Nubpl (nucleotide binding protein-like) - Rat Genome Database

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Gene: Nubpl (nucleotide binding protein-like) Mus musculus
Analyze
Symbol: Nubpl
Name: nucleotide binding protein-like
RGD ID: 1552806
MGI Page MGI
Description: Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 21. Orthologous to human NUBPL (NUBP iron-sulfur cluster assembly factor, mitochondrial).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2410170E07Rik; iron-sulfur cluster transfer protein NUBPL; iron-sulfur protein NUBPL; nucleotide-binding protein-like
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391252,144,529 - 52,357,753 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1252,144,520 - 52,359,527 (+)EnsemblGRCm39 Ensembl
GRCm381252,097,746 - 52,310,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1252,097,737 - 52,312,744 (+)EnsemblGRCm38mm10GRCm38
MGSCv371253,198,733 - 53,411,946 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361253,019,357 - 53,234,357 (+)NCBIMGSCv36mm8
Celera1253,404,089 - 53,607,597 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (HDA,IBA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18614015   PMID:21677750   PMID:21873635   PMID:23055939   PMID:27626380   PMID:29539633  
PMID:30973865   PMID:36280881   PMID:38355793  


Genomics

Comparative Map Data
Nubpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391252,144,529 - 52,357,753 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1252,144,520 - 52,359,527 (+)EnsemblGRCm39 Ensembl
GRCm381252,097,746 - 52,310,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1252,097,737 - 52,312,744 (+)EnsemblGRCm38mm10GRCm38
MGSCv371253,198,733 - 53,411,946 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361253,019,357 - 53,234,357 (+)NCBIMGSCv36mm8
Celera1253,404,089 - 53,607,597 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.11NCBI
NUBPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381431,561,404 - 31,861,224 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1431,489,956 - 31,861,224 (+)EnsemblGRCh38hg38GRCh38
GRCh371432,030,610 - 32,330,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361431,100,342 - 31,400,181 (+)NCBINCBI36Build 36hg18NCBI36
Build 341431,100,428 - 31,399,259NCBI
Celera1411,895,904 - 12,195,785 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1412,147,896 - 12,447,827 (+)NCBIHuRef
CHM1_11432,029,883 - 32,329,829 (+)NCBICHM1_1
T2T-CHM13v2.01425,758,636 - 26,058,537 (+)NCBIT2T-CHM13v2.0
Nubpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8675,294,609 - 75,516,603 (+)NCBIGRCr8
mRatBN7.2669,559,278 - 69,781,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl669,559,291 - 69,781,253 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx669,990,443 - 70,205,300 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0670,297,085 - 70,511,949 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0669,736,622 - 69,951,482 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0672,891,758 - 73,147,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl672,891,725 - 73,148,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0682,453,631 - 82,517,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0682,557,115 - 82,709,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4672,264,459 - 72,306,567 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1672,267,584 - 72,479,338 (+)NCBI
Celera668,435,325 - 68,646,422 (+)NCBICelera
Cytogenetic Map6q23NCBI
Nubpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540928,872,189 - 29,073,206 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540928,873,609 - 29,073,196 (-)NCBIChiLan1.0ChiLan1.0
NUBPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21532,890,880 - 33,180,961 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11432,107,388 - 32,397,543 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01412,338,341 - 12,628,346 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11430,534,997 - 30,822,227 (+)NCBIpanpan1.1PanPan1.1panPan2
NUBPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1810,796,462 - 11,026,804 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl810,796,459 - 11,090,920 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha810,659,000 - 10,889,204 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0810,898,957 - 11,129,569 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl810,898,349 - 11,129,522 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1810,580,802 - 10,814,041 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0810,664,161 - 10,894,603 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0810,942,563 - 11,173,068 (+)NCBIUU_Cfam_GSD_1.0
Nubpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864042,635,534 - 42,858,568 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364946,141,476 - 6,363,830 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364946,141,444 - 6,365,537 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUBPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl767,784,639 - 68,028,552 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1767,785,652 - 68,028,561 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2772,498,664 - 72,573,328 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nubpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624820567,217 - 791,817 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624820562,180 - 767,434 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nubpl
5865 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:770
Count of miRNA genes:536
Interacting mature miRNAs:606
Transcripts:ENSMUST00000040090, ENSMUST00000159485, ENSMUST00000159567, ENSMUST00000159708, ENSMUST00000162111
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121825996652260067Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121973983353739833Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse

Markers in Region
13.MMHAP22FRE7.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381252,167,484 - 52,167,657UniSTSGRCm38
MGSCv371253,268,471 - 53,268,644UniSTSGRCm37
Celera1253,467,766 - 53,467,938UniSTS
Cytogenetic Map12C1UniSTS
Whitehead_YAC12 UniSTS
UniSTS:235802  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387140,992,408 - 140,992,621UniSTSGRCm38
GRCm381252,310,723 - 52,310,935UniSTSGRCm38
MGSCv371253,411,710 - 53,411,922UniSTSGRCm37
MGSCv377148,178,307 - 148,178,520UniSTSGRCm37
Celera1253,607,361 - 53,607,573UniSTS
Celera7140,785,057 - 140,785,270UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map7F5UniSTS
ND  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381252,272,943 - 52,273,103UniSTSGRCm38
MGSCv371253,373,930 - 53,374,090UniSTSGRCm37
Celera1253,569,633 - 53,569,793UniSTS
Cytogenetic Map12C1UniSTS
Whitehead/MRC_RH12424.99UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000040090   ⟹   ENSMUSP00000044292
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1252,144,520 - 52,359,527 (+)Ensembl
GRCm38.p6 Ensembl1252,097,737 - 52,312,744 (+)Ensembl
Ensembl Acc Id: ENSMUST00000159485
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1252,144,544 - 52,147,866 (+)Ensembl
GRCm38.p6 Ensembl1252,097,761 - 52,101,083 (+)Ensembl
Ensembl Acc Id: ENSMUST00000159567   ⟹   ENSMUSP00000125177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1252,179,167 - 52,349,504 (+)Ensembl
GRCm38.p6 Ensembl1252,132,384 - 52,302,721 (+)Ensembl
Ensembl Acc Id: ENSMUST00000159708
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1252,144,539 - 52,191,563 (+)Ensembl
GRCm38.p6 Ensembl1252,097,756 - 52,144,780 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162111
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1252,222,870 - 52,317,862 (+)Ensembl
GRCm38.p6 Ensembl1252,176,087 - 52,271,079 (+)Ensembl
RefSeq Acc Id: NM_029760   ⟹   NP_084036
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391252,144,529 - 52,357,742 (+)NCBI
GRCm381252,097,746 - 52,310,959 (+)NCBI
MGSCv371253,198,733 - 53,411,946 (+)RGD
Celera1253,404,089 - 53,607,597 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516362   ⟹   XP_006516425
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391252,312,473 - 52,357,753 (+)NCBI
GRCm381252,265,690 - 52,310,970 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006516363   ⟹   XP_006516426
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391252,179,149 - 52,357,753 (+)NCBI
GRCm381252,132,366 - 52,310,968 (+)NCBI
Sequence:
RefSeq Acc Id: NP_084036   ⟸   NM_029760
- Peptide Label: precursor
- UniProtKB: Q6P6K2 (UniProtKB/Swiss-Prot),   Q9CWD8 (UniProtKB/Swiss-Prot),   Q3URR8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006516426   ⟸   XM_006516363
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006516425   ⟸   XM_006516362
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000125177   ⟸   ENSMUST00000159567
Ensembl Acc Id: ENSMUSP00000044292   ⟸   ENSMUST00000040090

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CWD8-F1-model_v2 AlphaFold Q9CWD8 1-319 view protein structure

Promoters
RGD ID:8678256
Promoter ID:EPDNEW_M17159
Type:multiple initiation site
Name:Nubpl_1
Description:Mus musculus nucleotide binding protein-like , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381252,097,756 - 52,097,816EPDNEW
RGD ID:6823237
Promoter ID:MM_KWN:11623
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000085402,   OTTMUST00000082106,   OTTMUST00000082107,   OTTMUST00000082136
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361253,198,571 - 53,199,071 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924076 AgrOrtholog
Ensembl Genes ENSMUSG00000035142 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000040090 ENTREZGENE
  ENSMUST00000040090.16 UniProtKB/Swiss-Prot
  ENSMUST00000159567.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Mrp/NBP35_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mrp_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUBPL-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YlxH/NBP35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:76826 UniProtKB/Swiss-Prot
MGD MGI:1924076 ENTREZGENE
NCBI Gene 76826 ENTREZGENE
PANTHER IRON-SULFUR PROTEIN NUBPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR42961 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ParA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nubpl PhenoGen
PROSITE MRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7D3P0_MOUSE UniProtKB/TrEMBL
  NUBPL_MOUSE UniProtKB/Swiss-Prot
  Q3URR8 ENTREZGENE, UniProtKB/TrEMBL
  Q6P6K2 ENTREZGENE
  Q8BNI3_MOUSE UniProtKB/TrEMBL
  Q9CWD8 ENTREZGENE
UniProt Secondary Q6P6K2 UniProtKB/Swiss-Prot