Gna11 (guanine nucleotide binding protein, alpha 11) - Rat Genome Database

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Gene: Gna11 (guanine nucleotide binding protein, alpha 11) Mus musculus
Analyze
Symbol: Gna11
Name: guanine nucleotide binding protein, alpha 11
RGD ID: 1551128
MGI Page MGI
Description: Enables G protein activity and enzyme regulator activity. Involved in several processes, including G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within several processes, including cellular response to pH; phospholipase C-activating dopamine receptor signaling pathway; and regulation of melanocyte differentiation. Is active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; cardiovascular system; central nervous system; and genitourinary system. Used to study autosomal dominant hypocalcemia 2. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Dsk; Dsk7; E430025L19; g alpha-11; G-protein subunit alpha-11; guanine nucleotide-binding protein subunit alpha-11; heterotrimeric guanine nucleotide-binding protein 1k; Hg1k
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,364,558 - 81,380,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,364,558 - 81,381,024 (-)EnsemblGRCm39 Ensembl
GRCm381081,528,724 - 81,545,162 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,528,724 - 81,545,190 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,991,477 - 81,007,791 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,931,861 - 80,948,175 (-)NCBIMGSCv36mm8
Celera1082,551,913 - 82,568,227 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbachol  (ISO)
cisplatin  (ISO)
D-glucose  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
fluoxetine  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furfural  (ISO)
glucose  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-ethyl-5'-carboxamidoadenosine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
progesterone  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
streptozocin  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
heterotrimeric G-protein complex  (IBA,ISA,ISO,TAS)
membrane  (IEA)
plasma membrane  (IDA,IEA,IGI,ISO)
presynapse  (ISO)
synapse  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alisphenoid bone morphology  (IAGP)
abnormal behavior  (IEA)
abnormal bone mineralization  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal circulating calcium level  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal heart size  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal larynx morphology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal parathyroid gland morphology  (IAGP)
abnormal pterygoid process morphology  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal thyroid follicular cell morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal thyroid gland physiology  (IAGP)
abnormal tympanic ring morphology  (IAGP)
abnormal urine calcium level  (IAGP)
abnormal vascular wound healing  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
clonic seizures  (IAGP)
common ventricle  (IAGP)
darkened coat color  (IAGP)
decreased activity of thyroid gland  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone trabecula number  (IAGP)
decreased circulating amylase level  (IEA)
decreased circulating calcium level  (IAGP)
decreased circulating parathyroid hormone level  (IAGP)
decreased circulating phosphate level  (IEA)
decreased circulating thyroxine level  (IAGP)
decreased circulating total protein level  (IEA)
decreased circulating triglyceride level  (IEA)
decreased compact bone thickness  (IAGP)
decreased erythrocyte cell number  (IEA)
decreased hematocrit  (IEA)
decreased hemoglobin content  (IEA)
decreased mean corpuscular volume  (IEA)
decreased mean systemic arterial blood pressure  (IAGP)
decreased nitrate level  (IAGP)
decreased pulmonary respiratory rate  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased susceptibility to type I hypersensitivity reaction  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased vascular permeability  (IAGP)
decreased vasoconstriction  (IAGP)
decreased vasodilation  (IAGP)
delayed endochondral bone ossification  (IAGP)
domed cranium  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
gliosis  (IAGP)
heart hypoplasia  (IAGP)
hemopericardium  (IAGP)
hepatic steatosis  (IAGP)
hippocampal neuron degeneration  (IAGP)
hyperpigmentation  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
hypoxia  (IAGP)
increased bone resorption  (IAGP)
increased bone trabecular spacing  (IAGP)
increased circulating calcium level  (IEA)
increased circulating parathyroid hormone level  (IAGP)
increased circulating phosphate level  (IAGP)
increased circulating thyroid-stimulating hormone level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased ear pigmentation  (IAGP)
increased foot pad pigmentation  (IAGP)
increased liver triglyceride level  (IAGP)
increased red blood cell distribution width  (IEA)
increased susceptibility to hypertension  (IAGP)
increased tail pigmentation  (IAGP)
increased urine calcium level  (IAGP)
incus hypoplasia  (IAGP)
lower jaw to upper jaw transformation  (IAGP)
malleus hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
proportional dwarf  (IAGP)
rachitic rosary  (IAGP)
seizures  (IAGP)
short mandible  (IAGP)
short snout  (IAGP)
small thyroid gland  (IAGP)
stapes hypoplasia  (IAGP)
thrombocytopenia  (IEA)
tonic-clonic seizures  (IAGP)
trabecula carnea hypoplasia  (IAGP)
ventricular myocardium compact layer hypoplasia  (IAGP)
vertebral fusion  (IEA)
wide cranial sutures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Molecular properties of muscarinic acetylcholine receptors. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
2. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
3. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. Offermanns S, etal., EMBO J 1998 Aug 3;17(15):4304-12.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Puttagunta R, etal., Genome Res 2000 Sep;10(9):1369-80.
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
Additional References at PubMed
PMID:1302014   PMID:1707501   PMID:1846707   PMID:2123549   PMID:2508088   PMID:3133654   PMID:8588930   PMID:8836152   PMID:8838318   PMID:8858601   PMID:8889548   PMID:9607776  
PMID:9765251   PMID:10349636   PMID:10629036   PMID:10818132   PMID:10829070   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11438569   PMID:11443126   PMID:11544199   PMID:11689889  
PMID:11826096   PMID:12351712   PMID:12477932   PMID:12533510   PMID:12648486   PMID:14610273   PMID:15175381   PMID:15322542   PMID:15340067   PMID:15713647   PMID:15782199   PMID:15872115  
PMID:15936338   PMID:16141072   PMID:16141073   PMID:16251183   PMID:16602821   PMID:16847339   PMID:16988000   PMID:17023430   PMID:17194762   PMID:17374359   PMID:17482476   PMID:17694176  
PMID:18084302   PMID:18086886   PMID:18199583   PMID:18287559   PMID:18583341   PMID:18854320   PMID:18991294   PMID:19171764   PMID:19320717   PMID:20023120   PMID:20372981   PMID:20440069  
PMID:20715175   PMID:20886089   PMID:21190563   PMID:21267068   PMID:21345793   PMID:21357625   PMID:21677750   PMID:21812758   PMID:21873635   PMID:22562663   PMID:22580821   PMID:22733973  
PMID:22794259   PMID:22972902   PMID:23129751   PMID:23696743   PMID:23836924   PMID:23973358   PMID:23988737   PMID:24081657   PMID:24194600   PMID:24308950   PMID:24591653   PMID:24838176  
PMID:24870805   PMID:24958088   PMID:25093805   PMID:25495873   PMID:25595485   PMID:25832730   PMID:25857352   PMID:26075576   PMID:26168216   PMID:26208885   PMID:26272756   PMID:26377475  
PMID:26410627   PMID:26476043   PMID:26531127   PMID:26595811   PMID:26628681   PMID:26843449   PMID:26938869   PMID:27006198   PMID:27300035   PMID:27348266   PMID:27364226   PMID:27797339  
PMID:27811142   PMID:28194446   PMID:28194447   PMID:28301547   PMID:28378742   PMID:28578927   PMID:28706196   PMID:28883467   PMID:29046478   PMID:29107092   PMID:29490280   PMID:29747224  
PMID:30068389   PMID:30270038   PMID:30301804   PMID:30936140   PMID:31091422   PMID:31461351   PMID:31549965   PMID:31857598   PMID:31896584   PMID:32325033   PMID:32332099   PMID:32576659  
PMID:33166186   PMID:33378226   PMID:34864945   PMID:35382561   PMID:37102682   PMID:38355793   PMID:38530370  


Genomics

Comparative Map Data
Gna11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,364,558 - 81,380,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,364,558 - 81,381,024 (-)EnsemblGRCm39 Ensembl
GRCm381081,528,724 - 81,545,162 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,528,724 - 81,545,190 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,991,477 - 81,007,791 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,931,861 - 80,948,175 (-)NCBIMGSCv36mm8
Celera1082,551,913 - 82,568,227 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
GNA11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,094,362 - 3,123,999 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,094,362 - 3,123,999 (+)EnsemblGRCh38hg38GRCh38
GRCh37193,094,360 - 3,123,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,045,408 - 3,072,468 (+)NCBINCBI36Build 36hg18NCBI36
Build 34193,045,529 - 3,072,452NCBI
Celera193,028,658 - 3,055,719 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,861,199 - 2,888,094 (+)NCBIHuRef
CHM1_1193,110,108 - 3,121,429 (+)NCBICHM1_1
T2T-CHM13v2.0193,068,114 - 3,097,735 (+)NCBIT2T-CHM13v2.0
Gna11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,814,285 - 8,828,628 (+)NCBIGRCr8
GRCr8 Ensembl78,814,327 - 8,830,558 (+)EnsemblGRCr8 Ensembl
mRatBN7.278,163,520 - 8,177,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,162,750 - 8,179,812 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,049,827 - 11,063,675 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,925,490 - 12,939,339 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,792,631 - 10,806,445 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,033,400 - 11,047,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,033,317 - 11,047,437 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,200,712 - 11,214,475 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,636,748 - 9,662,492 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera76,354,654 - 6,368,340 (+)NCBICelera
RGSC_v3.179,636,747 - 9,662,492 (+)NCBI
Cytogenetic Map7q11NCBI
Gna11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,285,380 - 5,302,631 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,286,891 - 5,302,631 (-)NCBIChiLan1.0ChiLan1.0
GNA11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,490,517 - 7,520,487 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,723,350 - 6,753,319 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,120,398 - 2,149,161 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,074,484 - 3,102,124 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,074,483 - 3,102,124 (+)Ensemblpanpan1.1panPan2
GNA11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2055,871,216 - 55,890,787 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,806,259 - 56,825,830 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,806,259 - 56,825,830 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,861,412 - 55,880,956 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,345,542 - 56,365,145 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,544,290 - 56,563,840 (-)NCBIUU_Cfam_GSD_1.0
Gna11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,045,637 - 216,064,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,770,771 - 1,789,170 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,770,777 - 1,789,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNA11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,437,201 - 75,457,092 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,439,405 - 75,456,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,071,093 - 76,088,406 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q21-q24NCBI
GNA11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,858,880 - 2,887,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,858,937 - 2,887,704 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660815,694,672 - 5,723,312 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gna11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,077,851 - 6,093,750 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,078,485 - 6,093,744 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gna11
327 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1511
Count of miRNA genes:663
Interacting mature miRNAs:851
Transcripts:ENSMUST00000043604, ENSMUST00000134354, ENSMUST00000146984
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
RH127565  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381081,528,793 - 81,528,994UniSTSGRCm38
MGSCv371080,991,538 - 80,991,739UniSTSGRCm37
Celera1082,551,974 - 82,552,175UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
Gna11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371080,993,366 - 80,993,563UniSTSGRCm37
Celera1082,553,802 - 82,553,999UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
UniSTS:236416  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381081,529,666 - 81,529,928UniSTSGRCm38
MGSCv371080,992,411 - 80,992,673UniSTSGRCm37
Celera1082,552,847 - 82,553,109UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
UniSTS:224669  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381081,530,616 - 81,530,719UniSTSGRCm38
MGSCv371080,993,361 - 80,993,464UniSTSGRCm37
Celera1082,553,797 - 82,553,900UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
Gna11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381081,530,621 - 81,530,818UniSTSGRCm38
MGSCv371080,993,366 - 80,993,563UniSTSGRCm37
Celera1082,553,802 - 82,553,999UniSTS
Cytogenetic Map10C1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000043604   ⟹   ENSMUSP00000043190
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,364,558 - 81,381,024 (-)Ensembl
GRCm38.p6 Ensembl1081,528,724 - 81,545,190 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134354
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,368,967 - 81,370,967 (-)Ensembl
GRCm38.p6 Ensembl1081,533,133 - 81,535,133 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146984
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,366,121 - 81,367,849 (-)Ensembl
GRCm38.p6 Ensembl1081,530,287 - 81,532,015 (-)Ensembl
RefSeq Acc Id: NM_010301   ⟹   NP_034431
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,364,558 - 81,380,996 (-)NCBI
GRCm381081,528,724 - 81,545,162 (-)NCBI
MGSCv371080,991,477 - 81,007,791 (-)RGD
Celera1082,551,913 - 82,568,227 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034431   ⟸   NM_010301
- UniProtKB: Q61939 (UniProtKB/Swiss-Prot),   P21278 (UniProtKB/Swiss-Prot),   Q3UPA1 (UniProtKB/TrEMBL),   Q91X95 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000043190   ⟸   ENSMUST00000043604
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21278-F1-model_v2 AlphaFold P21278 1-359 view protein structure

Promoters
RGD ID:6819382
Promoter ID:MM_KWN:5017
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Spleen
Transcripts:UC007GIK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361080,994,106 - 80,995,307 (-)MPROMDB
RGD ID:6819383
Promoter ID:MM_KWN:5018
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000074980
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361080,997,206 - 80,997,706 (-)MPROMDB
RGD ID:6819381
Promoter ID:MM_KWN:5019
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000074975
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361081,007,476 - 81,008,322 (-)MPROMDB
RGD ID:8672826
Promoter ID:EPDNEW_M14444
Type:initiation region
Name:Gna11_1
Description:Mus musculus guanine nucleotide binding protein, alpha 11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381081,545,091 - 81,545,151EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95766 AgrOrtholog
Ensembl Genes ENSMUSG00000034781 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000043604 ENTREZGENE
  ENSMUST00000043604.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro Gprotein_alpha_Q UniProtKB/Swiss-Prot
  Gprotein_alpha_su UniProtKB/Swiss-Prot
  GproteinA_insert UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:14672 UniProtKB/Swiss-Prot
MGD MGI:95766 ENTREZGENE
NCBI Gene 14672 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11 UniProtKB/Swiss-Prot
  PTHR10218 UniProtKB/Swiss-Prot
Pfam G-alpha UniProtKB/Swiss-Prot
PhenoGen Gna11 PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot
  GPROTEINAQ UniProtKB/Swiss-Prot
PROSITE G_ALPHA UniProtKB/Swiss-Prot
SMART G_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt GNA11_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UPA1 ENTREZGENE, UniProtKB/TrEMBL
  Q61939 ENTREZGENE
  Q8C2E2_MOUSE UniProtKB/TrEMBL
  Q91X95 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q61939 UniProtKB/Swiss-Prot