Uba1 (ubiquitin-like modifier activating enzyme 1) - Rat Genome Database

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Gene: Uba1 (ubiquitin-like modifier activating enzyme 1) Mus musculus
Analyze
Symbol: Uba1
Name: ubiquitin-like modifier activating enzyme 1
RGD ID: 1550651
MGI Page MGI
Description: Enables ubiquitin activating enzyme activity. Predicted to be involved in DNA damage response; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with bounding membrane of organelle; desmosome; and heterochromatin. Is expressed in adrenal gland; brain; gonad; liver; and lung. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A1; A1S9; AA989744; Sb; Sbx; Ube-1; Ube1x; ubiquitin-activating enzyme E1 X; ubiquitin-activating enzyme E1, Chr X; ubiquitin-like modifier-activating enzyme 1; ubiquitin-like modifier-activating enzyme 1 X
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,524,660 - 20,549,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,524,565 - 20,549,418 (+)EnsemblGRCm39 Ensembl
GRCm38X20,658,302 - 20,683,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,658,326 - 20,683,179 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,235,547 - 20,260,305 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,815,380 - 19,840,138 (+)NCBIMGSCv36mm8
CeleraX18,792,750 - 18,813,110 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,5-hexanedione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
amitrole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (ISO)
benomyl  (ISO)
Benoxacor  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diethyldithiocarbamic acid  (ISO)
dimethyldithiocarbamate  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
FR900359  (ISO)
furan  (ISO)
glafenine  (ISO)
indometacin  (ISO)
inulin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
lead(0)  (EXP)
lead(II) chloride  (EXP)
maneb  (ISO)
manganese(II) chloride  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
molinate  (ISO)
N-nitrosodiethylamine  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
PhIP  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
prostaglandin A1  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
SKF 38393  (ISO)
sodium arsenite  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
zearalenone  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO)
desmosome  (IEA,ISO)
endosome membrane  (IEA,ISO)
heterochromatin  (IEA,ISO)
lysosomal membrane  (IEA,ISO)
mitochondrion  (ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO,ISS)
rough endoplasmic reticulum membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Estimating the intensity of male-driven evolution in rodents by using X-linked and Y-linked Ube 1 genes and pseudogenes. Chang BH and Li WH, J Mol Evol 1995 Jan;40(1):70-7.
2. A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1. Kay GF, etal., Nature 1991 Dec 12;354(6353):486-9.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Ubiquitin-activating enzyme, E1, is phosphorylated in mammalian cells by the protein kinase Cdc2. Nagai Y, etal., J Cell Sci 1995 Jun;108 ( Pt 6):2145-52.
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. An evaluation of the inactive mouse X chromosome in somatic cell hybrids. Salido EC, etal., Somat Cell Mol Genet 1993 Jan;19(1):65-71.
11. Immunofluorescent localization of the ubiquitin-activating enzyme, E1, to the nucleus and cytoskeleton. Trausch JS, etal., Am J Physiol 1993 Jan;264(1 Pt 1):C93-102.
Additional References at PubMed
PMID:1511901   PMID:1617221   PMID:1684224   PMID:7928394   PMID:7937138   PMID:8625802   PMID:8678984   PMID:8852665   PMID:8948595   PMID:9736774   PMID:9857172   PMID:10349636  
PMID:10509675   PMID:10656933   PMID:10922068   PMID:11004499   PMID:11042159   PMID:11076861   PMID:11172053   PMID:11217851   PMID:12023983   PMID:12477932   PMID:12506099   PMID:14610273  
PMID:14733918   PMID:14762062   PMID:15187125   PMID:15489334   PMID:15774460   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18307411   PMID:18799693   PMID:18818210   PMID:19571810  
PMID:20360068   PMID:21267068   PMID:21471155   PMID:21873635   PMID:22573614   PMID:23022194   PMID:23055941   PMID:23754746   PMID:24456201   PMID:24457600   PMID:24590288   PMID:24948797  
PMID:25737280   PMID:26514267   PMID:27325702   PMID:27507650   PMID:27899360   PMID:28190767   PMID:28378742   PMID:28634551   PMID:28671696   PMID:29199018   PMID:30068389   PMID:30196744  
PMID:30333137   PMID:30457570   PMID:30562941   PMID:30595499   PMID:31162944   PMID:32258175   PMID:32325033   PMID:33230847   PMID:34133714   PMID:35440748   PMID:35601919   PMID:36069228  
PMID:36114006   PMID:36278411   PMID:36293380   PMID:36417873   PMID:37142655   PMID:37839992  


Genomics

Comparative Map Data
Uba1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,524,660 - 20,549,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,524,565 - 20,549,418 (+)EnsemblGRCm39 Ensembl
GRCm38X20,658,302 - 20,683,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,658,326 - 20,683,179 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,235,547 - 20,260,305 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,815,380 - 19,840,138 (+)NCBIMGSCv36mm8
CeleraX18,792,750 - 18,813,110 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.15NCBI
UBA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,190,847 - 47,215,128 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,190,861 - 47,215,128 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,050,246 - 47,074,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,935,204 - 46,959,471 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX51,245,489 - 51,269,819 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,761,319 - 44,784,789 (+)NCBIHuRef
CHM1_1X47,081,686 - 47,106,022 (+)NCBICHM1_1
T2T-CHM13v2.0X46,600,543 - 46,624,827 (+)NCBIT2T-CHM13v2.0
Uba1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,062,216 - 4,084,192 (-)NCBIGRCr8
mRatBN7.2X1,508,700 - 1,530,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,508,666 - 1,530,636 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,542,708 - 1,561,181 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,018,410 - 5,036,883 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,333,715 - 1,352,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,723,135 - 1,745,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,723,174 - 1,741,701 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,516,602 - 2,538,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,926,049 - 12,944,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,931,605 - 12,950,078 (-)NCBI
CeleraX2,072,832 - 2,091,181 (-)NCBICelera
Cytogenetic MapXq11NCBI
Uba1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516876,354 - 891,206 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516876,542 - 898,763 (-)NCBIChiLan1.0ChiLan1.0
UBA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X48,818,274 - 48,842,554 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X48,821,657 - 48,845,930 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,627,753 - 39,652,023 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,485,374 - 47,509,654 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,493,331 - 47,509,654 (+)Ensemblpanpan1.1panPan2
UBA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,784,240 - 40,807,072 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,783,809 - 40,807,069 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,159,372 - 15,182,235 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,918,209 - 40,941,099 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,918,225 - 40,941,097 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,905,897 - 40,928,783 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,893,780 - 40,916,640 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,986,880 - 41,009,744 (+)NCBIUU_Cfam_GSD_1.0
Uba1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,120,490 - 33,143,491 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,969,145 - 12,984,238 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650212,961,236 - 12,984,235 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,814,101 - 41,832,812 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,810,726 - 41,832,818 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,779,768 - 46,793,857 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,377,765 - 44,402,378 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,385,940 - 44,405,051 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660769,636,110 - 9,660,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uba1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,963,871 - 3,984,243 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,961,699 - 3,983,772 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uba1
508 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1167
Count of miRNA genes:574
Interacting mature miRNAs:671
Transcripts:ENSMUST00000001989, ENSMUST00000089217, ENSMUST00000130694, ENSMUST00000136915, ENSMUST00000137892, ENSMUST00000152235
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
1301551Spha1_msperm head anomaly 1 (mouse)Not determinedX1026622539921652Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse

Markers in Region
Ube1x  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X20,682,519 - 20,682,703UniSTSGRCm38
MGSCv37X20,259,645 - 20,259,829UniSTSGRCm37
CeleraX18,812,450 - 18,812,634UniSTS
Cytogenetic MapXA2-A3UniSTS
cM MapX5.7UniSTS
cM MapX5.7UniSTS
AA989744  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X20,682,476 - 20,682,574UniSTSGRCm38
MGSCv37X20,259,602 - 20,259,700UniSTSGRCm37
CeleraX18,812,407 - 18,812,505UniSTS
Cytogenetic MapXA2-A3UniSTS
Whitehead/MRC_RHX360.84UniSTS
Ube1x  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X20,678,422 - 20,678,595UniSTSGRCm38
MGSCv37X20,255,548 - 20,255,721UniSTSGRCm37
CeleraX18,808,331 - 18,808,526UniSTS
Cytogenetic MapXA2-A3UniSTS
cM MapX5.7UniSTS
Ube1x  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA2-A3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001136085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030251302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK081808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK176944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL807240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB858760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY004827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY316912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY499679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S70396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U09051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000001989   ⟹   ENSMUSP00000001989
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,529,137 - 20,549,418 (+)Ensembl
GRCm38.p6 EnsemblX20,662,898 - 20,683,179 (+)Ensembl
Ensembl Acc Id: ENSMUST00000089217   ⟹   ENSMUSP00000086626
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,524,565 - 20,549,418 (+)Ensembl
GRCm38.p6 EnsemblX20,658,326 - 20,683,179 (+)Ensembl
Ensembl Acc Id: ENSMUST00000130694
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,525,666 - 20,535,456 (+)Ensembl
GRCm38.p6 EnsemblX20,659,427 - 20,669,217 (+)Ensembl
Ensembl Acc Id: ENSMUST00000136915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,546,834 - 20,548,444 (+)Ensembl
GRCm38.p6 EnsemblX20,680,595 - 20,682,205 (+)Ensembl
Ensembl Acc Id: ENSMUST00000137892
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,544,316 - 20,547,439 (+)Ensembl
GRCm38.p6 EnsemblX20,678,077 - 20,681,200 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152235
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,524,660 - 20,536,542 (+)Ensembl
GRCm38.p6 EnsemblX20,658,421 - 20,670,303 (+)Ensembl
RefSeq Acc Id: NM_001136085   ⟹   NP_001129557
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,529,170 - 20,549,420 (+)NCBI
GRCm38X20,662,896 - 20,683,179 (+)NCBI
MGSCv37X20,235,547 - 20,260,305 (+)RGD
CeleraX18,789,333 - 18,813,110 (+)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001276316   ⟹   NP_001263245
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,524,660 - 20,549,420 (+)NCBI
GRCm38X20,658,302 - 20,683,179 (+)NCBI
CeleraX18,789,333 - 18,813,110 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001276317   ⟹   NP_001263246
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,524,660 - 20,549,420 (+)NCBI
GRCm38X20,658,504 - 20,683,179 (+)NCBI
CeleraX18,789,333 - 18,813,110 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009457   ⟹   NP_033483
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,524,660 - 20,549,420 (+)NCBI
GRCm38X20,658,302 - 20,683,179 (+)NCBI
MGSCv37X20,235,547 - 20,260,305 (+)RGD
CeleraX18,789,333 - 18,813,110 (+)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030251302   ⟹   XP_030107162
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,524,743 - 20,548,945 (+)NCBI
GRCm38X20,658,504 - 20,682,706 (+)NCBI
Sequence:
RefSeq Acc Id: NP_033483   ⟸   NM_009457
- UniProtKB: A6H6S6 (UniProtKB/Swiss-Prot),   Q542H8 (UniProtKB/Swiss-Prot),   Q02053 (UniProtKB/Swiss-Prot),   P31253 (UniProtKB/Swiss-Prot),   B9EHN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129557   ⟸   NM_001136085
- UniProtKB: P31253 (UniProtKB/Swiss-Prot),   A6H6S6 (UniProtKB/Swiss-Prot),   Q542H8 (UniProtKB/Swiss-Prot),   Q02053 (UniProtKB/Swiss-Prot),   B9EHN0 (UniProtKB/TrEMBL),   A0A1S6GWH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263246   ⟸   NM_001276317
- UniProtKB: P31253 (UniProtKB/Swiss-Prot),   A6H6S6 (UniProtKB/Swiss-Prot),   Q542H8 (UniProtKB/Swiss-Prot),   Q02053 (UniProtKB/Swiss-Prot),   B9EHN0 (UniProtKB/TrEMBL),   A0A1S6GWH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263245   ⟸   NM_001276316
- UniProtKB: P31253 (UniProtKB/Swiss-Prot),   A6H6S6 (UniProtKB/Swiss-Prot),   Q542H8 (UniProtKB/Swiss-Prot),   Q02053 (UniProtKB/Swiss-Prot),   B9EHN0 (UniProtKB/TrEMBL),   A0A1S6GWH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030107162   ⟸   XM_030251302
- Peptide Label: isoform X1
- UniProtKB: Q02053 (UniProtKB/Swiss-Prot),   P31253 (UniProtKB/Swiss-Prot),   A6H6S6 (UniProtKB/Swiss-Prot),   Q542H8 (UniProtKB/Swiss-Prot),   A0A1S6GWH5 (UniProtKB/TrEMBL),   B9EHN0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000086626   ⟸   ENSMUST00000089217
Ensembl Acc Id: ENSMUSP00000001989   ⟸   ENSMUST00000001989
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02053-F1-model_v2 AlphaFold Q02053 1-1058 view protein structure

Promoters
RGD ID:6846478
Promoter ID:MM_KWN:59738
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   ES_Cell,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000089217,   OTTMUST00000041534
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X20,235,146 - 20,235,652 (+)MPROMDB
RGD ID:6846481
Promoter ID:MM_KWN:59739
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   BoneMarrow_4Hour,   Spleen
Transcripts:OTTMUST00000041535
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X20,235,569 - 20,236,069 (+)MPROMDB
RGD ID:6846480
Promoter ID:MM_KWN:59740
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000041533
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X20,240,026 - 20,240,526 (+)MPROMDB
RGD ID:6849294
Promoter ID:MM_XEF:7793
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_001038315,   NM_001038316,   NM_001040127,   NM_001082371,   NM_001086716,   NM_001135028,   NM_057962,   NM_120729,   NM_211335,   NM_213062
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X20,245,639 - 20,246,139 (+)MPROMDB
RGD ID:6846483
Promoter ID:MM_KWN:59741
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000041536
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X20,254,476 - 20,255,702 (+)MPROMDB
RGD ID:6846485
Promoter ID:MM_KWN:59742
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B6
Transcripts:OTTMUST00000041537
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X20,256,831 - 20,258,182 (+)MPROMDB
RGD ID:13680186
Promoter ID:EPDNEW_M24242
Type:initiation region
Name:Uba1_2
Description:Mus musculus ubiquitin-like modifier activating enzyme 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24243  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X20,658,421 - 20,658,481EPDNEW
RGD ID:13680188
Promoter ID:EPDNEW_M24243
Type:initiation region
Name:Uba1_1
Description:Mus musculus ubiquitin-like modifier activating enzyme 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24242  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X20,662,931 - 20,662,991EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98890 AgrOrtholog
Ensembl Genes ENSMUSG00000001924 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000001989 ENTREZGENE
  ENSMUST00000001989.9 UniProtKB/Swiss-Prot
  ENSMUST00000089217 ENTREZGENE
  ENSMUST00000089217.11 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.2660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.30.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.290.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro E1_4HB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1_FCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1_FCCH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF/MoeB/HesA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF_NAD_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ub-activating_enz_E1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ub-E1_IAD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA_E1_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA_E1_Cys UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubi_acti_E1_SCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-activ_enz_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-activ_enz_E1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-activ_enz_E1_Cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ/SUMO-activ_enz_E1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22201 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98890 ENTREZGENE
NCBI Gene 22201 ENTREZGENE
PANTHER PTHR10953 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E1_4HB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1_FCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1_UFD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA_e1_thiolCys UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uba1 PhenoGen
PRINTS UBIQUITINACT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE UBIQUITIN_ACTIVAT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN_ACTIVAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART UBA_e1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69572 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1S6GWH5 ENTREZGENE, UniProtKB/TrEMBL
  A6H6S6 ENTREZGENE
  B9EHN0 ENTREZGENE, UniProtKB/TrEMBL
  P31253 ENTREZGENE
  Q02053 ENTREZGENE
  Q542H8 ENTREZGENE
  UBA1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A6H6S6 UniProtKB/Swiss-Prot
  P31253 UniProtKB/Swiss-Prot
  Q542H8 UniProtKB/Swiss-Prot