Gch1 (GTP cyclohydrolase 1) - Rat Genome Database

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Gene: Gch1 (GTP cyclohydrolase 1) Mus musculus
Analyze
Symbol: Gch1
Name: GTP cyclohydrolase 1
RGD ID: 1551245
MGI Page MGI
Description: Enables GTP cyclohydrolase I activity. Involved in positive regulation of heart rate. Acts upstream of or within regulation of lung blood pressure. Predicted to be located in several cellular components, including cytosol; mitochondrion; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study BH4-deficient hyperphenylalaninemia B. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gch; GTP cyclohydrolase I; GTP-C; GTP-CH; GTP-CH-I; GTPC; GTPCH
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391447,391,352 - 47,426,870 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1447,391,352 - 47,426,870 (-)EnsemblGRCm39 Ensembl
GRCm381447,153,895 - 47,189,413 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1447,153,895 - 47,189,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv371447,773,570 - 47,809,077 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361446,075,772 - 46,111,279 (-)NCBIMGSCv36mm8
Celera1443,334,771 - 43,370,387 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic GMP  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5,6,7,8-tetrahydrobiopterin  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetylcholine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adenine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP)
benzo[b]fluoranthene  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP,ISO)
chrysene  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
cyclosporin A  (ISO)
cyproconazole  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethyl methanesulfonate  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gentamycin  (ISO)
glutathione  (ISO)
glyphosate  (EXP)
GW 501516  (ISO)
hydrogen peroxide  (EXP)
inulin  (EXP)
L-erythro-7,8-dihydrobiopterin  (EXP)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
mitomycin C  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalenes  (ISO)
nefazodone  (ISO)
neopterin  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
profenofos  (ISO)
propiconazole  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sapropterin  (EXP,ISO)
sarin  (ISO)
SB 431542  (ISO)
sepiapterin  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
Soman  (ISO)
succimer  (EXP)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triptonide  (EXP)
undecane  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis. Almudéver P, etal., Thorax. 2013 Oct;68(10):938-48. doi: 10.1136/thoraxjnl-2013-203408. Epub 2013 Jun 5.
2. Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status. Asensio Lopez MDC, etal., Sci Rep. 2020 Aug 11;10(1):13553. doi: 10.1038/s41598-020-70454-8.
3. Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease. Azzouz M, etal., J Neurosci 2002 Dec 1;22(23):10302-12.
4. Isoflurane favorably modulates guanosine triphosphate cyclohydrolase-1 and endothelial nitric oxide synthase during myocardial ischemia and reperfusion injury in rats. Baotic I, etal., Anesthesiology. 2015 Sep;123(3):582-9. doi: 10.1097/ALN.0000000000000778.
5. A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia. Belfer I, etal., Am J Hematol. 2014 Feb;89(2):187-93. doi: 10.1002/ajh.23613.
6. Evidence of a role for GTP cyclohydrolase-1 in visceral pain. Bulmer DC, etal., Neurogastroenterol Motil. 2015 May;27(5):656-62. doi: 10.1111/nmo.12538. Epub 2015 Mar 17.
7. Inhibition of tetrahydrobiopterin synthesis reduces in vivo nitric oxide production in experimental endotoxic shock. Bune AJ, etal., Biochem Biophys Res Commun. 1996 Mar 7;220(1):13-9. doi: 10.1006/bbrc.1996.0348.
8. Controlled Striatal DOPA Production From a Gene Delivery System in a Rodent Model of Parkinson's Disease. Cederfjäll E, etal., Mol Ther. 2015 May;23(5):896-906. doi: 10.1038/mt.2015.8. Epub 2015 Jan 16.
9. Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease. Cederfjäll E, etal., Sci Rep. 2013;3:2157. doi: 10.1038/srep02157.
10. Limb remote ischemic post-conditioning reduces brain reperfusion injury by reversing eNOS uncoupling. Chen G, etal., Indian J Exp Biol. 2014 Jun;52(6):597-605.
11. Sodium Tanshinone IIA sulfonate improves post-ischemic angiogenesis in hyperglycemia. Chen L, etal., Biochem Biophys Res Commun. 2019 Dec 10;520(3):580-585. doi: 10.1016/j.bbrc.2019.09.106. Epub 2019 Oct 14.
12. Blockade of tetrahydrobiopterin synthesis protects neurons after transient forebrain ischemia in rat: a novel role for the cofactor. Cho S, etal., J Neurosci. 1999 Feb 1;19(3):878-89. doi: 10.1523/JNEUROSCI.19-03-00878.1999.
13. Time-of-Day-Dependent Effects of Bromocriptine to Ameliorate Vascular Pathology and Metabolic Syndrome in SHR Rats Held on High Fat Diet. Ezrokhi M, etal., Int J Mol Sci. 2021 Jun 7;22(11):6142. doi: 10.3390/ijms22116142.
14. Possible involvement of tetrahydrobiopterin in the disturbance of redox homeostasis in sepsis - Induced brain dysfunction. Gamal M, etal., Brain Res. 2018 Apr 15;1685:19-28. doi: 10.1016/j.brainres.2018.02.008. Epub 2018 Feb 9.
15. Glucocorticoid regulation of nitric oxide and tetrahydrobiopterin in a rat model of endotoxic shock. Hattori Y, etal., Biochem Biophys Res Commun. 1997 Nov 17;240(2):298-303. doi: 10.1006/bbrc.1997.7653.
16. Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene. Ichinose H, etal., Nat Genet. 1994 Nov;8(3):236-42.
17. Linkage and candidate gene analysis of 14q22-24 in bipolar disorder: support for GCHI as a novel susceptibility gene. Kealey C, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136(1):75-80.
18. Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing inducible NO synthase and peroxynitrite in ischemic stroke. Kidd GA, etal., Stroke. 2005 Dec;36(12):2705-11. doi: 10.1161/01.STR.0000190000.98707.6d. Epub 2005 Nov 10.
19. Effective relief of neuropathic pain by adeno-associated virus-mediated expression of a small hairpin RNA against GTP cyclohydrolase 1. Kim SJ, etal., Mol Pain. 2009 Nov 18;5:67. doi: 10.1186/1744-8069-5-67.
20. Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease. Kim SU, etal., Neuropathology. 2006 Apr;26(2):129-40. doi: 10.1111/j.1440-1789.2006.00688.x.
21. Pre-treatment of acupuncture stimulation of ST36 (Zusanli) significantly attenuates CAT-2, CAT-2B and GTPCH transcription in septic rat lungs. Lao HC, etal., Acta Anaesthesiol Taiwan. 2006 Jun;44(2):83-91.
22. Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability. Lee KC, etal., Clin Sci (Lond). 2010 Apr 7;119(1):45-55. doi: 10.1042/CS20090601.
23. Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats. Li HY, etal., Crit Care Med. 2002 Nov;30(11):2520-7. doi: 10.1097/00003246-200211000-00020.
24. Association of a functional polymorphism (C59038T) in GTP cyclohydrolase 1 gene and Type 2 diabetic macrovascular disease in the Chinese population. Liao YF, etal., J Diabetes Complications. 2010 Sep-Oct;24(5):313-9. doi: 10.1016/j.jdiacomp.2009.04.003. Epub 2009 Jun 9.
25. The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis. Matei V, etal., Hepatology. 2006 Jul;44(1):44-52. doi: 10.1002/hep.21228.
26. Changes of GTP cyclohydrolase I and neuronal apoptosis in rat spinal dorsal cord induced by sciatic nerve injury. Meng C, etal., Neurol Sci. 2013 Dec;34(12):2145-50. doi: 10.1007/s10072-013-1353-5. Epub 2013 Mar 21.
27. MGDs mouse GO annotations MGD data from the GO Consortium
28. GTP cyclohydrolase 1 downregulation contributes to glucocorticoid hypertension in rats. Mitchell BM, etal., Hypertension. 2003 Mar;41(3 Pt 2):669-74. doi: 10.1161/01.HYP.0000051889.62249.5D. Epub 2003 Jan 13.
29. Phenylalanine improves dilation and blood pressure in GTP cyclohydrolase inhibition-induced hypertensive rats. Mitchell BM, etal., J Cardiovasc Pharmacol. 2004 Jun;43(6):758-63. doi: 10.1097/00005344-200406000-00004.
30. Dopa responsive dystonia with Turner's syndrome: clinical, genetic, and neuropsychological studies in a family with a new mutation in the GTP-cyclohydrolase I gene. Nitschke M, etal., J Neurol Neurosurg Psychiatry. 1998 Jun;64(6):806-8. doi: 10.1136/jnnp.64.6.806.
31. Suppressed expression of GTP cyclohydrolase I mRNA and accelerated expression of inducible nitric oxide synthase mRNA in endomyocardial biopsy specimens from patients with dilated cardiomyopathy. Ohtsuki M, etal., Clin Chim Acta. 2005 Mar;353(1-2):103-7. doi: 10.1016/j.cccn.2004.10.004.
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy. Satoh M, etal., Nephrol Dial Transplant. 2008 Dec;23(12):3806-13. doi: 10.1093/ndt/gfn357. Epub 2008 Jul 2.
38. Exercise training augments neuronal nitric oxide synthase dimerization in the paraventricular nucleus of rats with chronic heart failure. Sharma NM, etal., Nitric Oxide. 2019 Jun 1;87:73-82. doi: 10.1016/j.niox.2019.03.005. Epub 2019 Mar 13.
39. Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease. Sun M, etal., Hum Gene Ther. 2004 Dec;15(12):1177-96.
40. GTP cyclohydrolase 1 gene 3'-UTR C+243T variant predicts worsening outcome in patients with first-onset ischemic stroke. Tang L, etal., J Huazhong Univ Sci Technolog Med Sci. 2010 Dec;30(6):694-8. doi: 10.1007/s11596-010-0642-y. Epub 2010 Dec 22.
41. Identification of gene variants related to the nitric oxide pathway in patients with acute coronary syndrome. Umman B, etal., Gene. 2015 Dec 10;574(1):76-81. doi: 10.1016/j.gene.2015.07.081. Epub 2015 Jul 30.
42. L-phenylalanine attenuates high salt-induced hypertension in Dahl SS rats through activation of GCH1-BH4. Wang Z, etal., PLoS One. 2021 Apr 15;16(4):e0250126. doi: 10.1371/journal.pone.0250126. eCollection 2021.
43. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Wenzel P, etal., Atherosclerosis. 2008 May;198(1):65-76. Epub 2007 Dec 3.
44. Bacterial translocation up-regulates GTP-cyclohydrolase I in mesenteric vasculature of cirrhotic rats. Wiest R, etal., Hepatology. 2003 Dec;38(6):1508-15. doi: 10.1016/j.hep.2003.09.039.
45. GTP cyclohydrolase I gene polymorphisms are associated with endothelial dysfunction and oxidative stress in patients with type 2 diabetes mellitus. Wolkow PP, etal., PLoS One. 2014 Nov 4;9(11):e108587. doi: 10.1371/journal.pone.0108587. eCollection 2014.
46. Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy. Wu HE, etal., Sci Rep. 2016 Jun 13;6:27925. doi: 10.1038/srep27925.
47. Polymorphisms of genes in nitric oxide-forming pathway associated with ischemic stroke in Chinese Han population. Yan JT, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1357-63. doi: 10.1038/aps.2011.114. Epub 2011 Oct 3.
48. Ionizing radiation induces BH4 deficiency by downregulating GTP-cyclohydrolase 1, a novel target for preventing and treating radiation enteritis. Yan T, etal., Biochem Pharmacol. 2020 Oct;180:114102. doi: 10.1016/j.bcp.2020.114102. Epub 2020 Jun 17.
49. Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH4/eNOS to Improve Intestinal Ischemia. Yan T, etal., Front Pharmacol. 2021 Apr 22;12:629125. doi: 10.3389/fphar.2021.629125. eCollection 2021.
50. Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. Zhang L, etal., J Clin Invest. 2007 Sep;117(9):2658-71. doi: 10.1172/JCI31093.
51. COX-2/sEH Dual Inhibitor PTUPB Alleviates CCl 4 -Induced Liver Fibrosis and Portal Hypertension. Zhao Z, etal., Front Med (Lausanne). 2021 Dec 23;8:761517. doi: 10.3389/fmed.2021.761517. eCollection 2021.
52. Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. Zheng JS, etal., Circulation. 2003 Sep 9;108(10):1238-45. doi: 10.1161/01.CIR.0000089082.40285.C3. Epub 2003 Aug 18.
Additional References at PubMed
PMID:7524491   PMID:7730309   PMID:8304101   PMID:8461009   PMID:8889548   PMID:9930750   PMID:10349636   PMID:10479487   PMID:10582619   PMID:10727395   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11677059   PMID:12466851   PMID:12477932   PMID:12535931   PMID:14681479   PMID:15234340   PMID:15489334   PMID:15824199   PMID:15946242   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:17394463   PMID:17679617   PMID:18268143   PMID:18554416   PMID:18645049   PMID:19011239   PMID:19104007   PMID:19286659   PMID:19336662   PMID:19780901   PMID:19926872  
PMID:20818386   PMID:21059996   PMID:21267068   PMID:21343293   PMID:21677750   PMID:21873635   PMID:21963838   PMID:21982896   PMID:22241166   PMID:22753274   PMID:22798524   PMID:22984419  
PMID:23421753   PMID:23620395   PMID:24054139   PMID:24161960   PMID:24644242   PMID:24777984   PMID:24952961   PMID:25451639   PMID:25557619   PMID:25642596   PMID:26087165   PMID:26343845  
PMID:26826575   PMID:29596571   PMID:30135482   PMID:30405245   PMID:30450838   PMID:30573728   PMID:30742839   PMID:31269442   PMID:31676569   PMID:32325033   PMID:34402860   PMID:34689592  
PMID:36399957   PMID:36443440   PMID:36735402   PMID:38355793  


Genomics

Comparative Map Data
Gch1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391447,391,352 - 47,426,870 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1447,391,352 - 47,426,870 (-)EnsemblGRCm39 Ensembl
GRCm381447,153,895 - 47,189,413 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1447,153,895 - 47,189,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv371447,773,570 - 47,809,077 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361446,075,772 - 46,111,279 (-)NCBIMGSCv36mm8
Celera1443,334,771 - 43,370,387 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.6NCBI
GCH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381454,842,017 - 54,902,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1454,842,008 - 54,902,826 (-)EnsemblGRCh38hg38GRCh38
GRCh371455,308,735 - 55,369,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361454,378,473 - 54,439,292 (-)NCBINCBI36Build 36hg18NCBI36
Build 341454,378,484 - 54,439,279NCBI
Celera1435,358,210 - 35,419,030 (-)NCBICelera
Cytogenetic Map14q22.2NCBI
HuRef1435,471,338 - 35,532,109 (-)NCBIHuRef
CHM1_11455,247,346 - 55,308,167 (-)NCBICHM1_1
T2T-CHM13v2.01449,047,244 - 49,108,020 (-)NCBIT2T-CHM13v2.0
Gch1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81522,884,006 - 22,917,412 (-)NCBIGRCr8
mRatBN7.21520,404,267 - 20,437,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,402,527 - 20,437,698 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1523,184,907 - 23,218,319 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01524,142,871 - 24,176,283 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,394,011 - 22,427,378 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01523,935,011 - 23,968,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1523,934,585 - 23,969,011 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01527,876,253 - 27,910,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41523,023,996 - 23,139,794 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11523,039,695 - 23,155,494 (-)NCBI
Celera1520,799,206 - 20,832,598 (-)NCBICelera
Cytogenetic Map15p14NCBI
Gch1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,624,468 - 8,668,614 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,624,225 - 8,670,436 (+)NCBIChiLan1.0ChiLan1.0
GCH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21555,932,208 - 56,026,639 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11455,179,865 - 55,240,594 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01435,428,676 - 35,489,359 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11453,706,723 - 53,767,393 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1453,706,723 - 53,767,393 (-)Ensemblpanpan1.1panPan2
GCH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1830,733,422 - 30,784,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl830,732,608 - 30,784,156 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha830,501,844 - 30,552,428 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0830,989,520 - 31,040,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl830,967,731 - 31,040,294 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1830,593,993 - 30,644,489 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0830,669,980 - 30,720,620 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0831,035,484 - 31,086,113 (-)NCBIUU_Cfam_GSD_1.0
Gch1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864074,457,811 - 74,501,265 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936697232,048 - 275,420 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1184,199,679 - 184,257,315 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11184,201,232 - 184,264,060 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21204,648,349 - 204,712,905 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GCH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12432,029,997 - 32,079,656 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2432,027,648 - 32,079,490 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605320,264,246 - 20,316,487 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gch1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,459,303 - 14,500,429 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,459,164 - 14,502,485 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gch1
1317 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:619
Count of miRNA genes:418
Interacting mature miRNAs:487
Transcripts:ENSMUST00000089959
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse

Markers in Region
Gch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C2-3UniSTS
cM Map1419.5UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000089959   ⟹   ENSMUSP00000087405
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1447,391,352 - 47,426,870 (-)Ensembl
GRCm38.p6 Ensembl1447,153,895 - 47,189,413 (-)Ensembl
Ensembl Acc Id: ENSMUST00000227883
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1447,395,822 - 47,399,329 (-)Ensembl
GRCm38.p6 Ensembl1447,158,365 - 47,161,872 (-)Ensembl
RefSeq Acc Id: NM_008102   ⟹   NP_032128
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391447,391,352 - 47,426,870 (-)NCBI
GRCm381447,153,895 - 47,189,413 (-)NCBI
MGSCv371447,773,570 - 47,809,077 (-)RGD
Celera1443,334,771 - 43,370,387 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032128   ⟸   NM_008102
- UniProtKB: Q05915 (UniProtKB/Swiss-Prot),   Q3U7P6 (UniProtKB/TrEMBL),   Q3UC70 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000087405   ⟸   ENSMUST00000089959
Protein Domains
GTP cyclohydrolase I

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05915-F1-model_v2 AlphaFold Q05915 1-241 view protein structure

Promoters
RGD ID:8682066
Promoter ID:EPDNEW_M19063
Type:multiple initiation site
Name:Gch1_1
Description:Mus musculus GTP cyclohydrolase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381447,189,413 - 47,189,473EPDNEW
RGD ID:6847107
Promoter ID:MM_ACW:15798
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:GCH1.BSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361447,781,946 - 47,782,446 (-)MPROMDB
RGD ID:6824948
Promoter ID:MM_KWN:16466
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:ENSMUST00000089959
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361447,808,734 - 47,809,234 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95675 AgrOrtholog
Ensembl Genes ENSMUSG00000037580 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000089959 ENTREZGENE
  ENSMUST00000089959.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.286.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1130.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GTP-CH-I_C/QueF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GTP-CH-I_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GTP_CycHdrlase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GTP_CycHdrlase_I_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GTP_CycHdrlase_I_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95675 ENTREZGENE
NCBI Gene 14528 ENTREZGENE
PANTHER GTP CYCLOHYDROLASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GTP_cyclohydroI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GCH1 RGD
PhenoGen Gch1 PhenoGen
PROSITE GTP_CYCLOHYDROL_1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GTP_CYCLOHYDROL_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Tetrahydrobiopterin biosynthesis enzymes-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GCH1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U7P6 ENTREZGENE, UniProtKB/TrEMBL
  Q3UC70 ENTREZGENE, UniProtKB/TrEMBL