Ace2 (angiotensin converting enzyme 2) - Rat Genome Database

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Gene: Ace2 (angiotensin converting enzyme 2) Mus musculus
Analyze
Symbol: Ace2
Name: angiotensin converting enzyme 2
RGD ID: 1550521
MGI Page MGI
Description: Enables metallocarboxypeptidase activity. Involved in angiotensin maturation; positive regulation of cardiac muscle contraction; and tryptophan transport. Located in brush border membrane and cytoplasm. Is active in extracellular region. Is expressed in several structures, including blastocyst; brain; early embryo; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010305L05Rik; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,922,328 - 162,971,416 (+)EnsemblGRCm39 Ensembl
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBIMGSCv36mm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Lung Injury  (IEP,IMP,ISO)
adult respiratory distress syndrome  (ISO)
Alveolar Bone Loss  (ISO)
anxiety disorder  (ISO)
autistic disorder  (ISO)
avian influenza  (IMP,ISO)
bacterial pneumonia  (IEP)
Cardiac Fibrosis  (ISO)
cardiomyopathy  (ISO)
Cardiovirus Infections  (IEP)
cerebral malaria  (ISO)
chemical colitis  (IMP)
congestive heart failure  (IAGP,ISO)
Coronary Disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (IAGP,ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (IAGP,ISO)
diabetic retinopathy  (ISO)
endomyocardial fibrosis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fanconi anemia  (ISO)
focal segmental glomerulosclerosis  (ISO)
glaucoma  (ISO)
hypertension  (IMP,ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
middle cerebral artery infarction  (ISO)
multiple congenital anomalies-hypotonia-seizures syndrome 2  (ISO)
myocardial infarction  (ISO)
Neurodevelopmental Disorders  (ISO)
pancreatic ductal carcinoma  (ISO)
Pleural Effusion  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (IMP,ISO)
severe acute respiratory syndrome  (HEP,IEP,IMP,ISO)
Spontaneous Abortions  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
thrombosis  (ISO)
Ventricular Remodeling  (IMP,ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
(S,S,S)-nicotianamine  (ISO)
1,2-dimethylhydrazine  (EXP)
14,15-EET  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,5-dihydroxybenzoic acid  (EXP)
3-chloropropane-1,2-diol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (EXP)
acarbose  (ISO)
acetic acid [4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenyl] ester  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
amitriptyline  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
angiotensin I  (EXP)
angiotensin II  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aprindine  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
benazepril  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
Butralin  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
captopril  (EXP,ISO)
carbon nanotube  (EXP)
ceftriaxone  (ISO)
CGP 52608  (ISO)
chloramphenicol  (ISO)
Chlormadinone acetate  (ISO)
chlorpromazine  (ISO)
chlorpropamide  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
danazol  (ISO)
dantrolene  (ISO)
DDE  (ISO)
desloratadine  (ISO)
dexamethasone  (ISO)
diazepam  (ISO)
diclofenac  (ISO)
diminazene  (ISO)
diminazene diaceturate  (EXP,ISO)
dioxygen  (EXP)
disopyramide  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxepin  (ISO)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
endosulfan  (ISO)
ethambutol  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
etoposide  (ISO)
flutamide  (ISO)
gemfibrozil  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
glyphosate  (ISO)
goralatide  (EXP)
griseofulvin  (ISO)
GW 4064  (EXP)
hydroquinone  (ISO)
hydroxyzine  (ISO)
Ile(5)-angiotensin II  (EXP)
imidapril  (ISO)
imipramine  (ISO)
inulin  (EXP)
Iodine aqueous  (ISO)
irbesartan  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
labetalol  (ISO)
lead diacetate  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (EXP,ISO)
lomustine  (ISO)
loratadine  (ISO)
losartan  (EXP,ISO)
Magnolol  (ISO)
melatonin  (EXP)
metformin  (EXP,ISO)
methimazole  (ISO)
metronidazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylnicotinate  (EXP,ISO)
naproxen  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nicotianamine  (ISO)
nicotinamide  (EXP)
nimesulide  (ISO)
okadaic acid  (ISO)
olmesartan  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (ISO)
orphenadrine  (ISO)
papaverine  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PD123319  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perindopril  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
pioglitazone  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
pregabalin  (ISO)
quercetin  (ISO)
quinidine  (ISO)
rifampicin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
telmisartan  (EXP,ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
Thiorphan  (EXP)
titanium dioxide  (ISO)
trandolapril  (EXP)
tributylstannane  (EXP)
triclosan  (ISO)
triptonide  (EXP)
tryptophan  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vancomycin  (ISO)
xanthone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IEA,ISO)
brush border membrane  (IDA,ISO)
cell surface  (ISO,ISS)
cilium  (IEA)
cytoplasm  (IDA)
extracellular region  (IDA,ISO)
extracellular space  (IBA,IEA,ISO)
plasma membrane  (IBA,IDA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiovascular system physiology  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal cornea epithelium morphology  (IAGP)
abnormal cornea wound healing  (IAGP)
abnormal cytokine level  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal feces composition  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart morphology  (IEA)
abnormal intestine morphology  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lens morphology  (IEA)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal retina morphology  (IEA)
abnormal spleen morphology  (IEA)
abnormal susceptibility to injury induced morbidity/mortality  (IAGP)
abnormal thymus morphology  (IEA)
abnormal uterus morphology  (IEA)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
congestive heart failure  (IAGP)
cornea opacity  (IAGP)
cornea vascularization  (IAGP)
decreased angiotensin II level  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased circulating angiotensin II level  (IAGP)
decreased colon length  (IAGP)
decreased heart left ventricle wall thickness  (IAGP)
decreased heart rate  (IAGP)
decreased heart ventricle muscle contractility  (IAGP)
decreased lean body mass  (IEA)
decreased pulmonary artery pressure  (IAGP)
decreased susceptibility to Coronaviridae infection  (IAGP)
decreased susceptibility to injury  (IAGP)
diarrhea  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart ventricle  (IAGP)
enlarged heart  (IEA)
enlarged spleen  (IEA)
enlarged thymus  (IEA)
heart inflammation  (IAGP)
hydrometra  (IEA)
hypertension  (IAGP)
hypotension  (IAGP)
impaired intestine regeneration  (IAGP)
increased angiotensin I-converting enzyme activity  (IAGP)
increased angiotensin II level  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased circulating angiotensin II level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-9 level  (IAGP)
increased heart weight  (IAGP)
increased incidence of corneal inflammation  (IAGP)
increased left ventricle diastolic pressure  (IAGP)
increased lung elastance  (IAGP)
increased lung weight  (IAGP)
increased NAD(P)H oxidase activity  (IAGP)
increased neutrophil cell number  (IAGP)
increased pulmonary respiratory rate  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to Coronaviridae infection  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to injury  (IAGP)
increased susceptibility to Orthomyxoviridae infection  (IAGP)
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to pulmonary hyaline membrane formation  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased total body fat amount  (IEA)
increased vascular permeability  (IAGP)
interstitial pneumonia  (IAGP)
intestinal edema  (IAGP)
intestinal inflammation  (IAGP)
lung hemorrhage  (IAGP)
lung inflammation  (IAGP)
melena  (IAGP)
oxidative stress  (IAGP)
pulmonary edema  (IAGP)
pulmonary hypertension  (IAGP)
pulmonary vascular congestion  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
yellow coat color  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Olmesartan is an angiotensin II receptor blocker with an inhibitory effect on angiotensin-converting enzyme. Agata J, etal., Hypertens Res. 2006 Nov;29(11):865-74.
2. The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. Bao L, etal., Nature. 2020 May 7. pii: 10.1038/s41586-020-2312-y. doi: 10.1038/s41586-020-2312-y.
3. Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2-Mediated COVID-19. Bos JM, etal., Mayo Clin Proc. 2020 Jul;95(7):1354-1368. doi: 10.1016/j.mayocp.2020.04.028. Epub 2020 Apr 28.
4. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
5. Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression. Burchill L, etal., Exp Physiol. 2008 May;93(5):622-30. doi: 10.1113/expphysiol.2007.040386. Epub 2008 Jan 25.
6. Myocardial infarction increases ACE2 expression in rat and humans. Burrell LM, etal., Eur Heart J 2005 Feb;26(4):369-75; discussion 322-4. Epub 2005 Jan 25.
7. Effects of the ACE2 inhibitor GL1001 on acute dextran sodium sulfate-induced colitis in mice. Byrnes JJ, etal., Inflamm Res. 2009 Nov;58(11):819-27. doi: 10.1007/s00011-009-0053-3. Epub 2009 Jun 11.
8. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Chen L, etal., Cardiovasc Res. 2020 May 1;116(6):1097-1100. doi: 10.1093/cvr/cvaa078.
9. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Crackower MA, etal., Nature 2002 Jun 20;417(6891):822-8.
10. ACE2-angiotensin-(1-7)-Mas axis in renal ischaemia/reperfusion injury in rats. da Silveira KD, etal., Clin Sci (Lond). 2010 Jul 23;119(9):385-94. doi: 10.1042/CS20090554.
11. The host's angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections. Delanghe JR, etal., Clin Chim Acta. 2020 Jun;505:192-193. doi: 10.1016/j.cca.2020.03.031. Epub 2020 Mar 24.
12. Gene polymorphisms in angiotensin I converting enzyme (ACE I/D) and angiotensin II converting enzyme (ACE2 C-->T) protect against cerebral malaria in Indian adults. Dhangadamajhi G, etal., Infect Genet Evol. 2010 Mar;10(2):337-41. doi: 10.1016/j.meegid.2010.01.009. Epub 2010 Feb 1.
13. ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR. Diez-Freire C, etal., Physiol Genomics. 2006 Oct 3;27(1):12-9. Epub 2006 Jun 20.
14. Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy. Dong B, etal., J Am Coll Cardiol. 2012 Feb 21;59(8):739-47. doi: 10.1016/j.jacc.2011.09.071.
15. The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus. Dong W, etal., J Virol. 2022 Jan 12;96(1):e0096421. doi: 10.1128/JVI.00964-21. Epub 2021 Oct 20.
16. Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases. Ferreira AJ, etal., Exp Physiol. 2011 Mar;96(3):287-94. doi: 10.1113/expphysiol.2010.055277. Epub 2010 Dec 10.
17. Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2. Foureaux G, etal., Invest Ophthalmol Vis Sci. 2013 Jun 21;54(6):4296-306. doi: 10.1167/iovs.12-11427.
18. ACE2 activation promotes antithrombotic activity. Fraga-Silva RA, etal., Mol Med. 2010 May-Jun;16(5-6):210-5. doi: 10.2119/molmed.2009.00160. Epub 2010 Jan 22.
19. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Gu H, etal., Sci Rep. 2016 Jan 27;6:19840. doi: 10.1038/srep19840.
20. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Hashimoto T, etal., Nature. 2012 Jul 25;487(7408):477-81. doi: 10.1038/nature11228.
21. A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies. Hassan AO, etal., Cell. 2020 Jun 10. pii: S0092-8674(20)30742-X. doi: 10.1016/j.cell.2020.06.011.
22. Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis. Herath CB, etal., J Hepatol. 2007 Sep;47(3):387-95. Epub 2007 Apr 2.
23. ACE/ACE2 ratio and MMP-9 activity as potential biomarkers in tuberculous pleural effusions. Hsieh WY, etal., Int J Biol Sci. 2012;8(8):1197-205. doi: 10.7150/ijbs.5087. Epub 2012 Oct 17.
24. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Hsu CN, etal., Int J Mol Sci. 2020 Jun 26;21(12):4552. doi: 10.3390/ijms21124552.
25. Upregulation Of Angiotensin Converting Enzyme 2 In Hepatic Fibrosis By Angiotensin Converting Enzyme Inhibitors: An In Vivo And In Vitro Study. Huang ML, etal., Clin Exp Pharmacol Physiol. 2009 Sep 28.
26. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Imai Y, etal., Nature. 2005 Jul 7;436(7047):112-6. doi: 10.1038/nature03712.
27. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
28. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Kuba K, etal., Nat Med. 2005 Aug;11(8):875-9. doi: 10.1038/nm1267. Epub 2005 Jul 10.
29. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
30. Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Lee DK, etal., Endocrinology. 2005 Jan;146(1):231-6. Epub 2004 Oct 14.
31. Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis. Liu J, etal., Life Sci. 2018 Sep 1;208:139-148. doi: 10.1016/j.lfs.2018.07.013. Epub 2018 Jul 7.
32. The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. Lu J, etal., Neuropeptides. 2013 Oct;47(5):289-95. doi: 10.1016/j.npep.2013.09.002. Epub 2013 Sep 18.
33. MGDs mouse GO annotations MGD data from the GO Consortium
34. MGD IEA MGD IEA
35. Renal ACE and ACE2 expression in early diabetic rats. Moon JY, etal., Nephron Exp Nephrol. 2008;110(1):e8-e16. Epub 2008 Aug 4.
36. Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction. Murca TM, etal., Regul Pept. 2012 Aug 20;177(1-3):107-15. doi: 10.1016/j.regpep.2012.05.093. Epub 2012 May 14.
37. ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. Neves LA, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R151-61. Epub 2007 Oct 31.
38. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
39. SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. Oudit GY, etal., Eur J Clin Invest. 2009 Jul;39(7):618-25. doi: 10.1111/j.1365-2362.2009.02153.x. Epub 2009 May 6.
40. Angiotensin-converting enzyme I/D polymorphism in chronic obstructive pulmonary disease. Pabst S, etal., Eur J Med Res. 2009 Dec 7;14 Suppl 4:177-81.
41. Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2. Paizis G, etal., Gut. 2005 Dec;54(12):1790-6. doi: 10.1136/gut.2004.062398. Epub 2005 Sep 15.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. Diminazene aceturate enhances angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology. Qi Y, etal., Hypertension. 2013 Oct;62(4):746-52. doi: 10.1161/HYPERTENSIONAHA.113.01337. Epub 2013 Aug 19.
44. [Effect of atorvastatin on ACE2 expression in pressure overload induced cardiac hypertrophy in rats]. Qin XT, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 May;33(5):438-42.
45. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases Qiu QM, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010 Apr;28(4):275-9.
46. Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Reich HN, etal., Kidney Int. 2008 Dec;74(12):1610-6. Epub 2008 Oct 1.
47. A place in our hearts for the lowly angiotensin 1-7 peptide? Reudelhuber TL Hypertension. 2006 May;47(5):811-5. Epub 2006 Mar 6.
48. Mouse MP Annotation Import Pipeline RGD automated import pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat. Riviere G, etal., Hypertension. 2005 Nov;46(5):1169-74. Epub 2005 Oct 3.
52. The ACE2/Ang-(1-7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension. Shenoy V, etal., Am J Respir Crit Care Med. 2010 Jun 25.
53. Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension. Shenoy V, etal., Hypertension. 2014 Dec;64(6):1248-59. doi: 10.1161/HYPERTENSIONAHA.114.03871. Epub 2014 Sep 15.
54. Oral delivery of ACE2/Ang-(1-7) bioencapsulated in plant cells protects against experimental uveitis and autoimmune uveoretinitis. Shil PK, etal., Mol Ther. 2014 Dec;22(12):2069-2082. doi: 10.1038/mt.2014.179. Epub 2014 Sep 17.
55. A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice. Sodhi CP, etal., J Immunol. 2019 Dec 1;203(11):3000-3012. doi: 10.4049/jimmunol.1900579. Epub 2019 Oct 23.
56. ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes. Tikellis C, etal., Diabetes. 2008 Apr;57(4):1018-25. Epub 2008 Jan 30.
57. Expression of Human ACE2 in Lactobacillus and Beneficial Effects in Diabetic Retinopathy in Mice. Verma A, etal., Mol Ther Methods Clin Dev. 2019 Jul 10;14:161-170. doi: 10.1016/j.omtm.2019.06.007. eCollection 2019 Sep 13.
58. ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Verma A, etal., Mol Ther. 2012 Jan;20(1):28-36. doi: 10.1038/mt.2011.155. Epub 2011 Jul 26.
59. Discrepancy between intrarenal messenger RNA and protein expression of ACE and ACE2 in human diabetic nephropathy. Wang G, etal., Am J Nephrol. 2009;29(6):524-31. Epub 2008 Dec 12.
60. Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis. Wang G, etal., Kidney Blood Press Res. 2011;34(3):141-9. doi: 10.1159/000324521. Epub 2011 Feb 24.
61. SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice. Winkler ES, etal., J Virol. 2022 Jan 12;96(1):e0151121. doi: 10.1128/JVI.01511-21. Epub 2021 Oct 20.
62. [Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus] Yan QN, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug;28(8):1365-8.
63. ACE2 correlated with immune infiltration serves as a prognostic biomarker in endometrial carcinoma and renal papillary cell carcinoma: implication for COVID-19. Yang J, etal., Aging (Albany NY). 2020 Apr 27;12(8):6518-6535. doi: 10.18632/aging.103100. Epub 2020 Apr 27.
64. Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Yang P, etal., Sci Rep. 2014 Nov 13;4:7027. doi: 10.1038/srep07027.
65. Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection. Yang XH, etal., Comp Med. 2007 Oct;57(5):450-9.
66. ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction. Zhao YX, etal., Hum Gene Ther. 2010 Nov;21(11):1545-54. doi: 10.1089/hum.2009.160.
67. Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome. Zhong J, etal., J Lab Clin Med. 2006 Feb;147(2):91-5.
68. Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression. Zhong JC, etal., Regul Pept. 2011 Jan 17;166(1-3):90-7. doi: 10.1016/j.regpep.2010.09.005. Epub 2010 Sep 18.
69. Decreased expression of angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression. Zhou L, etal., Tohoku J Exp Med. 2009 Feb;217(2):123-31.
70. Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Zou Z, etal., Nat Commun. 2014 May 6;5:3594. doi: 10.1038/ncomms4594.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12487024   PMID:12967627   PMID:15356152   PMID:15452268   PMID:15489334   PMID:15561968   PMID:15949646   PMID:16141072  
PMID:16141073   PMID:16505206   PMID:16723697   PMID:16738017   PMID:16804085   PMID:16878172   PMID:16946085   PMID:17198697   PMID:17340620   PMID:17499227   PMID:17579661   PMID:17600118  
PMID:18164957   PMID:18192335   PMID:18263657   PMID:18287559   PMID:18310259   PMID:18356559   PMID:18376006   PMID:18403726   PMID:18441099   PMID:18448662   PMID:18554416   PMID:18650320  
PMID:18660448   PMID:18956256   PMID:19004932   PMID:19015603   PMID:19124678   PMID:19185582   PMID:19334288   PMID:19478081   PMID:19521566   PMID:19650157   PMID:19759332   PMID:19808375  
PMID:19880118   PMID:19926873   PMID:19948988   PMID:20186149   PMID:20357030   PMID:20562862   PMID:20671240   PMID:20679547   PMID:20798044   PMID:21188549   PMID:21208466   PMID:21252069  
PMID:21267068   PMID:21285291   PMID:21481527   PMID:21677750   PMID:21814048   PMID:21818366   PMID:21873635   PMID:21880865   PMID:21946695   PMID:21968754   PMID:22036945   PMID:22246130  
PMID:22288735   PMID:22289845   PMID:22330342   PMID:22460555   PMID:22474255   PMID:22508831   PMID:22518292   PMID:22580272   PMID:22616805   PMID:22665126   PMID:22677001   PMID:22693641  
PMID:22790597   PMID:22933108   PMID:22947377   PMID:23043153   PMID:23127535   PMID:23160880   PMID:23328447   PMID:23392115   PMID:23462816   PMID:23535237   PMID:23608725   PMID:23671869  
PMID:23761674   PMID:23951161   PMID:24048198   PMID:24067190   PMID:24161906   PMID:24177423   PMID:24193738   PMID:24379178   PMID:24400109   PMID:24414175   PMID:24446061   PMID:24454948  
PMID:24464749   PMID:24477684   PMID:24581232   PMID:24695436   PMID:24728465   PMID:24756097   PMID:24760518   PMID:24799609   PMID:24911884   PMID:25175177   PMID:25249154   PMID:25291359  
PMID:25301841   PMID:25448263   PMID:25484288   PMID:25489058   PMID:25519733   PMID:25650385   PMID:25721616   PMID:25867182   PMID:25890286   PMID:25968123   PMID:25968580   PMID:26029927  
PMID:26078188   PMID:26144375   PMID:26224885   PMID:26245758   PMID:26389599   PMID:26441236   PMID:26498282   PMID:26767952   PMID:26883384   PMID:27018342   PMID:27019629   PMID:27053009  
PMID:27070147   PMID:27113764   PMID:27379538   PMID:27592222   PMID:27601681   PMID:27612496   PMID:27649628   PMID:27806985   PMID:27917469   PMID:27927599   PMID:28101297   PMID:28142259  
PMID:28249676   PMID:28273875   PMID:28721275   PMID:28808068   PMID:28842425   PMID:28845018   PMID:28935640   PMID:28935757   PMID:29128354   PMID:29138810   PMID:29196099   PMID:29211853  
PMID:29225087   PMID:29266779   PMID:29363860   PMID:29559844   PMID:29570986   PMID:29679094   PMID:29706566   PMID:29761600   PMID:29884907   PMID:30207087   PMID:30604460   PMID:30628484  
PMID:31393582   PMID:31440756   PMID:31484552   PMID:31519791   PMID:31564162   PMID:31610731   PMID:31775868   PMID:31786979   PMID:31805278   PMID:31853045   PMID:31861139   PMID:31987854  
PMID:32015507   PMID:32275855   PMID:32316719   PMID:32322207   PMID:32338605   PMID:32368013   PMID:32379417   PMID:32404477   PMID:32413319   PMID:32418199   PMID:32441816   PMID:32472097  
PMID:32485164   PMID:32511354   PMID:32513532   PMID:32525008   PMID:32558150   PMID:32564694   PMID:32607866   PMID:32669323   PMID:32725927   PMID:32726802   PMID:32750141   PMID:32820248  
PMID:32837584   PMID:32966801   PMID:32967005   PMID:32971570   PMID:32991738   PMID:33008593   PMID:33057007   PMID:33078906   PMID:33097186   PMID:33106680   PMID:33168188   PMID:33275517  
PMID:33284956   PMID:33339432   PMID:33372179   PMID:33422505   PMID:33488611   PMID:33558541   PMID:33566370   PMID:33626084   PMID:33636719   PMID:33658332   PMID:33725024   PMID:33727353  
PMID:33774649   PMID:33811970   PMID:33932339   PMID:33963249   PMID:33991451   PMID:34018203   PMID:34158856   PMID:34216827   PMID:34267318   PMID:34290590   PMID:34305888   PMID:34708340  
PMID:34774871   PMID:34854526   PMID:34907154   PMID:34907257   PMID:34932561   PMID:34937050   PMID:35014608   PMID:35023830   PMID:35344711   PMID:35368365   PMID:35603169   PMID:35641567  
PMID:35658928   PMID:35754185   PMID:35767531   PMID:35821014   PMID:35834347   PMID:35896894   PMID:36000843   PMID:36207334   PMID:36256797   PMID:36265585   PMID:36405683   PMID:36448480  
PMID:36451809   PMID:36591353   PMID:36611813   PMID:36640338   PMID:36652473   PMID:36688655   PMID:36705419   PMID:36740662   PMID:36745682   PMID:36812267   PMID:36841831   PMID:36951969  
PMID:36971701   PMID:36998145   PMID:37014274   PMID:37018380   PMID:37036004   PMID:37046278   PMID:37161607   PMID:37252952   PMID:37312182   PMID:37329995   PMID:37404465   PMID:37452090  
PMID:37595771   PMID:37638055   PMID:37732000   PMID:37763673   PMID:37823176   PMID:37848036   PMID:37914927   PMID:37943512   PMID:38097099   PMID:38141575   PMID:38168680   PMID:38185937  
PMID:38203500   PMID:38240986   PMID:38246001   PMID:38355793   PMID:38463024   PMID:38488938   PMID:38532242   PMID:38654010   PMID:38742107   PMID:38834299   PMID:38986737   PMID:39050847  
PMID:39086603   PMID:39142369   PMID:39273464   PMID:39279412   PMID:39480813   PMID:39779976  


Genomics

Comparative Map Data
Ace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,922,328 - 162,971,416 (+)EnsemblGRCm39 Ensembl
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBIMGSCv36mm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
ACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,518,197 - 15,607,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,494,566 - 15,607,236 (-)EnsemblGRCh38hg38GRCh38
GRCh37X15,536,320 - 15,625,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
T2T-CHM13v2.0X15,101,170 - 15,190,203 (-)NCBIT2T-CHM13v2.0
Ace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,925,458 - 33,972,851 (-)NCBIGRCr8
mRatBN7.2X30,293,597 - 30,340,961 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,293,589 - 30,340,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX31,326,034 - 31,372,619 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,763,480 - 34,809,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,950,895 - 30,996,838 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
Ace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBIChiLan1.0ChiLan1.0
ACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,358,905 - 17,402,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,362,290 - 17,405,412 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X8,189,267 - 8,229,415 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,470,896 - 15,510,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,470,896 - 15,510,891 (-)Ensemblpanpan1.1panPan2
ACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,798,839 - 11,839,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,798,839 - 11,900,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,706,330 - 11,745,360 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,760,479 - 11,822,897 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,759,554 - 11,789,618 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,824,224 - 11,862,960 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,818,311 - 11,856,868 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,843,799 - 11,882,613 (-)NCBIUU_Cfam_GSD_1.0
Ace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,964,502 - 5,012,706 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,965,332 - 5,011,702 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,093,242 - 12,151,286 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,099,849 - 12,152,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,061,317 - 13,089,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,866,608 - 15,915,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ace2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829344,933 - 391,527 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624829344,823 - 391,451 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ace2
1513 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1527
Count of miRNA genes:597
Interacting mature miRNAs:756
Transcripts:ENSMUST00000073973, ENSMUST00000112271, ENSMUST00000131543
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
12738421Lfibq17_mliver fibrosis QTL 17 (mouse)X148148453164945064Mouse
1357619Obsty5_mobesity 5 (mouse)Not determinedX160212893164149284Mouse

Markers in Region
Ace2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF5UniSTS
cM MapX70.5UniSTS
cM MapX70.5UniSTS
BE098785  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X164,188,229 - 164,188,387UniSTSGRCm38
MGSCv37X160,626,161 - 160,626,319UniSTSGRCm37
CeleraX147,402,715 - 147,402,873UniSTS
Cytogenetic MapXF5UniSTS
cM MapX70.5UniSTS
D1S2869  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,688,356 - 93,689,529UniSTSGRCm38
GRCm38X164,153,557 - 164,154,374UniSTSGRCm38
MGSCv37195,584,933 - 95,586,106UniSTSGRCm37
MGSCv37X160,591,489 - 160,592,306UniSTSGRCm37
CeleraX147,367,932 - 147,368,749UniSTS
Celera196,633,400 - 96,634,573UniSTS
Cytogenetic MapXF5UniSTS
Cytogenetic Map1DUniSTS
cM MapX70.5UniSTS
Ace2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF5UniSTS
cM MapX70.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000073973   ⟹   ENSMUSP00000073626
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX162,923,474 - 162,971,416 (+)Ensembl
GRCm38.p6 EnsemblX164,140,478 - 164,188,420 (+)Ensembl
Ensembl Acc Id: ENSMUST00000112271   ⟹   ENSMUSP00000107890
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX162,922,328 - 162,971,416 (+)Ensembl
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)Ensembl
Ensembl Acc Id: ENSMUST00000131543   ⟹   ENSMUSP00000123313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX162,945,174 - 162,968,820 (+)Ensembl
GRCm38.p6 EnsemblX164,162,178 - 164,185,824 (+)Ensembl
RefSeq Acc Id: NM_001130513   ⟹   NP_001123985
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X162,922,338 - 162,971,414 (+)NCBI
GRCm38X164,139,342 - 164,188,418 (+)ENTREZGENE
MGSCv37X160,577,274 - 160,626,350 (+)RGD
CeleraX147,353,722 - 147,402,904 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_027286   ⟹   NP_081562
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X162,923,476 - 162,971,414 (+)NCBI
GRCm38X164,140,480 - 164,188,418 (+)NCBI
MGSCv37X160,577,274 - 160,626,350 (+)RGD
CeleraX147,353,722 - 147,402,904 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_081562   ⟸   NM_027286
- Peptide Label: precursor
- UniProtKB: Q99N70 (UniProtKB/Swiss-Prot),   Q99N71 (UniProtKB/Swiss-Prot),   Q8R0I0 (UniProtKB/Swiss-Prot),   Q3URC9 (UniProtKB/TrEMBL),   C7ECU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001123985   ⟸   NM_001130513
- Peptide Label: precursor
- UniProtKB: Q99N70 (UniProtKB/Swiss-Prot),   Q99N71 (UniProtKB/Swiss-Prot),   Q8R0I0 (UniProtKB/Swiss-Prot),   Q3URC9 (UniProtKB/TrEMBL),   C7ECU2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000073626   ⟸   ENSMUST00000073973
Ensembl Acc Id: ENSMUSP00000107890   ⟸   ENSMUST00000112271
Ensembl Acc Id: ENSMUSP00000123313   ⟸   ENSMUST00000131543
Protein Domains
Collectrin-like   Peptidase M2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R0I0-F1-model_v2 AlphaFold Q8R0I0 1-805 view protein structure
ACE2 pdb 1r42 Q8R0I0 18-740 view protein structure

Promoters
RGD ID:6845417
Promoter ID:MM_KWN:62686
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000073973
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X160,577,946 - 160,578,446 (+)MPROMDB
RGD ID:13681808
Promoter ID:EPDNEW_M25053
Type:initiation region
Name:Ace2_2
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M25054  EPDNEW_M25055  EPDNEW_M25056  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,139,390 - 164,139,450EPDNEW
RGD ID:13681810
Promoter ID:EPDNEW_M25054
Type:initiation region
Name:Ace2_4
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M25053  EPDNEW_M25055  EPDNEW_M25056  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,140,504 - 164,140,564EPDNEW
RGD ID:13681812
Promoter ID:EPDNEW_M25055
Type:multiple initiation site
Name:Ace2_1
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M25053  EPDNEW_M25054  EPDNEW_M25056  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,140,632 - 164,140,692EPDNEW
RGD ID:13681814
Promoter ID:EPDNEW_M25056
Type:initiation region
Name:Ace2_3
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M25053  EPDNEW_M25054  EPDNEW_M25055  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,162,177 - 164,162,237EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917258 AgrOrtholog
Ensembl Genes ENSMUSG00000015405 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000073973 ENTREZGENE
  ENSMUST00000073973.11 UniProtKB/Swiss-Prot
  ENSMUST00000112271 ENTREZGENE
  ENSMUST00000112271.10 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1370.30 UniProtKB/Swiss-Prot
InterPro Collectrin_dom UniProtKB/Swiss-Prot
  Peptidase_M2 UniProtKB/Swiss-Prot
KEGG Report mmu:70008 UniProtKB/Swiss-Prot
MGD MGI:1917258 ENTREZGENE
NCBI Gene 70008 ENTREZGENE
PANTHER ANGIOTENSIN-CONVERTING ENZYME 2 UniProtKB/Swiss-Prot
  PTHR10514 UniProtKB/Swiss-Prot
Pfam Collectrin UniProtKB/Swiss-Prot
  Peptidase_M2 UniProtKB/Swiss-Prot
PharmGKB ACE2 RGD
PhenoGen Ace2 PhenoGen
PRINTS PEPDIPTASEA UniProtKB/Swiss-Prot
PROSITE COLLECTRIN_LIKE UniProtKB/Swiss-Prot
  PEPTIDASE_M2 UniProtKB/Swiss-Prot
  WD_REPEATS_1 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
UniProt ACE2_MOUSE UniProtKB/Swiss-Prot
  C7ECU2 ENTREZGENE, UniProtKB/TrEMBL
  F6X479_MOUSE UniProtKB/TrEMBL
  Q3URC9 ENTREZGENE, UniProtKB/TrEMBL
  Q3UXR1_MOUSE UniProtKB/TrEMBL
  Q8R0I0 ENTREZGENE
  Q99N70 ENTREZGENE
  Q99N71 ENTREZGENE
  Q9D836_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q99N70 UniProtKB/Swiss-Prot
  Q99N71 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Ace2  angiotensin converting enzyme 2  Ace2  angiotensin I converting enzyme (peptidyl-dipeptidase A) 2  Symbol and/or name change 5135510 APPROVED