Panx3 (pannexin 3) - Rat Genome Database

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Gene: Panx3 (pannexin 3) Mus musculus
Analyze
Symbol: Panx3
Name: pannexin 3
RGD ID: 1552785
MGI Page MGI
Description: Enables calcium channel activity and gap junction hemi-channel activity. Involved in osteoblast differentiation. Located in endoplasmic reticulum membrane; gap junction; and plasma membrane. Is expressed in several structures, including alimentary system; connective tissue; limb; sensory organ; and skeleton. Orthologous to human PANX3 (pannexin 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3230401P04; 4833413G11Rik; pannexin-3; RIKEN cDNA 4833413G11 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39937,571,198 - 37,580,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl937,571,198 - 37,580,531 (-)EnsemblGRCm39 Ensembl
GRCm38937,659,902 - 37,669,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl937,659,902 - 37,669,235 (-)EnsemblGRCm38mm10GRCm38
MGSCv37937,467,487 - 37,476,807 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36937,409,573 - 37,418,893 (-)NCBIMGSCv36mm8
Celera934,876,995 - 34,886,243 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15028292   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17925379   PMID:18649185   PMID:19009624   PMID:19692571  
PMID:20086016   PMID:20332104   PMID:20404334   PMID:20589901   PMID:21267068   PMID:21677750   PMID:21690309   PMID:21752992   PMID:21873635   PMID:21915903   PMID:23233153   PMID:24338011  
PMID:26138248   PMID:26183770   PMID:26749194   PMID:26759176   PMID:27506198   PMID:27626380   PMID:27784763   PMID:28494020   PMID:29735531   PMID:29744875   PMID:30389492   PMID:30918989  
PMID:31202927   PMID:31822768   PMID:33426805   PMID:33469169   PMID:33499145   PMID:34897286   PMID:36813158   PMID:36963497   PMID:38289985   PMID:38355793   PMID:38355795   PMID:38992988  


Genomics

Comparative Map Data
Panx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39937,571,198 - 37,580,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl937,571,198 - 37,580,531 (-)EnsemblGRCm39 Ensembl
GRCm38937,659,902 - 37,669,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl937,659,902 - 37,669,235 (-)EnsemblGRCm38mm10GRCm38
MGSCv37937,467,487 - 37,476,807 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36937,409,573 - 37,418,893 (-)NCBIMGSCv36mm8
Celera934,876,995 - 34,886,243 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.79NCBI
PANX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811124,611,428 - 124,620,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11124,611,428 - 124,620,356 (+)EnsemblGRCh38hg38GRCh38
GRCh3711124,481,324 - 124,490,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611123,986,663 - 123,995,462 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411123,986,662 - 123,995,459NCBI
Celera11121,641,631 - 121,650,429 (+)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11120,423,913 - 120,432,711 (+)NCBIHuRef
CHM1_111124,367,559 - 124,376,376 (+)NCBICHM1_1
T2T-CHM13v2.011124,640,092 - 124,649,020 (+)NCBIT2T-CHM13v2.0
Panx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8845,554,474 - 45,566,378 (-)NCBIGRCr8
mRatBN7.2837,366,758 - 37,377,640 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl837,366,862 - 37,377,640 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx841,383,133 - 41,393,828 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0839,666,197 - 39,676,892 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0837,529,079 - 37,539,775 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0840,126,379 - 40,137,390 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl840,126,342 - 40,137,390 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0840,127,203 - 40,138,214 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4838,902,317 - 38,913,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1838,593,394 - 38,921,856 (-)NCBI
Celera837,077,755 - 37,088,527 (+)NCBICelera
Cytogenetic Map8q22NCBI
Panx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541225,676,286 - 25,684,841 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541225,676,286 - 25,684,841 (+)NCBIChiLan1.0ChiLan1.0
PANX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29125,307,247 - 125,319,314 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111126,412,210 - 126,423,820 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011119,438,866 - 119,452,174 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111123,354,919 - 123,363,463 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11123,354,919 - 123,363,463 (+)Ensemblpanpan1.1panPan2
PANX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.159,787,513 - 9,794,292 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl59,787,947 - 9,794,166 (-)EnsemblCanFam3.1canFam3CanFam3.1
Panx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947106,835,538 - 106,842,852 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367431,083,227 - 1,090,777 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367431,083,217 - 1,092,023 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PANX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl951,853,949 - 51,861,331 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1951,854,148 - 51,860,330 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2957,372,024 - 57,378,298 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PANX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,757,147 - 115,767,034 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,757,901 - 115,766,295 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604310,350,082 - 10,392,302 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Panx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624927612,750 - 620,564 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624927612,686 - 621,282 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Panx3
270 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:479
Count of miRNA genes:346
Interacting mature miRNAs:394
Transcripts:ENSMUST00000011262, ENSMUST00000142228
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92850333341799326Mouse
1301007Pid2_mprion incubation determinant 2 (mouse)Not determined93715336244251323Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1558949Igan3_mIgA nephropathy 3 (mouse)Not determined93041469440565914Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1357682Phdlc1_mplasma HDL cholesterol 1 (mouse)Not determined93410461942764866Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000011262   ⟹   ENSMUSP00000011262
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl937,571,198 - 37,580,531 (-)Ensembl
GRCm38.p6 Ensembl937,659,902 - 37,669,235 (-)Ensembl
Ensembl Acc Id: ENSMUST00000142228   ⟹   ENSMUSP00000114539
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl937,575,517 - 37,580,469 (-)Ensembl
GRCm38.p6 Ensembl937,664,221 - 37,669,173 (-)Ensembl
Ensembl Acc Id: ENSMUST00000215047
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl937,579,409 - 37,580,486 (-)Ensembl
GRCm38.p6 Ensembl937,668,113 - 37,669,190 (-)Ensembl
RefSeq Acc Id: NM_172454   ⟹   NP_766042
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39937,571,198 - 37,580,518 (-)NCBI
GRCm38937,659,902 - 37,669,222 (-)ENTREZGENE
MGSCv37937,467,487 - 37,476,807 (-)RGD
Celera934,876,995 - 34,886,243 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_766042   ⟸   NM_172454
- UniProtKB: Q8CEG0 (UniProtKB/Swiss-Prot),   Q8CB28 (UniProtKB/Swiss-Prot),   Q6IMP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000011262   ⟸   ENSMUST00000011262
Ensembl Acc Id: ENSMUSP00000114539   ⟸   ENSMUST00000142228

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CEG0-F1-model_v2 AlphaFold Q8CEG0 1-392 view protein structure

Promoters
RGD ID:8669250
Promoter ID:EPDNEW_M12655
Type:initiation region
Name:Panx3_1
Description:Mus musculus pannexin 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38937,669,190 - 37,669,250EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918881 AgrOrtholog
Ensembl Genes ENSMUSG00000011118 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000011262 ENTREZGENE
  ENSMUST00000011262.4 UniProtKB/Swiss-Prot
  ENSMUST00000142228.2 UniProtKB/TrEMBL
InterPro Innexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pannexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:208098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1918881 ENTREZGENE
NCBI Gene Panx3 ENTREZGENE
PANTHER PANNEXIN-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15759 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Innexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Panx3 PhenoGen
PROSITE PANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RDS8_MOUSE UniProtKB/TrEMBL
  PANX3_MOUSE UniProtKB/Swiss-Prot
  Q6IMP0 ENTREZGENE, UniProtKB/TrEMBL
  Q8CB28 ENTREZGENE
  Q8CEG0 ENTREZGENE
UniProt Secondary Q8CB28 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Panx3  pannexin 3  4833413G11Rik  RIKEN cDNA 4833413G11 gene  Symbol and/or name change 5135510 APPROVED
2024-08-21 4833413G11Rik  RIKEN cDNA 4833413G11 gene  Panx3  pannexin 3  Symbol and/or name change 5135510 APPROVED