Chi3l1 (chitinase 3 like 1) - Rat Genome Database

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Gene: Chi3l1 (chitinase 3 like 1) Mus musculus
Symbol: Chi3l1
Name: chitinase 3 like 1
RGD ID: 1552317
Description: Predicted to enable chitin binding activity. Involved in positive regulation of interleukin-8 production; positive regulation of peptidyl-threonine phosphorylation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; limb; liver; and skeleton. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW208766; breast regression protein 39; Brp; Brp39; cartilage glycoprotein 39; CGP-39; Chi3; Chil1; chitinase 3-like 1; chitinase-3-like protein 1; chitinase-like 1; GP-39; Gp3; Gp39; YKL-40
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391134,109,894 - 134,117,769 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,109,914 - 134,117,919 (+)EnsemblGRCm39 Ensembl
GRCm381134,182,156 - 134,190,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,182,176 - 134,190,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv371136,078,981 - 136,086,608 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,998,892 - 136,006,442 (+)NCBIMGSCv36mm8
Celera1136,794,910 - 136,802,547 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (EXP)
etoposide  (ISO)
fulvestrant  (ISO)
furan  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isotretinoin  (ISO)
ketamine  (ISO)
Mesaconitine  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
naphthalene  (EXP)
nefazodone  (ISO)
nickel dichloride  (EXP)
nitrofen  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
pioglitazone  (EXP)
pirinixic acid  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
Soman  (ISO)
sulfadimethoxine  (ISO)
Sunset Yellow FCF  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP,ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
XL147  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemia. Bergmann OJ, etal., Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8644-52.
2. Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. Boot RG, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):687-94.
3. Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma. Brasso K, etal., Prostate. 2006 Apr 1;66(5):503-13.
4. A chitinase-like protein in the lung and circulation of patients with severe asthma. Chupp GL, etal., N Engl J Med. 2007 Nov 15;357(20):2016-27.
5. High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival. Cintin C, etal., Cancer. 2002 Jul 15;95(2):267-74.
6. Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer. Diefenbach CS, etal., Gynecol Oncol. 2007 Feb;104(2):435-42. Epub 2006 Oct 4.
7. High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival. Hogdall EV, etal., Oncol Rep. 2003 Sep-Oct;10(5):1535-8.
8. Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Huang Y, etal., Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15044-9.
9. Identification of differentially expressed genes in rat silicosis model by suppression subtractive hybridization analysis. Jin Z, etal., Acta Biochim Biophys Sin (Shanghai). 2008 Aug;40(8):740-6.
10. YKL-40 in giant cells and macrophages from patients with giant cell arteritis. Johansen JS, etal., Arthritis Rheum. 1999 Dec;42(12):2624-30.
11. High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survival. Johansen JS, etal., Breast Cancer Res Treat. 2003 Jul;80(1):15-21.
12. High serum YKL-40 level in patients with small cell lung cancer is related to early death. Johansen JS, etal., Lung Cancer. 2004 Dec;46(3):333-40.
13. Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity? Johansen JS, etal., Respir Med. 2005 Apr;99(4):396-402. Epub 2004 Nov 5.
14. Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity. Johansen JS, etal., Rheumatology (Oxford). 1999 Jul;38(7):618-26.
15. Serum and BALF YKL-40 levels are predictors of survival in idiopathic pulmonary fibrosis. Korthagen NM, etal., Respir Med. 2011 Jan;105(1):106-13.
16. Serum YKL-40 levels in patients with coronary artery disease. Kucur M, etal., Coron Artery Dis. 2007 Aug;18(5):391-6.
17. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. Lee CG, etal., J Exp Med. 2009 May 11;206(5):1149-66. Epub 2009 May 4.
18. Chitotriosidase and YKL-40 in normal and pre-eclamptic pregnancies. Madazli R, etal., Int J Gynaecol Obstet. 2008 Mar;100(3):239-43. Epub 2007 Dec 3.
19. Differential gene expression profiling in human brain tumors. Markert JM, etal., Physiol Genomics. 2001 Feb 7;5(1):21-33.
20. Role of Breast Regression Protein (BRP)-39 in the Pathogenesis of Cigarette Smoke-Induced Inflammation and Emphysema. Matsuura H, etal., Am J Respir Cell Mol Biol. 2010 Jul 23.
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. Serum YKL-40 concentrations in newly diagnosed multiple myeloma patients and YKL-40 expression in malignant plasma cells. Mylin AK, etal., Eur J Haematol. 2006 Nov;77(5):416-24. Epub 2006 Aug 23.
23. Serum levels of YKL-40 increases in patients with acute myocardial infarction. Nojgaard C, etal., Coron Artery Dis. 2008 Jun;19(4):257-63.
24. YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization. Nordenbaek C, etal., J Infect Dis. 1999 Nov;180(5):1722-6.
25. High serum levels of YKL-40 in patients with systemic sclerosis are associated with pulmonary involvement. Nordenbaek C, etal., Scand J Rheumatol. 2005 Jul-Aug;34(4):293-7.
26. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis. Ostergaard C, etal., Clin Diagn Lab Immunol. 2002 May;9(3):598-604.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria. Rathcke CN, etal., Diabetes Care. 2009 Feb;32(2):323-8. Epub 2008 Oct 28.
31. Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults. Rathcke CN, etal., PLoS One. 2009 Jul 1;4(7):e6106.
32. Plasma YKL-40 levels are elevated in patients with chronic heart failure. Rathcke CN, etal., Scand Cardiovasc J. 2010 Apr;44(2):92-9.
33. Mouse MP Annotation Import Pipeline RGD automated import pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma. Schmidt H, etal., Cancer. 2006 Mar 1;106(5):1130-9.
37. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analyses. Sjogren H, etal., Am J Pathol. 2003 Mar;162(3):781-92.
38. The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury. Sohn MH, etal., Am J Respir Crit Care Med. 2010 Oct 1;182(7):918-28. Epub 2010 Jun 17.
39. Elevated pretreatment serum concentration of YKL-40-An independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancer. Thom I, etal., Cancer. 2010 Sep 1;116(17):4114-21.
40. Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease. Thomsen SB, etal., Cardiovasc Diabetol. 2010 Dec 8;9:86.
41. Gene expression profiles of major cytokines in the nucleus tractus solitarii of the spontaneously hypertensive rat. Waki H, etal., Auton Neurosci. 2008 Nov 3;142(1-2):40-4. Epub 2008 Aug 13.
Additional References at PubMed
PMID:7768902   PMID:7970700   PMID:8889548   PMID:9828134   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14681479   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:16472595   PMID:17660555   PMID:18490894   PMID:19041398   PMID:21362171   PMID:21408140   PMID:21473774   PMID:21546314   PMID:21677750   PMID:21866546   PMID:21873635  
PMID:21949714   PMID:21991364   PMID:22817986   PMID:23041842   PMID:23291472   PMID:23558346   PMID:23613996   PMID:23620511   PMID:23972995   PMID:24347826   PMID:24659093   PMID:24920662  
PMID:25047113   PMID:25294623   PMID:25326751   PMID:25377763   PMID:25511377   PMID:25681350   PMID:25955511   PMID:26079949   PMID:26121745   PMID:26238714   PMID:26393907   PMID:26431492  
PMID:26745185   PMID:27198666   PMID:27480124   PMID:28143526   PMID:28303416   PMID:28431248   PMID:28656528   PMID:28679671   PMID:29344304   PMID:29396296   PMID:29403003   PMID:29427412  
PMID:29996695   PMID:30214629   PMID:30402955   PMID:30935969   PMID:31397016   PMID:32127023   PMID:32402213   PMID:32816366   PMID:32962417   PMID:33222690   PMID:33328329   PMID:33471078  
PMID:33498326   PMID:33533316   PMID:33838225   PMID:34110284   PMID:34720089   PMID:34747367   PMID:35237278   PMID:36413508   PMID:36417796   PMID:36445537   PMID:36618349   PMID:37121124  
PMID:37166517   PMID:37285055   PMID:37340009   PMID:37558013   PMID:37575256   PMID:37839992   PMID:38039967   PMID:38042775   PMID:38062768   PMID:38092312   PMID:38291404  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391134,109,894 - 134,117,769 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,109,914 - 134,117,919 (+)EnsemblGRCm39 Ensembl
GRCm381134,182,156 - 134,190,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,182,176 - 134,190,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv371136,078,981 - 136,086,608 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,998,892 - 136,006,442 (+)NCBIMGSCv36mm8
Celera1136,794,910 - 136,802,547 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.15NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381203,178,931 - 203,186,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,178,931 - 203,186,704 (-)EnsemblGRCh38hg38GRCh38
GRCh371203,148,059 - 203,155,832 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,414,682 - 201,422,545 (-)NCBINCBI36Build 36hg18NCBI36
Build 341199,879,586 - 199,887,534NCBI
Celera1176,277,300 - 176,285,163 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,313,188 - 174,321,051 (-)NCBIHuRef
CHM1_11204,570,380 - 204,578,243 (-)NCBICHM1_1
T2T-CHM13v2.01202,441,684 - 202,449,457 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81348,193,839 - 48,201,822 (+)NCBIGRCr8
mRatBN7.21345,641,802 - 45,649,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,641,802 - 45,649,787 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,249,911 - 48,257,861 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,537,967 - 49,545,918 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,802,803 - 46,810,792 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,022,844 - 51,030,797 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,022,681 - 51,030,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,074,912 - 56,086,477 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,139,658 - 47,147,591 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,155,099 - 47,161,151 (+)NCBI
Celera1345,969,872 - 45,977,855 (+)NCBICelera
Cytogenetic Map13q13NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540639,191,073 - 39,202,020 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,195,101 - 39,201,808 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2146,191,248 - 46,200,704 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1146,155,762 - 46,166,214 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01178,778,081 - 178,789,704 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11183,073,287 - 183,083,229 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,075,312 - 183,083,229 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1725,620 - 32,954 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,316 - 33,427 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha782,048 - 88,664 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0736,653 - 43,433 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl736,715 - 43,899 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1725,021 - 31,646 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07134,620 - 141,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.07157,023 - 163,649 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934472,176,383 - 72,183,907 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365671,411,037 - 1,418,801 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365671,411,080 - 1,418,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl9113,885,542 - 113,895,131 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,885,541 - 113,895,033 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,344,018 - 125,353,512 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12526,160,993 - 26,169,005 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2526,160,961 - 26,169,566 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605526,937,390 - 26,945,433 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248077,655,620 - 7,662,362 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248077,655,777 - 7,664,484 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Chi3l1
321 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1472
Count of miRNA genes:463
Interacting mature miRNAs:532
Transcripts:ENSMUST00000082060, ENSMUST00000132873, ENSMUST00000133701, ENSMUST00000134812, ENSMUST00000139254, ENSMUST00000144819, ENSMUST00000153856, ENSMUST00000156873
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121727729139727738Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
13524520Bodwtq1_mbody wweight QTL 1 (mouse)1131191160135621161Mouse
13513913Heal51_mwound healing/ regeneration 51 (mouse)1131780648135499606Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381134,189,665 - 134,189,764UniSTSGRCm38
MGSCv371136,086,242 - 136,086,341UniSTSGRCm37
Celera1136,802,181 - 136,802,280UniSTS
Cytogenetic Map1E4UniSTS
cM Map172.3UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_001374626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_174385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_174386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_174387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_174388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC137104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI853039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ147225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU313768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X93035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000082060   ⟹   ENSMUSP00000080717
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,110,142 - 134,117,767 (+)Ensembl
GRCm38.p6 Ensembl1134,182,404 - 134,190,029 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132873   ⟹   ENSMUSP00000118289
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,110,219 - 134,114,299 (+)Ensembl
GRCm38.p6 Ensembl1134,182,481 - 134,186,561 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133701   ⟹   ENSMUSP00000121471
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,110,212 - 134,114,289 (+)Ensembl
GRCm38.p6 Ensembl1134,182,474 - 134,186,551 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134812
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,116,864 - 134,117,765 (+)Ensembl
GRCm38.p6 Ensembl1134,189,126 - 134,190,027 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139254
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,110,220 - 134,114,576 (+)Ensembl
GRCm38.p6 Ensembl1134,182,482 - 134,186,838 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144819
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,111,539 - 134,114,358 (+)Ensembl
GRCm38.p6 Ensembl1134,183,801 - 134,186,620 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153856   ⟹   ENSMUSP00000117117
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,110,142 - 134,117,919 (+)Ensembl
GRCm38.p6 Ensembl1134,182,404 - 134,190,181 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156873   ⟹   ENSMUSP00000119205
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,109,914 - 134,117,774 (+)Ensembl
GRCm38.p6 Ensembl1134,182,176 - 134,190,036 (+)Ensembl
RefSeq Acc Id: NM_001374626   ⟹   NP_001361555
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391134,109,894 - 134,117,769 (+)NCBI
GRCm381134,182,156 - 134,190,031 (+)NCBI
RefSeq Acc Id: NM_007695   ⟹   NP_031721
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391134,110,205 - 134,117,769 (+)NCBI
GRCm381134,182,404 - 134,190,031 (+)NCBI
MGSCv371136,078,981 - 136,086,608 (+)RGD
Celera1136,794,910 - 136,802,547 (+)RGD
RefSeq Acc Id: NR_174385
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391134,109,894 - 134,117,769 (+)NCBI
RefSeq Acc Id: NR_174386
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391134,109,894 - 134,117,769 (+)NCBI
RefSeq Acc Id: NR_174387
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391134,109,894 - 134,117,769 (+)NCBI
RefSeq Acc Id: NR_174388
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391134,110,205 - 134,117,769 (+)NCBI
RefSeq Acc Id: NP_031721   ⟸   NM_007695
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8BKL8 (UniProtKB/Swiss-Prot),   Q4FJW9 (UniProtKB/Swiss-Prot),   Q3U291 (UniProtKB/Swiss-Prot),   D3Z2P2 (UniProtKB/Swiss-Prot),   B0FEU7 (UniProtKB/Swiss-Prot),   Q99J84 (UniProtKB/Swiss-Prot),   Q61362 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001361555   ⟸   NM_001374626
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: ENSMUSP00000118289   ⟸   ENSMUST00000132873
RefSeq Acc Id: ENSMUSP00000121471   ⟸   ENSMUST00000133701
RefSeq Acc Id: ENSMUSP00000117117   ⟸   ENSMUST00000153856
RefSeq Acc Id: ENSMUSP00000119205   ⟸   ENSMUST00000156873
RefSeq Acc Id: ENSMUSP00000080717   ⟸   ENSMUST00000082060
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61362-F1-model_v2 AlphaFold Q61362 1-389 view protein structure

RGD ID:6874992
Promoter ID:EPDNEW_M947
Type:initiation region
Description:Mus musculus chitinase-like 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381134,182,467 - 134,182,527EPDNEW
RGD ID:6817512
Promoter ID:MM_KWN:2138
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:OTTMUST00000074544,   OTTMUST00000074545,   OTTMUST00000074546,   OTTMUST00000074548,   OTTMUST00000077094
Mouse AssemblyChrPosition (strand)Source
MGSCv361136,078,826 - 136,079,326 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1340899 AgrOrtholog
Ensembl Genes ENSMUSG00000064246 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000082060 ENTREZGENE
  ENSMUST00000082060.10 UniProtKB/Swiss-Prot
  ENSMUST00000132873.8 UniProtKB/TrEMBL
  ENSMUST00000133701.8 UniProtKB/TrEMBL
  ENSMUST00000153856.8 UniProtKB/Swiss-Prot
  ENSMUST00000156873.8 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot
  Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chitinase_II UniProtKB/Swiss-Prot
  Chitinase_insertion_sf UniProtKB/Swiss-Prot
  Glyco_hydro18_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12654 UniProtKB/Swiss-Prot
  PTHR11177:SF202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Chi3l1 PhenoGen
PROSITE GH18_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Glyco_18 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54556 UniProtKB/Swiss-Prot
  CH3L1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B0FEU7 UniProtKB/Swiss-Prot
  D3Z2P2 UniProtKB/Swiss-Prot
  Q3U291 UniProtKB/Swiss-Prot
  Q4FJW9 UniProtKB/Swiss-Prot
  Q8BKL8 UniProtKB/Swiss-Prot
  Q99J84 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-15 Chi3l1  chitinase 3 like 1  Chil1  chitinase-like 1  Symbol and/or name updated 27372883 PROVISIONAL
2013-12-03 Chil1  chitinase-like 1  Chi3l1  chitinase 3-like 1  Symbol and/or name change 5135510 APPROVED