Txnl4b (thioredoxin-like 4B) - Rat Genome Database

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Gene: Txnl4b (thioredoxin-like 4B) Mus musculus
Analyze
Symbol: Txnl4b
Name: thioredoxin-like 4B
RGD ID: 1552589
MGI Page MGI
Description: Predicted to be involved in RNA splicing and mRNA processing. Predicted to act upstream of or within mRNA splicing, via spliceosome and positive regulation of cell population proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of U4/U6 x U5 tri-snRNP complex; U5 snRNP; and spliceosomal complex. Orthologous to human TXNL4B (thioredoxin like 4B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI595343; D530025J19Rik; Dim; Dim2; DLP; thioredoxin-like protein 4B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm6331  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,292,524 - 110,300,683 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,292,524 - 110,300,683 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388109,565,892 - 109,574,051 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,565,892 - 109,574,051 (+)Ensemblmm10GRCm38
MGSCv378112,089,886 - 112,097,951 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368112,455,134 - 112,463,168 (+)NCBIMGSCv36mm8
Celera8113,791,263 - 113,799,328 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.1NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:15161931   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18799693  
PMID:21873635   PMID:32968282  


Genomics

Comparative Map Data
Txnl4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,292,524 - 110,300,683 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,292,524 - 110,300,683 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388109,565,892 - 109,574,051 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,565,892 - 109,574,051 (+)Ensemblmm10GRCm38
MGSCv378112,089,886 - 112,097,951 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368112,455,134 - 112,463,168 (+)NCBIMGSCv36mm8
Celera8113,791,263 - 113,799,328 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.1NCBI
TXNL4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,084,857 - 72,094,378 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1672,084,854 - 72,094,431 (-)Ensemblhg38GRCh38
GRCh371672,118,756 - 72,128,277 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,676,257 - 70,685,015 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341670,676,258 - 70,685,015NCBI
Celera1656,432,875 - 56,442,336 (-)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,885,588 - 57,895,049 (-)NCBIHuRef
CHM1_11673,532,104 - 73,541,565 (-)NCBICHM1_1
T2T-CHM13v2.01677,901,171 - 77,912,511 (-)NCBIT2T-CHM13v2.0
Txnl4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,439,686 - 54,449,777 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1954,439,680 - 54,448,052 (+)EnsemblGRCr8
mRatBN7.21937,530,157 - 37,539,827 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,530,152 - 37,538,521 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1944,346,085 - 44,351,778 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01944,999,413 - 45,005,106 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,309,120 - 47,314,813 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01942,101,081 - 42,110,223 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,101,902 - 42,107,601 (-)Ensemblrn6Rnor6.0
Rnor_5.01952,926,210 - 52,935,397 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41939,436,220 - 39,441,919 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1936,937,910 - 36,943,603 (+)NCBICelera
RGSC_v3.11939,441,100 - 39,446,800 (+)NCBI
Cytogenetic Map19q12NCBI
Txnl4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,744,620 - 4,752,737 (-)Ensembl
ChiLan1.0NW_0049554844,744,620 - 4,752,737 (-)NCBIChiLan1.0ChiLan1.0
TXNL4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,035,403 - 82,125,155 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11687,962,655 - 88,064,689 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01652,890,600 - 52,988,559 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,884,864 - 71,955,735 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,946,172 - 71,954,951 (-)EnsemblpanPan2panpan1.1
TXNL4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,765,461 - 77,810,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,803,575 - 77,810,637 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha577,727,180 - 77,772,583 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0578,204,805 - 78,250,237 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,215,059 - 78,250,107 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1578,024,865 - 78,070,379 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,847,747 - 77,893,148 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,346,890 - 78,392,513 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Txnl4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,750,295 - 37,758,471 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647521,830,610 - 21,839,578 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647521,830,630 - 21,838,819 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNL4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,985,474 - 14,998,017 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1614,985,063 - 14,998,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,647,741 - 14,654,710 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TXNL4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,180,335 - 55,244,607 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl555,235,939 - 55,243,848 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604717,988,279 - 18,032,726 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txnl4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474614,293,179 - 14,301,668 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474614,293,415 - 14,301,700 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Txnl4b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11729,287,978 - 29,293,338 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Txnl4b
554 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:643
Count of miRNA genes:381
Interacting mature miRNAs:438
Transcripts:ENSMUST00000034159, ENSMUST00000178445
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8102486208111650036Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
35673316Ari3_mantibody response to influenza 3, day 15, IgM (mouse)8109426632113826632Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
36049782Arc2_mantibody response to CHIKV 2, day 7, IgM (mouse)8109426632113826632Mouse
36049783Arc3_mantibody response to CHIKV 3, day 7, FRNT50 (mouse)8109426632113826632Mouse
36049780Ars12_mantibody response to SARS-CoV 12, 4 days post-rechallenge, IgM (mouse)8109426632113826632Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
36049781Arc1_mantibody response to CHIKV 1, day 7, IgG (mouse)8109426632113826632Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8102486208116025457Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse

Markers in Region
AI595343  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388109,573,922 - 109,574,019UniSTSGRCm38
MGSCv378112,097,822 - 112,097,919UniSTSGRCm37
Celera8113,799,199 - 113,799,296UniSTS
Cytogenetic Map8D3UniSTS
Whitehead/MRC_RH81287.18UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000034159   ⟹   ENSMUSP00000034159
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,292,524 - 110,300,683 (+)Ensembl
GRCm38.p6 Ensembl8109,565,892 - 109,574,051 (+)Ensembl
Ensembl Acc Id: ENSMUST00000178445   ⟹   ENSMUSP00000137524
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,295,520 - 110,300,155 (+)Ensembl
GRCm38.p6 Ensembl8109,568,888 - 109,573,523 (+)Ensembl
RefSeq Acc Id: NM_175646   ⟹   NP_783577
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398110,292,524 - 110,300,683 (+)NCBI
GRCm388109,565,892 - 109,574,051 (+)NCBI
MGSCv378112,089,886 - 112,097,951 (+)RGD
Celera8113,791,263 - 113,799,328 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_783577 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI32374 (Get FASTA)   NCBI Sequence Viewer  
  AAI38334 (Get FASTA)   NCBI Sequence Viewer  
  BAC39394 (Get FASTA)   NCBI Sequence Viewer  
  EDL11422 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000034159
  ENSMUSP00000034159.2
  ENSMUSP00000137524.2
GenBank Protein Q8BUH1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_783577   ⟸   NM_175646
- UniProtKB: Q52KF0 (UniProtKB/Swiss-Prot),   Q8BUH1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000137524   ⟸   ENSMUST00000178445
Ensembl Acc Id: ENSMUSP00000034159   ⟸   ENSMUST00000034159

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BUH1-F1-model_v2 AlphaFold Q8BUH1 1-149 view protein structure

Promoters
RGD ID:8668231
Promoter ID:EPDNEW_M12147
Type:single initiation site
Name:Txnl4b_1
Description:Mus musculus thioredoxin-like 4B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388109,566,029 - 109,566,089EPDNEW
RGD ID:6843857
Promoter ID:MM_KWN:55687
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000034159,   ENSMUST00000042601,   UC009NIK.1,   UC009NIL.1,   UC009NIM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368112,088,966 - 112,089,997 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443724 AgrOrtholog
Ensembl Genes ENSMUSG00000031723 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034159 ENTREZGENE
  ENSMUST00000034159.8 UniProtKB/Swiss-Prot
  ENSMUST00000178445.2 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Dim1 UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:234723 UniProtKB/Swiss-Prot
MGD MGI:2443724 ENTREZGENE
NCBI Gene 234723 ENTREZGENE
PANTHER PTHR12052 UniProtKB/Swiss-Prot
  THIOREDOXIN-LIKE PROTEIN 4B UniProtKB/Swiss-Prot
Pfam DIM1 UniProtKB/Swiss-Prot
PhenoGen Txnl4b PhenoGen
PIRSF mRNA_splic_U5 UniProtKB/Swiss-Prot
SMART DIM1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt Q52KF0 ENTREZGENE
  Q8BUH1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q52KF0 UniProtKB/Swiss-Prot