F8 (coagulation factor VIII) - Rat Genome Database

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Gene: F8 (coagulation factor VIII) Mus musculus
Analyze
Symbol: F8
Name: coagulation factor VIII
RGD ID: 1550694
MGI Page MGI
Description: Predicted to enable copper ion binding activity and oxidoreductase activity. Predicted to be involved in blood coagulation, intrinsic pathway. Predicted to act upstream of or within acute-phase response and blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and liver and biliary system. Used to study factor VIII deficiency. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cf-8; Cf8; F; Factor VIII; FVIII; procoagulant component
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,213,950 - 74,426,342 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,216,321 - 74,426,221 (-)EnsemblGRCm39 Ensembl
GRCm38X75,170,344 - 75,382,738 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,172,715 - 75,382,615 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X72,418,054 - 72,625,380 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X71,425,450 - 71,632,761 (-)NCBIMGSCv36mm8
CeleraX66,576,966 - 66,780,957 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amphibole asbestos  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Ethyl icosapentate  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (ISO)
fipronil  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
gestodene  (ISO)
glycine betaine  (ISO)
glyphosate  (EXP)
irinotecan  (ISO)
levonorgestrel  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
norgestimate  (ISO)
orphenadrine  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium dodecyl sulfate  (ISO)
tamoxifen  (EXP,ISO)
thiram  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mutations of the factor VIII gene in thai hemophilia A patients. Akkarapatumwong V, etal., Hum Mutat. 2000 Jan;15(1):117-8.
2. Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis. Bank I, etal., J Thromb Haemost. 2005 Jan;3(1):79-84.
3. WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. Booth CJ, etal., J Thromb Haemost. 2010 Nov;8(11):2472-7. doi: 10.1111/j.1538-7836.2010.03978.x.
4. Expression patterns of adhesion receptors in the developing mouse lung: functional implications. Buck CA, etal., Cell Adhes Commun 1996 Aug;4(2):69-87.
5. Effect of factor VIIIc levels in pediatric stroke patients. Cangoz E, etal., Pediatr Hematol Oncol. 2004 Apr-May;21(3):255-60.
6. Genetic and physical mapping of the biglycan gene on the mouse X chromosome. Chatterjee A, etal., Mamm Genome 1993;4(1):33-6.
7. Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II. Ebbesen LS and Ingerslev J, J Nutr. 2005 Aug;135(8):1836-40.
8. Detection of 95 novel mutations in coagulation factor VIII gene F8 responsible for hemophilia A: results from a single institution. Guillet B, etal., Hum Mutat. 2006 Jul;27(7):676-85.
9. Haemostatic abnormalities persist despite glycaemic improvement by insulin therapy in lean type 2 diabetic patients. Knobl P, etal., Thromb Haemost. 1994 Jun;71(6):692-7.
10. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. A novel F8 -/- rat as a translational model of human hemophilia A. Nielsen LN, etal., J Thromb Haemost. 2014 Aug;12(8):1274-82. doi: 10.1111/jth.12635.
14. Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats. Nobukata H, etal., Toxicol Lett. 1999 Jan 11;104(1-2):93-101.
15. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Early embryonic expression of murine coagulation system components. Ong K, etal., Thromb Haemost 2000 Dec;84(6):1023-30.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. Cleavage of factor VIII light chain is required for maximal generation of factor VIIIa activity. Regan LM and Fay PJ, J Biol Chem. 1995 Apr 14;270(15):8546-52.
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression. Shi Q, etal., Blood Adv. 2020 Jan 14;4(1):55-65. doi: 10.1182/bloodadvances.2019000944.
25. How it all starts: Initiation of the clotting cascade. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
26. The F8(-/-) rat as a model of hemophilic arthropathy. Sørensen KR, etal., J Thromb Haemost. 2016 Jun;14(6):1216-25. doi: 10.1111/jth.13328. Epub 2016 May 10.
27. Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice. VandenDriessche T, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10379-84.
28. Preferential consumption of coagulation factors I, V, and VIII in rat endotoxemia. Yamaguchi K, etal., Shock. 2000 Nov;14(5):535-43.
29. [Study on changes of blood coagulation factors in rats with hemorrhagic shock]. Zhang YJ, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Feb;13(1):110-3.
Additional References at PubMed
PMID:1349842   PMID:1384789   PMID:1572636   PMID:1639415   PMID:1674728   PMID:1679744   PMID:1684949   PMID:1964443   PMID:2377456   PMID:2561974   PMID:2571569   PMID:2573045  
PMID:2899541   PMID:2903046   PMID:2906327   PMID:2922282   PMID:3243547   PMID:3416629   PMID:7590750   PMID:7621877   PMID:7647782   PMID:7777057   PMID:8088815   PMID:8268655  
PMID:8314577   PMID:8432533   PMID:8449515   PMID:8872469   PMID:8889548   PMID:8896409   PMID:9116285   PMID:9576953   PMID:9880679   PMID:10349636   PMID:10557319   PMID:10666206  
PMID:10779424   PMID:11042159   PMID:11076861   PMID:11154224   PMID:11157667   PMID:11217851   PMID:11313267   PMID:11583319   PMID:12011059   PMID:12070019   PMID:12466851   PMID:12477932  
PMID:12730105   PMID:12858167   PMID:12879061   PMID:14717974   PMID:15172967   PMID:15351848   PMID:15576475   PMID:15728582   PMID:15731176   PMID:15837921   PMID:15920033   PMID:16002674  
PMID:16091456   PMID:16141072   PMID:16141073   PMID:16359510   PMID:16359511   PMID:16493498   PMID:16762342   PMID:16823491   PMID:17119108   PMID:17376515   PMID:18495954   PMID:18559671  
PMID:18815284   PMID:19126686   PMID:19132238   PMID:19139414   PMID:19411636   PMID:19458355   PMID:19463774   PMID:19713458   PMID:19794141   PMID:19890094   PMID:19926856   PMID:20140858  
PMID:20194895   PMID:20533009   PMID:20606161   PMID:20624989   PMID:20852129   PMID:20889922   PMID:21041718   PMID:21160036   PMID:21267068   PMID:21705497   PMID:21777952   PMID:21788339  
PMID:21795745   PMID:21828144   PMID:21873635   PMID:22031860   PMID:22234691   PMID:22246033   PMID:22355108   PMID:22368271   PMID:22394599   PMID:22498747   PMID:22655063   PMID:22855607  
PMID:23178924   PMID:23231432   PMID:23335368   PMID:23372167   PMID:23426947   PMID:23526393   PMID:23722906   PMID:23982175   PMID:24358271   PMID:24705491   PMID:24719406   PMID:24825864  
PMID:24850761   PMID:24983320   PMID:25126862   PMID:25224783   PMID:25315236   PMID:25331117   PMID:25486042   PMID:25534204   PMID:25833958   PMID:25849132   PMID:25905473   PMID:25911555  
PMID:25955153   PMID:26297739   PMID:26341257   PMID:26426076   PMID:26456157   PMID:26588198   PMID:26668132   PMID:26687613   PMID:26775174   PMID:26825708   PMID:27034428   PMID:27144769  
PMID:27207787   PMID:27758819   PMID:28328977   PMID:28492697   PMID:28561280   PMID:28581694   PMID:28827327   PMID:28837614   PMID:29109275   PMID:29317453   PMID:29395036   PMID:29429943  
PMID:29656466   PMID:29776906   PMID:30021767   PMID:30026184   PMID:30064978   PMID:30124466   PMID:31465300   PMID:31594977   PMID:31843008   PMID:32294155   PMID:32369559   PMID:32453842  
PMID:32582142   PMID:32781510   PMID:33512448   PMID:34290295   PMID:34863021   PMID:35143636   PMID:35508619   PMID:35595575   PMID:35821634   PMID:36107620   PMID:36727518   PMID:37116753  
PMID:37720212   PMID:37756521   PMID:38053332  


Genomics

Comparative Map Data
F8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,213,950 - 74,426,342 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,216,321 - 74,426,221 (-)EnsemblGRCm39 Ensembl
GRCm38X75,170,344 - 75,382,738 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,172,715 - 75,382,615 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X72,418,054 - 72,625,380 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X71,425,450 - 71,632,761 (-)NCBIMGSCv36mm8
CeleraX66,576,966 - 66,780,957 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.17NCBI
F8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,835,792 - 155,022,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,835,788 - 155,026,940 (-)EnsemblGRCh38hg38GRCh38
GRCh37X154,064,067 - 154,250,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,717,260 - 153,904,192 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X153,627,773 - 153,678,176NCBI
CeleraX154,222,608 - 154,409,733 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,607,715 - 142,796,096 (-)NCBIHuRef
CHM1_1X153,975,773 - 154,162,623 (-)NCBICHM1_1
T2T-CHM13v2.0X153,072,193 - 153,259,125 (-)NCBIT2T-CHM13v2.0
F8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818155,237 - 187,186 (+)NCBIGRCr8
mRatBN7.218140,848 - 172,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18140,955 - 171,857 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx18158,788 - 190,293 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018946,627 - 978,133 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.018160,695 - 192,201 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.018367,862 - 399,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18367,862 - 399,242 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018413,447 - 444,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418121,134 - 162,008 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.118121,133 - 162,008 (+)NCBI
Celera18135,235 - 166,779 (+)NCBICelera
Cytogenetic Map18p13NCBI
F8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594658,523 - 802,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955594658,686 - 800,101 (+)NCBIChiLan1.0ChiLan1.0
F8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X154,815,145 - 155,000,578 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X154,820,124 - 155,004,186 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X144,316,192 - 144,505,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X154,156,864 - 154,345,635 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX154,156,873 - 154,341,317 (-)Ensemblpanpan1.1panPan2
F8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,894,974 - 123,046,343 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,885,162 - 123,043,414 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,890,270 - 108,036,564 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X126,024,520 - 126,170,925 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX126,011,129 - 126,170,899 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X121,771,228 - 121,918,614 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X124,294,452 - 124,441,038 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,987,629 - 124,161,753 (-)NCBIUU_Cfam_GSD_1.0
F8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,830,886 - 119,943,339 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936927190,111 - 301,609 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936927189,359 - 301,791 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,229,450 - 125,350,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,265,330 - 125,350,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,132,160 - 143,217,828 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X129,090,140 - 129,315,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX129,088,611 - 129,312,909 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606567,072,999 - 67,292,423 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624963252,943 - 424,718 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F8
4515 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:329
Count of miRNA genes:210
Interacting mature miRNAs:220
Transcripts:ENSMUST00000033539, ENSMUST00000114085, ENSMUST00000147349, ENSMUST00000151772
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5777196091771960Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6134360689843606Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
1357730Hstx1_mhybrid sterility, X chromosome 1 (mouse)Not determinedX7145385277600812Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse

Markers in Region
px-39a12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X75,379,780 - 75,379,959UniSTSGRCm38
MGSCv37X72,625,119 - 72,625,298UniSTSGRCm37
CeleraX66,780,696 - 66,780,875UniSTS
Cytogenetic MapXA7-BUniSTS
F8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA7-BUniSTS
cM MapX30.5UniSTS
GDB:177706  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X75,211,926 - 75,212,054UniSTSGRCm38
MGSCv37X72,457,265 - 72,457,393UniSTSGRCm37
CeleraX66,611,290 - 66,611,418UniSTS
Cytogenetic MapXA7-BUniSTS
F8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA7-BUniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001161373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001161374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006527789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006527790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006527791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006527792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ627040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL731844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL808110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW489638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L05573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000033539   ⟹   ENSMUSP00000033539
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,216,321 - 74,425,922 (-)Ensembl
GRCm38.p6 EnsemblX75,172,715 - 75,382,316 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114085   ⟹   ENSMUSP00000109719
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,216,325 - 74,423,647 (-)Ensembl
GRCm38.p6 EnsemblX75,172,719 - 75,380,041 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147349   ⟹   ENSMUSP00000114207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,381,888 - 74,426,221 (-)Ensembl
GRCm38.p6 EnsemblX75,338,282 - 75,382,615 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151772   ⟹   ENSMUSP00000117919
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,397,742 - 74,425,897 (-)Ensembl
GRCm38.p6 EnsemblX75,354,136 - 75,382,291 (-)Ensembl
RefSeq Acc Id: NM_001161373   ⟹   NP_001154845
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X74,216,321 - 74,423,647 (-)NCBI
GRCm38X75,172,715 - 75,380,041 (-)NCBI
MGSCv37X72,418,054 - 72,625,380 (-)RGD
CeleraX66,576,966 - 66,780,957 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001161374   ⟹   NP_001154846
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X74,216,321 - 74,423,647 (-)NCBI
GRCm38X75,172,715 - 75,380,041 (-)NCBI
MGSCv37X72,418,054 - 72,625,380 (-)RGD
CeleraX66,576,966 - 66,780,957 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_007977   ⟹   NP_032003
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X74,216,321 - 74,423,647 (-)NCBI
GRCm38X75,172,715 - 75,380,041 (-)NCBI
MGSCv37X72,418,054 - 72,625,380 (-)RGD
CeleraX66,576,966 - 66,780,957 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527789   ⟹   XP_006527852
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X74,213,950 - 74,425,795 (-)NCBI
GRCm38X75,170,344 - 75,382,234 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006527790   ⟹   XP_006527853
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X74,213,950 - 74,426,342 (-)NCBI
GRCm38X75,170,344 - 75,382,738 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006527791   ⟹   XP_006527854
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X74,213,950 - 74,425,846 (-)NCBI
GRCm38X75,170,344 - 75,382,240 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006527792   ⟹   XP_006527855
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X74,213,950 - 74,425,912 (-)NCBI
GRCm38X75,170,344 - 75,382,390 (-)NCBI
Sequence:
RefSeq Acc Id: NP_032003   ⟸   NM_007977
- Peptide Label: isoform 1 precursor
- UniProtKB: A2AN88 (UniProtKB/Swiss-Prot),   Q06194 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001154845   ⟸   NM_001161373
- Peptide Label: isoform 2 precursor
- UniProtKB: B2RRC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001154846   ⟸   NM_001161374
- Peptide Label: isoform 3 precursor
- UniProtKB: B7ZNH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006527852   ⟸   XM_006527789
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006527853   ⟸   XM_006527790
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006527855   ⟸   XM_006527792
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006527854   ⟸   XM_006527791
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000114207   ⟸   ENSMUST00000147349
RefSeq Acc Id: ENSMUSP00000117919   ⟸   ENSMUST00000151772
RefSeq Acc Id: ENSMUSP00000033539   ⟸   ENSMUST00000033539
RefSeq Acc Id: ENSMUSP00000109719   ⟸   ENSMUST00000114085
Protein Domains
F5/8 type A   F5/8 type C   Plastocyanin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06194-F1-model_v2 AlphaFold Q06194 1-2319 view protein structure

Promoters
RGD ID:6845686
Promoter ID:MM_KWN:60885
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000114085,   NM_001161373,   NM_001161374,   OTTMUST00000049293,   OTTMUST00000049294,   OTTMUST00000049295
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X72,627,466 - 72,627,966 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88383 AgrOrtholog
Ensembl Genes ENSMUSG00000031196 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033539 ENTREZGENE
  ENSMUST00000033539.13 UniProtKB/Swiss-Prot
  ENSMUST00000114085 ENTREZGENE
  ENSMUST00000114085.9 UniProtKB/TrEMBL
  ENSMUST00000147349.8 UniProtKB/TrEMBL
  ENSMUST00000151772.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cu-oxidase UniProtKB/TrEMBL
  Cu-oxidase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_oxidase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cupredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Factor_5/8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88383 ENTREZGENE
NCBI Gene 14069 ENTREZGENE
PANTHER COAGULATION FACTOR VIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F5/8 TYPE C DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cu-oxidase UniProtKB/TrEMBL
  Cu-oxidase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB F8 RGD
PhenoGen F8 PhenoGen
PIRSF Factors_V_VIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FA58C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MULTICOPPER_OXIDASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AN88 ENTREZGENE
  B1AW26_MOUSE UniProtKB/TrEMBL
  B2RRC9 ENTREZGENE, UniProtKB/TrEMBL
  B7ZNH8 ENTREZGENE, UniProtKB/TrEMBL
  D3YW61_MOUSE UniProtKB/TrEMBL
  FA8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q684Q7_MOUSE UniProtKB/TrEMBL
  Q8BQ43_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2AN88 UniProtKB/Swiss-Prot