Pnpla2 (patatin-like phospholipase domain containing 2) - Rat Genome Database

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Gene: Pnpla2 (patatin-like phospholipase domain containing 2) Mus musculus
Analyze
Symbol: Pnpla2
Name: patatin-like phospholipase domain containing 2
RGD ID: 1552545
MGI Page MGI
Description: Enables triglyceride lipase activity. Involved in several processes, including acylglycerol metabolic process; negative regulation of sequestering of triglyceride; and positive regulation of triglyceride catabolic process. Acts upstream of or within cellular lipid catabolic process and lipid droplet organization. Located in cytosol and lipid droplet. Is expressed in brown fat. Orthologous to human PNPLA2 (patatin like phospholipase domain containing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610039C21Rik; 1110001C14Rik; adipose triglyceride lipase; At; Atgl; calcium-independent phospholipase A2-zeta; desn; desnutrin; iPLA2-zeta; patatin-like phospholipase domain-containing protein 2; transport-secretion protein; triglyceride hydrolase; TTS-2.2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,035,101 - 141,040,656 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,035,111 - 141,040,656 (+)EnsemblGRCm39 Ensembl
GRCm387141,455,188 - 141,460,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,455,198 - 141,460,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,641,087 - 148,646,642 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,306,527 - 141,311,414 (+)NCBIMGSCv36mm8
Celera7141,248,977 - 141,254,535 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dichloropropan-2-ol  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (EXP)
alpha-Zearalanol  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (ISO)
cadmium dichloride  (EXP)
canrenoic acid  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (EXP)
corosolic acid  (ISO)
cortisol  (ISO)
cycloheximide  (EXP)
D-glucose  (ISO)
DDE  (ISO)
deoxycholic acid  (EXP)
dexamethasone  (EXP,ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP)
diuron  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
folic acid  (EXP)
FR900359  (ISO)
fructose  (EXP,ISO)
glucose  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
ketamine  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
Licarin A  (EXP)
Licochalcone B  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
MK-2206  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nevirapine  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
NMN zwitterion  (EXP)
olanzapine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phosphatidylcholine  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
propiconazole  (EXP)
quercetin  (EXP)
raspberry ketone  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
scopoletin  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
tamoxifen  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
tioguanine  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
tributylstannane  (ISO)
triphenyl phosphate  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zearalenone  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue physiology  (IAGP)
abnormal brown adipose tissue morphology  (IAGP)
abnormal cardiomyocyte apoptosis  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cholangiocyte morphology  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal gas homeostasis  (IAGP)
abnormal glucose tolerance  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lipid level  (IAGP)
abnormal metabolism  (IAGP)
abnormal myocardial fiber mitochondrial morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal respiratory quotient  (IAGP)
abnormal white adipose tissue morphology  (IAGP)
cardiac edema  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
congestive heart failure  (IAGP)
decreased adipocyte glucose uptake  (IAGP)
decreased basal metabolism  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating VLDL triglyceride level  (IAGP)
decreased fatty acid oxidation  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased heart ventricle muscle contractility  (IAGP)
decreased oxygen consumption  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart right ventricle  (IAGP)
hepatic steatosis  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired lipolysis  (IAGP)
improved glucose tolerance  (IAGP)
increased body mass index  (IAGP)
increased body weight  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased brown fat cell size  (IAGP)
increased cardiac muscle glycogen level  (IAGP)
increased cardiac muscle triglyceride level  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating leptin level  (IAGP)
increased fatty acids level  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased heart left ventricle weight  (IAGP)
increased heart rate  (IAGP)
increased heart weight  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased insulin sensitivity  (IAGP)
increased interscapular fat pad weight  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased renal fat pad weight  (IAGP)
increased respiratory quotient  (IAGP)
increased skeletal muscle triglyceride level  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased total fat pad weight  (IAGP)
increased triglyceride level  (IAGP)
increased white adipose tissue amount  (IAGP)
increased white fat cell size  (IAGP)
macrovesicular hepatic steatosis  (IAGP)
microvesicular hepatic steatosis  (IAGP)
premature death  (IAGP)
pulmonary vascular congestion  (IAGP)
thick interventricular septum  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9798653   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15337759   PMID:15550674   PMID:15782199   PMID:16009485  
PMID:16141072   PMID:16141073   PMID:16267052   PMID:16380488   PMID:16675698   PMID:16679289   PMID:16705060   PMID:17074755   PMID:17114792   PMID:17237500   PMID:17245390   PMID:17848638  
PMID:18191271   PMID:18337240   PMID:18390901   PMID:18445597   PMID:18572100   PMID:18952573   PMID:19010445   PMID:19026557   PMID:19067489   PMID:19136649   PMID:19190264   PMID:19297333  
PMID:19389712   PMID:19491295   PMID:19692632   PMID:19723629   PMID:19850935   PMID:19965578   PMID:20023287   PMID:20107043   PMID:20164531   PMID:20197052   PMID:20424161   PMID:20842343  
PMID:20967758   PMID:21030715   PMID:21106876   PMID:21148142   PMID:21196579   PMID:21267068   PMID:21393244   PMID:21464445   PMID:21465509   PMID:21543206   PMID:21641555   PMID:21680814  
PMID:21743036   PMID:21757733   PMID:21857651   PMID:21873635   PMID:21951135   PMID:21969372   PMID:22039468   PMID:22101529   PMID:22158969   PMID:22225876   PMID:22374972   PMID:22383686  
PMID:22496349   PMID:22733971   PMID:22993196   PMID:23066022   PMID:23124680   PMID:23204327   PMID:23220585   PMID:23296636   PMID:23297223   PMID:23349479   PMID:23413028   PMID:23583398  
PMID:23704323   PMID:23708736   PMID:23740967   PMID:23835334   PMID:23850519   PMID:23858058   PMID:23867907   PMID:23878361   PMID:23886955   PMID:24002947   PMID:24086110   PMID:24096872  
PMID:24196706   PMID:24268737   PMID:24358267   PMID:24440819   PMID:24610891   PMID:24657704   PMID:24801391   PMID:25086775   PMID:25096179   PMID:25176985   PMID:25193997   PMID:25316883  
PMID:25351614   PMID:25381252   PMID:25418045   PMID:25422441   PMID:25535287   PMID:25662011   PMID:25662615   PMID:25700221   PMID:25732851   PMID:25783895   PMID:25814662   PMID:25852007  
PMID:25879679   PMID:25953897   PMID:26109679   PMID:26143381   PMID:26196542   PMID:26220403   PMID:26236747   PMID:26260790   PMID:26263173   PMID:26411340   PMID:26427354   PMID:26508640  
PMID:26569053   PMID:27050511   PMID:27179362   PMID:27185873   PMID:27185876   PMID:27213586   PMID:27248498   PMID:27357546   PMID:27396333   PMID:27596982   PMID:27677764   PMID:27754788  
PMID:27759039   PMID:27851965   PMID:27858140   PMID:27974211   PMID:27986537   PMID:28194887   PMID:28364022   PMID:28380348   PMID:28400046   PMID:28404638   PMID:28459858   PMID:28488768  
PMID:28510703   PMID:28726642   PMID:28877455   PMID:28988821   PMID:29232702   PMID:29320510   PMID:29599420   PMID:29692363   PMID:29932770   PMID:30033199   PMID:30802154   PMID:31185001  
PMID:31353262   PMID:31412256   PMID:31757217   PMID:31806624   PMID:31917686   PMID:32029223   PMID:32302523   PMID:32312867   PMID:32376415   PMID:32661391   PMID:32958928   PMID:33059001  
PMID:33097799   PMID:33231284   PMID:33372146   PMID:33508319   PMID:33605986   PMID:33732701   PMID:34185433   PMID:34352257   PMID:34387896   PMID:34489438   PMID:34508728   PMID:35045287  
PMID:35150895   PMID:35265813   PMID:35269472   PMID:35508110   PMID:35676490   PMID:35731039   PMID:35733999   PMID:35863637   PMID:36108743   PMID:36115595   PMID:36229459   PMID:36346641  
PMID:36473459   PMID:36476935   PMID:36748188   PMID:36763501   PMID:36934843   PMID:37777008   PMID:38135254   PMID:38280449   PMID:38561547   PMID:38736904  


Genomics

Comparative Map Data
Pnpla2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,035,101 - 141,040,656 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,035,111 - 141,040,656 (+)EnsemblGRCm39 Ensembl
GRCm387141,455,188 - 141,460,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,455,198 - 141,460,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,641,087 - 148,646,642 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,306,527 - 141,311,414 (+)NCBIMGSCv36mm8
Celera7141,248,977 - 141,254,535 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.81NCBI
PNPLA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811818,914 - 825,573 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11818,914 - 825,573 (+)EnsemblGRCh38hg38GRCh38
GRCh3711818,914 - 825,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611808,902 - 815,217 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411808,901 - 815,216NCBI
Celera11885,450 - 892,225 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11634,726 - 640,840 (+)NCBIHuRef
CHM1_111817,799 - 824,534 (+)NCBICHM1_1
T2T-CHM13v2.011870,350 - 877,008 (+)NCBIT2T-CHM13v2.0
Pnpla2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,982,279 - 205,987,361 (+)NCBIGRCr8
mRatBN7.21196,552,723 - 196,557,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,552,723 - 196,557,805 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,898,082 - 204,903,154 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,026,596 - 212,031,676 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,700,734 - 204,705,814 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,434,638 - 214,439,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,434,626 - 214,439,720 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,997,709 - 214,002,815 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,914,961 - 220,920,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,641,939 - 201,647,021 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1194,186,305 - 194,191,301 (+)NCBICelera
Cytogenetic Map1q41NCBI
Pnpla2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,303,843 - 11,309,181 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,304,660 - 11,309,755 (-)NCBIChiLan1.0ChiLan1.0
PNPLA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,217,710 - 3,224,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,428,305 - 2,434,123 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011838,339 - 844,035 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111883,279 - 887,258 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11881,934 - 886,896 (+)Ensemblpanpan1.1panPan2
PNPLA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,182,569 - 45,187,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,182,566 - 45,187,268 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1843,849,713 - 43,854,935 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01845,847,672 - 45,852,617 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,847,350 - 45,852,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,312,419 - 45,317,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,877,261 - 44,882,484 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,615,387 - 45,620,610 (+)NCBIUU_Cfam_GSD_1.0
Pnpla2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947580,773 - 585,949 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888580,767 - 587,083 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888580,773 - 585,949 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2513,077 - 518,182 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12513,065 - 517,962 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22156,833 - 161,266 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNPLA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11626,060 - 631,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603897,715,973 - 97,721,418 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnpla2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,690,873 - 21,697,009 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,692,023 - 21,697,018 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pnpla2
169 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2860
Count of miRNA genes:652
Interacting mature miRNAs:816
Transcripts:ENSMUST00000026583, ENSMUST00000064151, ENSMUST00000164016, ENSMUST00000164924, ENSMUST00000165487, ENSMUST00000169665, ENSMUST00000169723
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse

Markers in Region
UniSTS:235813  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,454,258 - 141,454,467UniSTSGRCm38
MGSCv377148,640,157 - 148,640,366UniSTSGRCm37
Celera7141,248,004 - 141,248,213UniSTS
Cytogenetic Map7F5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001163689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_025802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_028142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY510273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY731699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY894805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB574719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF725975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000026583   ⟹   ENSMUSP00000026583
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,035,119 - 141,040,005 (+)Ensembl
GRCm38.p6 Ensembl7141,455,206 - 141,460,092 (+)Ensembl
RefSeq Acc Id: ENSMUST00000064151   ⟹   ENSMUSP00000065116
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,035,120 - 141,040,007 (+)Ensembl
GRCm38.p6 Ensembl7141,455,207 - 141,460,094 (+)Ensembl
RefSeq Acc Id: ENSMUST00000164016   ⟹   ENSMUSP00000127149
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,035,111 - 141,040,656 (+)Ensembl
GRCm38.p6 Ensembl7141,455,198 - 141,460,743 (+)Ensembl
RefSeq Acc Id: ENSMUST00000164924   ⟹   ENSMUSP00000129632
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,035,142 - 141,040,016 (+)Ensembl
GRCm38.p6 Ensembl7141,455,229 - 141,460,103 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165487   ⟹   ENSMUSP00000132038
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,035,520 - 141,038,064 (+)Ensembl
GRCm38.p6 Ensembl7141,455,607 - 141,458,151 (+)Ensembl
RefSeq Acc Id: ENSMUST00000169665   ⟹   ENSMUSP00000127983
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,035,132 - 141,038,851 (+)Ensembl
GRCm38.p6 Ensembl7141,455,219 - 141,458,938 (+)Ensembl
RefSeq Acc Id: ENSMUST00000169723
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,036,931 - 141,038,599 (+)Ensembl
GRCm38.p6 Ensembl7141,457,018 - 141,458,686 (+)Ensembl
RefSeq Acc Id: NM_001163689   ⟹   NP_001157161
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397141,035,101 - 141,040,656 (+)NCBI
GRCm387141,455,188 - 141,460,743 (+)ENTREZGENE
MGSCv377148,641,087 - 148,646,642 (+)RGD
Celera7141,248,977 - 141,254,535 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_025802   ⟹   NP_080078
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397141,035,101 - 141,040,656 (+)NCBI
GRCm387141,455,188 - 141,460,743 (+)ENTREZGENE
MGSCv377148,641,087 - 148,646,642 (+)RGD
Celera7141,248,977 - 141,254,535 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_028142
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397141,035,101 - 141,040,656 (+)NCBI
GRCm387141,455,188 - 141,460,743 (+)ENTREZGENE
MGSCv377148,641,087 - 148,646,642 (+)RGD
Celera7141,248,977 - 141,254,535 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080078   ⟸   NM_025802
- Peptide Label: isoform 2
- UniProtKB: Q8BJ56 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001157161   ⟸   NM_001163689
- Peptide Label: isoform 1
- UniProtKB: Q9D1Q9 (UniProtKB/Swiss-Prot),   Q6P234 (UniProtKB/Swiss-Prot),   Q643S0 (UniProtKB/Swiss-Prot),   Q3UD97 (UniProtKB/Swiss-Prot),   Q05BJ0 (UniProtKB/Swiss-Prot),   O89080 (UniProtKB/Swiss-Prot),   Q9DCF6 (UniProtKB/Swiss-Prot),   Q8BJ56 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000129632   ⟸   ENSMUST00000164924
RefSeq Acc Id: ENSMUSP00000127149   ⟸   ENSMUST00000164016
RefSeq Acc Id: ENSMUSP00000026583   ⟸   ENSMUST00000026583
RefSeq Acc Id: ENSMUSP00000132038   ⟸   ENSMUST00000165487
RefSeq Acc Id: ENSMUSP00000065116   ⟸   ENSMUST00000064151
RefSeq Acc Id: ENSMUSP00000127983   ⟸   ENSMUST00000169665
Protein Domains
PNPLA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BJ56-F1-model_v2 AlphaFold Q8BJ56 1-486 view protein structure

Promoters
RGD ID:8666131
Promoter ID:EPDNEW_M11097
Type:initiation region
Name:Pnpla2_1
Description:Mus musculus patatin-like phospholipase domain containing 2 ,transcript variant 3, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387141,455,207 - 141,455,267EPDNEW
RGD ID:6841785
Promoter ID:MM_KWN:53271
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001163689,   NM_025802,   NR_028142
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,640,301 - 148,641,562 (+)MPROMDB
RGD ID:6848192
Promoter ID:MM_ACW:46521
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:PNPLA2.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,641,951 - 148,643,192 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914103 AgrOrtholog
Ensembl Genes ENSMUSG00000025509 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026583.15 UniProtKB/TrEMBL
  ENSMUST00000064151 ENTREZGENE
  ENSMUST00000064151.13 UniProtKB/Swiss-Prot
  ENSMUST00000164016 ENTREZGENE
  ENSMUST00000164016.8 UniProtKB/Swiss-Prot
  ENSMUST00000164924.8 UniProtKB/TrEMBL
  ENSMUST00000165487.2 UniProtKB/TrEMBL
  ENSMUST00000169665.8 UniProtKB/TrEMBL
Gene3D-CATH Cytosolic phospholipase A2 catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PNPLA2 UniProtKB/Swiss-Prot
  PNPLA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66853 UniProtKB/Swiss-Prot
MGD MGI:1914103 ENTREZGENE
NCBI Gene 66853 ENTREZGENE
PANTHER PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12406 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Patatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pnpla2 PhenoGen
PROSITE PNPLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52151 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PZA4_MOUSE UniProtKB/TrEMBL
  E9Q323_MOUSE UniProtKB/TrEMBL
  H3BIT5_MOUSE UniProtKB/TrEMBL
  O89080 ENTREZGENE
  PLPL2_MOUSE UniProtKB/Swiss-Prot
  Q05BJ0 ENTREZGENE
  Q3UD97 ENTREZGENE
  Q643S0 ENTREZGENE
  Q6P234 ENTREZGENE
  Q8BJ56 ENTREZGENE
  Q9D1Q9 ENTREZGENE
  Q9DCF6 ENTREZGENE
UniProt Secondary O89080 UniProtKB/Swiss-Prot
  Q05BJ0 UniProtKB/Swiss-Prot
  Q3UD97 UniProtKB/Swiss-Prot
  Q643S0 UniProtKB/Swiss-Prot
  Q6P234 UniProtKB/Swiss-Prot
  Q9D1Q9 UniProtKB/Swiss-Prot
  Q9DCF6 UniProtKB/Swiss-Prot