Isca1 (iron-sulfur cluster assembly 1) - Rat Genome Database

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Gene: Isca1 (iron-sulfur cluster assembly 1) Mus musculus
Analyze
Symbol: Isca1
Name: iron-sulfur cluster assembly 1
RGD ID: 1550512
MGI Page MGI
Description: Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1810010A06Rik; Hbld; Hbld2; HESB like domain containing 2; HESB-like domain-containing protein 2; iron sulfur assembly protein IscA; iron-sulfur assembly protein IscA; iron-sulfur cluster assembly 1 homolog; iron-sulfur cluster assembly 1 homolog, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391359,903,229 - 59,917,603 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1359,903,223 - 59,917,624 (-)EnsemblGRCm39 Ensembl
GRCm381359,755,415 - 59,769,789 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1359,755,409 - 59,769,810 (-)EnsemblGRCm38mm10GRCm38
MGSCv371359,856,776 - 59,871,150 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361359,765,038 - 59,779,412 (-)NCBIMGSCv36mm8
Celera1360,813,565 - 60,829,332 (-)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1331.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:18614015   PMID:19521500   PMID:19656490   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24194600   PMID:24577088   PMID:28492233   PMID:30550785   PMID:32325033   PMID:32376682  
PMID:38355793  


Genomics

Comparative Map Data
Isca1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391359,903,229 - 59,917,603 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1359,903,223 - 59,917,624 (-)EnsemblGRCm39 Ensembl
GRCm381359,755,415 - 59,769,789 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1359,755,409 - 59,769,810 (-)EnsemblGRCm38mm10GRCm38
MGSCv371359,856,776 - 59,871,150 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361359,765,038 - 59,779,412 (-)NCBIMGSCv36mm8
Celera1360,813,565 - 60,829,332 (-)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1331.88NCBI
ISCA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38986,264,546 - 86,282,538 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl986,264,546 - 86,283,102 (-)EnsemblGRCh38hg38GRCh38
GRCh37988,879,461 - 88,897,453 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36988,069,281 - 88,087,310 (-)NCBINCBI36Build 36hg18NCBI36
Build 34986,109,015 - 86,127,044NCBI
Celera959,449,572 - 59,467,604 (-)NCBICelera
Cytogenetic Map9q21.33NCBI
HuRef958,702,212 - 58,720,322 (-)NCBIHuRef
CHM1_1989,025,905 - 89,043,932 (-)NCBICHM1_1
T2T-CHM13v2.0998,415,772 - 98,433,767 (-)NCBIT2T-CHM13v2.0
Isca1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,910,816 - 4,923,478 (+)NCBIGRCr8
mRatBN7.2174,905,291 - 4,917,955 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl174,905,287 - 4,917,955 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,924,890 - 4,937,662 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0176,466,859 - 6,479,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0174,921,330 - 4,934,105 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0175,281,727 - 5,294,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,281,727 - 5,294,384 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0177,507,069 - 7,519,772 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41710,808,966 - 10,821,681 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11710,808,965 - 10,821,679 (+)NCBI
Celera175,026,823 - 5,039,495 (+)NCBICelera
Cytogenetic Map17p14NCBI
Isca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554321,335,481 - 1,349,847 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554321,335,481 - 1,349,852 (+)NCBIChiLan1.0ChiLan1.0
ISCA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21153,120,297 - 53,141,390 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1953,125,609 - 53,143,778 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0957,410,328 - 57,428,477 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1985,467,139 - 85,485,107 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl985,467,145 - 85,485,107 (-)Ensemblpanpan1.1panPan2
Isca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947120,048,452 - 120,064,421 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366801,673,666 - 1,689,635 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366801,673,666 - 1,689,646 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100513185
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11670,893,220 - 70,893,762 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21676,999,935 - 77,000,396 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ISCA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11296,900,619 - 96,915,611 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1296,897,849 - 96,915,540 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603885,250,660 - 85,266,902 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Isca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480911,099,485 - 11,114,917 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480911,099,483 - 11,114,917 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Isca1
561 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:633
Count of miRNA genes:448
Interacting mature miRNAs:504
Transcripts:ENSMUST00000057115, ENSMUST00000160628
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135647045676971314Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse

Markers in Region
RH124995  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A3.1UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000057115   ⟹   ENSMUSP00000054858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1359,903,223 - 59,917,624 (-)Ensembl
GRCm38.p6 Ensembl1359,755,409 - 59,769,810 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160628
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1359,908,210 - 59,917,590 (-)Ensembl
GRCm38.p6 Ensembl1359,760,396 - 59,769,776 (-)Ensembl
Ensembl Acc Id: ENSMUST00000224636
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1359,913,508 - 59,917,567 (-)Ensembl
GRCm38.p6 Ensembl1359,765,694 - 59,769,753 (-)Ensembl
Ensembl Acc Id: ENSMUST00000225284
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1359,908,864 - 59,911,381 (-)Ensembl
GRCm38.p6 Ensembl1359,761,050 - 59,763,567 (-)Ensembl
Ensembl Acc Id: ENSMUST00000225795
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1359,903,228 - 59,906,507 (-)Ensembl
GRCm38.p6 Ensembl1359,755,414 - 59,758,693 (-)Ensembl
Ensembl Acc Id: ENSMUST00000225850   ⟹   ENSMUSP00000153175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1359,903,225 - 59,917,602 (-)Ensembl
GRCm38.p6 Ensembl1359,755,411 - 59,769,788 (-)Ensembl
Ensembl Acc Id: ENSMUST00000225877
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1359,904,576 - 59,917,291 (-)Ensembl
GRCm38.p6 Ensembl1359,756,762 - 59,769,477 (-)Ensembl
RefSeq Acc Id: NM_026921   ⟹   NP_081197
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391359,903,229 - 59,917,603 (-)NCBI
GRCm381359,755,415 - 59,769,789 (-)ENTREZGENE
MGSCv371359,856,776 - 59,871,150 (-)RGD
Celera1360,813,565 - 60,829,332 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_081197   ⟸   NM_026921
- Peptide Label: precursor
- UniProtKB: Q5SZT5 (UniProtKB/Swiss-Prot),   Q9D924 (UniProtKB/Swiss-Prot),   I3ITR1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000153175   ⟸   ENSMUST00000225850
Ensembl Acc Id: ENSMUSP00000054858   ⟸   ENSMUST00000057115

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D924-F1-model_v2 AlphaFold Q9D924 1-129 view protein structure

Promoters
RGD ID:8680564
Promoter ID:EPDNEW_M18313
Type:initiation region
Name:Isca1_1
Description:Mus musculus iron-sulfur cluster assembly 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381359,769,776 - 59,769,836EPDNEW
RGD ID:6823887
Promoter ID:MM_KWN:14353
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NR_015349,   OTTMUST00000072226,   OTTMUST00000072279,   OTTMUST00000072280
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361359,871,076 - 59,872,062 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916296 AgrOrtholog
Ensembl Genes ENSMUSG00000035253
  ENSMUSG00000044792 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000057115 ENTREZGENE
  ENSMUST00000057115.7 UniProtKB/Swiss-Prot
  ENSMUST00000225850.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.300.12 UniProtKB/Swiss-Prot
InterPro Fe-S_cluster_asmbl/transfer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FeS_biogenesis UniProtKB/Swiss-Prot
  FeS_cluster_insertion UniProtKB/Swiss-Prot
  FeS_cluster_insertion_CS UniProtKB/Swiss-Prot
  HesB-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:69046 UniProtKB/Swiss-Prot
MGD MGI:1916296 ENTREZGENE
NCBI Gene 69046 ENTREZGENE
PANTHER IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRON-SULFUR CLUSTER ASSEMBLY PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fe-S_biosyn UniProtKB/Swiss-Prot
PhenoGen Isca1 PhenoGen
PROSITE HESB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF89360 UniProtKB/Swiss-Prot
UniProt A0A286YCW6_MOUSE UniProtKB/TrEMBL
  I3ITR1 ENTREZGENE
  ISCA1_MOUSE UniProtKB/Swiss-Prot
  Q5SZT5 ENTREZGENE
  Q9D924 ENTREZGENE
UniProt Secondary Q5SZT5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Isca1  iron-sulfur cluster assembly 1    iron-sulfur cluster assembly 1 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED