Irf6 (interferon regulatory factor 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Irf6 (interferon regulatory factor 6) Mus musculus
Analyze
Symbol: Irf6
Name: interferon regulatory factor 6
RGD ID: 1551327
MGI Page MGI
Description: Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in mammary gland epithelial cell differentiation and positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including keratinocyte differentiation; keratinocyte proliferation; and negative regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; non-neural ectoderm; sensory organ; and skin. Used to study Van der Woude syndrome; cleft lip; and popliteal pterygium syndrome. Human ortholog(s) of this gene implicated in several diseases, including Van der Woude syndrome; cleft lip; cleft palate; orofacial cleft 6; and popliteal pterygium syndrome. Orthologous to human IRF6 (interferon regulatory factor 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI876454; E230028I05Rik; IRF-6; mirf6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391192,835,420 - 192,854,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1192,835,419 - 192,854,331 (+)EnsemblGRCm39 Ensembl
GRCm381193,153,112 - 193,172,036 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,153,111 - 193,172,023 (+)EnsemblGRCm38mm10GRCm38
MGSCv371194,979,306 - 194,998,230 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,853,878 - 194,872,730 (+)NCBIMGSCv36mm8
Celera1200,028,192 - 200,047,120 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map197.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
clofibrate  (EXP)
copper(II) chloride  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
flusilazole  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
geraniol  (ISO)
glafenine  (ISO)
lead diacetate  (ISO)
methotrexate  (EXP,ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
tamoxifen  (EXP)
tebuconazole  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO,ISS)
nucleus  (IBA,IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal ameloblast morphology  (IAGP)
abnormal body wall morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal digit development  (IAGP)
abnormal digit morphology  (IAGP)
abnormal enamel development  (IAGP)
abnormal enamel mineralization  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal enamel rod pattern  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum spinosum morphology  (IAGP)
abnormal epidermis suprabasal layer morphology  (IAGP)
abnormal esophagus development  (IAGP)
abnormal esophagus morphology  (IAGP)
abnormal Hertwig epithelial root sheath morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal incisor color  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal mandibular angle morphology  (IAGP)
abnormal molar crown morphology  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal molar morphology  (IAGP)
abnormal molar root morphology  (IAGP)
abnormal mouth morphology  (IAGP)
abnormal oral cavity morphology  (IAGP)
abnormal palate development  (IAGP)
abnormal palatine bone horizontal plate morphology  (IAGP)
abnormal periderm development  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skin development  (IAGP)
abnormal skin morphology  (IAGP)
abnormal tooth development  (IAGP)
abnormal tooth morphology  (IAGP)
absent epidermis stratum corneum  (IAGP)
absent epidermis stratum granulosum  (IAGP)
absent outer ear  (IAGP)
absent presphenoid bone  (IAGP)
absent vibrissae  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
curly tail  (IAGP)
decreased hair follicle number  (IAGP)
decreased length of long bones  (IAGP)
decreased molar number  (IAGP)
delayed bone ossification  (IAGP)
delayed skin barrier formation  (IAGP)
failure of palatal shelf elevation  (IAGP)
fused phalanges  (IAGP)
glossopalatal ankylosis  (IAGP)
increased circulating aspartate transaminase level  (IEA)
increased circulating creatine kinase level  (IEA)
increased circulating creatinine level  (IEA)
increased keratinocyte proliferation  (IAGP)
kinked tail  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
palatal shelf fusion with tongue or mandible  (IAGP)
perinatal lethality, complete penetrance  (IEA)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
reduced enamel thickness  (IAGP)
round snout  (IAGP)
shiny skin  (IAGP)
short forelimb  (IAGP)
short limbs  (IAGP)
short snout  (IAGP)
short sternum  (IAGP)
short tail  (IAGP)
small mandible  (IAGP)
small vertebrae  (IAGP)
split xiphoid process  (IAGP)
supernumerary teeth  (IAGP)
syndactyly  (IAGP)
synostosis  (IAGP)
taurodontia  (IAGP)
thick epidermis  (IAGP)
thick epidermis stratum spinosum  (IAGP)
tight skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Kondo S, etal., Nat Genet. 2002 Oct;32(2):285-9. Epub 2002 Sep 3.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. Nikopensius T, etal., Birth Defects Res A Clin Mol Teratol. 2010 Sep;88(9):748-56. doi: 10.1002/bdra.20700.
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9560157   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:15361870   PMID:15747579   PMID:16002709   PMID:16141072  
PMID:16141073   PMID:16245336   PMID:16602821   PMID:16780827   PMID:17041601   PMID:17041603   PMID:17299133   PMID:17376812   PMID:17660535   PMID:18212048   PMID:18287559   PMID:18470539  
PMID:18836445   PMID:19036739   PMID:19439425   PMID:19527266   PMID:20003319   PMID:20059953   PMID:20196077   PMID:20412781   PMID:20424325   PMID:20424327   PMID:21267068   PMID:21362171  
PMID:21515572   PMID:21574244   PMID:21873635   PMID:21909072   PMID:21918538   PMID:21982646   PMID:22113860   PMID:22366192   PMID:22711520   PMID:22931925   PMID:22967998   PMID:23008150  
PMID:23029012   PMID:23239958   PMID:23406900   PMID:23451037   PMID:23563729   PMID:24337118   PMID:24357509   PMID:24360809   PMID:24442519   PMID:24590292   PMID:24777480   PMID:25133425  
PMID:25358290   PMID:25387952   PMID:25523394   PMID:25704602   PMID:26100917   PMID:26116174   PMID:26240017   PMID:27035130   PMID:27302476   PMID:27306759   PMID:27369589   PMID:27927890  
PMID:28481036   PMID:28526834   PMID:28643456   PMID:28645193   PMID:28732181   PMID:28769044   PMID:28817352   PMID:28898113   PMID:29771971   PMID:29913133   PMID:29981310   PMID:30684382  
PMID:30689861   PMID:31387937   PMID:31578523   PMID:31724286   PMID:31943082   PMID:33234718   PMID:33406080   PMID:35781329   PMID:37143676   PMID:38355793   PMID:38604478   PMID:38809584  


Genomics

Comparative Map Data
Irf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391192,835,420 - 192,854,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1192,835,419 - 192,854,331 (+)EnsemblGRCm39 Ensembl
GRCm381193,153,112 - 193,172,036 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,153,111 - 193,172,023 (+)EnsemblGRCm38mm10GRCm38
MGSCv371194,979,306 - 194,998,230 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,853,878 - 194,872,730 (+)NCBIMGSCv36mm8
Celera1200,028,192 - 200,047,120 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map197.6NCBI
IRF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381209,785,617 - 209,806,142 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1209,785,617 - 209,806,175 (-)EnsemblGRCh38hg38GRCh38
GRCh371209,958,962 - 209,979,487 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361208,027,885 - 208,046,102 (-)NCBINCBI36Build 36hg18NCBI36
Build 341206,349,656 - 206,367,874NCBI
Celera1183,192,156 - 183,210,363 (-)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1180,634,114 - 180,654,661 (-)NCBIHuRef
CHM1_11211,231,296 - 211,251,831 (-)NCBICHM1_1
T2T-CHM13v2.01209,032,385 - 209,052,912 (-)NCBIT2T-CHM13v2.0
Irf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813107,200,876 - 107,220,083 (+)NCBIGRCr8
mRatBN7.213104,672,179 - 104,691,386 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13104,672,179 - 104,691,386 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13107,189,790 - 107,208,999 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013108,573,644 - 108,592,851 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013105,791,610 - 105,810,817 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013111,870,121 - 111,889,328 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13111,870,121 - 111,889,328 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013116,425,025 - 116,444,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413108,986,973 - 109,006,180 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113109,176,076 - 109,195,282 (+)NCBI
Celera13104,102,428 - 104,121,635 (+)NCBICelera
Cytogenetic Map13q27NCBI
Irf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554892,415,925 - 2,437,837 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554892,404,773 - 2,434,729 (+)NCBIChiLan1.0ChiLan1.0
IRF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2139,591,466 - 39,612,943 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1139,557,629 - 39,581,840 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01185,361,612 - 185,382,516 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11190,226,722 - 190,247,145 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1190,226,727 - 190,247,145 (-)Ensemblpanpan1.1panPan2
IRF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.178,447,826 - 8,467,265 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl78,448,538 - 8,462,661 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha78,024,947 - 8,044,365 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.078,148,397 - 8,167,818 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl78,148,402 - 8,167,733 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.178,078,084 - 8,097,501 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.078,175,119 - 8,194,534 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.078,313,202 - 8,332,619 (-)NCBIUU_Cfam_GSD_1.0
Irf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934466,052,551 - 66,071,017 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365573,292,873 - 3,311,369 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365573,292,927 - 3,309,002 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9133,164,440 - 133,185,628 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19133,164,360 - 133,184,045 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29146,240,235 - 146,259,915 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12519,648,131 - 19,665,722 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605520,247,186 - 20,267,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248072,193,798 - 2,206,768 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248072,190,721 - 2,207,183 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irf6
894 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:894
Count of miRNA genes:524
Interacting mature miRNAs:651
Transcripts:ENSMUST00000076521, ENSMUST00000138826, ENSMUST00000140066
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172632197195154279Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172303451195154279Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172532197195154279Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172303451195154279Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1171983110195154279Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175468817194111528Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse

Markers in Region
AI876454  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381193,171,818 - 193,171,915UniSTSGRCm38
MGSCv371194,998,012 - 194,998,109UniSTSGRCm37
Celera1200,046,902 - 200,046,999UniSTS
Cytogenetic Map1H6UniSTS
cM Map1104.0UniSTS
Whitehead/MRC_RH12454.14UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000076521   ⟹   ENSMUSP00000075839
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1192,835,419 - 192,854,331 (+)Ensembl
GRCm38.p6 Ensembl1193,153,111 - 193,172,023 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138826
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1192,835,462 - 192,849,176 (+)Ensembl
GRCm38.p6 Ensembl1193,153,154 - 193,166,868 (+)Ensembl
Ensembl Acc Id: ENSMUST00000140066
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1192,838,977 - 192,846,489 (+)Ensembl
GRCm38.p6 Ensembl1193,156,669 - 193,164,181 (+)Ensembl
Ensembl Acc Id: ENSMUST00000193772
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1192,850,811 - 192,851,797 (+)Ensembl
GRCm38.p6 Ensembl1193,168,503 - 193,169,489 (+)Ensembl
RefSeq Acc Id: NM_016851   ⟹   NP_058547
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391192,835,420 - 192,854,344 (+)NCBI
GRCm381193,153,112 - 193,172,036 (+)ENTREZGENE
MGSCv371194,979,306 - 194,998,230 (+)RGD
Celera1200,028,192 - 200,047,120 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006497262   ⟹   XP_006497325
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391192,838,769 - 192,854,340 (+)NCBI
GRCm381193,156,461 - 193,172,032 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006497263   ⟹   XP_006497326
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391192,836,182 - 192,854,340 (+)NCBI
GRCm381193,153,874 - 193,172,032 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058547   ⟸   NM_016851
- UniProtKB: Q91VD0 (UniProtKB/Swiss-Prot),   P97431 (UniProtKB/Swiss-Prot),   Q3UEJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497326   ⟸   XM_006497263
- Peptide Label: isoform X1
- UniProtKB: Q91VD0 (UniProtKB/Swiss-Prot),   P97431 (UniProtKB/Swiss-Prot),   Q3UEJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497325   ⟸   XM_006497262
- Peptide Label: isoform X1
- UniProtKB: Q91VD0 (UniProtKB/Swiss-Prot),   P97431 (UniProtKB/Swiss-Prot),   Q3UEJ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000075839   ⟸   ENSMUST00000076521
Protein Domains
IRF tryptophan pentad repeat

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97431-F1-model_v2 AlphaFold P97431 1-467 view protein structure

Promoters
RGD ID:6876156
Promoter ID:EPDNEW_M1529
Type:initiation region
Name:Irf6_1
Description:Mus musculus interferon regulatory factor 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381193,153,150 - 193,153,210EPDNEW
RGD ID:6817957
Promoter ID:MM_KWN:3347
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000083863,   OTTMUST00000083865,   OTTMUST00000083866
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361194,979,106 - 194,979,606 (+)MPROMDB
RGD ID:6817954
Promoter ID:MM_KWN:3348
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000085552,   OTTMUST00000083864
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361194,982,531 - 194,983,031 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859211 AgrOrtholog
Ensembl Genes ENSMUSG00000026638 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000076521 ENTREZGENE
  ENSMUST00000076521.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Interferon_reg_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_reg_fact_DNA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_reg_factor-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54139 UniProtKB/Swiss-Prot
MGD MGI:1859211 ENTREZGENE
NCBI Gene 54139 ENTREZGENE
PANTHER INTERFERON REGULATORY FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERFERON REGULATORY FACTOR 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Irf6 PhenoGen
PRINTS INTFRNREGFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IRF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt IRF6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UEJ9 ENTREZGENE, UniProtKB/TrEMBL
  Q8C2Z7_MOUSE UniProtKB/TrEMBL
  Q91VD0 ENTREZGENE
UniProt Secondary Q91VD0 UniProtKB/Swiss-Prot