Spint1 (serine protease inhibitor, Kunitz type 1)

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Gene: Spint1 (serine protease inhibitor, Kunitz type 1) Mus musculus

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Symbol:

Spint1

Name:

serine protease inhibitor, Kunitz type 1

RGD ID:

1550885

MGI Page

MGI

Description:

Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within chordate embryonic development; extracellular matrix organization; and placenta blood vessel development. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; hemolymphoid system; and sensory organ. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

HAI; HAI-1; hepatocyte growth factor activator inhibitor type 1; kunitz-type protease inhibitor 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	119,067,841 - 119,079,995 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	119,067,843 - 119,080,008 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	119,237,360 - 119,249,535 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	119,237,362 - 119,249,527 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	119,063,096 - 119,075,250 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	118,928,918 - 118,940,633 (+)	NCBI		MGSCv36	mm8
Celera	2	120,387,921 - 120,400,196 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.97	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

biliary atresia (ISO)

Bloom syndrome (ISO)

breast cancer (ISO)

cholestasis (IEP)

colorectal cancer (ISO)

Colorectal Neoplasms (ISO)

ichthyosis (IMP)

liver cirrhosis (ISO)

mosaic variegated aneuploidy syndrome 1 (ISO)

ovarian cancer (ISO)

primary biliary cholangitis (IEP)

prostate carcinoma (ISO)

stomach carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

1-naphthyl isothiocyanate (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3',4,4',5-Pentachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-Nitrobenzanthrone (ISO)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (EXP)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

aldrin (EXP)

all-trans-retinoic acid (EXP,ISO)

aristolochic acid A (ISO)

Aroclor 1254 (EXP)

arsenous acid (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

butan-1-ol (ISO)

cadmium dichloride (ISO)

camptothecin (ISO)

choline (EXP)

cisplatin (ISO)

DDE (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

folic acid (EXP)

gentamycin (ISO)

hydralazine (ISO)

inulin (EXP)

L-methionine (EXP)

N-ethyl-N-nitrosourea (EXP)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (ISO)

Nutlin-3 (ISO)

oxaliplatin (ISO)

ozone (EXP)

paracetamol (EXP)

PCB138 (EXP,ISO)

perfluorooctane-1-sulfonic acid (EXP)

pirinixic acid (ISO)

potassium dichromate (EXP)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (EXP)

Soman (ISO)

sulforaphane (ISO)

sunitinib (ISO)

thioacetamide (ISO)

thiram (ISO)

topotecan (ISO)

tributylstannane (EXP)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

triptonide (EXP)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branching involved in labyrinthine layer morphogenesis (IMP)

cellular response to BMP stimulus (ISO)

embryonic placenta development (IMP)

epidermis development (IBA)

epithelium development (IBA)

extracellular matrix organization (IBA,IMP)

negative regulation of neural precursor cell proliferation (ISO)

negative regulation of peptidase activity (IEA)

neural tube closure (IGI)

placenta blood vessel development (IMP)

positive regulation of glial cell differentiation (ISO)

symbiont entry into host cell (ISO)

Cellular Component

cytoplasm (IEA)

extracellular region (IEA)

membrane (IEA)

plasma membrane (IBA,IDA)

Molecular Function

peptidase inhibitor activity (IEA)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IBA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal basement membrane morphology (IAGP)

abnormal chorionic plate morphology (IAGP)

abnormal coat appearance (IAGP)

abnormal corneocyte morphology (IAGP)

abnormal defecation (IAGP)

abnormal enterocyte proliferation (IAGP)

abnormal epidermal layer morphology (IAGP)

abnormal epidermis stratum corneum morphology (IAGP)

abnormal intestine physiology (IAGP)

abnormal large intestine crypts of Lieberkuhn morphology (IAGP)

abnormal placenta development (IAGP)

abnormal placenta labyrinth morphology (IAGP)

abnormal placenta morphology (IAGP)

abnormal placenta vasculature (IAGP)

abnormal placental labyrinth vasculature morphology (IAGP)

abnormal placental transport (IAGP)

abnormal trophoblast giant cell morphology (IAGP)

abnormal trophoblast layer morphology (IAGP)

absent gastric milk in neonates (IAGP)

absent placental labyrinth (IAGP)

absent vibrissae (IAGP)

curly tail (IAGP)

diarrhea (IAGP)

dry skin (IAGP)

embryonic growth arrest (IAGP)

embryonic growth retardation (IAGP)

embryonic lethality during organogenesis, complete penetrance (IAGP)

enlarged pericardium (IAGP)

exencephaly (IAGP)

increased embryonic tissue cell apoptosis (IAGP)

increased enterocyte apoptosis (IAGP)

increased susceptibility to induced colitis (IAGP)

increased susceptibility to weight loss (IAGP)

increased susceptibility to xenobiotic induced morbidity/mortality (IAGP)

intestinal ulcer (IAGP)

neonatal lethality, complete penetrance (IAGP)

prenatal lethality, incomplete penetrance (IAGP)

preweaning lethality, complete penetrance (IEA)

preweaning lethality, incomplete penetrance (IEA)

reddish skin (IAGP)

small cecum (IAGP)

spina bifida (IAGP)

thin epidermis (IAGP)

wrinkled skin (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation.	Huang HP, etal., Hepatology. 2012 Jan;55(1):161-72. doi: 10.1002/hep.24657. Epub 2011 Nov 16.
2.	Expressions of molecules associated with hepatocyte growth factor activation after hepatectomy in liver cirrhosis.	Kaido T, etal., Hepatogastroenterology. 2004 Mar-Apr;51(56):547-51.
3.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4.	MGDs mouse GO annotations	MGD data from the GO Consortium
5.	MGD IEA	MGD IEA
6.	Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.	Nagaike K, etal., Am J Pathol. 2008 Nov;173(5):1464-75. doi: 10.2353/ajpath.2008.071142. Epub 2008 Oct 2.
7.	Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters.	Oberst MD, etal., Clin Cancer Res. 2002 Apr;8(4):1101-7.
8.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9.	The hepatocyte growth factor regulatory factors in human breast cancer.	Parr C, etal., Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):202-11.
10.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor-1.	Saleem M, etal., Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):217-27.
13.	The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals.	Vogel LK, etal., BMC Cancer. 2006 Jul 4;6:176.
14.	White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues.	Yamada T, etal., Exp Neurol. 1998 Sep;153(1):60-4.
15.	Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract.	Zeng L, etal., World J Gastroenterol. 2005 Oct 21;11(39):6202-7.

Additional References at PubMed

PMID:10049781	PMID:10349636	PMID:10762618	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11406276	PMID:12477932	PMID:12874218	PMID:12904583	PMID:14610273	PMID:15964823
PMID:16141072	PMID:16141073	PMID:16983341	PMID:17174946	PMID:17328885	PMID:17673674	PMID:18402552	PMID:18713750	PMID:18799693	PMID:19389929	PMID:19592578	PMID:20152175
PMID:20858856	PMID:21267068	PMID:21491433	PMID:21677750	PMID:21840293	PMID:21873635	PMID:22262311	PMID:22952456	PMID:23409135	PMID:23447577	PMID:23467409	PMID:24962579
PMID:25758223	PMID:25842366	PMID:27189939	PMID:27385010	PMID:27612426	PMID:29976755	PMID:30193734	PMID:31436357	PMID:31997435	PMID:36288084	PMID:37539662	PMID:38355793

Genomics

Comparative Map Data

Spint1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	119,067,841 - 119,079,995 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	119,067,843 - 119,080,008 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	119,237,360 - 119,249,535 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	119,237,362 - 119,249,527 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	119,063,096 - 119,075,250 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	118,928,918 - 118,940,633 (+)	NCBI		MGSCv36	mm8
Celera	2	120,387,921 - 120,400,196 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.97	NCBI

SPINT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	40,844,048 - 40,858,207 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	40,844,018 - 40,858,207 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	41,136,246 - 41,150,405 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	38,923,538 - 38,937,145 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	17,904,155 - 17,917,761 (+)	NCBI		Celera
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	17,956,043 - 17,998,087 (+)	NCBI		HuRef
CHM1_1	15	41,254,190 - 41,267,796 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	38,650,076 - 38,664,232 (+)	NCBI		T2T-CHM13v2.0

Spint1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	126,685,017 - 126,697,957 (+)	NCBI		GRCr8
mRatBN7.2	3	106,231,082 - 106,244,121 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	106,231,444 - 106,244,119 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	109,904,232 - 109,916,890 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	118,499,779 - 118,512,434 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	116,160,160 - 116,172,815 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	111,049,132 - 111,061,991 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	111,049,118 - 111,062,011 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	105,757,666 - 105,770,345 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	105,654,093 - 105,666,772 (+)	NCBI
Celera	3	105,144,668 - 105,157,338 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

Spint1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	7,715,536 - 7,729,158 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	7,715,536 - 7,728,759 (+)	NCBI	ChiLan1.0	ChiLan1.0

SPINT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	30,086,766 - 30,100,403 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	34,238,095 - 34,251,732 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	19,786,621 - 19,800,297 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	38,036,638 - 38,050,303 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	38,036,638 - 38,050,303 (+)	Ensembl	panpan1.1		panPan2

SPINT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	7,976,094 - 7,989,019 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	7,975,235 - 7,988,339 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	8,030,789 - 8,043,874 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	8,104,320 - 8,117,280 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	8,104,237 - 8,117,684 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	8,026,984 - 8,039,921 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	8,134,558 - 8,147,504 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	8,264,088 - 8,277,146 (+)	NCBI		UU_Cfam_GSD_1.0

Spint1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	86,390,799 - 86,403,274 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	4,238,845 - 4,251,350 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	4,238,883 - 4,251,291 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPINT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	130,458,909 - 130,473,783 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	130,458,909 - 130,473,791 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	145,616,937 - 145,631,763 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPINT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	42,136,749 - 42,150,125 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	42,134,536 - 42,150,118 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	98,833,369 - 98,846,726 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spint1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	8,093,346 - 8,106,193 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	8,092,700 - 8,105,478 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Spint1
319 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	997
Count of miRNA genes:	373
Interacting mature miRNAs:	429
Transcripts:	ENSMUST00000028783, ENSMUST00000110816, ENSMUST00000110817, ENSMUST00000134872, ENSMUST00000139903
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301905	Lgth2_m	body length 2 (mouse)			Not determined		2	111173704	145173821	Mouse
1302033	Nsv1_m	Neuroadapted Sindbis viral RNA level 1 (mouse)			Not determined		2	111623386	145623526	Mouse
12904007	Cfq7_m	conditioned fear QTL 7 (mouse)					2	118356772	125048872	Mouse
13506762	Tbvq2_m	trabecular bone volume QTL 2 (mouse)					2	115430481	124741920	Mouse
13824983	Vclq1_m	curvilinear velocity QTL 1 (mouse)					2	61830344	136841920	Mouse
1301909	Smdq2_m	segregation of mitochondrial DNA QTL 2 (mouse)			Not determined		2	92778465	126778607	Mouse
11039520	Ltpr2h_m	Leishmania tropica response 2h (mouse)					2	112212746	146213005	Mouse
11039521	Ltpr2g_m	Leishmania tropica response 2g (mouse)					2	115212857	149212994	Mouse
12910799	Pwgrq2_m	pre-weaning growth rate QTL 2 (mouse)					2	118589253	160611165	Mouse
1302174	Dssc2_m	dextran sodium sulfate induced colitis QTL2 (mouse)			Not determined		2	24224632	148700377	Mouse
12910795	Pwbwq5_m	post-weaning body weight QTL 5 (mouse)					2	118589253	160611165	Mouse
11532731	Sluc31a_m	susceptibility to lung cancer 31a (mouse)					2	88015003	122015170	Mouse
27226761	Feml18_m	femur length 18, 16 week (mouse)					2	94230345	154241920	Mouse
12910812	Pwgrq1_m	pre-weaning growth rate QTL 1 (mouse)					2	118589253	160611165	Mouse
12910814	Pwbwq1_m	pre-weaning body weight QTL 1 (mouse)					2	118589253	160611165	Mouse
1357577	Trmq3_m	T cell ratio modifier QTL 3 (mouse)			Not determined		2	60520612	119355518	Mouse
4141854	T2dm2sa_m	type 2 diabetes mellitus 2 in SMXA RI mice (mouse)			Not determined		2	29307947	148374934	Mouse
12904935	Edlmmq2_m	extensor digitorum longus muscle mass QTL 2 (mouse)					2	97210364	131210364	Mouse
1302071	Fembrs1_m	femur breaking strength 1 (mouse)			Not determined		2	100942930	134943090	Mouse
10045885	Cplaq15_m	circadian period of locomotor activity 15 (mouse)			Not determined		2	110916118	154354667	Mouse
1302203	Gvhd3_m	graft-versus host disease 3 (mouse)			Not determined		2	100942930	134943090	Mouse
1300793	Pcfm2_m	periosteal circumference and femur length 2 (mouse)			Not determined		2	111173704	145173821	Mouse
10412082	Hylaq1_m	Hyperlocomotor activity related QTL 1 (mouse)			Not determined		2	84013198	148667470	Mouse
1300798	Actre3_m	activity response to ethanol 3 (mouse)			Not determined		2	112024987	128173821	Mouse
5491197	Mobq5_m	multigenic obesity QTL 5 (mouse)			Not determined		2	65269746	162518926	Mouse
5491196	Mobq6_m	multigenic obesity QTL 6 (mouse)			Not determined		2	85724269	180896594	Mouse
4142223	Femwf4_m	femur work to failure 4 (mouse)			Not determined			88143423	122143570	Mouse
1301415	Actre4_m	activity response to ethanol 4 (mouse)			Not determined		2	112024987	128173821	Mouse
1301029	T2dm3_m	type 2 diabetes mellitus 3 (mouse)			Not determined		2	114288075	132714157	Mouse
27226788	Feml13_m	femur length 13, 10 week (mouse)					2	102630345	159941920	Mouse
1301295	Prdt1_m	prion disease incubation time 1 (mouse)			Not determined		2	116077623	150077741	Mouse
12904954	Gmmq2_m	gastrocnemius muscle mass QTL 2 (mouse)					2	97210364	131210364	Mouse
1558825	Aabpr_m	aberrant activation of B cell proliferation (mouse)			Not determined		2	116033229	122207534	Mouse
11038696	Ltpr2f_m	Leishmania tropica response 2f (mouse)					2	115212857	149212994	Mouse
11038697	Ltpr2d_m	Leishmania tropica response 2d (mouse)					2	86095716	120095823	Mouse
1301330	Tbbmd2_m	total body bone mineral density 2 (mouse)			Not determined		2	100942930	134943090	Mouse
11038698	Ltpr2c_m	Leishmania tropica response 2c (mouse)					2	86095716	120095823	Mouse
1301201	Chab1_m	cholesterol absorption 1 (mouse)			Not determined		2	111551028	145551163	Mouse
11038699	Ltpr2b_m	Leishmania tropica response 2b (mouse)					2	112212746	146213005	Mouse
11038700	Ltpr2a_m	Leishmania tropica response 2a (mouse)					2	112212746	146213005	Mouse
11038702	Ltpr2_m	Leishmania tropica response 2 (mouse)					2	103095716	167212356	Mouse
11049568	Lmr28c_m	leishmaniasis resistance 28c (mouse)					2	97123370	131123532	Mouse
11049569	Lmr28d_m	leishmaniasis resistance 28d (mouse)					2	97123370	131123532	Mouse
11528549	Sluc31_m	susceptibility to lung cancer 31 (mouse)					2	74524117	129213005	Mouse
1301087	Bbaa15_m	B.burgdorferi-associated arthritis 15 (mouse)			Not determined		2	110489658	144489807	Mouse
1301825	Pbrgcsf1_m	peripheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)			Not determined		2	106233580	140233729	Mouse
4141802	Ignpq1_m	IgA nephropathy QTL 1 (mouse)			Not determined		2	100824060	134824269	Mouse
1301834	Bits1_m	bitterness sensitivity 1 (mouse)			Not determined		2	87440643	121440778	Mouse
1558990	Skmw9_m	skeletal muscle weight 9 (mouse)			Not determined		2	111173704	145173821	Mouse
11041906	Lmr28a_m	leishmaniasis resistance 28a (mouse)					2	103095716	129213005	Mouse
4141155	Plast2b_m	plasma plant sterol 2b (mouse)			Not determined		2	84013198	148522175	Mouse
1301618	Bglu1_m	blood glucose level 1 (mouse)			Not determined		2	117942930	174324863	Mouse
1300852	Lmr14_m	leishmaniasis resistance 14 (mouse)			Not determined		2	86095716	120095823	Mouse
1301755	Hrq1_m	heart rate quantitative locus 1 (mouse)			Not determined		2	111173704	145173821	Mouse
1301344	Lith1_m	lithogenic gene 1 (mouse)			Not determined		2	45347635	145312647	Mouse
11049565	Lmr28g_m	leishmaniasis resistance 28g (mouse)					2	86095716	120095823	Mouse
1558881	Ses7_m	salmonella enteritidis susceptibility 7 (mouse)			Not determined		2	116306330	150306474	Mouse
1301098	Cd8mts3_m	CD8 memory T cell subset 3 (mouse)			Not determined		2	91089974	125090104	Mouse
10043875	Bw25_m	body weight QTL 25 (mouse)			Not determined		2	107255676	141255676	Mouse

Markers in Region

Spint1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	2	119,248,370 - 119,248,797	UniSTS	GRCm38
MGSCv37	2	119,074,106 - 119,074,533	UniSTS	GRCm37
Celera	2	120,399,052 - 120,399,479	UniSTS
Cytogenetic Map	2	E5	UniSTS
cM Map	2		UniSTS

Spint1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	7	29,256,679 - 29,258,200	UniSTS	GRCm38
MGSCv37	7	30,041,698 - 30,043,219	UniSTS	GRCm37
Celera	7	23,827,943 - 23,829,464	UniSTS
Cytogenetic Map	7	B1	UniSTS
Cytogenetic Map	2	E5	UniSTS
cM Map	2		UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001412660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001412661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_016907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF099018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK017342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL929318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY013701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC005769	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000028783 ⟹ ENSMUSP00000028783

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	119,067,843 - 119,079,995 (+)	Ensembl
GRCm38.p6 Ensembl	2	119,237,362 - 119,249,514 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000110816 ⟹ ENSMUSP00000106440

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	119,067,958 - 119,079,676 (+)	Ensembl
GRCm38.p6 Ensembl	2	119,237,477 - 119,249,195 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000110817 ⟹ ENSMUSP00000106441

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	119,068,034 - 119,080,008 (+)	Ensembl
GRCm38.p6 Ensembl	2	119,237,553 - 119,249,527 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000134872

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	119,078,686 - 119,079,530 (+)	Ensembl
GRCm38.p6 Ensembl	2	119,248,205 - 119,249,049 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000139903

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	119,076,854 - 119,079,383 (+)	Ensembl
GRCm38.p6 Ensembl	2	119,246,373 - 119,248,902 (+)	Ensembl

RefSeq Acc Id:

NM_001412660 ⟹ NP_001399589

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	119,067,841 - 119,079,995 (+)	NCBI

RefSeq Acc Id:

NM_001412661 ⟹ NP_001399590

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	119,067,841 - 119,079,995 (+)	NCBI

RefSeq Acc Id:

NM_016907 ⟹ NP_058603

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	119,067,841 - 119,079,995 (+)	NCBI
GRCm38	2	119,237,360 - 119,249,514 (+)	NCBI
MGSCv37	2	119,063,096 - 119,075,250 (+)	RGD
Celera	2	120,387,921 - 120,400,196 (+)	RGD
cM Map	2		ENTREZGENE

Sequence:

show sequence

AGTTTCACCAGAAACTAGAAAGGCCGGGAGGAGGCAGCCAATCTTCCGTGCAGCCAGAGCCGGG
CGGAAGCCGGGCGGGATCGTCGGCGGTCCCACCCCGTTCACCTGCGCAGGTCACAAGCACCCTC
GGAACCCGGAGGCTCGCACTGTGAAGGTGACCCCCGCCTCGGGGAGGAGGGCGACGGCCCCTGG
GAGCACGATGGCGGGCCGCCGCCTGGCGCGGGCCAGCATCTCTGCGGTCGGCGTATGGCTCCTT
TGCGCGCTTGGCCTCCAGGCCACCGAGGCCGAGCTGCCGTCCGCACCCGCTGAGCTTCCCGGGG
GAGCCGCCTGCTTGAGCCGCTTTACCAGCGGGGTGCCGTCCTTTGTGCTGGACACCGAAGCCTC
AGTCAGCAACGGGGCCACCTTCCTGGGTTCCCCGACGGCGCGCCGCGGCTGGGACTGCGTGCGC
TCCTGCTGCACCACTCAGAACTGCAACCTGGCGCTGGTGGAGCTGCAGCCAGACGGCGGCGAGG
ACGCCATCTCTGCCTGCTTCCTCATGAACTGCCTGTACGAGCAGAACTTCGTGTGCAAGTTCGC
TCCGAAGGAGGGCTTCATCAACTATCTTACTCAGGAGCTTTACCGCTCCTACCGCGAGCTGCGG
ACTCGAGGCTTTGGAGGGTCCCGGATCCCTCGAATCTGGATGGGCATAGACTTGAAGGTCCAGC
TGCAGAAGCCCCTGGTACTGAACGAGGCAGACAACACAGACTGGCACCTACTGCAAGGTGACAG
TGATGTCAGAGTAGAGAGAAAACGTCCGGAAGAAGTGGAGCTGTGGGGACTTAAGGAGGGGACC
TACCTGTTCCAACTGACAAGAACTGACTCAGACCAACCAGAGGAAACAGCCAACCTGACTATCA
CTGTGCTAACTGCCAAGCAGACAGAAGATTATTGCCTCGCATCCTACAAGGTGGGCCGCTGCCG
GGGCTCCTTCCCACGCTGGTACTACGACCCCAAGGAACAGATCTGCAAAAGTTTTACTTTTGGA
GGTTGCCTGGGCAACAAGAACAACTACCTTCGTGAGGAAGAGTGCATGCTAGCCTGCAAGGATG
TGCAAGGAATCTCACCGAAAAGGCACCATCCAGTGTGCTCCGGCAGCTGCCATGCCACCCAGTT
CCGCTGTAGCAATGGCTGCTGTATCGATGGCTTCCTGGAGTGTGATGACACGCCAGACTGCCCT
GATGGCTCCGACGAGGCCACCTGTGAAAAATACACCAGCGGCTTTGATGAGCTTCAGAATATCC
ATTTCCTCAGTGACAAAGGGTACTGTGCAGAGCTGCCAGACACTGGGTTTTGCAAGGAGAACAT
CCCACGCTGGTATTACAACCCATTCAGTGAACGCTGTGCCCGATTCACCTATGGTGGTTGCTAT
GGGAACAAGAACAACTTTGAGGAGGAACAGCAGTGTCTTGAGTCCTGCCGTGGCATCTCCAAGA
AGGATGTGTTTGGTCTTCGGAGGGAAGGCTCCATTCCCACTGTAGGCTCCGCTGAGGTAGCTAT
TGCTGTATTTCTGGTCATCTGCATCATAGTGGTCTTAACCATCCTGGGCTACTGTTTCTTCAAG
AACCAAAGAAAGGAATTCCACAGTCCCCTGCACCACCCACCTCCCACACCAGCCAGCTCCACTG
TTTCCACCACAGAGGACACAGAGCACCTGGTCTATAATCACACAACCCAGCCTCTCTGAGCCTG
GGACTCTTGCCAGTCTTACCAGGTCCTGCTTGCCAAGACAGAAGCTAGAACCTGGAAAAACTTG
GGGACCAGACTCTTCCTACCTCTTTCCTGGGCATACTTACTCTGTCTCAGAAGACAGATCTCTG
GGCCTCTCGCAGGAGTCTCAGCTGCACTCAGGCCAGTTCTGGAGAAGGCCCAAGAGTCTGGAAG
GAGCAGAGCAGCCTTGAGCCAGGAGTACTGTATATAGAAGGACCTGCTTATCCAAGAGCTGGAG
AAAGTTGGTGTTTTGTGTCTTGTTCAAAGCTGCCCATCACCATCCGATGACGCTAGGACCTTGA
GTGGTATCAGAGGCCAGAAGCCACACACTGCCTTCCACATCTGTCCCTCCACTCTGCAACAGGC
TGAAGGATGTGTGTCTCTGCACACACTGAAGGATGTGTCTTTGTAGTTTGTGCTGTAAATAATT
GCTTTTGGGGCCCCAGGGTCATAGCTCAGTGGTAGAGTGTGTGTGGTCACCCTGAGCTCTCTAC
ACCGAACCACAAGCTACATTAAATTACAAAATAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001399589	(Get FASTA)	NCBI Sequence Viewer
	NP_001399590	(Get FASTA)	NCBI Sequence Viewer
	NP_058603	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF02490	(Get FASTA)	NCBI Sequence Viewer
	AAH05769	(Get FASTA)	NCBI Sequence Viewer
	BAB30697	(Get FASTA)	NCBI Sequence Viewer
	EDL27946	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000028783
	ENSMUSP00000028783.8
	ENSMUSP00000106440
	ENSMUSP00000106440.2
	ENSMUSP00000106441
	ENSMUSP00000106441.3
GenBank Protein	Q9R097	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_058603 ⟸ NM_016907
- Peptide Label:	precursor
- UniProtKB:	Q99J04 (UniProtKB/Swiss-Prot), Q9R097 (UniProtKB/Swiss-Prot), Q9D3K4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGRRLARASISAVGVWLLCALGLQATEAELPSAPAELPGGAACLSRFTSGVPSFVLDTEASVS NGATFLGSPTARRGWDCVRSCCTTQNCNLALVELQPDGGEDAISACFLMNCLYEQNFVCKFAPK EGFINYLTQELYRSYRELRTRGFGGSRIPRIWMGIDLKVQLQKPLVLNEADNTDWHLLQGDSDV RVERKRPEEVELWGLKEGTYLFQLTRTDSDQPEETANLTITVLTAKQTEDYCLASYKVGRCRGS FPRWYYDPKEQICKSFTFGGCLGNKNNYLREEECMLACKDVQGISPKRHHPVCSGSCHATQFRC SNGCCIDGFLECDDTPDCPDGSDEATCEKYTSGFDELQNIHFLSDKGYCAELPDTGFCKENIPR WYYNPFSERCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREGSIPTVGSAEVAIAV FLVICIIVVLTILGYCFFKNQRKEFHSPLHHPPPTPASSTVSTTEDTEHLVYNHTTQPL hide sequence

Ensembl Acc Id:

ENSMUSP00000106440 ⟸ ENSMUST00000110816

Ensembl Acc Id:

ENSMUSP00000106441 ⟸ ENSMUST00000110817

Ensembl Acc Id:

ENSMUSP00000028783 ⟸ ENSMUST00000028783

RefSeq Acc Id:	NP_001399590 ⟸ NM_001412661
- Peptide Label:	precursor
- UniProtKB:	Q9R097 (UniProtKB/Swiss-Prot), Q99J04 (UniProtKB/Swiss-Prot), Q9D3K4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001399589 ⟸ NM_001412660
- Peptide Label:	precursor
- UniProtKB:	Q9R097 (UniProtKB/Swiss-Prot), Q99J04 (UniProtKB/Swiss-Prot), Q9D3K4 (UniProtKB/TrEMBL)

Protein Domains

BPTI/Kunitz inhibitor LDL-receptor class A MANSC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9R097-F1-model_v2	AlphaFold	Q9R097	1-507	view protein structure

Promoters

RGD ID:

6830644

Promoter ID:

MM_KWN:31228

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

ES_Cell, Kidney, Lung

Transcripts:

AK018600_9130007G19RIK, ENSMUST00000110817, OTTMUST00000037745, UC008LTL.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	119,062,926 - 119,063,426 (-)	MPROMDB

RGD ID:

6832820

Promoter ID:

MM_KWN:31230

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney, Lung

Transcripts:

OTTMUST00000037749

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	119,073,861 - 119,074,362 (+)	MPROMDB

RGD ID:

6878342

Promoter ID:

EPDNEW_M2622

Type:

initiation region

Name:

Spint1_1

Description:

Mus musculus serine protease inhibitor, Kunitz type 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M2623

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	2	119,237,463 - 119,237,523	EPDNEW

RGD ID:

6878344

Promoter ID:

EPDNEW_M2623

Type:

initiation region

Name:

Spint1_2

Description:

Mus musculus serine protease inhibitor, Kunitz type 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M2622

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	2	119,237,733 - 119,237,793	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1338033	AgrOrtholog
Ensembl Genes	ENSMUSG00000027315	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000028783	ENTREZGENE
	ENSMUST00000028783.14	UniProtKB/Swiss-Prot
	ENSMUST00000110816	ENTREZGENE
	ENSMUST00000110816.8	UniProtKB/Swiss-Prot
	ENSMUST00000110817	ENTREZGENE
	ENSMUST00000110817.3	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	4.10.410.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kunitz_BPTI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kunitz_BPTI_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MANSC_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MANSC_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prtase_inh_Kunz-CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:20732	UniProtKB/Swiss-Prot
MGD	MGI:1338033	ENTREZGENE
NCBI Gene	20732	ENTREZGENE
PANTHER	KUNITZ-TYPE PROTEASE INHIBITOR 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR46750	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Kunitz_BPTI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ldl_recept_a	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MANEC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Spint1	PhenoGen
PRINTS	BASICPTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	BPTI_KUNITZ_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BPTI_KUNITZ_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLRA_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MANSC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	LDLa	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MANEC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00131	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF57362	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57424	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	Q99J04	ENTREZGENE
	Q9D3K4	ENTREZGENE, UniProtKB/TrEMBL
	Q9R097	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q99J04	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype