Plg (plasminogen) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Plg (plasminogen) Mus musculus
Analyze
Symbol: Plg
Name: plasminogen
RGD ID: 1550861
MGI Page MGI
Description: Enables kinase binding activity. Involved in trans-synaptic signaling by BDNF, modulating synaptic transmission. Acts upstream of or within several processes, including embryonic placenta development; muscle cell cellular homeostasis; and myoblast differentiation. Located in cell surface. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in early conceptus; embryo; liver; and secondary oocyte. Human ortholog(s) of this gene implicated in COVID-19; conjunctivitis; hereditary angioedema; plasminogen deficiency type I; and thrombophilia. Orthologous to human PLG (plasminogen).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI649309; angiostatin; P; Pg; plasmin heavy chain A; plasmin light chain B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,597,496 - 12,638,271 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,597,495 - 12,638,272 (+)EnsemblGRCm39 Ensembl
GRCm381712,378,609 - 12,419,384 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,378,608 - 12,419,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371712,571,475 - 12,612,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,221,966 - 12,262,743 (+)NCBIMGSCv36mm8
Celera1712,409,327 - 12,450,146 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-aminohexanoate  (EXP)
6-aminohexanoic acid  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
camostat  (ISO)
carbon nanotube  (EXP)
carnosic acid  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP)
cytarabine  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diisopropyl fluorophosphate  (EXP)
dioxygen  (EXP)
doxorubicin  (ISO)
entinostat  (ISO)
Ethyl icosapentate  (ISO)
ethylenediaminetetraacetic acid  (EXP)
folic acid  (EXP)
fructose  (EXP)
furan  (ISO)
genistein  (ISO)
gestodene  (ISO)
glucose  (EXP)
Goe 6976  (EXP)
heparin  (EXP)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
levonorgestrel  (ISO)
medroxyprogesterone acetate  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
morphine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nitrofen  (ISO)
nitroprusside  (ISO)
norethisterone  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
omeprazole  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
roxarsone  (ISO)
selenomethionine  (ISO)
senecionine  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraethyllead  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute phase protein level  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal body weight  (IAGP)
abnormal colon morphology  (IAGP)
abnormal conjunctiva morphology  (IAGP)
abnormal conjunctival epithelium morphology  (IAGP)
abnormal cornea epithelium morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal cornea stroma morphology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal involution of the mammary gland  (IAGP)
abnormal kidney thrombosis  (IAGP)
abnormal lactation  (IAGP)
abnormal larynx morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal mammary gland connective tissue morphology  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal thrombosis  (IAGP)
abnormal trachea morphology  (IAGP)
abnormal vagina morphology  (IAGP)
abnormal wound healing  (IAGP)
absent cornea epithelium  (IAGP)
atherosclerotic lesions  (IAGP)
cachexia  (IAGP)
colitis  (IAGP)
conjunctivitis  (IAGP)
cornea vascularization  (IAGP)
decreased angiogenesis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased keratinocyte migration  (IAGP)
decreased metastatic potential  (IAGP)
decreased susceptibility to induced choroidal neovascularization  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased susceptibility to neuronal excitotoxicity  (IAGP)
decreased tumor growth/size  (IAGP)
duodenal ulcer  (IAGP)
ectropion  (IAGP)
enlarged kidney  (IAGP)
enlarged lymph nodes  (IAGP)
esophageal ulcer  (IAGP)
eye hemorrhage  (IAGP)
eye inflammation  (IAGP)
focal hepatic necrosis  (IAGP)
gastric ulcer  (IAGP)
gastrointestinal ulcer  (IAGP)
hepatic necrosis  (IAGP)
impaired wound healing  (IAGP)
increased circulating fibrinogen level  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
intestinal ulcer  (IAGP)
lactation failure  (IAGP)
liver fibrosis  (IAGP)
perianal ulcer  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
proctitis  (IAGP)
pulmonary fibrosis  (IAGP)
rectal prolapse  (IAGP)
reduced female fertility  (IAGP)
venoocclusion  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Congenital plasminogen deficiency caused by a Ser572 to Pro mutation. Azuma H, etal., Blood. 1993 Jul 15;82(2):475-80.
2. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. Gralinski LE, etal., mBio. 2013 Aug 6;4(4). pii: mBio.00271-13. doi: 10.1128/mBio.00271-13.
3. The Chinese herbal formula Zhibai Dihuang Granule treat Yin-deficiency-heat syndrome rats by regulating the immune responses. Liu CM, etal., J Ethnopharmacol. 2018 Oct 28;225:271-278. doi: 10.1016/j.jep.2018.05.001. Epub 2018 May 2.
4. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
5. Imbalance of plasminogen activator inhibitor type-1 (PAI-1) and tissue plasminogen activator (t-PA) activity in patients with Noonan syndrome. Mehta P and Parker RI, J Pediatr Hematol Oncol. 2010 Oct;32(7):532-6. doi: 10.1097/MPH.0b013e3181e0d152.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Early embryonic expression of murine coagulation system components. Ong K, etal., Thromb Haemost 2000 Dec;84(6):1023-30.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis. Schuster V, etal., Blood. 1997 Aug 1;90(3):958-66.
17. Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population. Sun W, etal., Int Orthop. 2006 Jun;30(3):143-6. doi: 10.1007/s00264-005-0067-6. Epub 2006 Mar 18.
18. [Hematological changes and related gene mutation of post-severe acute respiratory syndrome patients with osteonecrosis]. Sun W, etal., Zhonghua Yi Xue Za Zhi. 2006 Feb 21;86(7):442-5.
19. Plasminogen improves lung lesions and hypoxemia in patients with COVID-19. Wu Y, etal., QJM. 2020 Apr 10. pii: 5818885. doi: 10.1093/qjmed/hcaa121.
Additional References at PubMed
PMID:1387105   PMID:1543918   PMID:1572657   PMID:1612602   PMID:1845916   PMID:2081600   PMID:6216475   PMID:7525077   PMID:7586361   PMID:7705657   PMID:7894168   PMID:8084607  
PMID:8111116   PMID:8406442   PMID:8612226   PMID:8704243   PMID:8854860   PMID:8929539   PMID:8987777   PMID:9226367   PMID:9268631   PMID:9275201   PMID:9294211   PMID:9373263  
PMID:9438420   PMID:9473227   PMID:9490683   PMID:9671388   PMID:9770530   PMID:9819364   PMID:9884337   PMID:9933568   PMID:10318667   PMID:10349636   PMID:10537128   PMID:10559390  
PMID:10634603   PMID:10642175   PMID:10816371   PMID:10854210   PMID:10880388   PMID:10885855   PMID:10903997   PMID:11003846   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11306011  
PMID:11306532   PMID:11404420   PMID:11438139   PMID:11500461   PMID:11557572   PMID:11562346   PMID:11641723   PMID:11733368   PMID:11818362   PMID:11848464   PMID:11916082   PMID:11929773  
PMID:12070304   PMID:12083480   PMID:12149246   PMID:12167431   PMID:12192005   PMID:12225871   PMID:12417566   PMID:12428098   PMID:12431907   PMID:12466851   PMID:12477932   PMID:12524546  
PMID:12559391   PMID:12657615   PMID:12702502   PMID:12857855   PMID:12875972   PMID:12900459   PMID:12911578   PMID:12911586   PMID:12928439   PMID:14651966   PMID:14709993   PMID:14988509  
PMID:15099286   PMID:15161662   PMID:15166500   PMID:15220341   PMID:15333838   PMID:15364412   PMID:15456492   PMID:15486301   PMID:15489334   PMID:15522965   PMID:15545316   PMID:15630096  
PMID:15721299   PMID:15737740   PMID:15743790   PMID:15760467   PMID:15841177   PMID:15985536   PMID:16006527   PMID:16052596   PMID:16103174   PMID:16141072   PMID:16141073   PMID:16147977  
PMID:16150044   PMID:16204191   PMID:16330749   PMID:16413499   PMID:16481742   PMID:16505491   PMID:16543819   PMID:16554301   PMID:16763560   PMID:16818777   PMID:16949567   PMID:16956791  
PMID:16964442   PMID:16966370   PMID:17022820   PMID:17122079   PMID:17135368   PMID:17267741   PMID:17293777   PMID:17301181   PMID:17395831   PMID:17431190   PMID:17482686   PMID:17596135  
PMID:17656680   PMID:17664291   PMID:17690254   PMID:17717150   PMID:17722076   PMID:17988229   PMID:18039665   PMID:18042398   PMID:18195371   PMID:18311818   PMID:18337830   PMID:18371407  
PMID:18420257   PMID:18566672   PMID:18608216   PMID:18628488   PMID:18647637   PMID:18677407   PMID:18685433   PMID:18957535   PMID:18997104   PMID:19147818   PMID:19210287   PMID:19220707  
PMID:19273908   PMID:19286661   PMID:19465692   PMID:19683575   PMID:19752236   PMID:20110420   PMID:20133625   PMID:20163454   PMID:20175210   PMID:20440070   PMID:20547128   PMID:20653841  
PMID:21062905   PMID:21115493   PMID:21190118   PMID:21239499   PMID:21267068   PMID:21273553   PMID:21311769   PMID:21326869   PMID:21354127   PMID:21614211   PMID:21704601   PMID:21719761  
PMID:21873635   PMID:21931322   PMID:21931850   PMID:21940822   PMID:22056679   PMID:22079981   PMID:22159717   PMID:22563086   PMID:22815383   PMID:23041318   PMID:23106863   PMID:23202729  
PMID:23239981   PMID:23401155   PMID:23456978   PMID:23527289   PMID:23555246   PMID:23646899   PMID:23702659   PMID:23721211   PMID:23943648   PMID:24090483   PMID:24196407   PMID:24574269  
PMID:24581498   PMID:24612416   PMID:24650562   PMID:24664548   PMID:24732409   PMID:24791857   PMID:24876560   PMID:25165151   PMID:25209997   PMID:25409527   PMID:25893677   PMID:25918552  
PMID:26214526   PMID:26473342   PMID:26647393   PMID:26791370   PMID:27283026   PMID:27319402   PMID:27530373   PMID:27592166   PMID:28071719   PMID:28270519   PMID:28275164   PMID:28320709  
PMID:28325863   PMID:28336948   PMID:28686706   PMID:29438518   PMID:30254165   PMID:30323258   PMID:30341568   PMID:31040226   PMID:31101623   PMID:31316511   PMID:31395599   PMID:31462325  
PMID:31690812   PMID:31819012   PMID:32315384   PMID:32325033   PMID:32694536   PMID:33543002   PMID:33720950   PMID:33827130   PMID:34378815   PMID:34380733   PMID:34423816   PMID:36577382  
PMID:37971174   PMID:38328826   PMID:38442019   PMID:38615036  


Genomics

Comparative Map Data
Plg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,597,496 - 12,638,271 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,597,495 - 12,638,272 (+)EnsemblGRCm39 Ensembl
GRCm381712,378,609 - 12,419,384 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,378,608 - 12,419,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371712,571,475 - 12,612,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,221,966 - 12,262,743 (+)NCBIMGSCv36mm8
Celera1712,409,327 - 12,450,146 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.5NCBI
PLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,702,193 - 160,754,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6160,702,194 - 160,754,097 (+)EnsemblGRCh38hg38GRCh38
GRCh376161,123,225 - 161,175,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,043,273 - 161,094,328 (+)NCBINCBI36Build 36hg18NCBI36
Build 346161,093,693 - 161,144,749NCBI
Celera6161,842,077 - 161,894,063 (+)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6158,568,041 - 158,620,052 (+)NCBIHuRef
CHM1_16161,385,876 - 161,437,750 (+)NCBICHM1_1
T2T-CHM13v2.06162,049,910 - 162,101,977 (+)NCBIT2T-CHM13v2.0
Plg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,872,927 - 50,915,406 (-)NCBIGRCr8
mRatBN7.2148,325,186 - 48,367,643 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,325,185 - 48,367,786 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,016,780 - 49,059,257 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,002,545 - 55,044,743 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,092,281 - 49,134,750 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,521,828 - 48,563,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,521,772 - 48,563,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,192,273 - 51,233,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,782,464 - 42,825,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,785,408 - 42,828,097 (-)NCBI
Celera144,117,228 - 44,159,691 (-)NCBICelera
Cytogenetic Map1q11NCBI
Plg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,317,552 - 20,366,475 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,317,814 - 20,366,724 (+)NCBIChiLan1.0ChiLan1.0
LOC100982214
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25180,891,286 - 180,942,564 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16178,794,251 - 178,845,478 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,662,192 - 158,713,413 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,674,142 - 163,722,630 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,673,464 - 163,736,777 (+)Ensemblpanpan1.1panPan2
PLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,497,229 - 49,535,260 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,497,229 - 49,535,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,340,229 - 50,378,262 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,682,496 - 49,720,525 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,682,496 - 49,720,525 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,564,853 - 49,602,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,436,580 - 49,474,619 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0150,051,672 - 50,089,725 (-)NCBIUU_Cfam_GSD_1.0
Plg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,523,021 - 144,556,568 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,775,243 - 11,805,651 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,775,243 - 11,808,482 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,061,192 - 7,110,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,062,399 - 7,109,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,740,127 - 8,787,546 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11388,266,054 - 88,321,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1388,268,198 - 88,322,644 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604060,598,947 - 60,654,431 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248552,360,229 - 2,402,079 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248552,362,793 - 2,401,519 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plg
1213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:106
Interacting mature miRNAs:112
Transcripts:ENSMUST00000014578
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171263668226401133Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17126189355Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4142507Obrq13_mobesity resistance QTL 13 (mouse)Not determined1219832925076769Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1357452Vtbt18_mvertebral trabecular bone trait 18 (mouse)Not determined17120975022Mouse
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125662076Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17397489026401133Mouse
1302196Myaa1_mmodifier of Yaa 1 (mouse)Not determined17120975022Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17126194456Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse

Markers in Region
AI649309  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381712,419,186 - 12,419,320UniSTSGRCm38
MGSCv371712,612,052 - 12,612,186UniSTSGRCm37
Celera1712,449,948 - 12,450,082UniSTS
Cytogenetic Map17A1UniSTS
cM Map177.3UniSTS
Whitehead/MRC_RH17214.85UniSTS
Plg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381712,419,101 - 12,419,358UniSTSGRCm38
MGSCv371712,611,967 - 12,612,224UniSTSGRCm37
Celera1712,449,863 - 12,450,120UniSTS
Cytogenetic Map17A1UniSTS
cM Map177.3UniSTS
J04766  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381712,419,180 - 12,419,355UniSTSGRCm38
MGSCv371712,612,046 - 12,612,221UniSTSGRCm37
Celera1712,449,942 - 12,450,117UniSTS
Cytogenetic Map17A1UniSTS
cM Map177.3UniSTS
Whitehead_YAC17 UniSTS
D17Mit114  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381712,417,795 - 12,417,944UniSTSGRCm38
MGSCv371712,610,661 - 12,610,810UniSTSGRCm37
Celera1712,448,557 - 12,448,706UniSTS
Cytogenetic Map17A1UniSTS
cM Map1711.0UniSTS
Whitehead Genetic173.3UniSTS
Whitehead_YAC17 UniSTS
PLG_3841  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381712,419,006 - 12,419,590UniSTSGRCm38
MGSCv371712,611,872 - 12,612,456UniSTSGRCm37
Celera1712,449,768 - 12,450,352UniSTS
Cytogenetic Map17A1UniSTS
cM Map177.3UniSTS
Plg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A1UniSTS
Plg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381712,418,979 - 12,419,355UniSTSGRCm38
MGSCv371712,611,845 - 12,612,221UniSTSGRCm37
Celera1712,449,741 - 12,450,117UniSTS
Cytogenetic Map17A1UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000014578   ⟹   ENSMUSP00000014578
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1712,597,495 - 12,638,272 (+)Ensembl
GRCm38.p6 Ensembl1712,378,608 - 12,419,385 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232767
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1712,597,546 - 12,610,197 (+)Ensembl
GRCm38.p6 Ensembl1712,378,659 - 12,391,310 (+)Ensembl
RefSeq Acc Id: NM_008877   ⟹   NP_032903
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391712,597,496 - 12,638,271 (+)NCBI
GRCm381712,378,609 - 12,419,384 (+)ENTREZGENE
MGSCv371712,571,475 - 12,612,250 (+)RGD
Celera1712,409,327 - 12,450,146 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032903   ⟸   NM_008877
- Peptide Label: precursor
- UniProtKB: Q8CIS2 (UniProtKB/Swiss-Prot),   Q91WJ5 (UniProtKB/Swiss-Prot),   P20918 (UniProtKB/Swiss-Prot),   Q3V1T9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000014578   ⟸   ENSMUST00000014578
Protein Domains
Apple   Kringle   PAN   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20918-F1-model_v2 AlphaFold P20918 1-812 view protein structure

Promoters
RGD ID:13674744
Promoter ID:EPDNEW_M21521
Type:initiation region
Name:Plg_1
Description:Mus musculus plasminogen , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381712,378,612 - 12,378,672EPDNEW
RGD ID:6828481
Promoter ID:MM_KWN:22112
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_008877_PLG,   UC008AKS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361712,571,146 - 12,571,646 (+)MPROMDB
RGD ID:6847430
Promoter ID:MM_ACW:21691
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:PLG.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361712,611,646 - 12,612,146 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97620 AgrOrtholog
Ensembl Genes ENSMUSG00000059481 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000014578 ENTREZGENE
  ENSMUST00000014578.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hepatocyte Growth Factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pan_app UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S1A_plasmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serine_protease_kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18815 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97620 ENTREZGENE
NCBI Gene 18815 ENTREZGENE
PANTHER PLASMINOGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLASMINOGEN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plg PhenoGen
PIRSF Plasmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAN_AP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Hairpin loop containing domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P20918 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3V1T9 ENTREZGENE, UniProtKB/TrEMBL
  Q6TCI0_MOUSE UniProtKB/TrEMBL
  Q8CIS2 ENTREZGENE
  Q91WJ5 ENTREZGENE
UniProt Secondary Q8CIS2 UniProtKB/Swiss-Prot
  Q91WJ5 UniProtKB/Swiss-Prot