Gjb6 (gap junction protein, beta 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gjb6 (gap junction protein, beta 6) Mus musculus
Analyze
Symbol: Gjb6
Name: gap junction protein, beta 6
RGD ID: 1551751
MGI Page MGI
Description: Predicted to enable cytoskeletal protein binding activity and gap junction channel activity involved in cell communication by electrical coupling. Acts upstream of or within ear morphogenesis and sensory perception of sound. Located in gap junction. Is expressed in bladder; spiral ligament; urinary system; and urothelium of bladder. Used to study Clouston syndrome and autosomal recessive nonsyndromic deafness 1A. Human ortholog(s) of this gene implicated in Clouston syndrome; autosomal dominant nonsyndromic deafness 3B; autosomal recessive nonsyndromic deafness 1A; autosomal recessive nonsyndromic deafness 1B; and ectodermal dysplasia. Orthologous to human GJB6 (gap junction protein beta 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA958971; connexin 30; connexin f; connexin-30; Cx30; Cxnf; D14Bwg0506e; gap junction beta-6 protein; gap junction membrane channel protein beta 6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391457,360,760 - 57,370,764 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1457,360,760 - 57,371,068 (-)EnsemblGRCm39 Ensembl
GRCm381457,123,301 - 57,133,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1457,123,303 - 57,133,611 (-)EnsemblGRCm38mm10GRCm38
MGSCv371457,742,140 - 57,752,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361456,077,413 - 56,087,687 (-)NCBIMGSCv36mm8
Celera1454,913,863 - 54,924,132 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of connexin 30 and connexin 32 in hippocampus of rat during epileptogenesis in a kindling model of epilepsy. Akbarpour B, etal., Neurosci Bull. 2012 Dec;28(6):729-36. doi: 10.1007/s12264-012-1279-6. Epub 2012 Nov 12.
2. Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications. Ball KK, etal., J Neurosci Res. 2011 Dec;89(12):2052-67. doi: 10.1002/jnr.22663. Epub 2011 May 2.
3. Absence of GJB6 mutations in Indian patients with non-syndromic hearing loss. Bhalla S, etal., Int J Pediatr Otorhinolaryngol. 2011 Mar;75(3):356-9. doi: 10.1016/j.ijporl.2010.12.003. Epub 2011 Jan 11.
4. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
5. Hearing loss features in GJB2 biallelic mutations and GJB2/GJB6 digenic inheritance in a large Italian cohort. Cama E, etal., Int J Audiol. 2009 Jan;48(1):12-7. doi: 10.1080/14992020802400654.
6. Prevalence of GJB6 mutations in Chinese patients with non-syndromic hearing loss. Chen P, etal., Int J Pediatr Otorhinolaryngol. 2012 Feb;76(2):265-7. doi: 10.1016/j.ijporl.2011.11.018. Epub 2011 Dec 18.
7. Connexin-30 mRNA is up-regulated in astrocytes and expressed in apoptotic neuronal cells of rat brain following kainate-induced seizures. Condorelli DF, etal., Mol Cell Neurosci 2002 Sep;21(1):94-113.
8. Prevalence of DFNB1 mutations in Argentinean children with non-syndromic deafness. Report of a novel mutation in GJB2. Gravina LP, etal., Int J Pediatr Otorhinolaryngol. 2010 Mar;74(3):250-4. doi: 10.1016/j.ijporl.2009.11.014. Epub 2009 Dec 22.
9. Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Hugyecz M, etal., Brain Res. 2011 Aug 2;1404:31-8. Epub 2011 Jun 12.
10. Layer specific changes of astroglial gap junctions in the rat cerebellar cortex by persistent Borna Disease Virus infection. Koster-Patzlaff C, etal., Brain Res. 2008 Jul 11;1219:143-58. doi: 10.1016/j.brainres.2008.04.062. Epub 2008 Apr 30.
11. Mutations in GJB6 cause hidrotic ectodermal dysplasia. Lamartine J, etal., Nat Genet. 2000 Oct;26(2):142-4.
12. Molecular screening of patients with nonsyndromic hearing loss from Nanjing city of China. Lu Y, etal., J Biomed Res. 2011 Sep;25(5):309-18. doi: 10.1016/S1674-8301(11)60042-0.
13. High glucose-induced downregulation of connexin 30.2 promotes retinal vascular lesions: implications for diabetic retinopathy. Manasson J, etal., Invest Ophthalmol Vis Sci. 2013 Mar 28;54(3):2361-6. doi: 10.1167/iovs.12-10815.
14. Spectrum and frequency of GJB2 mutations in a cohort of 264 Portuguese nonsyndromic sensorineural hearing loss patients. Matos TD, etal., Int J Audiol. 2013 Jul;52(7):466-71. doi: 10.3109/14992027.2013.783719. Epub 2013 May 13.
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice. Schutz M, etal., Hum Mol Genet. 2010 Dec 15;19(24):4759-73. doi: 10.1093/hmg/ddq402. Epub 2010 Sep 21.
22. Expression of connexins in the normal and obstructed developing kidney. Silverstein DM, etal., Pediatr Nephrol. 2003 Mar;18(3):216-24. Epub 2003 Feb 7.
23. Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential. Teubner B, etal., Hum Mol Genet. 2003 Jan 1;12(1):13-21.
24. Differential expression of hippocampal connexins after acute hypoxia in the developing brain. Zeinieh MP, etal., Brain Dev. 2010 Nov;32(10):810-7. doi: 10.1016/j.braindev.2009.11.003. Epub 2010 Jan 19.
Additional References at PubMed
PMID:8663509   PMID:8889548   PMID:10197766   PMID:10349636   PMID:10610709   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11967204   PMID:12466851   PMID:12477932   PMID:12840073  
PMID:12859965   PMID:12911759   PMID:14595769   PMID:14681012   PMID:15081111   PMID:15466892   PMID:15489334   PMID:15692151   PMID:16045494   PMID:16101586   PMID:16141072   PMID:16141073  
PMID:16217030   PMID:16579977   PMID:16707796   PMID:17120054   PMID:17227867   PMID:17400755   PMID:17446259   PMID:17640036   PMID:17702002   PMID:18199768   PMID:18287559   PMID:18512249  
PMID:18942753   PMID:19047635   PMID:19047647   PMID:19050930   PMID:19056987   PMID:19116647   PMID:19478095   PMID:19535586   PMID:19549869   PMID:19673007   PMID:19679680   PMID:19864490  
PMID:20089884   PMID:20813869   PMID:21075848   PMID:21264956   PMID:21536893   PMID:21571253   PMID:21873635   PMID:21997206   PMID:22025386   PMID:22032925   PMID:22037505   PMID:22098503  
PMID:22142852   PMID:22275221   PMID:22342190   PMID:22399755   PMID:22472609   PMID:22649229   PMID:22859373   PMID:22891314   PMID:22951907   PMID:23219093   PMID:23303923   PMID:23424196  
PMID:23618652   PMID:23627777   PMID:23637189   PMID:23665355   PMID:24081156   PMID:24133139   PMID:24144139   PMID:24349371   PMID:24522190   PMID:24584052   PMID:24590285   PMID:24685692  
PMID:24732355   PMID:24952082   PMID:25037920   PMID:25643695   PMID:25698924   PMID:25944877   PMID:26035172   PMID:26232528   PMID:26400258   PMID:26490746   PMID:26586821   PMID:26758214  
PMID:27391799   PMID:27785828   PMID:28077706   PMID:28138563   PMID:28220769   PMID:28689039   PMID:28779115   PMID:28823936   PMID:29143947   PMID:29234270   PMID:29386634   PMID:29475972  
PMID:30103794   PMID:30337521   PMID:30464764   PMID:30534054   PMID:30559251   PMID:30794327   PMID:30804003   PMID:31001720   PMID:31271200   PMID:32046059   PMID:32553574   PMID:32700707  
PMID:32755449   PMID:33569381   PMID:33589833   PMID:33735099   PMID:33973274   PMID:34210880   PMID:34376651   PMID:35263595   PMID:35573684   PMID:35790771   PMID:35831953   PMID:36016655  
PMID:36555685   PMID:37040348   PMID:37279265   PMID:38359484   PMID:38388443   PMID:38605287   PMID:38722742   PMID:38996064  


Genomics

Comparative Map Data
Gjb6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391457,360,760 - 57,370,764 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1457,360,760 - 57,371,068 (-)EnsemblGRCm39 Ensembl
GRCm381457,123,301 - 57,133,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1457,123,303 - 57,133,611 (-)EnsemblGRCm38mm10GRCm38
MGSCv371457,742,140 - 57,752,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361456,077,413 - 56,087,687 (-)NCBIMGSCv36mm8
Celera1454,913,863 - 54,924,132 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.1NCBI
GJB6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381320,221,962 - 20,232,319 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1320,221,962 - 20,232,365 (-)EnsemblGRCh38hg38GRCh38
GRCh371320,796,101 - 20,806,458 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361319,694,101 - 19,703,067 (-)NCBINCBI36Build 36hg18NCBI36
Build 341319,694,101 - 19,703,067NCBI
Celera131,857,920 - 1,868,353 (-)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef131,601,586 - 1,612,019 (-)NCBIHuRef
CHM1_11320,764,612 - 20,775,034 (-)NCBICHM1_1
T2T-CHM13v2.01319,418,446 - 19,428,785 (-)NCBIT2T-CHM13v2.0
Gjb6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81535,400,147 - 35,410,649 (-)NCBIGRCr8
mRatBN7.21531,284,561 - 31,294,552 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1531,284,419 - 31,294,582 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1533,275,886 - 33,285,877 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01534,426,541 - 34,436,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01532,684,670 - 32,694,661 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01537,400,888 - 37,411,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,400,889 - 37,410,848 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01541,248,072 - 41,258,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41536,177,736 - 36,186,513 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11536,193,435 - 36,202,213 (-)NCBI
Celera1530,996,679 - 31,005,456 (-)NCBICelera
Cytogenetic Map15p12NCBI
Gjb6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554971,018,610 - 1,027,360 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554971,018,610 - 1,027,593 (-)NCBIChiLan1.0ChiLan1.0
GJB6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21419,852,221 - 19,862,541 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11310,964,567 - 10,974,876 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0131,549,089 - 1,559,452 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11319,864,208 - 19,874,385 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1319,864,939 - 19,865,724 (-)Ensemblpanpan1.1panPan2
GJB6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12517,912,036 - 17,922,310 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2517,911,262 - 17,921,605 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2517,942,707 - 17,952,942 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02518,049,941 - 18,060,202 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2518,049,939 - 18,062,858 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12517,916,508 - 17,926,768 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02517,928,188 - 17,938,444 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02517,984,771 - 17,995,017 (+)NCBIUU_Cfam_GSD_1.0
Gjb6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945119,938,223 - 119,947,042 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367201,493,733 - 1,494,518 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367201,485,895 - 1,494,673 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJB6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl11793,280 - 800,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.111793,276 - 800,109 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GJB6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.13775,410 - 783,770 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl3782,251 - 783,036 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605743,801,650 - 43,810,335 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gjb6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477617,477,966 - 17,487,303 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477617,477,947 - 17,487,304 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gjb6
394 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:364
Count of miRNA genes:305
Interacting mature miRNAs:323
Transcripts:ENSMUST00000039380, ENSMUST00000160703, ENSMUST00000162931
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse

Markers in Region
AA958971  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381457,123,359 - 57,123,468UniSTSGRCm38
MGSCv371457,742,196 - 57,742,305UniSTSGRCm37
Celera1454,913,919 - 54,914,028UniSTS
Cytogenetic Map14C3UniSTS
cM Map1422.5UniSTS
Whitehead/MRC_RH14650.08UniSTS
RH125213  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381457,123,306 - 57,123,417UniSTSGRCm38
MGSCv371457,742,143 - 57,742,254UniSTSGRCm37
Celera1454,913,866 - 54,913,977UniSTS
Cytogenetic Map14C3UniSTS
cM Map1422.5UniSTS
D14Bwg0506e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381457,123,352 - 57,123,503UniSTSGRCm38
MGSCv371457,742,189 - 57,742,340UniSTSGRCm37
Celera1454,913,912 - 54,914,063UniSTS
Cytogenetic Map14C3UniSTS
cM Map1422.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000039380   ⟹   ENSMUSP00000035630
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1457,360,760 - 57,371,068 (-)Ensembl
GRCm38.p6 Ensembl1457,123,303 - 57,133,611 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160703   ⟹   ENSMUSP00000124927
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1457,361,739 - 57,370,738 (-)Ensembl
GRCm38.p6 Ensembl1457,124,282 - 57,133,281 (-)Ensembl
Ensembl Acc Id: ENSMUST00000162931
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1457,368,294 - 57,369,516 (-)Ensembl
GRCm38.p6 Ensembl1457,130,837 - 57,132,059 (-)Ensembl
Ensembl Acc Id: ENSMUST00000224544
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1457,360,761 - 57,362,678 (-)Ensembl
GRCm38.p6 Ensembl1457,123,304 - 57,125,221 (-)Ensembl
RefSeq Acc Id: NM_001010937   ⟹   NP_001010937
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391457,360,760 - 57,370,764 (-)NCBI
GRCm381457,123,301 - 57,133,611 (-)NCBI
MGSCv371457,742,140 - 57,752,414 (-)RGD
Celera1454,913,861 - 54,924,166 (-)NCBI
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001271663   ⟹   NP_001258592
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391457,360,760 - 57,370,764 (-)NCBI
GRCm381457,123,301 - 57,133,611 (-)NCBI
Celera1454,913,861 - 54,924,166 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001424448   ⟹   NP_001411377
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391457,360,760 - 57,370,000 (-)NCBI
RefSeq Acc Id: NM_001424449   ⟹   NP_001411378
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391457,360,760 - 57,369,516 (-)NCBI
RefSeq Acc Id: NM_001424450   ⟹   NP_001411379
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391457,360,760 - 57,369,516 (-)NCBI
RefSeq Acc Id: NP_001010937   ⟸   NM_001010937
- UniProtKB: P70689 (UniProtKB/Swiss-Prot),   Q3URC5 (UniProtKB/TrEMBL),   Q3UYK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258592   ⟸   NM_001271663
- UniProtKB: P70689 (UniProtKB/Swiss-Prot),   Q3URC5 (UniProtKB/TrEMBL),   Q3UYK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000124927   ⟸   ENSMUST00000160703
Ensembl Acc Id: ENSMUSP00000035630   ⟸   ENSMUST00000039380
RefSeq Acc Id: NP_001411377   ⟸   NM_001424448
- UniProtKB: P70689 (UniProtKB/Swiss-Prot),   Q3URC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411378   ⟸   NM_001424449
- UniProtKB: P70689 (UniProtKB/Swiss-Prot),   Q3URC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411379   ⟸   NM_001424450
- UniProtKB: P70689 (UniProtKB/Swiss-Prot),   Q3URC5 (UniProtKB/TrEMBL)
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70689-F1-model_v2 AlphaFold P70689 1-261 view protein structure

Promoters
RGD ID:8682544
Promoter ID:EPDNEW_M19302
Type:multiple initiation site
Name:Gjb6_2
Description:Mus musculus gap junction protein, beta 6 , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19303  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381457,133,302 - 57,133,362EPDNEW
RGD ID:8682546
Promoter ID:EPDNEW_M19303
Type:initiation region
Name:Gjb6_1
Description:Mus musculus gap junction protein, beta 6 , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19302  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381457,133,603 - 57,133,663EPDNEW
RGD ID:6824954
Promoter ID:MM_KWN:17052
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_008128
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361457,744,726 - 57,745,226 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107588 AgrOrtholog
Ensembl Genes ENSMUSG00000040055 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039380 ENTREZGENE
  ENSMUST00000039380.9 UniProtKB/Swiss-Prot
  ENSMUST00000160703.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14623 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107588 ENTREZGENE
NCBI Gene 14623 ENTREZGENE
PANTHER GAP JUNCTION BETA-6 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11984 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gjb6 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CXB6_MOUSE UniProtKB/Swiss-Prot
  E0CX48_MOUSE UniProtKB/TrEMBL
  P70689 ENTREZGENE
  Q3URC5 ENTREZGENE, UniProtKB/TrEMBL
  Q3UYK0 ENTREZGENE, UniProtKB/TrEMBL