Btk (Bruton agammaglobulinemia tyrosine kinase) - Rat Genome Database

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Gene: Btk (Bruton agammaglobulinemia tyrosine kinase) Mus musculus
Analyze
Symbol: Btk
Name: Bruton agammaglobulinemia tyrosine kinase
RGD ID: 1551411
MGI Page MGI
Description: Enables protein tyrosine kinase activity. Involved in negative regulation of cytokine production and positive regulation of NLRP3 inflammasome complex assembly. Acts upstream of or within several processes, including B cell affinity maturation; cellular response to interleukin-7; and negative regulation of B cell proliferation. Located in cytoplasmic vesicle; membrane raft; and nucleus. Is expressed in liver left lobe; liver right lobe; spleen; and thymus primordium. Used to study X-linked agammaglobulinemia. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human BTK (Bruton tyrosine kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AI528679; ATK; B-cell progenitor kinase; BPK; bruton tyrosine kinase; Bruton's tyrosine kinase; kinase EMB; tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); X-linked immune deficiency; xi; xid
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,443,083 - 133,484,366 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,443,085 - 133,484,319 (-)EnsemblGRCm39 Ensembl
GRCm38X134,542,334 - 134,583,628 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,542,336 - 134,583,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,076,880 - 131,117,679 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,888,761 - 129,929,466 (-)NCBIMGSCv36mm8
CeleraX117,421,885 - 117,462,725 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX56.18NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IBA)
apoptotic process  (IEA)
B cell affinity maturation  (IMP)
B cell receptor signaling pathway  (IBA,ISO)
cell maturation  (IMP)
cellular response to interleukin-7  (IMP)
cellular response to molecule of fungal origin  (ISO)
cellular response to reactive oxygen species  (ISO)
eosinophil homeostasis  (ISO)
histamine secretion by mast cell  (ISO)
immune system process  (IEA)
innate immune response  (IEA)
intracellular signal transduction  (ISO)
monocyte proliferation  (ISO)
negative regulation of B cell activation  (ISO)
negative regulation of B cell proliferation  (IMP)
negative regulation of cytokine production  (IMP)
negative regulation of interleukin-10 production  (ISO)
negative regulation of leukocyte proliferation  (ISO)
neutrophil homeostasis  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (IDA,ISO)
phosphorylation  (IEA)
positive regulation of B cell proliferation  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-17A production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IDA,ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of synoviocyte proliferation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I hypersensitivity  (ISO)
positive regulation of type III hypersensitivity  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (IBA,IDA)
proteoglycan catabolic process  (ISO)
response to lipopolysaccharide  (ISO)
T cell receptor signaling pathway  (IBA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell calcium ion homeostasis  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal B cell proliferation  (IAGP)
abnormal bone marrow cell number  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal leukocyte morphology  (IEA)
abnormal lymph node germinal center morphology  (IAGP)
abnormal lymphocyte cell number  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal pre-B cell morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal spleen marginal zone morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
absent B-1a cells  (IAGP)
absent limbs  (IAGP)
absent lymph node germinal center  (IAGP)
absent mature B cells  (IAGP)
absent spleen germinal center  (IAGP)
arrested B cell differentiation  (IAGP)
autoimmune response  (IAGP)
decreased acute inflammation  (IAGP)
decreased B cell apoptosis  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased body weight  (IAGP)
decreased follicular B cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgD level  (IEA)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immature B cell number  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased mature B cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased platelet aggregation  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased splenocyte number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased transitional stage B cell number  (IAGP)
impaired myelopoiesis  (IAGP)
impaired neutrophil phagocytosis  (IAGP)
increased autoantibody level  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IEA)
increased IgE level  (IEA)
increased IgG level  (IEA)
increased IgM level  (IAGP)
increased immature B cell number  (IEA)
increased pre-B cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased splenocyte proliferation  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced colitis  (IAGP)
premature death  (IAGP)
spleen hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. Advani RH, etal., J Clin Oncol. 2013 Jan 1;31(1):88-94. doi: 10.1200/JCO.2012.42.7906. Epub 2012 Oct 8.
2. Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. Angst D, etal., J Med Chem. 2020 May 28;63(10):5102-5118. doi: 10.1021/acs.jmedchem.9b01916. Epub 2020 Mar 4.
3. Role of Bruton's Tyrosine Kinase in Stage III Colorectal Cancer. Basile D, etal., Cancers (Basel). 2019 Jun 24;11(6). pii: cancers11060880. doi: 10.3390/cancers11060880.
4. BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining. Bi KW, etal., Front Oncol. 2020 Apr 15;10:424. doi: 10.3389/fonc.2020.00424. eCollection 2020.
5. Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation,in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model. Chu Y, etal., Oncoimmunology. 2018 Oct 11;8(1):e1512455. doi: 10.1080/2162402X.2018.1512455. eCollection 2019.
6. Bruton tyrosine kinase gene mutations in Argentina. Danielian S, etal., Hum Mutat. 2003 Apr;21(4):451.
7. Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia. de Porto AP, etal., Mol Med. 2019 Jan 15;25(1):3. doi: 10.1186/s10020-018-0069-7.
8. Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis. de Porto APNA, etal., Thromb Haemost. 2019 Jun;119(6):930-940. doi: 10.1055/s-0039-1681046. Epub 2019 Mar 14.
9. Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice. de Weers M, etal., Hum Mol Genet. 1994 Jan;3(1):161-6.
10. Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury. Florence JM, etal., Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L52-L58. doi: 10.1152/ajplung.00047.2018. Epub 2018 Mar 8.
11. p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma. Giordano F, etal., J Exp Clin Cancer Res. 2019 Jun 14;38(1):260. doi: 10.1186/s13046-019-1199-7.
12. Evaluation of Experimental Infection with L. ( L.) Amazonensis in X-Linked Immunodeficient Mice. Gonzaga WFKM, etal., J Parasitol. 2017 Dec;103(6):708-717. doi: 10.1645/16-145. Epub 2017 Aug 7.
13. Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide. Huang W, etal., J Allergy Clin Immunol. 2016 Apr;137(4):1197-205. doi: 10.1016/j.jaci.2015.08.056. Epub 2015 Nov 12.
14. The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection. Köprülü AD, etal., PLoS One. 2013;8(3):e60476. doi: 10.1371/journal.pone.0060476. Epub 2013 Mar 27.
15. BTK inhibitors synergise with 5-FU to treat drug-resistant TP53-null colon cancers. Lavitrano M, etal., J Pathol. 2020 Feb;250(2):134-147. doi: 10.1002/path.5347. Epub 2019 Dec 2.
16. Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma. Lionakis MS, etal., Cancer Cell. 2017 Jun 12;31(6):833-843.e5. doi: 10.1016/j.ccell.2017.04.012. Epub 2017 May 25.
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. MGD IEA MGD IEA
19. Fatal disseminated mouse adenovirus type 1 infection in mice lacking B cells or Bruton's tyrosine kinase. Moore ML, etal., J Virol. 2004 Jun;78(11):5584-90. doi: 10.1128/JVI.78.11.5584-5590.2004.
20. Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK. Ng YY, etal., Leukemia. 2010 Sep;24(9):1617-30. doi: 10.1038/leu.2010.140. Epub 2010 Jun 24.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion. Pinschewer DD, etal., Eur J Immunol. 1999 Sep;29(9):2981-7. doi: 10.1002/(SICI)1521-4141(199909)29:09<2981::AID-IMMU2981>3.0.CO;2-Y.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. PKC-interacting proteins: from function to pharmacology. Poole AW, etal., Trends Pharmacol Sci. 2004 Oct;25(10):528-35.
27. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Rawlings DJ, etal., Science. 1993 Jul 16;261(5119):358-61.
28. Mouse MP Annotation Import Pipeline RGD automated import pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. B lymphocytes inactivation by Ibrutinib limits endometriosis progression in mice. Riccio LGC, etal., Hum Reprod. 2019 Jul 8;34(7):1225-1234. doi: 10.1093/humrep/dez071.
32. Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Roschewski M, etal., Sci Immunol. 2020 Jun 5;5(48). pii: 5/48/eabd0110. doi: 10.1126/sciimmunol.abd0110. Epub 2020 Jun 5.
33. Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in mouse lymphoma. Sagiv-Barfi I, etal., Blood. 2015 Mar 26;125(13):2079-86. doi: 10.1182/blood-2014-08-593137. Epub 2015 Feb 6.
34. Intestinal colonization by Candida albicans alters inflammatory responses in Bruton's tyrosine kinase-deficient mice. Strijbis K, etal., PLoS One. 2014 Nov 7;9(11):e112472. doi: 10.1371/journal.pone.0112472. eCollection 2014.
35. X-linked immunodeficient mice exhibit enhanced susceptibility to Cryptococcus neoformans Infection. Szymczak WA, etal., mBio. 2013 Jul 2;4(4). pii: mBio.00265-13. doi: 10.1128/mBio.00265-13.
36. Identification of the bruton tyrosine kinase (BTK) gene mutations in 20 Australian families with X-linked agammaglobulinemia (XLA). Velickovic M, etal., Hum Mutat. 2004 Apr;23(4):398-9.
37. RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents. Xu D, etal., J Pharmacol Exp Ther. 2012 Apr;341(1):90-103. doi: 10.1124/jpet.111.187740. Epub 2012 Jan 6.
38. Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Yu PW, etal., Blood. 2004 Sep 1;104(5):1281-90. doi: 10.1182/blood-2003-09-3044. Epub 2004 May 13.
39. B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy. Zhang L, etal., Clin Cancer Res. 2017 Aug 1;23(15):4212-4223. doi: 10.1158/1078-0432.CCR-16-2703. Epub 2017 Mar 27.
Additional References at PubMed
PMID:305463   PMID:311819   PMID:805203   PMID:1080788   PMID:1385525   PMID:1434498   PMID:1506683   PMID:1541830   PMID:1632468   PMID:1711566   PMID:2333032   PMID:2884254  
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PMID:3916931   PMID:4403476   PMID:6215838   PMID:6227659   PMID:6235926   PMID:6358897   PMID:6381637   PMID:6415204   PMID:6600493   PMID:6605990   PMID:6607282   PMID:6610721  
PMID:6886419   PMID:6980900   PMID:7365241   PMID:7486535   PMID:7514102   PMID:7517360   PMID:7519204   PMID:7522330   PMID:7545546   PMID:7552994   PMID:7552995   PMID:7565679  
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PMID:9200448   PMID:9240435   PMID:9294206   PMID:9352351   PMID:9371815   PMID:9394795   PMID:9421270   PMID:9529324   PMID:9547335   PMID:9547343   PMID:9556577   PMID:9560157  
PMID:9620599   PMID:9730885   PMID:9821307   PMID:9870661   PMID:9888854   PMID:9888855   PMID:10067860   PMID:10075019   PMID:10201977   PMID:10343129   PMID:10352268   PMID:10358768  
PMID:10359786   PMID:10367907   PMID:10383938   PMID:10395682   PMID:10403925   PMID:10438910   PMID:10604987   PMID:10611342   PMID:10684864   PMID:10757034   PMID:10811866   PMID:10811867  
PMID:10829070   PMID:10852954   PMID:10856225   PMID:10872802   PMID:10903718   PMID:10987665   PMID:11007757   PMID:11013082   PMID:11104803   PMID:11114734   PMID:11120822   PMID:11282988  
PMID:11369788   PMID:11371362   PMID:11381084   PMID:11449370   PMID:11466342   PMID:11717191   PMID:11751885   PMID:11756681   PMID:11785667   PMID:11878875   PMID:11884435   PMID:11884437  
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PMID:12835482   PMID:12842985   PMID:12874264   PMID:12902486   PMID:12917264   PMID:14597404   PMID:14597636   PMID:14610273   PMID:14634110   PMID:14657254   PMID:14734712   PMID:14742524  
PMID:14993283   PMID:15007095   PMID:15087455   PMID:15102471   PMID:15117762   PMID:15128795   PMID:15196959   PMID:15214046   PMID:15331445   PMID:15361883   PMID:15375214   PMID:15379984  
PMID:15384044   PMID:15385481   PMID:15456761   PMID:15500621   PMID:15520044   PMID:15661902   PMID:15728476   PMID:15743806   PMID:15778496   PMID:15814670   PMID:15885131   PMID:16141072  
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PMID:35422819   PMID:35537415   PMID:36031013   PMID:36882061   PMID:38000306   PMID:38129902   PMID:38355793   PMID:38365047   PMID:38507738   PMID:38696257  


Genomics

Comparative Map Data
Btk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,443,083 - 133,484,366 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,443,085 - 133,484,319 (-)EnsemblGRCm39 Ensembl
GRCm38X134,542,334 - 134,583,628 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,542,336 - 134,583,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,076,880 - 131,117,679 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,888,761 - 129,929,466 (-)NCBIMGSCv36mm8
CeleraX117,421,885 - 117,462,725 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX56.18NCBI
BTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,349,450 - 101,390,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX101,349,338 - 101,390,796 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,604,438 - 100,645,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,491,098 - 100,527,838 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X100,410,586 - 100,447,327NCBI
CeleraX101,123,894 - 101,160,669 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,410,583 - 90,447,505 (-)NCBIHuRef
CHM1_1X100,497,918 - 100,534,692 (-)NCBICHM1_1
T2T-CHM13v2.0X99,793,571 - 99,834,908 (-)NCBIT2T-CHM13v2.0
Btk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,016,070 - 102,055,448 (-)NCBIGRCr8
mRatBN7.2X97,722,796 - 97,762,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,722,802 - 97,761,853 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,397,016 - 99,436,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,907,749 - 102,946,794 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X100,410,180 - 100,449,237 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X105,360,922 - 105,390,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,360,922 - 105,390,580 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,250,666 - 105,279,934 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X121,998,935 - 122,030,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X122,072,367 - 122,103,722 (-)NCBI
CeleraX98,764,036 - 98,794,122 (-)NCBICelera
Cytogenetic MapXq32NCBI
Btk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555037,482,793 - 7,515,120 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555037,483,819 - 7,515,085 (-)NCBIChiLan1.0ChiLan1.0
BTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X100,948,666 - 100,985,544 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X100,952,265 - 100,989,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X90,551,874 - 90,588,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X100,684,017 - 100,720,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,684,017 - 100,725,187 (-)Ensemblpanpan1.1panPan2
BTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X75,270,952 - 75,302,663 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX75,270,979 - 75,302,562 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,691,359 - 76,723,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,691,367 - 76,723,042 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X74,255,464 - 74,287,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,915,885 - 75,947,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,678,325 - 75,710,045 (-)NCBIUU_Cfam_GSD_1.0
Btk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X63,007,672 - 63,045,710 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936813429,224 - 463,441 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936813429,400 - 467,481 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX82,981,515 - 83,014,573 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X82,981,512 - 83,014,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,690,569 - 89,727,420 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606514,609,796 - 14,647,019 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,182,682 - 1,216,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,173,101 - 1,216,662 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Btk
821 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:563
Count of miRNA genes:355
Interacting mature miRNAs:390
Transcripts:ENSMUST00000033617, ENSMUST00000113213, ENSMUST00000128333, ENSMUST00000132664, ENSMUST00000150245
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse

Markers in Region
AI528679  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X134,542,598 - 134,542,719UniSTSGRCm38
MGSCv37X131,077,137 - 131,077,258UniSTSGRCm37
CeleraX117,422,142 - 117,422,263UniSTS
Cytogenetic MapXE3UniSTS
cM MapX51.0UniSTS
cM MapX51.0UniSTS
Whitehead/MRC_RHX1481.68UniSTS
PMC24278P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X134,573,897 - 134,574,029UniSTSGRCm38
MGSCv37X131,108,436 - 131,108,568UniSTSGRCm37
CeleraX117,453,393 - 117,453,525UniSTS
Cytogenetic MapXE3UniSTS
cM MapX51.0UniSTS
Btk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXE3UniSTS
cM MapX51.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH003106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX004852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY596531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ044967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DT921900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L30156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U58105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000033617   ⟹   ENSMUSP00000033617
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,443,085 - 133,483,889 (-)Ensembl
GRCm38.p6 EnsemblX134,542,336 - 134,583,140 (-)Ensembl
Ensembl Acc Id: ENSMUST00000113213   ⟹   ENSMUSP00000108839
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,443,119 - 133,483,877 (-)Ensembl
GRCm38.p6 EnsemblX134,542,370 - 134,583,128 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,473,958 - 133,484,319 (-)Ensembl
GRCm38.p6 EnsemblX134,573,209 - 134,583,570 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132664
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,449,970 - 133,483,889 (-)Ensembl
GRCm38.p6 EnsemblX134,549,221 - 134,583,140 (-)Ensembl
Ensembl Acc Id: ENSMUST00000150245
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,469,654 - 133,483,222 (-)Ensembl
GRCm38.p6 EnsemblX134,568,905 - 134,582,473 (-)Ensembl
RefSeq Acc Id: NM_013482   ⟹   NP_038510
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X133,443,090 - 133,483,889 (-)NCBI
GRCm38X134,542,341 - 134,583,140 (-)NCBI
MGSCv37X131,076,880 - 131,117,679 (-)RGD
CeleraX117,421,885 - 117,462,725 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006528483   ⟹   XP_006528546
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X133,443,083 - 133,484,366 (-)NCBI
GRCm38X134,542,334 - 134,583,628 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006528484   ⟹   XP_006528547
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X133,443,083 - 133,483,275 (-)NCBI
GRCm38X134,542,334 - 134,582,534 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006528485   ⟹   XP_006528548
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X133,443,083 - 133,484,366 (-)NCBI
GRCm38X134,542,334 - 134,583,620 (-)NCBI
Sequence:
RefSeq Acc Id: NP_038510   ⟸   NM_013482
- UniProtKB: Q61365 (UniProtKB/Swiss-Prot),   P35991 (UniProtKB/Swiss-Prot),   Q7TMU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528548   ⟸   XM_006528485
- Peptide Label: isoform X1
- UniProtKB: Q61365 (UniProtKB/Swiss-Prot),   P35991 (UniProtKB/Swiss-Prot),   Q7TMU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528546   ⟸   XM_006528483
- Peptide Label: isoform X1
- UniProtKB: Q61365 (UniProtKB/Swiss-Prot),   P35991 (UniProtKB/Swiss-Prot),   Q7TMU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528547   ⟸   XM_006528484
- Peptide Label: isoform X1
- UniProtKB: Q61365 (UniProtKB/Swiss-Prot),   P35991 (UniProtKB/Swiss-Prot),   Q7TMU1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000108839   ⟸   ENSMUST00000113213
Ensembl Acc Id: ENSMUSP00000033617   ⟸   ENSMUST00000033617
Protein Domains
PH   Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35991-F1-model_v2 AlphaFold P35991 1-659 view protein structure

Promoters
RGD ID:6845538
Promoter ID:MM_KWN:61867
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:OTTMUST00000046187
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X131,116,571 - 131,117,372 (-)MPROMDB
RGD ID:6845536
Promoter ID:MM_KWN:61868
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000113213,   ENSMUST00000113214,   OTTMUST00000046138,   OTTMUST00000046186,   OTTMUST00000046188
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X131,117,331 - 131,117,831 (-)MPROMDB
RGD ID:13681356
Promoter ID:EPDNEW_M24827
Type:single initiation site
Name:Btk_2
Description:Mus musculus Bruton agammaglobulinemia tyrosine kinase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24828  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X134,580,524 - 134,580,584EPDNEW
RGD ID:13681358
Promoter ID:EPDNEW_M24828
Type:multiple initiation site
Name:Btk_1
Description:Mus musculus Bruton agammaglobulinemia tyrosine kinase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24827  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X134,583,140 - 134,583,200EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88216 AgrOrtholog
Ensembl Genes ENSMUSG00000031264 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033617 ENTREZGENE
  ENSMUST00000033617.13 UniProtKB/Swiss-Prot
  ENSMUST00000113213.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTK_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_Btk_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12229 UniProtKB/Swiss-Prot
MGD MGI:88216 ENTREZGENE
NCBI Gene 12229 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE BTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Btk PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TECBTKDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_BTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2BDW0_MOUSE UniProtKB/TrEMBL
  BTK_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q61365 ENTREZGENE
  Q7TMU1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q61365 UniProtKB/Swiss-Prot