Sgpl1 (sphingosine phosphate lyase 1) - Rat Genome Database

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Gene: Sgpl1 (sphingosine phosphate lyase 1) Mus musculus
Analyze
Symbol: Sgpl1
Name: sphingosine phosphate lyase 1
RGD ID: 1552269
MGI Page MGI
Description: Predicted to enable sphinganine-1-phosphate aldolase activity. Acts upstream of or within several processes, including face morphogenesis; gonad development; and vasculogenesis. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI428538; D10Xrf45; D10Xrf456; mSPL; S1PL; SP-lyase 1; sphingosine-1-phosphate aldolase; sphingosine-1-phosphate lyase 1; Spl; SPL 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,934,421 - 60,983,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,934,421 - 60,983,482 (-)EnsemblGRCm39 Ensembl
GRCm381061,098,642 - 61,147,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,098,642 - 61,147,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv371060,561,390 - 60,610,413 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,493,999 - 60,542,956 (-)NCBIMGSCv36mm8
Celera1062,199,269 - 62,248,215 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal cell migration  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal epididymis morphology  (IEA)
abnormal frontal bone morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal regulatory T cell number  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal/urinary system morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal smooth muscle morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spleen periarteriolar lymphoid sheath morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal testis cord formation  (IAGP)
abnormal testis morphology  (IAGP)
abnormal testosterone level  (IAGP)
abnormal thymus lobule morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal type IV hypersensitivity reaction  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal urothelium morphology  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral arch morphology  (IAGP)
absent corpus luteum  (IAGP)
absent podocyte slit diaphragm  (IAGP)
anemia  (IAGP)
anovulation  (IAGP)
asymmetric sternocostal joints  (IAGP)
decreased B cell number  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating estradiol level  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fibroblast cell migration  (IAGP)
decreased follicular B cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased Leydig cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased palatine bone horizontal plate size  (IAGP)
decreased pre-B cell number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased T cell number  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
decreased theca cell number  (IAGP)
enlarged epididymis  (IEA)
female infertility  (IAGP)
hemorrhage  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased granulocyte number  (IAGP)
increased monocyte cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased single-positive T cell number  (IAGP)
increased thymocyte number  (IAGP)
kidney inflammation  (IAGP)
lymph node hypoplasia  (IAGP)
lymphoid hypoplasia  (IAGP)
male infertility  (IAGP)
multinucleated giant male germ cells  (IAGP)
no abnormal phenotype detected  (IAGP)
pale kidney  (IAGP)
podocyte foot process effacement  (IAGP)
polychromatophilia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
reticulocytosis  (IAGP)
small kidney  (IAGP)
small ovary  (IAGP)
small presphenoid bone  (IAGP)
small testis  (IAGP)
spleen hypoplasia  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thymus cortex hypoplasia  (IAGP)
thymus hypoplasia  (IAGP)
thymus medulla hyperplasia  (IAGP)
uterus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9464245   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12477932   PMID:12584204   PMID:12682045   PMID:14610273  
PMID:14681479   PMID:15368895   PMID:15489334   PMID:15522238   PMID:15737611   PMID:15782199   PMID:15938718   PMID:16141072   PMID:16141073   PMID:16151014   PMID:17090686   PMID:17143286  
PMID:18172856   PMID:18799693   PMID:19056881   PMID:19073640   PMID:19119317   PMID:19251691   PMID:19748984   PMID:19913094   PMID:19934311   PMID:20097939   PMID:21148740   PMID:21173151  
PMID:21267068   PMID:21319224   PMID:21331079   PMID:21335477   PMID:21368890   PMID:21556483   PMID:21873635   PMID:22291021   PMID:22606350   PMID:22606352   PMID:22750505   PMID:22781001  
PMID:22908849   PMID:23041657   PMID:23544080   PMID:23700419   PMID:23904439   PMID:23933064   PMID:23936150   PMID:24158395   PMID:24194600   PMID:24323699   PMID:24343820   PMID:24457600  
PMID:24808180   PMID:25180446   PMID:25333900   PMID:25347472   PMID:25381637   PMID:25385827   PMID:26273529   PMID:26286721   PMID:26741365   PMID:27034005   PMID:27343196   PMID:27626380  
PMID:27720306   PMID:27810923   PMID:27883090   PMID:28165339   PMID:28165343   PMID:28262793   PMID:28378742   PMID:28521611   PMID:28538737   PMID:28706199   PMID:28931805   PMID:29301259  
PMID:29662200   PMID:30196744   PMID:30457570   PMID:30550785   PMID:30816345   PMID:31040226   PMID:31231866   PMID:31314788   PMID:32098917   PMID:32283310   PMID:32325033   PMID:32554809  
PMID:32560809   PMID:32565314   PMID:32581705   PMID:32614038   PMID:32998447   PMID:33755599   PMID:34073605   PMID:34083520   PMID:34321999   PMID:34638955   PMID:35452878   PMID:35670107  
PMID:35886926   PMID:35973936   PMID:37115925  


Genomics

Comparative Map Data
Sgpl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,934,421 - 60,983,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,934,421 - 60,983,482 (-)EnsemblGRCm39 Ensembl
GRCm381061,098,642 - 61,147,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,098,642 - 61,147,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv371060,561,390 - 60,610,413 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,493,999 - 60,542,956 (-)NCBIMGSCv36mm8
Celera1062,199,269 - 62,248,215 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.14NCBI
SGPL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,815,948 - 70,881,184 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,815,905 - 70,895,816 (+)EnsemblGRCh38hg38GRCh38
GRCh371072,575,704 - 72,640,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361072,245,722 - 72,309,873 (+)NCBINCBI36Build 36hg18NCBI36
Build 341072,245,721 - 72,309,871NCBI
Celera1065,857,672 - 65,923,231 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,569,390 - 66,634,948 (+)NCBIHuRef
CHM1_11072,858,499 - 72,923,730 (+)NCBICHM1_1
T2T-CHM13v2.01071,685,701 - 71,750,988 (+)NCBIT2T-CHM13v2.0
Sgpl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,590,652 - 29,637,064 (-)NCBIGRCr8
mRatBN7.22029,047,793 - 29,094,209 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,047,796 - 29,094,084 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,065,894 - 30,110,041 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,452,195 - 29,496,346 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,194,650 - 30,238,806 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,699,936 - 30,769,178 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,699,872 - 30,749,940 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,497,280 - 32,543,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,459,734 - 28,505,017 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,473,533 - 28,518,817 (-)NCBI
Celera2030,483,317 - 30,527,561 (-)NCBICelera
Cytogenetic Map20q11NCBI
Sgpl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,488,330 - 20,547,171 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,489,641 - 20,547,105 (-)NCBIChiLan1.0ChiLan1.0
SGPL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2882,966,349 - 83,030,587 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11082,971,702 - 83,039,487 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01067,286,349 - 67,351,574 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,812,082 - 69,876,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,812,092 - 69,876,438 (+)Ensemblpanpan1.1panPan2
SGPL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,666,264 - 21,717,476 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,660,939 - 21,715,155 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha421,795,341 - 21,851,669 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0421,939,185 - 21,995,525 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,944,334 - 21,995,521 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,834,799 - 21,891,148 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,040,063 - 22,096,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,392,266 - 22,448,632 (+)NCBIUU_Cfam_GSD_1.0
Sgpl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,357,640 - 59,407,321 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365217,848,972 - 7,900,041 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365217,850,370 - 7,899,998 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SGPL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,724,100 - 73,781,800 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,696,902 - 73,781,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21479,572,301 - 79,628,480 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SGPL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1960,425,703 - 60,487,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl960,424,305 - 60,487,146 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604821,148,927 - 21,211,740 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sgpl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,844,552 - 4,886,709 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247544,844,472 - 4,889,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sgpl1
1552 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3585
Count of miRNA genes:807
Interacting mature miRNAs:1068
Transcripts:ENSMUST00000092498, ENSMUST00000122259, ENSMUST00000124896, ENSMUST00000126307, ENSMUST00000137833, ENSMUST00000142192, ENSMUST00000143225, ENSMUST00000150258, ENSMUST00000152316, ENSMUST00000155919
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102972040363720483Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103097449964974630Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103157713665577284Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103377599670835830Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4123732675237326Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104557609669135830Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104627609669235830Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104797449970112651Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
12904011Cfq11_mconditioned fear QTL 11 (mouse)105648015660940841Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse

Markers in Region
AF036894  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,100,794 - 61,100,872UniSTSGRCm38
MGSCv371060,563,542 - 60,563,620UniSTSGRCm37
Celera1062,201,421 - 62,201,499UniSTS
Cytogenetic Map10B4UniSTS
cM Map1032.0UniSTS
Whitehead/MRC_RH10691.05UniSTS
AI428538  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,098,670 - 61,098,890UniSTSGRCm38
MGSCv371060,561,418 - 60,561,638UniSTSGRCm37
Celera1062,199,297 - 62,199,517UniSTS
Cytogenetic Map10B4UniSTS
cM Map1032.0UniSTS
Whitehead/MRC_RH10688.24UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001316673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001316674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC153515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF036894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI428538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  AK150053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  BY075752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  CH466553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000092498   ⟹   ENSMUSP00000090155
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1060,934,421 - 60,983,453 (-)Ensembl
GRCm38.p6 Ensembl1061,098,642 - 61,147,674 (-)Ensembl
RefSeq Acc Id: ENSMUST00000122259   ⟹   ENSMUSP00000112975
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1060,934,421 - 60,983,423 (-)Ensembl
GRCm38.p6 Ensembl1061,098,642 - 61,147,644 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124896
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1060,981,674 - 60,983,383 (-)Ensembl
GRCm38.p6 Ensembl1061,145,895 - 61,147,604 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126307   ⟹   ENSMUSP00000115907
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1060,959,106 - 60,982,677 (-)Ensembl
GRCm38.p6 Ensembl1061,123,327 - 61,146,898 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137833   ⟹   ENSMUSP00000119550
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1060,949,873 - 60,983,455 (-)Ensembl
GRCm38.p6 Ensembl1061,114,094 - 61,147,676 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142192
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1060,953,231 - 60,983,431 (-)Ensembl
GRCm38.p6 Ensembl1061,117,452 - 61,147,652 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143225
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1060,936,604 - 60,938,904 (-)Ensembl
GRCm38.p6 Ensembl1061,100,825 - 61,103,125 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150258   ⟹   ENSMUSP00000117848
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1060,934,424 - 60,983,423 (-)Ensembl
GRCm38.p6 Ensembl1061,098,645 - 61,147,644 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152316
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1060,939,974 - 60,941,256 (-)Ensembl
GRCm38.p6 Ensembl1061,104,195 - 61,105,477 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155919   ⟹   ENSMUSP00000115561
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1060,947,959 - 60,983,482 (-)Ensembl
GRCm38.p6 Ensembl1061,112,180 - 61,147,703 (-)Ensembl
RefSeq Acc Id: NM_001316673   ⟹   NP_001303602
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391060,934,421 - 60,983,463 (-)NCBI
GRCm381061,098,642 - 61,147,684 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001316674   ⟹   NP_001303603
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391060,934,421 - 60,983,463 (-)NCBI
GRCm381061,098,642 - 61,147,684 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009163   ⟹   NP_033189
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391060,934,421 - 60,983,463 (-)NCBI
GRCm381061,098,642 - 61,147,684 (-)NCBI
MGSCv371060,561,390 - 60,610,413 (-)RGD
Celera1062,199,269 - 62,248,215 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017313860   ⟹   XP_017169349
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391060,934,535 - 60,983,239 (-)NCBI
GRCm381061,098,756 - 61,147,498 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155711   ⟹   XP_036011604
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391060,934,535 - 60,983,429 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033189   ⟸   NM_009163
- UniProtKB: O54955 (UniProtKB/Swiss-Prot),   Q8C942 (UniProtKB/Swiss-Prot),   Q8R0X7 (UniProtKB/Swiss-Prot),   Q3UDJ2 (UniProtKB/TrEMBL),   Q4FK38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303603   ⟸   NM_001316674
- UniProtKB: O54955 (UniProtKB/Swiss-Prot),   Q8C942 (UniProtKB/Swiss-Prot),   Q8R0X7 (UniProtKB/Swiss-Prot),   Q3UDJ2 (UniProtKB/TrEMBL),   Q4FK38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303602   ⟸   NM_001316673
- UniProtKB: O54955 (UniProtKB/Swiss-Prot),   Q8C942 (UniProtKB/Swiss-Prot),   Q8R0X7 (UniProtKB/Swiss-Prot),   Q3UDJ2 (UniProtKB/TrEMBL),   Q4FK38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169349   ⟸   XM_017313860
- Peptide Label: isoform X1
- UniProtKB: O54955 (UniProtKB/Swiss-Prot),   Q8C942 (UniProtKB/Swiss-Prot),   Q8R0X7 (UniProtKB/Swiss-Prot),   Q3UDJ2 (UniProtKB/TrEMBL),   Q4FK38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000117848   ⟸   ENSMUST00000150258
RefSeq Acc Id: ENSMUSP00000115907   ⟸   ENSMUST00000126307
RefSeq Acc Id: ENSMUSP00000090155   ⟸   ENSMUST00000092498
RefSeq Acc Id: ENSMUSP00000119550   ⟸   ENSMUST00000137833
RefSeq Acc Id: ENSMUSP00000112975   ⟸   ENSMUST00000122259
RefSeq Acc Id: ENSMUSP00000115561   ⟸   ENSMUST00000155919
RefSeq Acc Id: XP_036011604   ⟸   XM_036155711
- Peptide Label: isoform X1
- UniProtKB: Q8R0X7 (UniProtKB/Swiss-Prot),   O54955 (UniProtKB/Swiss-Prot),   Q8C942 (UniProtKB/Swiss-Prot),   Q3UDJ2 (UniProtKB/TrEMBL),   Q4FK38 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R0X7-F1-model_v2 AlphaFold Q8R0X7 1-568 view protein structure

Promoters
RGD ID:6819904
Promoter ID:MM_KWN:4253
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Liver,   Spleen
Transcripts:OTTMUST00000079262
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361060,565,906 - 60,566,672 (-)MPROMDB
RGD ID:6819903
Promoter ID:MM_KWN:4254
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Liver
Transcripts:OTTMUST00000079261
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361060,568,851 - 60,569,351 (-)MPROMDB
RGD ID:6819902
Promoter ID:MM_KWN:4255
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   MEF_B6,   Spleen
Transcripts:OTTMUST00000079259
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361060,609,131 - 60,610,637 (-)MPROMDB
RGD ID:6819901
Promoter ID:MM_KWN:4256
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:ENSMUST00000122259,   OTTMUST00000079253,   OTTMUST00000079255,   OTTMUST00000079256,   OTTMUST00000079257,   OTTMUST00000079258,   OTTMUST00000079260
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361060,610,106 - 60,610,606 (-)MPROMDB
RGD ID:8672080
Promoter ID:EPDNEW_M14071
Type:initiation region
Name:Sgpl1_1
Description:Mus musculus sphingosine phosphate lyase 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381061,147,613 - 61,147,673EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1261415 AgrOrtholog
Ensembl Genes ENSMUSG00000020097 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000092498 ENTREZGENE
  ENSMUST00000092498.12 UniProtKB/Swiss-Prot
  ENSMUST00000122259 ENTREZGENE
  ENSMUST00000122259.8 UniProtKB/Swiss-Prot
  ENSMUST00000126307.2 UniProtKB/TrEMBL
  ENSMUST00000137833.2 UniProtKB/TrEMBL
  ENSMUST00000150258.8 UniProtKB/TrEMBL
  ENSMUST00000155919.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.2150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PyrdxlP-dep_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20397 UniProtKB/Swiss-Prot
MGD MGI:1261415 ENTREZGENE
NCBI Gene 20397 ENTREZGENE
PANTHER PTHR42735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPHINGOSINE-1-PHOSPHATE LYASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pyridoxal_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sgpl1 PhenoGen
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YY13_MOUSE UniProtKB/TrEMBL
  D3YZT4_MOUSE UniProtKB/TrEMBL
  D3Z1Z3_MOUSE UniProtKB/TrEMBL
  D6REF7_MOUSE UniProtKB/TrEMBL
  O54955 ENTREZGENE
  Q3UDJ2 ENTREZGENE, UniProtKB/TrEMBL
  Q4FK38 ENTREZGENE, UniProtKB/TrEMBL
  Q69ZN1_MOUSE UniProtKB/TrEMBL
  Q8C942 ENTREZGENE
  Q8R0X7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O54955 UniProtKB/Swiss-Prot
  Q8C942 UniProtKB/Swiss-Prot