Atg101 (autophagy related 101) - Rat Genome Database

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Gene: Atg101 (autophagy related 101) Mus musculus
Analyze
Symbol: Atg101
Name: autophagy related 101
RGD ID: 1552128
MGI Page MGI
Description: Predicted to enable identical protein binding activity and protein kinase binding activity. Involved in several processes, including autophagosome assembly; positive regulation of autophagy; and regulation of protein lipidation. Located in phagophore assembly site. Is expressed in adrenal gland. Orthologous to human ATG101 (autophagy related 101).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9430023L20Rik; AA407441; AU022967; autophagy-related protein 101
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,182,182 - 101,188,855 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,182,153 - 101,188,826 (+)EnsemblGRCm39 Ensembl
GRCm3815101,284,301 - 101,290,947 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,284,272 - 101,290,945 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,114,732 - 101,121,365 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,112,335 - 101,118,968 (+)NCBIMGSCv36mm8
Celera15103,432,360 - 103,438,993 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Development and validation of prognostic model based on the analysis of autophagy-related genes in colon cancer. Wang Y, etal., Aging (Albany NY). 2021 Jul 27;13(14):19028-19047. doi: 10.18632/aging.203352. Epub 2021 Jul 27.
6. Comprehensive Analysis of the Potential Immune-Related Biomarker ATG101 that Regulates Apoptosis of Cholangiocarcinoma Cells After Photodynamic Therapy. Zhang ZJ, etal., Front Pharmacol. 2022 May 3;13:857774. doi: 10.3389/fphar.2022.857774. eCollection 2022.
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18799693   PMID:18936157   PMID:19225151   PMID:21258367  
PMID:21267068   PMID:21795849   PMID:21873635   PMID:32968282   PMID:33296658   PMID:35670107  


Genomics

Comparative Map Data
Atg101
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,182,182 - 101,188,855 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,182,153 - 101,188,826 (+)EnsemblGRCm39 Ensembl
GRCm3815101,284,301 - 101,290,947 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,284,272 - 101,290,945 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,114,732 - 101,121,365 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,112,335 - 101,118,968 (+)NCBIMGSCv36mm8
Celera15103,432,360 - 103,438,993 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.67NCBI
ATG101
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,065,300 - 52,077,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,069,246 - 52,077,495 (+)EnsemblGRCh38hg38GRCh38
GRCh371252,463,762 - 52,471,279 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,750,025 - 50,757,546 (+)NCBINCBI36Build 36hg18NCBI36
Celera1251,266,432 - 51,273,953 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,496,921 - 49,504,446 (+)NCBIHuRef
CHM1_11252,430,002 - 52,437,523 (+)NCBICHM1_1
T2T-CHM13v2.01252,028,879 - 52,041,075 (+)NCBIT2T-CHM13v2.0
Atg101
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,277,223 - 134,286,387 (+)NCBIGRCr8
mRatBN7.27132,398,477 - 132,407,643 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,398,483 - 132,407,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,200,027 - 134,209,527 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,429,543 - 136,439,043 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,339,980 - 136,348,905 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,929,381 - 142,938,559 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,929,400 - 142,938,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,730,251 - 140,739,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,029,813 - 140,038,925 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,106,249 - 140,115,362 (+)NCBI
Celera7128,863,838 - 128,872,961 (+)NCBICelera
Cytogenetic Map7q36NCBI
Atg101
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,436,895 - 2,446,849 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555472,436,974 - 2,446,849 (+)NCBIChiLan1.0ChiLan1.0
ATG101
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,118,333 - 42,126,618 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,115,096 - 42,123,381 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,685,897 - 36,693,613 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,462,533 - 37,470,277 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,462,533 - 37,470,062 (-)Ensemblpanpan1.1panPan2
ATG101
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,931,595 - 2,934,914 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,931,893 - 2,935,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,317,316 - 43,324,391 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,928,791 - 2,935,881 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,928,794 - 2,935,861 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,945,425 - 2,950,072 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,931,788 - 2,938,961 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,715,530 - 43,722,606 (+)NCBIUU_Cfam_GSD_1.0
Atg101
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,638,844 - 63,646,743 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,518,074 - 9,526,961 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,518,128 - 9,525,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATG101
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,418,121 - 17,425,624 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,418,085 - 17,425,770 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ATG101
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,243,200 - 48,251,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,243,216 - 48,251,371 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037197,841,049 - 197,849,553 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atg101
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816255,432 - 262,151 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624816255,443 - 261,636 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atg101
138 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:134
Interacting mature miRNAs:140
Transcripts:ENSMUST00000048393
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597697881103008427Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92788640103425899Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse

Markers in Region
AU022967  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815101,290,696 - 101,290,801UniSTSGRCm38
MGSCv3715101,121,127 - 101,121,232UniSTSGRCm37
Celera15103,438,755 - 103,438,860UniSTS
Cytogenetic Map15F3UniSTS
Whitehead/MRC_RH15896.63UniSTS
RH124598  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815101,290,657 - 101,290,888UniSTSGRCm38
MGSCv3715101,121,088 - 101,121,319UniSTSGRCm37
Celera15103,438,716 - 103,438,947UniSTS
Cytogenetic Map15F3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000048393   ⟹   ENSMUSP00000045474
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15101,182,153 - 101,188,826 (+)Ensembl
GRCm38.p6 Ensembl15101,284,272 - 101,290,945 (+)Ensembl
Ensembl Acc Id: ENSMUST00000229525   ⟹   ENSMUSP00000154849
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15101,184,488 - 101,185,132 (+)Ensembl
GRCm38.p6 Ensembl15101,286,607 - 101,287,251 (+)Ensembl
Ensembl Acc Id: ENSMUST00000230525   ⟹   ENSMUSP00000154855
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15101,184,614 - 101,188,235 (+)Ensembl
GRCm38.p6 Ensembl15101,286,733 - 101,290,354 (+)Ensembl
RefSeq Acc Id: NM_001418341   ⟹   NP_001405270
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915101,184,501 - 101,188,855 (+)NCBI
RefSeq Acc Id: NM_026566   ⟹   NP_080842
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915101,182,182 - 101,188,855 (+)NCBI
GRCm3815101,284,301 - 101,290,934 (+)NCBI
MGSCv3715101,114,732 - 101,121,365 (+)RGD
Celera15103,432,360 - 103,438,993 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080842   ⟸   NM_026566
- UniProtKB: Q9D8Z6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000045474   ⟸   ENSMUST00000048393
Ensembl Acc Id: ENSMUSP00000154855   ⟸   ENSMUST00000230525
Ensembl Acc Id: ENSMUSP00000154849   ⟸   ENSMUST00000229525
RefSeq Acc Id: NP_001405270   ⟸   NM_001418341
- UniProtKB: Q9D8Z6 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D8Z6-F1-model_v2 AlphaFold Q9D8Z6 1-218 view protein structure

Promoters
RGD ID:6825636
Promoter ID:MM_KWN:19776
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000048393
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615101,113,926 - 101,114,852 (+)MPROMDB
RGD ID:6847156
Promoter ID:MM_ACW:19443
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   Kidney
Transcripts:9430023L20RIK.ASEP07,   9430023L20RIK.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615101,117,171 - 101,117,671 (+)MPROMDB
RGD ID:8685104
Promoter ID:EPDNEW_M20583
Type:multiple initiation site
Name:Atg101_1
Description:Mus musculus autophagy related 101 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815101,284,301 - 101,284,361EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915368 AgrOrtholog
Ensembl Genes ENSMUSG00000037204 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048393 ENTREZGENE
  ENSMUST00000048393.8 UniProtKB/Swiss-Prot
  ENSMUST00000229525.2 UniProtKB/TrEMBL
  ENSMUST00000230525.2 UniProtKB/TrEMBL
InterPro ATG101 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:68118 UniProtKB/Swiss-Prot
MGD MGI:1915368 ENTREZGENE
NCBI Gene 68118 ENTREZGENE
PANTHER AUTOPHAGY-RELATED PROTEIN 101 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13292 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATG101 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atg101 PhenoGen
UniProt A0A2R8VH88_MOUSE UniProtKB/TrEMBL
  A0A2R8VJN5_MOUSE UniProtKB/TrEMBL
  ATGA1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-26 Atg101  autophagy related 101  9430023L20Rik  RIKEN cDNA 9430023L20 gene  Symbol and/or name change 5135510 APPROVED