Mrgpre (MAS-related GPR, member E) - Rat Genome Database

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Gene: Mrgpre (MAS-related GPR, member E) Mus musculus
Analyze
Symbol: Mrgpre
Name: MAS-related GPR, member E
RGD ID: 1550915
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cartilage; eye; genitourinary system; and nervous system. Orthologous to human MRGPRE (MAS related GPR family member E).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C130069N09Rik; Ebrt3; evolutionary breakpoint transcript 3 protein; G protein-coupled receptor MrgE; Mas-related G protein-coupled receptor f; mas-related G-protein coupled receptor member E; Mgrf; Mrg; MrgE
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397143,332,100 - 143,338,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7143,332,100 - 143,338,237 (-)EnsemblGRCm39 Ensembl
GRCm387143,778,363 - 143,784,500 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,778,363 - 143,784,500 (-)EnsemblGRCm38mm10GRCm38
MGSCv377150,964,268 - 150,970,405 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367143,587,755 - 143,593,708 (-)NCBIMGSCv36mm8
Celera7143,534,742 - 143,540,879 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11551509   PMID:12397184   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18197975   PMID:21267068  
PMID:21873635   PMID:21912971   PMID:21947380   PMID:24194600   PMID:24583173   PMID:34321999   PMID:34647371   PMID:38355793  


Genomics

Comparative Map Data
Mrgpre
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397143,332,100 - 143,338,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7143,332,100 - 143,338,237 (-)EnsemblGRCm39 Ensembl
GRCm387143,778,363 - 143,784,500 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,778,363 - 143,784,500 (-)EnsemblGRCm38mm10GRCm38
MGSCv377150,964,268 - 150,970,405 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367143,587,755 - 143,593,708 (-)NCBIMGSCv36mm8
Celera7143,534,742 - 143,540,879 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.31NCBI
MRGPRE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38113,225,030 - 3,232,417 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl113,225,030 - 3,232,417 (-)EnsemblGRCh38hg38GRCh38
GRCh37113,246,260 - 3,253,647 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36113,205,617 - 3,210,192 (-)NCBINCBI36Build 36hg18NCBI36
Celera113,284,634 - 3,289,260 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
CHM1_1113,248,699 - 3,253,274 (-)NCBICHM1_1
T2T-CHM13v2.0113,316,000 - 3,323,368 (-)NCBIT2T-CHM13v2.0
Mrgpre
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81208,393,141 - 208,401,252 (-)NCBIGRCr8
mRatBN7.21198,963,786 - 198,969,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,963,787 - 198,969,521 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1207,345,752 - 207,346,681 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01214,427,692 - 214,428,621 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,101,860 - 207,102,789 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,969,464 - 216,973,936 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,970,254 - 216,971,183 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,825,104 - 223,830,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41204,171,075 - 204,172,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11204,324,527 - 204,325,457 (-)NCBI
Celera1196,529,375 - 196,530,304 (-)NCBICelera
Cytogenetic Map1q42NCBI
Mrgpre
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542214,976,730 - 14,982,295 (-)NCBIChiLan1.0ChiLan1.0
MRGPRE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v295,626,066 - 5,634,066 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1114,837,374 - 4,845,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0113,239,980 - 3,247,880 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1113,262,444 - 3,267,440 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl113,263,249 - 3,264,187 (-)Ensemblpanpan1.1panPan2
Mrgpre
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049473,401,521 - 3,406,868 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367941,346,350 - 1,347,939 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367941,346,350 - 1,347,291 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRGPRE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.113,041,908 - 3,049,499 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl13,045,744 - 3,046,673 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038100,238,653 - 100,243,615 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrgpre
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,979,561 - 15,988,846 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476715,976,090 - 15,988,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrgpre
143 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:899
Count of miRNA genes:538
Interacting mature miRNAs:617
Transcripts:ENSMUST00000054048
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse


Sequence


Ensembl Acc Id: ENSMUST00000054048   ⟹   ENSMUSP00000058000
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7143,332,100 - 143,338,237 (-)Ensembl
GRCm38.p6 Ensembl7143,778,363 - 143,784,500 (-)Ensembl
RefSeq Acc Id: NM_175534   ⟹   NP_780743
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397143,332,100 - 143,338,237 (-)NCBI
GRCm387143,778,363 - 143,784,500 (-)ENTREZGENE
MGSCv377150,964,268 - 150,970,405 (-)RGD
Celera7143,534,742 - 143,540,879 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036153126   ⟹   XP_036009019
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397143,332,767 - 143,337,855 (-)NCBI
Sequence:
RefSeq Acc Id: NP_780743   ⟸   NM_175534
- UniProtKB: Q711I9 (UniProtKB/Swiss-Prot),   Q91ZB7 (UniProtKB/Swiss-Prot),   Q4V9R2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000058000   ⟸   ENSMUST00000054048
RefSeq Acc Id: XP_036009019   ⟸   XM_036153126
- Peptide Label: isoform X1
- UniProtKB: Q91ZB7 (UniProtKB/Swiss-Prot),   Q711I9 (UniProtKB/Swiss-Prot),   Q4V9R2 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZB7-F1-model_v2 AlphaFold Q91ZB7 1-310 view protein structure

Promoters
RGD ID:8666269
Promoter ID:EPDNEW_M11166
Type:multiple initiation site
Name:Mrgpre_1
Description:Mus musculus MAS-related GPR, member E , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387143,784,294 - 143,784,354EPDNEW
RGD ID:6841568
Promoter ID:MM_KWN:53410
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_175534,   NM_175534_MRGPRE
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367150,970,106 - 150,971,012 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2441884 AgrOrtholog
Ensembl Genes ENSMUSG00000048965 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000054048 ENTREZGENE
  ENSMUST00000054048.10 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:244238 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2441884 ENTREZGENE
NCBI Gene 244238 ENTREZGENE
PANTHER PTHR11334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11334:SF26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mrgpre PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MRGRE_MOUSE UniProtKB/Swiss-Prot
  Q4V9R2 ENTREZGENE, UniProtKB/TrEMBL
  Q711I9 ENTREZGENE
  Q91ZB7 ENTREZGENE
UniProt Secondary Q711I9 UniProtKB/Swiss-Prot