Sgtb (small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sgtb (small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta) Mus musculus
Analyze
Symbol: Sgtb
Name: small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
RGD ID: 1552415
MGI Page MGI
Description: Predicted to enable Hsp70 protein binding activity; molecular adaptor activity; and protein dimerization activity. Predicted to be involved in post-translational protein targeting to endoplasmic reticulum membrane; protein heterooligomerization; and protein homooligomerization. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in nervous system and sensory organ. Orthologous to human SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-SGT; C630001O05Rik; MGC27660; small glutamine-rich tetratricopeptide repeat-containing protein beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913104,246,233 - 104,278,369 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13104,246,249 - 104,278,243 (+)EnsemblGRCm39 Ensembl
GRCm3813104,109,723 - 104,141,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13104,109,741 - 104,141,735 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713104,899,870 - 104,931,532 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613105,230,172 - 105,261,834 (+)NCBIMGSCv36mm8
Celera13108,500,860 - 108,532,740 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1356.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IBA)
TRC complex  (IBA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. Tobaben S, etal., J Biol Chem 2003 Oct 3;278(40):38376-83. Epub 2003 Jul 23.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21267068  
PMID:21873635   PMID:30639199   PMID:32325033   PMID:34321999   PMID:38355793  


Genomics

Comparative Map Data
Sgtb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913104,246,233 - 104,278,369 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13104,246,249 - 104,278,243 (+)EnsemblGRCm39 Ensembl
GRCm3813104,109,723 - 104,141,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13104,109,741 - 104,141,735 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713104,899,870 - 104,931,532 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613105,230,172 - 105,261,834 (+)NCBIMGSCv36mm8
Celera13108,500,860 - 108,532,740 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1356.23NCBI
SGTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38565,665,928 - 65,723,013 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl565,665,928 - 65,723,035 (-)EnsemblGRCh38hg38GRCh38
GRCh37564,961,755 - 65,017,936 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36564,997,511 - 65,053,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 34564,999,553 - 65,053,652NCBI
Celera561,960,213 - 62,016,409 (-)NCBICelera
Cytogenetic Map5q12.3NCBI
HuRef561,917,765 - 61,976,027 (-)NCBIHuRef
CHM1_1564,961,442 - 65,017,635 (-)NCBICHM1_1
T2T-CHM13v2.0566,487,700 - 66,547,014 (-)NCBIT2T-CHM13v2.0
Sgtb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8236,966,840 - 37,003,318 (+)NCBIGRCr8
mRatBN7.2235,233,045 - 35,269,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl235,233,042 - 35,269,518 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx242,346,065 - 42,379,852 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0240,404,761 - 40,438,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0235,261,478 - 35,295,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0234,185,938 - 34,222,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl234,186,091 - 34,219,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0253,314,253 - 53,350,728 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4235,031,975 - 35,065,686 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1234,952,343 - 34,986,055 (+)NCBI
Celera231,209,705 - 31,243,401 (+)NCBICelera
Cytogenetic Map2q13NCBI
Sgtb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554463,374,363 - 3,426,284 (+)NCBIChiLan1.0ChiLan1.0
SGTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2448,197,335 - 48,256,170 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1546,350,080 - 46,409,797 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0548,282,532 - 48,341,083 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1549,938,579 - 49,991,778 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl549,938,579 - 49,995,514 (+)Ensemblpanpan1.1panPan2
SGTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1251,397,606 - 51,446,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl251,402,856 - 51,445,278 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha248,353,481 - 48,401,108 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0251,888,977 - 51,936,615 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl251,892,384 - 51,936,588 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1248,948,720 - 48,996,130 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0249,738,052 - 49,785,443 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0250,630,250 - 50,677,679 (-)NCBIUU_Cfam_GSD_1.0
Sgtb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213194,544,704 - 194,587,773 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364803,481,166 - 3,521,038 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364803,481,172 - 3,524,241 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SGTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1644,186,562 - 44,225,633 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11644,184,536 - 44,225,896 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21647,536,146 - 47,574,847 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SGTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1461,858,519 - 61,918,011 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl461,862,279 - 61,917,539 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604910,501,021 - 10,561,494 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sgtb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248154,162,332 - 4,211,078 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248154,162,308 - 4,211,078 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sgtb
951 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:735
Count of miRNA genes:461
Interacting mature miRNAs:530
Transcripts:ENSMUST00000044385, ENSMUST00000159574, ENSMUST00000160322
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100741519120883175Mouse
13824989Pbsq1_mpercent broken sperm QTL 1 (mouse)13102136508112136534Mouse
4141102Sod1m_msuperoxide dismutase 1, soluble, modifier (mouse)Not determined99739968110699911Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1378036508112036508Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87901985112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
25394543Skmw79_mskeletal muscle weight 79, soleus (mouse)13103286625107663775Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined76132600112431103Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
4141826Tbqt5_mtibia bone quality traits 5 (mouse)Not determined13103341617117043216Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
4142400Tgq24_mtriglyceride QTL 24 (mouse)Not determined102602630120883175Mouse
14746974Manh75_mmandible shape 75 (mouse)1399386647120883175Mouse

Markers in Region
RH132947  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera13108,499,426 - 108,500,523UniSTS
Cytogenetic Map13D1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000044385   ⟹   ENSMUSP00000041307
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13104,246,249 - 104,278,243 (+)Ensembl
GRCm38.p6 Ensembl13104,109,741 - 104,141,735 (+)Ensembl
Ensembl Acc Id: ENSMUST00000159574   ⟹   ENSMUSP00000124895
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13104,246,337 - 104,276,306 (+)Ensembl
GRCm38.p6 Ensembl13104,109,829 - 104,139,798 (+)Ensembl
Ensembl Acc Id: ENSMUST00000160322   ⟹   ENSMUSP00000125569
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13104,246,281 - 104,268,495 (+)Ensembl
GRCm38.p6 Ensembl13104,109,773 - 104,131,987 (+)Ensembl
RefSeq Acc Id: NM_001361054   ⟹   NP_001347983
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913104,246,249 - 104,278,369 (+)NCBI
GRCm3813104,109,741 - 104,141,861 (+)NCBI
Sequence:
RefSeq Acc Id: NM_144838   ⟹   NP_659087
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913104,246,249 - 104,278,369 (+)NCBI
GRCm3813104,109,741 - 104,141,861 (+)NCBI
MGSCv3713104,899,870 - 104,931,532 (+)RGD
Celera13108,500,860 - 108,532,740 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_003950448
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913104,246,233 - 104,276,385 (+)NCBI
GRCm3813104,109,723 - 104,139,877 (+)NCBI
Sequence:
RefSeq Acc Id: NP_659087   ⟸   NM_144838
- UniProtKB: Q8VD33 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001347983   ⟸   NM_001361054
- UniProtKB: Q8VD33 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000124895   ⟸   ENSMUST00000159574
Ensembl Acc Id: ENSMUSP00000125569   ⟸   ENSMUST00000160322
Ensembl Acc Id: ENSMUSP00000041307   ⟸   ENSMUST00000044385
Protein Domains
SGTA homodimerisation

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VD33-F1-model_v2 AlphaFold Q8VD33 1-304 view protein structure

Promoters
RGD ID:8681216
Promoter ID:EPDNEW_M18639
Type:initiation region
Name:Sgtb_1
Description:Mus musculus small glutamine-rich tetratricopeptide repeat -containing,beta , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813104,109,771 - 104,109,831EPDNEW
RGD ID:6824379
Promoter ID:MM_KWN:15137
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000109315,   NM_144838,   UC007RSQ.1,   UC007RSR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613104,899,471 - 104,900,357 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444615 AgrOrtholog
Ensembl Genes ENSMUSG00000042743 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000044385 ENTREZGENE
  ENSMUST00000044385.14 UniProtKB/Swiss-Prot
  ENSMUST00000159574.2 UniProtKB/TrEMBL
  ENSMUST00000160322.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin FC, subunit C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SGTA_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:218544 UniProtKB/Swiss-Prot
MGD MGI:2444615 ENTREZGENE
NCBI Gene 218544 ENTREZGENE
PANTHER LD24721P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SGTA_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sgtb PhenoGen
PROSITE TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E0CX61_MOUSE UniProtKB/TrEMBL
  E0CZ99_MOUSE UniProtKB/TrEMBL
  Q8VD33 ENTREZGENE, UniProtKB/Swiss-Prot