Galc (galactosylceramidase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Galc (galactosylceramidase) Mus musculus
Analyze
Symbol: Galc
Name: galactosylceramidase
RGD ID: 1552188
MGI Page MGI
Description: Enables galactosylceramidase activity. Acts upstream of or within galactosylceramide catabolic process and myelination. Located in mitochondrion. Is expressed in brain and medial ganglionic eminence. Used to study Krabbe disease. Human ortholog(s) of this gene implicated in Krabbe disease. Orthologous to human GALC (galactosylceramidase).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2310068B06Rik; A930008M05Rik; AW212969; AW413532; Gac; Gacy; galactocerebrosidase; galactocerebroside beta-galactosidase; galactosylceramide beta-galactosidase; GALCERase; twi; twitcher
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391298,168,543 - 98,226,565 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1298,168,553 - 98,225,718 (-)EnsemblGRCm39 Ensembl
GRCm381298,202,287 - 98,259,459 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1298,202,294 - 98,259,459 (-)EnsemblGRCm38mm10GRCm38
MGSCv371299,440,510 - 99,497,547 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361298,603,350 - 98,660,387 (-)NCBIMGSCv36mm8
Celera1299,428,771 - 99,484,984 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1249.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
lysosome  (IBA,TAS)
mitochondrion  (HDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal axon morphology  (IAGP)
abnormal blood-brain barrier function  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain white matter morphology  (IEA)
abnormal cerebellum white matter morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal gait  (IAGP)
abnormal glial cell apoptosis  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney epithelium morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal leukocyte morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver morphology  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal medulla oblongata morphology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal oligodendrocyte morphology  (IAGP)
abnormal oligodendrocyte physiology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal pons morphology  (IAGP)
abnormal protein level  (IAGP)
abnormal renal glomerular capsule morphology  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal sphingomyelin level  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal spinal cord white matter morphology  (IEA)
abnormal tumor necrosis factor level  (IAGP)
abnormal vertebral column morphology  (IAGP)
absent incisors  (IAGP)
astrocytosis  (IAGP)
ataxia  (IAGP)
axon degeneration  (IEA)
axonal spheroids  (IAGP)
cachexia  (IAGP)
CNS inflammation  (IAGP)
decreased apoptosis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone trabecula number  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased femur size  (IAGP)
decreased femur weight  (IAGP)
decreased heart rate  (IEA)
decreased oligodendrocyte number  (IAGP)
decreased oligodendrocyte progenitor number  (IAGP)
demyelination  (IAGP)
domed cranium  (IAGP)
edema  (IAGP)
enlarged liver  (IAGP)
enlarged spleen  (IAGP)
gliosis  (IAGP)
hindlimb paralysis  (IAGP)
impaired limb coordination  (IEA)
impaired macrophage chemotaxis  (IAGP)
impaired righting response  (IAGP)
increased mean systemic arterial blood pressure  (IEA)
increased oligodendrocyte progenitor number  (IAGP)
increased systemic arterial diastolic blood pressure  (IEA)
induced hyperactivity  (IAGP)
kyphosis  (IAGP)
muscle twitch  (IAGP)
neurodegeneration  (IAGP)
paraparesis  (IAGP)
paresis  (IAGP)
peripheral nervous system degeneration  (IEA)
postnatal lethality, incomplete penetrance  (IEA)
premature death  (IAGP)
progressive muscle weakness  (IAGP)
seizures  (IAGP)
slow postnatal weight gain  (IAGP)
tremors  (IAGP)
weakness  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Altered gene transcription linked to astrocytes and oligodendrocytes in frontal cortex in Creutzfeldt-Jakob disease. Andres Benito P, etal., Prion. 2018;12(3-4):216-225. doi: 10.1080/19336896.2018.1500076. Epub 2018 Jul 27.
2. Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome. Ang CW, etal., J Neuroimmunol. 2002 Sep;130(1-2):179-83. doi: 10.1016/s0165-5728(02)00209-6.
3. The twitcher mouse: immunocytochemical study of Ia expression in macrophages. Higashi Y, etal., J Neuropathol Exp Neurol 1992 Jan;51(1):47-57.
4. Progressive impairment of Schwann cell proliferation in vitro in murine globoid cell leukodystrophy (twitcher). Komiyama A and Suzuki K, Brain Res 1992 Dec 11;598(1-2):1-9.
5. Morphological features of degenerating oligodendrocytes in twitcher mice. LeVine SM and Torres MV, Brain Res 1992 Aug 7;587(2):348-52.
6. Mycoplasma pneumoniae triggering the Guillain-Barré syndrome: A case-control study. Meyer Sauteur PM, etal., Ann Neurol. 2016 Oct;80(4):566-80. doi: 10.1002/ana.24755. Epub 2016 Aug 26.
7. Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against Mycoplasma pneumoniae. Meyer Sauteur PM, etal., Infect Immun. 2019 Jan 24;87(2). pii: IAI.00663-18. doi: 10.1128/IAI.00663-18. Print 2019 Feb.
8. Intrathecal antibody responses to GalC in Guillain-Barré syndrome triggered by Mycoplasma pneumoniae. Meyer Sauteur PM, etal., J Neuroimmunol. 2018 Jan 15;314:13-16. doi: 10.1016/j.jneuroim.2017.11.011. Epub 2017 Nov 16.
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Ruggeri B, etal., Cancer Res 1991 Dec 15;51(24):6615-21.
18. Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease. Sakai N, etal., J Neurochem 1996 Mar;66(3):1118-24.
19. Saposins (sphingolipid activator proteins) in the twitcher mutant mouse. Shigematsu H, etal., J Neurochem. 1990 Nov;55(5):1659-62. doi: 10.1111/j.1471-4159.1990.tb04953.x.
Additional References at PubMed
PMID:1348528   PMID:1820026   PMID:1971996   PMID:2079710   PMID:3402356   PMID:3895053   PMID:6306338   PMID:6319815   PMID:6382609   PMID:6633639   PMID:6693925   PMID:6719111  
PMID:7074355   PMID:7207584   PMID:7417782   PMID:7437911   PMID:7526605   PMID:7528964   PMID:7568889   PMID:7728526   PMID:7745626   PMID:8069913   PMID:8101401   PMID:8180787  
PMID:8275302   PMID:8281019   PMID:8448672   PMID:8520724   PMID:8527855   PMID:8661004   PMID:8911769   PMID:9058758   PMID:9620692   PMID:9728334   PMID:9972877   PMID:10349636  
PMID:10374755   PMID:10415153   PMID:10650875   PMID:10650876   PMID:10854208   PMID:10861297   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11371512   PMID:11461188   PMID:11526455  
PMID:11734583   PMID:12077186   PMID:12270695   PMID:12466851   PMID:12477932   PMID:14681479   PMID:14684827   PMID:15207267   PMID:15248301   PMID:15290897   PMID:15489334   PMID:15647513  
PMID:15707574   PMID:15782199   PMID:15851012   PMID:16141072   PMID:16141073   PMID:16169269   PMID:16199167   PMID:16352725   PMID:16530726   PMID:16602821   PMID:16624958   PMID:16732552  
PMID:16759875   PMID:16805770   PMID:17391983   PMID:17883393   PMID:18077684   PMID:18602885   PMID:18614015   PMID:19185028   PMID:19439584   PMID:19637231   PMID:19748497   PMID:20385825  
PMID:20418135   PMID:20441793   PMID:20511539   PMID:21267068   PMID:21389217   PMID:21677750   PMID:21809420   PMID:21873635   PMID:21876145   PMID:22371338   PMID:22704480   PMID:22849820  
PMID:22859505   PMID:23404611   PMID:23620143   PMID:23755134   PMID:23761900   PMID:24057669   PMID:24316110   PMID:24415155   PMID:24441827   PMID:24607884   PMID:25192051   PMID:25236689  
PMID:25240259   PMID:25382142   PMID:25533112   PMID:25632136   PMID:25694553   PMID:25749991   PMID:25904800   PMID:26115766   PMID:27626380   PMID:27638595   PMID:27638600   PMID:27977664  
PMID:28169300   PMID:28531236   PMID:28575206   PMID:30146317   PMID:30176352   PMID:30550785   PMID:31036560   PMID:31108173   PMID:32127495   PMID:32253319   PMID:32375064   PMID:33097716  
PMID:33374753   PMID:33842284   PMID:34050187   PMID:34142127   PMID:34172992   PMID:34262084   PMID:35290889   PMID:35620447   PMID:35789331   PMID:36012705   PMID:36362324   PMID:37048066  
PMID:37337846   PMID:37892244   PMID:38355793   PMID:38734898  


Genomics

Comparative Map Data
Galc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391298,168,543 - 98,226,565 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1298,168,553 - 98,225,718 (-)EnsemblGRCm39 Ensembl
GRCm381298,202,287 - 98,259,459 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1298,202,294 - 98,259,459 (-)EnsemblGRCm38mm10GRCm38
MGSCv371299,440,510 - 99,497,547 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361298,603,350 - 98,660,387 (-)NCBIMGSCv36mm8
Celera1299,428,771 - 99,484,984 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1249.83NCBI
GALC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381487,933,014 - 87,993,667 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1487,837,820 - 87,993,665 (-)EnsemblGRCh38hg38GRCh38
GRCh371488,399,358 - 88,460,009 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361487,469,111 - 87,529,660 (-)NCBINCBI36Build 36hg18NCBI36
Build 341487,469,112 - 87,529,596NCBI
Celera1468,445,026 - 68,505,593 (-)NCBICelera
Cytogenetic Map14q31.3NCBI
HuRef1468,569,486 - 68,630,135 (-)NCBIHuRef
CHM1_11488,337,479 - 88,398,139 (-)NCBICHM1_1
T2T-CHM13v2.01482,153,629 - 82,214,299 (-)NCBIT2T-CHM13v2.0
Galc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,182,636 - 123,252,024 (-)NCBIGRCr8
mRatBN7.26117,452,888 - 117,522,281 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,452,895 - 117,515,830 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6117,607,772 - 117,669,061 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06117,904,558 - 117,965,859 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,239,449 - 117,300,736 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,177,195 - 122,239,411 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,178,602 - 122,239,614 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06131,392,298 - 131,454,514 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46122,355,659 - 122,416,986 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16122,359,405 - 122,420,733 (-)NCBI
Celera6115,018,409 - 115,078,607 (-)NCBICelera
Cytogenetic Map6q32NCBI
Galc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543810,667,807 - 10,704,384 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543810,667,807 - 10,704,386 (-)NCBIChiLan1.0ChiLan1.0
GALC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21589,071,492 - 89,132,963 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11488,287,998 - 88,349,469 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01468,545,070 - 68,605,730 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11487,905,098 - 87,965,769 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1487,905,098 - 87,965,770 (-)Ensemblpanpan1.1panPan2
GALC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1859,266,693 - 59,324,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl859,267,818 - 59,324,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha858,846,151 - 58,903,131 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0859,531,522 - 59,589,663 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl859,531,533 - 59,589,716 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1859,214,260 - 59,271,257 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0859,260,650 - 59,317,658 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0859,594,667 - 59,651,690 (-)NCBIUU_Cfam_GSD_1.0
Galc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864016,532,259 - 16,624,784 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648815,444,801 - 15,518,856 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648815,444,184 - 15,519,395 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GALC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7109,894,578 - 109,961,413 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17109,894,576 - 109,961,407 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27116,348,927 - 116,415,759 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GALC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12465,556,763 - 65,621,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2465,558,074 - 65,621,258 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605352,874,548 - 52,988,107 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Galc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473414,355,435 - 14,407,087 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473414,355,349 - 14,462,869 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Galc
2265 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:421
Count of miRNA genes:327
Interacting mature miRNAs:352
Transcripts:ENSMUST00000021390
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
12910790Pwgrq7_mpre-weaning growth rate QTL 7 (mouse)1290937367108645308Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4142402Ccs1_mcolon cancer susceptibility 1 (mouse)Not determined90887422100023109Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
10412192Bbaa27_mB.burgdorferi-associated arthritis 27 (mouse)Not determined1291254220107308393Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
AW212969  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381298,203,625 - 98,203,708UniSTSGRCm38
MGSCv371299,441,835 - 99,441,918UniSTSGRCm37
Celera1299,430,096 - 99,430,179UniSTS
Cytogenetic Map12EUniSTS
cM Map1248.0UniSTS
Whitehead/MRC_RH12884.06UniSTS
AW413532  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381298,202,377 - 98,202,478UniSTSGRCm38
MGSCv371299,440,587 - 99,440,688UniSTSGRCm37
Celera1299,428,848 - 99,428,949UniSTS
Cytogenetic Map12EUniSTS
cM Map1248.0UniSTS
Whitehead/MRC_RH12884.16UniSTS
D38557  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381298,203,802 - 98,203,886UniSTSGRCm38
MGSCv371299,442,012 - 99,442,096UniSTSGRCm37
Celera1299,430,273 - 99,430,357UniSTS
Cytogenetic Map12EUniSTS
cM Map1248.0UniSTS
Whitehead/MRC_RH12882.44UniSTS
Whitehead_YAC12 UniSTS
Galc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12EUniSTS
cM Map1248.0UniSTS
UniSTS:236919  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381298,218,427 - 98,218,621UniSTSGRCm38
GRCm381079,864,115 - 79,864,309UniSTSGRCm38
MGSCv371299,456,637 - 99,456,831UniSTSGRCm37
MGSCv371079,326,860 - 79,327,054UniSTSGRCm37
Celera1080,878,928 - 80,879,122UniSTS
Celera1299,444,899 - 99,445,093UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map12EUniSTS
cM Map1043.0UniSTS
cM Map1248.0UniSTS
D38557  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381298,203,805 - 98,203,886UniSTSGRCm38
MGSCv371299,442,015 - 99,442,096UniSTSGRCm37
Celera1299,430,276 - 99,430,357UniSTS
Cytogenetic Map12EUniSTS
Whitehead/MRC_RH12882.44UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC125537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000021390   ⟹   ENSMUSP00000021390
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1298,168,553 - 98,225,718 (-)Ensembl
GRCm38.p6 Ensembl1298,202,294 - 98,259,459 (-)Ensembl
Ensembl Acc Id: ENSMUST00000220501
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1298,205,829 - 98,225,042 (-)Ensembl
GRCm38.p6 Ensembl1298,239,570 - 98,258,783 (-)Ensembl
Ensembl Acc Id: ENSMUST00000221063   ⟹   ENSMUSP00000152540
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1298,170,055 - 98,209,724 (-)Ensembl
GRCm38.p6 Ensembl1298,203,796 - 98,243,465 (-)Ensembl
Ensembl Acc Id: ENSMUST00000221322
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1298,221,454 - 98,225,606 (-)Ensembl
GRCm38.p6 Ensembl1298,255,195 - 98,259,347 (-)Ensembl
Ensembl Acc Id: ENSMUST00000222042
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1298,186,261 - 98,225,557 (-)Ensembl
GRCm38.p6 Ensembl1298,220,002 - 98,259,298 (-)Ensembl
Ensembl Acc Id: ENSMUST00000222379
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1298,199,497 - 98,203,267 (-)Ensembl
GRCm38.p6 Ensembl1298,233,238 - 98,237,008 (-)Ensembl
Ensembl Acc Id: ENSMUST00000222703
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1298,173,712 - 98,182,787 (-)Ensembl
GRCm38.p6 Ensembl1298,207,453 - 98,216,528 (-)Ensembl
RefSeq Acc Id: NM_008079   ⟹   NP_032105
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391298,168,559 - 98,225,718 (-)NCBI
GRCm381298,202,300 - 98,259,459 (-)NCBI
MGSCv371299,440,510 - 99,497,547 (-)RGD
Celera1299,428,771 - 99,485,106 (-)NCBI
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006515472   ⟹   XP_006515535
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391298,185,520 - 98,226,565 (-)NCBI
GRCm381298,219,261 - 98,259,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017314960   ⟹   XP_017170449
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391298,168,543 - 98,225,360 (-)NCBI
GRCm381298,202,287 - 98,259,109 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246561   ⟹   XP_030102421
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391298,168,543 - 98,225,360 (-)NCBI
GRCm381298,202,287 - 98,259,109 (-)NCBI
Sequence:
RefSeq Acc Id: NP_032105   ⟸   NM_008079
- Peptide Label: precursor
- UniProtKB: O35151 (UniProtKB/Swiss-Prot),   Q3U3H7 (UniProtKB/Swiss-Prot),   P54818 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006515535   ⟸   XM_006515472
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017170449   ⟸   XM_017314960
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VM63 (UniProtKB/TrEMBL),   Q3TTJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030102421   ⟸   XM_030246561
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VM63 (UniProtKB/TrEMBL),   Q3TTJ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000021390   ⟸   ENSMUST00000021390
Ensembl Acc Id: ENSMUSP00000152540   ⟸   ENSMUST00000221063
Protein Domains
Glycosyl hydrolase family 59 C-terminal lectin   Glycosyl hydrolase family 59 catalytic   Glycosyl hydrolase family 59 central

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54818-F1-model_v2 AlphaFold P54818 1-684 view protein structure

Promoters
RGD ID:8678960
Promoter ID:EPDNEW_M17509
Type:initiation region
Name:Galc_1
Description:Mus musculus galactosylceramidase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381298,259,352 - 98,259,412EPDNEW
RGD ID:6822965
Promoter ID:MM_KWN:12384
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000021390
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361299,497,186 - 99,497,897 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95636 AgrOrtholog
Ensembl Genes ENSMUSG00000021003 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021390 ENTREZGENE
  ENSMUST00000021390.9 UniProtKB/Swiss-Prot
  ENSMUST00000221063 ENTREZGENE
  ENSMUST00000221063.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
  Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  GH59_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GH59_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_59 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_59_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14420 UniProtKB/Swiss-Prot
MGD MGI:95636 ENTREZGENE
NCBI Gene 14420 ENTREZGENE
PANTHER GALACTOCEREBROSIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15172 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_59 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_59_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_59M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Galc PhenoGen
PRINTS GLHYDRLASE59 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VM63 ENTREZGENE, UniProtKB/TrEMBL
  GALC_MOUSE UniProtKB/Swiss-Prot
  O35151 ENTREZGENE
  P54818 ENTREZGENE
  Q3TTJ1 ENTREZGENE, UniProtKB/TrEMBL
  Q3U3H7 ENTREZGENE
UniProt Secondary O35151 UniProtKB/Swiss-Prot
  Q3U3H7 UniProtKB/Swiss-Prot