Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) - Rat Genome Database

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Gene: Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) Mus musculus
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Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
RGD ID: 1551142
MGI Page MGI
Description: Enables 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to hydrostatic pressure; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of with a negative effect on autosome genomic imprinting. Acts upstream of or within several processes, including adipose tissue development; cellular response to glucose stimulus; and negative regulation of apoptotic process. Located in intercalated disc and lamellipodium. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including early embryo; eye; and nervous system. Used to study CLOVES syndrome and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6330412C24Rik; caP; caPI3K; MGC161268; p110; p110alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; ptdIns-3-kinase subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,451,203 - 32,520,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,451,820 - 32,522,635 (+)EnsemblGRCm39 Ensembl
GRCm38332,397,065 - 32,466,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,397,671 - 32,468,486 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,335,073 - 32,367,408 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,627,755 - 32,654,380 (+)NCBIMGSCv36mm8
Celera332,346,082 - 32,378,426 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Agenesis of Corpus Callosum  (ISO)
arteriovenous malformation  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Bannayan-Riley-Ruvalcaba syndrome  (ISO)
basal cell carcinoma  (ISO)
Brain Neoplasms  (ISO)
breast adenocarcinoma  (ISO)
breast angiosarcoma  (ISO)
breast cancer  (IAGP,ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Capillary Malformation-Arteriovenous Malformation 1  (ISO)
Cardiovascular Abnormalities  (ISO)
Cerebral Cavernous Malformation 4  (ISO)
CLAPO Syndrome  (ISO)
CLOVES syndrome  (IAGP,ISO)
colon adenocarcinoma  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
Cowden syndrome  (ISO)
Cowden syndrome 5  (ISO)
Currarino syndrome  (ISO)
cutaneous Paget's disease  (ISO)
Developmental Disabilities  (ISO)
Diabetic Cardiomyopathies  (IEP)
diaphragmatic eventration  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Down syndrome  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
epidermal nevus  (ISO)
esophageal cancer  (ISO)
esophageal carcinoma  (ISO)
esophagus adenocarcinoma  (ISO)
estrogen-receptor positive breast cancer  (ISO)
Facial Asymmetry  (ISO)
familial multiple nevi flammei  (ISO)
gallbladder cancer  (ISO)
gallbladder carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
Gastrointestinal Neoplasms  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glycogen storage disease II  (ISO)
Growth Disorders  (ISO)
head and neck cancer  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hemifacial Myohyperplasia  (ISO)
Hemimegalencephaly  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hyperplasia  (IMP,ISO)
Hypertelorism  (ISO)
keratoacanthoma  (ISO)
Klippel-Trenaunay syndrome  (ISO)
liver cancer  (IMP)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphangioma  (ISO)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
medulloblastoma  (ISO)
Megalencephaly - Cutis Marmorata Telangiectatica Congenita  (ISO)
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome  (ISO)
Megalodactyly  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neoplasm Metastasis  (ISO)
neuroblastoma  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
non-Hodgkin lymphoma  (ISO)
Noonan syndrome 8  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
Penile Neoplasms  (ISO)
plasma cell neoplasm  (ISO)
polycystic kidney disease  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
PTEN hamartoma tumor syndrome  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
rosette-forming glioneuronal tumor  (ISO)
sarcoma  (ISO)
seborrheic keratosis  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Malformations  (IMP)
Ventricular Dysfunction, Left  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
baicalein  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carvacrol  (ISO)
CGP 52608  (ISO)
chitosan  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
dactolisib  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ergothioneine  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
fenvalerate  (ISO)
geldanamycin  (ISO)
ginsenoside Rg1  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
idelalisib  (EXP)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lithium chloride  (ISO)
LY294002  (EXP,ISO)
metformin  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (EXP)
monosodium L-glutamate  (ISO)
morusin  (ISO)
N-nitrosodiethylamine  (ISO)
naringin  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
orotic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
pioglitazone  (ISO)
pyrethrins  (ISO)
pyrvinium  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
SB 431542  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
streptozocin  (EXP)
succimer  (EXP)
sucrose  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (EXP,ISO)
tamoxifen  (ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
tungsten  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
wogonin  (EXP)
wortmannin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IMP)
adipose tissue development  (IMP)
angiogenesis  (IEA)
autosome genomic imprinting  (IDA)
cardiac muscle cell contraction  (IMP)
cell migration  (IBA)
cellular response to glucose stimulus  (IMP)
cellular response to hydrostatic pressure  (IMP)
cellular response to insulin stimulus  (ISO)
energy homeostasis  (IMP)
glucose metabolic process  (IMP)
insulin receptor signaling pathway  (IMP)
insulin-like growth factor receptor signaling pathway  (IDA,IMP)
liver development  (IMP)
negative regulation of actin filament depolymerization  (IMP)
negative regulation of anoikis  (ISO)
negative regulation of fibroblast apoptotic process  (IDA)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (IMP)
phagocytosis  (IEA)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IDA,IMP,ISO)
phosphatidylinositol phosphate biosynthetic process  (ISO)
phosphatidylinositol-3-phosphate biosynthetic process  (IBA)
phosphatidylinositol-mediated signaling  (IBA)
phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein localization to membrane  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
regulation of actin filament organization  (IMP)
regulation of cellular respiration  (IMP)
regulation of gene expression  (IMP)
regulation of multicellular organism growth  (IMP)
regulation of protein phosphorylation  (IDA)
relaxation of cardiac muscle  (IMP)
response to activity  (ISO)
response to butyrate  (ISO)
response to dexamethasone  (ISO)
response to L-leucine  (ISO)
response to muscle inactivity  (ISO)
response to muscle stretch  (IMP)
TORC2 signaling  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
adenosine signaling pathway   (ISO)
aldosterone signaling pathway  (IEA)
altered phosphatidylinositol 3-kinase signaling pathway  (ISO)
altered phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway   (ISO)
endometrial cancer pathway  (IEA,ISO)
Entamoebiasis pathway  (IEA)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway   (IEA,ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (ISO)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway   (ISO)
Hedgehog signaling pathway  (ISO)
hepatitis C pathway  (IEA)
influenza A pathway  (IEA)
inositol metabolic pathway  (ISO)
inositol phosphate metabolic pathway   (IEA)
insulin signaling pathway  (IEA,ISO)
insulin-like growth factor signaling pathway   (ISO)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
interleukin-23 signaling pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
interleukin-5 signaling pathway   (ISO)
interleukin-6 signaling pathway   (ISO)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway   (IEA)
mTOR signaling pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA,ISO)
nuclear factor kappa B signaling pathway   (ISO)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
phosphoinositide metabolic pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA,ISO)
Reelin signaling pathway   (ISO)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway   (ISO)
type 2 diabetes mellitus pathway  (IEA)
type II interferon signaling pathway   (ISO)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal anogenital distance  (IAGP)
abnormal anterior cardinal vein morphology  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cell physiology  (IAGP)
abnormal circulating androgen level  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal endocardium morphology  (IAGP)
abnormal hormone level  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal lymphangiogenesis  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal mammary duct terminal end bud morphology  (IAGP)
abnormal mammary gland duct morphology  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland myoepithelium morphology  (IAGP)
abnormal mammary gland stroma morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal ovary physiology  (IAGP)
abnormal perineural vascular plexus morphology  (IAGP)
abnormal peritoneum morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal testis physiology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
abnormal white adipose tissue physiology  (IAGP)
blood vessel congestion  (IAGP)
chylous ascites  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased embryo size  (IAGP)
decreased fibroblast apoptosis  (IAGP)
decreased heart weight  (IAGP)
decreased incidence of induced tumors  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased lean body mass  (IAGP)
decreased lung tumor incidence  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased testis weight  (IAGP)
delayed balanopreputial separation  (IAGP)
delayed sexual maturation  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
fetal growth retardation  (IAGP)
hemorrhage  (IAGP)
hemorrhagic ascites  (IAGP)
impaired glucose tolerance  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased body weight  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating testosterone level  (IAGP)
increased fat cell size  (IAGP)
increased fibroadenoma incidence  (IAGP)
increased fibroblast proliferation  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased heart left ventricle size  (IAGP)
increased mammary adenoacanthoma incidence  (IAGP)
increased mammary gland epithelial cell proliferation  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased medulloblastoma incidence  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased skin hamartoma incidence  (IAGP)
increased total body fat amount  (IAGP)
insulin resistance  (IAGP)
internal hemorrhage  (IAGP)
male infertility  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
ovary hemorrhage  (IAGP)
pale yolk sac  (IAGP)
polyphagia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
retina cone cell degeneration  (IAGP)
skin lesions  (IAGP)
thick epidermis stratum basale  (IAGP)
thick skin  (IAGP)
thick ventricular wall  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
2. The mutational landscape of prostate cancer. Barbieri CE, etal., Eur Urol. 2013 Oct;64(4):567-76. doi: 10.1016/j.eururo.2013.05.029. Epub 2013 May 18.
3. Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. Beca F, etal., Mod Pathol. 2020 Aug;33(8):1518-1526. doi: 10.1038/s41379-020-0511-6. Epub 2020 Mar 2.
4. Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus-associated gastric carcinoma. Dong M, etal., Hum Pathol. 2016 Jul;53:25-34. doi: 10.1016/j.humpath.2016.02.007. Epub 2016 Mar 4.
5. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
6. PI3K/Akt: getting it right matters. Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
7. Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. Guo XN, etal., Cancer Res. 2007 Jun 15;67(12):5851-8.
8. Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects. Hare LM, etal., Dev Biol. 2015 Aug 1;404(1):14-26. doi: 10.1016/j.ydbio.2015.04.022. Epub 2015 May 7.
9. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
10. Correlation of DLC1 gene methylation with oncogenic PIK3CA mutations in extramammary Paget's disease. Kang Z, etal., Mod Pathol. 2012 Aug;25(8):1160-8. doi: 10.1038/modpathol.2012.65. Epub 2012 Apr 20.
11. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
12. Clinicopathological characteristics of PIK3CA and HBx mutations in Korean patients with hepatocellular carcinomas. Kim DC, etal., APMIS. 2014 Oct;122(10):1001-6. doi: 10.1111/apm.12245. Epub 2014 Mar 28.
13. An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice. Kinross KM, etal., J Clin Invest. 2012 Feb;122(2):553-7. doi: 10.1172/JCI59309. Epub 2012 Jan 3.
14. PIK3CA polymorphisms associated with susceptibility to hepatocellular carcinoma. Li HG, etal., Int J Clin Exp Pathol. 2015 Nov 1;8(11):15255-9. eCollection 2015.
15. [A study of the relationship between the mutation of PIK3CA, PTEN and the occurrence of liver metastasis of colorectal cancer: survival analysis]. Liang L, etal., Zhonghua Wai Ke Za Zhi. 2012 Nov;50(11):1007-10.
16. Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA. Lindhurst MJ, etal., Nat Genet. 2012 Jun 24;44(8):928-33. doi: 10.1038/ng.2332.
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. MGD IEA MGD IEA
19. Mutations of the PIK3CA gene in hereditary colorectal cancers. Miyaki M, etal., Int J Cancer. 2007 Oct 1;121(7):1627-30. doi: 10.1002/ijc.22829.
20. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. New driver mutations in non-small-cell lung cancer. Pao W and Girard N, Lancet Oncol. 2011 Feb;12(2):175-80.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat. Ren XS, etal., PLoS One. 2014 Jan 30;9(1):e87660. doi: 10.1371/journal.pone.0087660. eCollection 2014.
27. Mouse MP Annotation Import Pipeline RGD automated import pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Somatic mutations of signaling genes in non-small-cell lung cancer. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
31. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. Schubert M, etal., J Neurosci 2003 Aug 6;23(18):7084-92.
32. Exon 9 Mutation of PIK3CA Associated With Poor Survival in Patients With Epstein-Barr Virus-associated Gastric Cancer. Seo AN, etal., Anticancer Res. 2019 Apr;39(4):2145-2154. doi: 10.21873/anticanres.13328.
33. Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. Slattery ML, etal., Carcinogenesis. 2010 Sep;31(9):1604-11. Epub 2010 Jul 9.
34. Analysis of ESR1 and PIK3CA mutations in plasma cell-free DNA from ER-positive breast cancer patients. Takeshita T, etal., Oncotarget. 2017 Jun 14;8(32):52142-52155. doi: 10.18632/oncotarget.18479. eCollection 2017 Aug 8.
35. Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients. Tanaka Y, etal., Oncogene. 2006 May 11;25(20):2950-2. doi: 10.1038/sj.onc.1209311.
36. LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. Wang S, etal., Aging (Albany NY). 2022 Aug 30;14(16):6809-6828. doi: 10.18632/aging.204256. Epub 2022 Aug 30.
37. PIK3CA and PIK3CB expression and relationship with multidrug resistance in colorectal carcinoma. Wen F, etal., Int J Clin Exp Pathol. 2014 Oct 15;7(11):8295-303. eCollection 2014.
38. MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. Wu YR, etal., Tumour Biol. 2016 Sep;37(9):12061-12070. doi: 10.1007/s13277-016-5074-2. Epub 2016 May 17.
39. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
40. Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Zhang XF, etal., Hepatology. 2010 Sep;52(3):954-65. doi: 10.1002/hep.23747.
41. Expression and significance of EBV, ARID1A and PIK3CA in gastric carcinoma. Zhou H, etal., Mol Med Rep. 2019 Mar;19(3):2125-2136. doi: 10.3892/mmr.2019.9886. Epub 2019 Jan 22.
Additional References at PubMed
PMID:7534285   PMID:7542745   PMID:8139567   PMID:8889548   PMID:8947469   PMID:9235916   PMID:9671713   PMID:9852579   PMID:9927325   PMID:10094829   PMID:10196176   PMID:10349636  
PMID:10462494   PMID:10835352   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11784871   PMID:11902114   PMID:11903815   PMID:11919689   PMID:12086468   PMID:12162464   PMID:12477932  
PMID:12486171   PMID:12704201   PMID:14507992   PMID:14597618   PMID:14610273   PMID:14657280   PMID:14681479   PMID:15102471   PMID:15192701   PMID:15197263   PMID:15249583   PMID:15377662  
PMID:15496927   PMID:15687236   PMID:15713620   PMID:15829307   PMID:16005454   PMID:16039615   PMID:16141072   PMID:16141073   PMID:16467569   PMID:16514418   PMID:16625210   PMID:16647110  
PMID:17060635   PMID:17202264   PMID:17475835   PMID:17540175   PMID:17579043   PMID:17596516   PMID:17682062   PMID:17846664   PMID:17908814   PMID:17920279   PMID:18070887   PMID:18187452  
PMID:18239469   PMID:18285463   PMID:18287559   PMID:18367611   PMID:18449193   PMID:18590694   PMID:18594509   PMID:18653476   PMID:18668519   PMID:18799693   PMID:18932194   PMID:18988856  
PMID:19033389   PMID:19047141   PMID:19047410   PMID:19126672   PMID:19172191   PMID:19196980   PMID:19505983   PMID:19509054   PMID:19597047   PMID:19604150   PMID:19679877   PMID:19815551  
PMID:19819947   PMID:19822807   PMID:19834495   PMID:19883613   PMID:20167228   PMID:20167866   PMID:20197055   PMID:20237330   PMID:20505078   PMID:20534549   PMID:20620998   PMID:20665729  
PMID:20699475   PMID:20847309   PMID:20953381   PMID:21037083   PMID:21047779   PMID:21059846   PMID:21188463   PMID:21219477   PMID:21246652   PMID:21267068   PMID:21367821   PMID:21454528  
PMID:21464441   PMID:21540297   PMID:21593423   PMID:21677750   PMID:21703185   PMID:21731673   PMID:21757757   PMID:21780115   PMID:21872252   PMID:21873635   PMID:21912691   PMID:21917798  
PMID:21946561   PMID:22038742   PMID:22084313   PMID:22120714   PMID:22150431   PMID:22212451   PMID:22370636   PMID:22378847   PMID:22525701   PMID:22539774   PMID:22628411   PMID:22666336  
PMID:22673621   PMID:22683270   PMID:22705768   PMID:22722829   PMID:22737248   PMID:22750293   PMID:22777522   PMID:22802530   PMID:22806988   PMID:22824041   PMID:22905202   PMID:22972933  
PMID:23001375   PMID:23023391   PMID:23029326   PMID:23051731   PMID:23066026   PMID:23137199   PMID:23142539   PMID:23258246   PMID:23275335   PMID:23384338   PMID:23386617   PMID:23418602  
PMID:23483710   PMID:23499052   PMID:23514933   PMID:23541372   PMID:23568272   PMID:23633485   PMID:23671068   PMID:23706742   PMID:23708654   PMID:23873941   PMID:23940356   PMID:24019382  
PMID:24043760   PMID:24131925   PMID:24169049   PMID:24200692   PMID:24229709   PMID:24320611   PMID:24415347   PMID:24553178   PMID:24569456   PMID:24645666   PMID:24651434   PMID:24691033  
PMID:24737887   PMID:24770869   PMID:24806753   PMID:24885555   PMID:24896346   PMID:24903091   PMID:24991009   PMID:24996183   PMID:25003191   PMID:25095381   PMID:25106857   PMID:25269483  
PMID:25311989   PMID:25327288   PMID:25398937   PMID:25452273   PMID:25471065   PMID:25472943   PMID:25526474   PMID:25536376   PMID:25550458   PMID:25589743   PMID:25618408   PMID:25625625  
PMID:25688987   PMID:25698082   PMID:25742742   PMID:25772358   PMID:25826091   PMID:25908763   PMID:25937176   PMID:26040420   PMID:26058079   PMID:26123589   PMID:26169833   PMID:26201094  
PMID:26202910   PMID:26238783   PMID:26266985   PMID:26276752   PMID:26279473   PMID:26375425   PMID:26442967   PMID:26459773   PMID:26553657   PMID:26559013   PMID:26567140   PMID:26633882  
PMID:26716908   PMID:26814435   PMID:26863299   PMID:26872540   PMID:26876212   PMID:26880557   PMID:26883061   PMID:26896753   PMID:26905199   PMID:26988598   PMID:27022680   PMID:27030594  
PMID:27030595   PMID:27050100   PMID:27071537   PMID:27119228   PMID:27138914   PMID:27197196   PMID:27235117   PMID:27304846   PMID:27321283   PMID:27402769   PMID:27474268   PMID:27482546  
PMID:27522498   PMID:27588403   PMID:27621448   PMID:27647425   PMID:27681437   PMID:27700986   PMID:27708159   PMID:27799550   PMID:27910071   PMID:27965101   PMID:28122344   PMID:28273403  
PMID:28292957   PMID:28350865   PMID:28357399   PMID:28542142   PMID:28692045   PMID:28710365   PMID:28783168   PMID:28847905   PMID:28923937   PMID:29097657   PMID:29103956   PMID:29170395  
PMID:29212950   PMID:29346447   PMID:29449337   PMID:29505847   PMID:29535720   PMID:29581096   PMID:29581176   PMID:29718345   PMID:29902570   PMID:29983910   PMID:30076411   PMID:30106118  
PMID:30332649   PMID:30354258   PMID:30361695   PMID:30446640   PMID:30530704   PMID:30568254   PMID:30590030   PMID:30592646   PMID:30627910   PMID:30728366   PMID:30905780   PMID:30948720  
PMID:30982732   PMID:31094678   PMID:31120863   PMID:31241463   PMID:31266893   PMID:31336140   PMID:31363081   PMID:31373426   PMID:31391455   PMID:31452510   PMID:31844152   PMID:31881983  
PMID:31915252   PMID:32059806   PMID:32152233   PMID:32290105   PMID:32325033   PMID:32365913   PMID:32414808   PMID:32513927   PMID:32997991   PMID:33031974   PMID:33065020   PMID:33094520  
PMID:33159421   PMID:33378226   PMID:33431926   PMID:33539876   PMID:33577435   PMID:33876772   PMID:33887328   PMID:33910229   PMID:34079126   PMID:34193412   PMID:34203838   PMID:34321999  
PMID:34445401   PMID:34496175   PMID:34748271   PMID:34899181   PMID:35008427   PMID:35013322   PMID:35264433   PMID:35538223   PMID:35676931   PMID:35976093   PMID:36078116   PMID:36469488  
PMID:36490341   PMID:36539073   PMID:36719480   PMID:36812307   PMID:36899933   PMID:37188724   PMID:37544503   PMID:37606694   PMID:37704707   PMID:38330136   PMID:38656871   PMID:38842935  


Genomics

Comparative Map Data
Pik3ca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,451,203 - 32,520,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,451,820 - 32,522,635 (+)EnsemblGRCm39 Ensembl
GRCm38332,397,065 - 32,466,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,397,671 - 32,468,486 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,335,073 - 32,367,408 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,627,755 - 32,654,380 (+)NCBIMGSCv36mm8
Celera332,346,082 - 32,378,426 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.7NCBI
PIK3CA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383179,148,126 - 179,240,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3179,148,114 - 179,240,093 (+)EnsemblGRCh38hg38GRCh38
GRCh373178,866,145 - 178,957,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,349,005 - 180,435,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 343180,349,012 - 180,435,197NCBI
Celera3177,295,797 - 177,383,366 (+)NCBICelera
Cytogenetic Map3q26.32NCBI
HuRef3176,269,843 - 176,355,772 (+)NCBIHuRef
CHM1_13178,829,221 - 178,915,414 (+)NCBICHM1_1
T2T-CHM13v2.03181,951,917 - 182,043,930 (+)NCBIT2T-CHM13v2.0
Pik3ca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82117,103,643 - 117,177,411 (+)NCBIGRCr8
mRatBN7.22115,175,275 - 115,249,034 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2115,174,984 - 115,249,032 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2121,832,703 - 121,862,791 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02119,945,342 - 119,975,430 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02114,646,275 - 114,676,345 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02118,831,350 - 118,861,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,831,350 - 118,861,454 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02138,491,967 - 138,521,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,640,277 - 118,672,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12118,603,330 - 118,613,969 (+)NCBI
Celera2110,329,861 - 110,360,075 (+)NCBICelera
Cytogenetic Map2q24NCBI
Pik3ca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554208,356,353 - 8,427,024 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554208,355,415 - 8,427,024 (+)NCBIChiLan1.0ChiLan1.0
PIK3CA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22177,018,967 - 177,103,829 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13177,023,686 - 177,108,546 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03176,182,765 - 176,272,024 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13184,355,789 - 184,441,997 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3184,355,785 - 184,441,977 (+)Ensemblpanpan1.1panPan2
PIK3CA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13412,600,140 - 12,681,905 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3412,600,233 - 12,675,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,743,641 - 16,822,678 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03412,496,918 - 12,576,076 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3412,497,011 - 12,573,751 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13412,551,928 - 12,630,858 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03412,531,843 - 12,610,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,771,120 - 12,850,124 (+)NCBIUU_Cfam_GSD_1.0
Pik3ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602109,269,676 - 109,296,792 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365663,923,934 - 3,951,073 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365663,924,013 - 3,951,052 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13117,180,544 - 117,274,587 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113117,193,935 - 117,282,151 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213126,401,142 - 126,461,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11510,218,034 - 10,304,874 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1510,218,805 - 10,294,316 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606319,096,074 - 19,187,036 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3ca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473056,938,215 - 56,966,137 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473056,895,065 - 56,970,563 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3ca
2286 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2871
Count of miRNA genes:717
Interacting mature miRNAs:886
Transcripts:ENSMUST00000029201, ENSMUST00000108242, ENSMUST00000108243
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32017486254180103Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1828816852288168Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3452541938525519Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31163045345630591Mouse

Markers in Region
RH126565  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38332,464,113 - 32,464,339UniSTSGRCm38
MGSCv37332,363,035 - 32,363,261UniSTSGRCm37
Celera332,374,044 - 32,374,270UniSTS
Cytogenetic Map3BUniSTS
cM Map312.4UniSTS
Pik3ca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38332,432,971 - 32,433,224UniSTSGRCm38
MGSCv37332,331,893 - 32,332,146UniSTSGRCm37
Celera332,342,902 - 32,343,155UniSTS
Cytogenetic Map3BUniSTS
cM Map312.4UniSTS
Pik3ca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3BUniSTS
Pik3ca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38332,436,281 - 32,436,539UniSTSGRCm38
MGSCv37332,335,203 - 32,335,461UniSTSGRCm37
Celera332,346,212 - 32,346,470UniSTS
Cytogenetic Map3BUniSTS
Pik3ca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3BUniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC006868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000029201   ⟹   ENSMUSP00000029201
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,490,300 - 32,522,635 (+)Ensembl
GRCm38.p6 Ensembl332,436,151 - 32,468,486 (+)Ensembl
Ensembl Acc Id: ENSMUST00000108242   ⟹   ENSMUSP00000103877
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,490,525 - 32,520,256 (+)Ensembl
GRCm38.p6 Ensembl332,436,376 - 32,466,107 (+)Ensembl
Ensembl Acc Id: ENSMUST00000108243   ⟹   ENSMUSP00000103878
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,451,820 - 32,520,256 (+)Ensembl
GRCm38.p6 Ensembl332,397,671 - 32,466,107 (+)Ensembl
Ensembl Acc Id: ENSMUST00000195230
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,515,826 - 32,516,977 (+)Ensembl
GRCm38.p6 Ensembl332,461,677 - 32,462,828 (+)Ensembl
RefSeq Acc Id: NM_008839   ⟹   NP_032865
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39332,451,214 - 32,520,256 (+)NCBI
GRCm38332,397,065 - 32,466,107 (+)NCBI
MGSCv37332,335,073 - 32,367,408 (+)RGD
Celera332,346,082 - 32,378,426 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004941295
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39332,451,203 - 32,517,929 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032865   ⟸   NM_008839
- UniProtKB: Q0VGQ5 (UniProtKB/Swiss-Prot),   P42337 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000103878   ⟸   ENSMUST00000108243
Ensembl Acc Id: ENSMUSP00000103877   ⟸   ENSMUST00000108242
Ensembl Acc Id: ENSMUSP00000029201   ⟸   ENSMUST00000029201
Protein Domains
C2 PI3K-type   PI3K-ABD   PI3K-RBD   PI3K/PI4K catalytic   PIK helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42337-F1-model_v2 AlphaFold P42337 1-1068 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1206581 AgrOrtholog
Ensembl Genes ENSMUSG00000027665 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029201.14 UniProtKB/Swiss-Prot
  ENSMUST00000108242.2 UniProtKB/TrEMBL
  ENSMUST00000108243 ENTREZGENE
  ENSMUST00000108243.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_adapt-bd_dom UniProtKB/Swiss-Prot
  PI3K_C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_Ras-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kalpha_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI_Kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18706 UniProtKB/Swiss-Prot
MGD MGI:1206581 ENTREZGENE
NCBI Gene 18706 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10048 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/Swiss-Prot
  PI3K_rbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PIK3CA RGD
PhenoGen Pik3ca PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/Swiss-Prot
  PI3K_rbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YY41_MOUSE UniProtKB/TrEMBL
  P42337 ENTREZGENE, UniProtKB/Swiss-Prot
  Q0VGQ5 ENTREZGENE
UniProt Secondary Q0VGQ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-09 Pik3ca  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha    phosphatidylinositol 3-kinase, catalytic, alpha polypeptide  Symbol and/or name change 5135510 APPROVED