATGTGCATGGCCAGGACTCAGCCAGCCCCATCAGGAACACCCACAGGGGTCAGGTG
AGAGGCAGCTTTGTCCACGTGAAGGACACTAAATCTGGTGTCCATGCCTTCCTGGGAATCCCCT
TTGCCAAGCCTCCTGTAGGACTACTGCGCTTTGCACCTCCTGAGGACCCTGAGCCATGGAGTGG
TGTGAGAGATGGGACCTCACAGCCGGCCATGTGTCTGCAGCCTGATATAATGAATTTAGAGGAT
GCGAAGGAAATGAATCTGATCCTGCCTCCCATCTCTATGTCCGAGGACTGCCTGTATCTCAACA
TCTACACACCAACCCACGCCCAGGAGGGCTCTAACCTGCCTGTGATGGTATGGATCCACGGTGG
TGGACTGGTTGTAGGATCAGCTTCCATGAATGATGTATCTAAACTGGCAGCCACTGAGGAAATA
GTAATTGTCGCCATCCAGTATCGCTTGGGGGTCCTTGGCTTCTTCAGCACTGGAGACCAGCATG
CCAGAGGCAACTGGGGATACCTGGACCAAGTGGCTGCCTTACGCTGGGTGCAGAAGAATATTGC
TTACTTTGGAGGCAACCGTGACAGGGTCACTATATTTGGAGTCTCAGCAGGAGGTACAAGTGTG
TCTTCTCATATTCTGTCCCCAATGTCCAAAGGACTCTTTCATGGAGCCATTATGCAGAGTGGAG
TGGCCCTGCTGCCTGACCTCATCTCTGACACTTCTGAGGTGGTCTACAAGACAGTAGCCAACCT
ATCTGGTTGTGAAGCCACAGACTCAGAAGCCCTGATCCACTGCCTGAGAGCAAAGAGTAAACAA
GAGATCCTGGCTATTAACCAGGTCTTCAAGATGATCCCTGCTGTGGTGGATGGGGAGTTCCTAC
CCAAGCATCCTCAGGAGCTGCTGACCTCTATGGATTTTCACCCTGTCCCCAGCATCATTGGTGT
CAACACAGATGAATGTGGCTGGGGAGTCCCCATGTTCATGGGCCTTGACCATATCATAAAGAAC
ATAACCAGAGAGACCCTGCCAGCTGTTCTGAAGAACACAGCAGCACGGATGATGTTGCCTCCAG
AATGTAGTCACCTGCTAGTGGAGGAGTATATGGGGGACACTGAGGACCCAGAGACCCTGCAAGC
ACAGTTCAGAGAGATGCTGGGGGACTTCATGTTTGTGATCCCTGCTCTCCAAGTGGCACATTTC
CAGCGTTCCCAGGCTCCTGTCTACTTCTATGAGTTCCAGCATCTGTCCAGCTTCATCAAGCATG
TCAGGCCATCACATGTGAAGGCAGACCATGGTGATGACGTTGCCTTTGTCTTTGGCTCCTATTT
GTGGGACATGAATTTGGACCTCACTGAGGAGGAGGAGCTGCTAAAGAGGATGATGATGAAGTAC
TGGGCCAATTTCGCAAGAAATGGGAACCCCAACAGTGAGGGTCTACCCTCCTGGCCTGTGTTGG
ACCATGATGAGCAGTACCTGCAGCTGGACACCCAGCCTGCTGTGGGTCGAGCCCTGAAGGCCAG
AAGGCTGCAGTTCTGGACCAAGACTCTGCCCCAGAAGATCCAGGAGCTCAAGGGTTCTCAGGAC
AAGCATGCAGAGCTGTAGCGTCCTGTGTCAGGGAAGGTGTGTGAGATTAAAAGCAGATGGTGTA
ATTCTGAGGTTACAAAGTCCATTTATTCATTTTTATTTGTTCTAATACTTATGGAAGCATTTCT
AATATCAGCATTTGCCCTTCCAGACATGTATGAAGAGCAGTCAGTGTTATTTCTTATCATTCTG
GGCAAACATTCATTAGAATCAATAAAAGCTCTCATAACAGTGTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001177259	(Get FASTA)	NCBI Sequence Viewer
	NP_598721	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH21609	(Get FASTA)	NCBI Sequence Viewer
	AAH24082	(Get FASTA)	NCBI Sequence Viewer
	AAH24491	(Get FASTA)	NCBI Sequence Viewer
	AAH24517	(Get FASTA)	NCBI Sequence Viewer
	AAH25537	(Get FASTA)	NCBI Sequence Viewer
	AAH25812	(Get FASTA)	NCBI Sequence Viewer
	AAH26643	(Get FASTA)	NCBI Sequence Viewer
	AAH31295	(Get FASTA)	NCBI Sequence Viewer
	BAC37476	(Get FASTA)	NCBI Sequence Viewer
	BAE38379	(Get FASTA)	NCBI Sequence Viewer
	EDL11232	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000034346
	ENSMUSP00000034346.8
	ENSMUSP00000127346
	ENSMUSP00000127346.3
	ENSMUSP00000148459.2
	ENSMUSP00000148699.2
GenBank Protein	Q8QZR3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_598721 ⟸ NM_133960
- Peptide Label:	isoform 1 precursor
- UniProtKB:	E9Q3D0 (UniProtKB/Swiss-Prot), Q3TMR2 (UniProtKB/Swiss-Prot), Q8QZR3 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MPLARLPGWLCVVACGLLLLLQHVHGQDSASPIRNTHRGQVRGSFVHVKDTKSGVHAFLGIPFA KPPVGLLRFAPPEDPEPWSGVRDGTSQPAMCLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIY TPTHAQEGSNLPVMVWIHGGGLVVGSASMNDVSKLAATEEIVIVAIQYRLGVLGFFSTGDQHAR GNWGYLDQVAALRWVQKNIAYFGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVA LLPDLISDTSEVVYKTVANLSGCEATDSEALIHCLRAKSKQEILAINQVFKMIPAVVDGEFLPK HPQELLTSMDFHPVPSIIGVNTDECGWGVPMFMGLDHIIKNITRETLPAVLKNTAARMMLPPEC SHLLVEEYMGDTEDPETLQAQFREMLGDFMFVIPALQVAHFQRSQAPVYFYEFQHLSSFIKHVR PSHVKADHGDDVAFVFGSYLWDMNLDLTEEEELLKRMMMKYWANFARNGNPNSEGLPSWPVLDH DEQYLQLDTQPAVGRALKARRLQFWTKTLPQKIQELKGSQDKHAEL hide sequence

RefSeq Acc Id:	NP_001177259 ⟸ NM_001190330
- Peptide Label:	isoform 2 precursor
- UniProtKB:	Q8QZR3 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MPLARLPGWLCVVACGLLLLLQHVHGQDSASPIRNTHRGQVRGSFVHVKDTKSGVHAFLGIPFA KPPVGLLRFAPPEDPEPWSGVRDGTSQPAMCLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIY TPTHAQEGSNLPVMVWIHGGGLVVGSASMNDVSKLAATEEIVIVAIQYRLGVLGFFSTGDQHAR GNWGYLDQVAALRWVQKNIAYFGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVA LLPDLISDTSEVVYKVFKMIPAVVDGEFLPKHPQELLTSMDFHPVPSIIGVNTDECGWGVPMFM GLDHIIKNITRETLPAVLKNTAARMMLPPECSHLLVEEYMGDTEDPETLQAQFREMLGDFMFVI PALQVAHFQRSQAPVYFYEFQHLSSFIKHVRPSHVKADHGDDVAFVFGSYLWDMNLDLTEEEEL LKRMMMKYWANFARNGNPNSEGLPSWPVLDHDEQYLQLDTQPAVGRALKARRLQFWTKTLPQKI QELKGSQDKHAEL hide sequence

Ensembl Acc Id:

ENSMUSP00000148459 ⟸ ENSMUST00000159303

Ensembl Acc Id:

ENSMUSP00000127346 ⟸ ENSMUST00000164182

Ensembl Acc Id:

ENSMUSP00000034346 ⟸ ENSMUST00000034346

Ensembl Acc Id:

ENSMUSP00000148699 ⟸ ENSMUST00000161824

Protein Domains

Carboxylesterase type B

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8QZR3-F1-model_v2	AlphaFold	Q8QZR3	1-558	view protein structure

Promoters

RGD ID:

8668033

Promoter ID:

EPDNEW_M12048

Type:

multiple initiation site

Name:

Ces2a_1

Description:

Mus musculus carboxylesterase 2A , transcript variant 2, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	104,734,008 - 104,734,068	EPDNEW

RGD ID:

6842935

Promoter ID:

MM_KWN:55503

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Liver

Transcripts:

OTTMUST00000067808, OTTMUST00000067810

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	8	107,257,561 - 107,258,061 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2142491	AgrOrtholog
Ensembl Genes	ENSMUSG00000055730	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000034346	ENTREZGENE
	ENSMUST00000034346.15	UniProtKB/Swiss-Prot
	ENSMUST00000159303.3	UniProtKB/TrEMBL
	ENSMUST00000161824.2	UniProtKB/TrEMBL
	ENSMUST00000164182	ENTREZGENE
	ENSMUST00000164182.3	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CarbesteraseB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Carboxylesterase_B_AS	UniProtKB/Swiss-Prot
	Carboxylesterase_B_CS	UniProtKB/Swiss-Prot
	Type-B_Carboxylest/Lipase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:102022	UniProtKB/Swiss-Prot
MGD	MGI:2142491	ENTREZGENE
NCBI Gene	102022	ENTREZGENE
PANTHER	CARBOXYLESTERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PYRETHROID HYDROLASE CES2A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	COesterase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ces2a	PhenoGen
PROSITE	CARBOXYLESTERASE_B_1	UniProtKB/Swiss-Prot
	CARBOXYLESTERASE_B_2	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A1D5RLQ1_MOUSE	UniProtKB/TrEMBL
	A0A1D5RMA7_MOUSE	UniProtKB/TrEMBL
	E9Q3D0	ENTREZGENE
	EST2A_MOUSE	UniProtKB/Swiss-Prot
	Q3TMR2	ENTREZGENE
	Q8QZR3	ENTREZGENE
	Q8VC76_MOUSE	UniProtKB/TrEMBL
UniProt Secondary	E9Q3D0	UniProtKB/Swiss-Prot
	Q3TMR2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-07-27	Ces2a	carboxylesterase 2A	Ces6	carboxylesterase 6	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Mammalian Phenotype