Angpt2 (angiopoietin 2) - Rat Genome Database

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Gene: Angpt2 (angiopoietin 2) Mus musculus
Analyze
Symbol: Angpt2
Name: angiopoietin 2
RGD ID: 1550503
MGI Page MGI
Description: Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within angiogenesis; negative regulation of angiogenesis; and negative regulation of cell-substrate adhesion. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; hemolymphoid system; limb interdigital region; and metanephros. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Agpt2; An; Ang; Ang-2; Ang2; angiopoietin-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39818,740,279 - 18,791,578 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl818,740,279 - 18,791,578 (-)EnsemblGRCm39 Ensembl
GRCm38818,690,263 - 18,741,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl818,690,263 - 18,741,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv37818,691,337 - 18,741,551 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36818,691,314 - 18,741,528 (-)NCBIMGSCv36mm8
Celera818,824,534 - 18,875,113 (-)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
astemizole  (ISO)
atorvastatin calcium  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
BQ 123  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
Curcumol  (ISO)
daunorubicin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP,ISO)
diquat  (EXP)
dorsomorphin  (ISO)
enalapril  (ISO)
epoxiconazole  (EXP)
furosemide  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
iloprost  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
letrozole  (EXP)
lidocaine  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nicotinic acid  (EXP)
NORCANTHARIDIN  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
ozone  (EXP)
palytoxin  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PD123319  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
progesterone  (ISO)
propranolol  (ISO)
purine-6-thiol  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sulfadimethoxine  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (EXP)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tyrphostin AG 1478  (ISO)
urethane  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Ardelt AA, etal., Stroke. 2005 Feb;36(2):337-41. Epub 2005 Jan 6.
2. Angiopoietin 1 and 2 gene and protein expression is differentially regulated in acute anti-Thy1.1 glomerulonephritis. Campean V, etal., Am J Physiol Renal Physiol. 2008 May;294(5):F1174-84. Epub 2008 Feb 13.
3. Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension. Cho YJ, etal., Comp Med. 2009 Aug;59(4):350-6.
4. Compensatory growth of coronary arterioles in postinfarcted heart: regional differences in DNA synthesis and growth factor/receptor expression patterns. Dedkov EI, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1686-93. Epub 2006 May 19.
5. Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases. Fabris L, etal., Hepatology. 2006 May;43(5):1001-12.
6. Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy. Hammes HP, etal., Diabetes. 2004 Apr;53(4):1104-10.
7. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Holash J, etal., Science. 1999 Jun 18;284(5422):1994-8.
8. Angiogenesis-related biomarkers in patients with alcoholic liver disease: their association with liver disease complications and outcome. Kasztelan-Szczerbinska B, etal., Mediators Inflamm. 2014;2014:673032. doi: 10.1155/2014/673032. Epub 2014 May 18.
9. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
10. The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats. Keogh CL, etal., J Pharmacol Exp Ther. 2007 Aug;322(2):521-8. Epub 2007 May 9.
11. Angiopoietin/tie receptors system may play a role during reconstruction and capillarization of the hepatic sinusoids after partial hepatectomy and liver necrosis in rats. Kimura H, etal., Hepatol Res. 2004 May;29(1):51-59.
12. Pathological but not physiological retinal neovascularization is altered in TNF-Rp55-receptor-deficient mice. Kociok N, etal., Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5057-65.
13. Angiopoietin-1 and angiopoietin-2 in diabetes mellitus: relationship to VEGF, glycaemic control, endothelial damage/dysfunction and atherosclerosis. Lim HS, etal., Atherosclerosis. 2005 May;180(1):113-8. Epub 2004 Dec 21.
14. Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy. Lin J, etal., Diabetologia. 2006 May;49(5):1089-96. Epub 2006 Mar 7.
15. Angiopoietic factors and retinopathy in pregnancies complicated with Type 1 diabetes. Loukovaara S, etal., Diabet Med. 2004 Jul;21(7):697-704.
16. Expressions of Angiopoietin-1, Angiopoietin-2, and Tie2 and their roles in rat renal allografts with chronic allograft nephropathy. Ma X, etal., Transplant Proc. 2008 Oct;40(8):2795-9.
17. Rapamycin and cyclosporine have different effects on expression of Ang-1 and Ang-2 and Tie2 in rat renal allograft with chronic allograft nephropathy. Ma X, etal., Transplant Proc. 2008 Oct;40(8):2804-7.
18. Effects of atorvastatin on angiogenesis in hindlimb ischemia and endothelial progenitor cell formation in rats. Matsumura M, etal., J Atheroscler Thromb. 2009 Aug;16(4):319-26. Epub 2009 Aug 11.
19. Vascular endothelial growth factor and angiopoietin-2 play a major role in the pathogenesis of vascular leakage in cirrhotic rats. Melgar-Lesmes P, etal., Gut. 2009 Feb;58(2):285-92. Epub 2008 Oct 31.
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. MGD IEA MGD IEA
22. Expression of angiopoietin-1 and -2, and its clinical significance in human bladder cancer. Oka N, etal., BJU Int. 2005 Mar;95(4):660-3.
23. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: role of the renin-angiotensin system. Rizkalla B, etal., J Hypertens. 2005 Jan;23(1):153-64.
27. Downregulation of angiogenic factors and their downstream target molecules affects the deterioration of erectile function in a rat model of hypercholesterolemia. Ryu JK, etal., Urology. 2006 Jun;67(6):1329-34.
28. Angiogenic factors in normal endometrium and endometrial adenocarcinoma. Saito M, etal., Pathol Int. 2007 Mar;57(3):140-7.
29. Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion. Shyu KG, etal., Clin Sci (Lond). 2003 Sep;105(3):287-94.
30. Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients. Smadja DM, etal., Angiogenesis. 2020 May 27. pii: 10.1007/s10456-020-09730-0. doi: 10.1007/s10456-020-09730-0.
31. Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension. Tiani C, etal., J Hepatol. 2009 Feb;50(2):296-305. Epub 2008 Dec 4.
32. Zone-specific remodeling of tumor blood vessels affects tumor growth. Tilki D, etal., Cancer. 2007 Nov 15;110(10):2347-62.
33. Gene array analysis of a rat model of pulmonary arteriovenous malformations after superior cavopulmonary anastomosis. Tipps RS, etal., J Thorac Cardiovasc Surg. 2008 Aug;136(2):283-9.
34. Assessment of blood volume, vessel size, and the expression of angiogenic factors in two rat glioma models: a longitudinal in vivo and ex vivo study. Valable S, etal., NMR Biomed. 2008 Nov;21(10):1043-56.
35. Kinetics of strain-dependent differential gene expression in oxygen-induced retinopathy in the rat. van Wijngaarden P, etal., Exp Eye Res. 2007 Oct;85(4):508-17. Epub 2007 Jul 10.
36. Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing. Wen CY, etal., J Gastroenterol. 2003;38(5):431-5.
37. Peritoneal morphologic changes in a peritoneal dialysis rat model correlate with angiopoietin/Tie-2. Yuan J, etal., Pediatr Nephrol. 2009 Jan;24(1):163-70. Epub 2008 Aug 28.
Additional References at PubMed
PMID:8384837   PMID:9204896   PMID:9846489   PMID:10051567   PMID:10323857   PMID:10349636   PMID:10359181   PMID:10446940   PMID:10700190   PMID:10716993   PMID:10820169   PMID:10943840  
PMID:11032855   PMID:11042159   PMID:11076861   PMID:11084652   PMID:11507774   PMID:11801735   PMID:11901186   PMID:12048246   PMID:12093914   PMID:12115724   PMID:12221099   PMID:12361591  
PMID:12361603   PMID:12368264   PMID:12427764   PMID:12469114   PMID:12477932   PMID:12588999   PMID:12766907   PMID:12810677   PMID:12834865   PMID:12858538   PMID:12960064   PMID:15184386  
PMID:15193536   PMID:15489334   PMID:15579434   PMID:15582152   PMID:15782199   PMID:15802489   PMID:15882861   PMID:15889140   PMID:16045902   PMID:16107612   PMID:16141072   PMID:16141073  
PMID:16234353   PMID:16354539   PMID:16396910   PMID:16462802   PMID:16514057   PMID:16602821   PMID:16645151   PMID:16778080   PMID:16836957   PMID:17187775   PMID:17235601   PMID:17273793  
PMID:17540977   PMID:17573777   PMID:17625119   PMID:17670746   PMID:17705680   PMID:17965409   PMID:18039971   PMID:18209480   PMID:18287559   PMID:18310225   PMID:18477666   PMID:18508041  
PMID:18514180   PMID:18559662   PMID:18599509   PMID:18621714   PMID:18772493   PMID:18804439   PMID:18836739   PMID:19015235   PMID:19164599   PMID:19208835   PMID:19208839   PMID:19217887  
PMID:19398761   PMID:19403561   PMID:19407242   PMID:19471095   PMID:19572076   PMID:19644017   PMID:19710174   PMID:19815705   PMID:19881219   PMID:19902545   PMID:20018779   PMID:20059958  
PMID:20088942   PMID:20123094   PMID:20185832   PMID:20230750   PMID:20299672   PMID:20332116   PMID:20346953   PMID:20371769   PMID:20388654   PMID:20463289   PMID:20688736   PMID:20708158  
PMID:20952594   PMID:20978081   PMID:21113176   PMID:21127017   PMID:21163623   PMID:21179479   PMID:21267068   PMID:21270129   PMID:21576085   PMID:21593423   PMID:21677750   PMID:21851472  
PMID:21868579   PMID:21873635   PMID:21904637   PMID:22058148   PMID:22272235   PMID:22343031   PMID:22357955   PMID:22412848   PMID:22585576   PMID:22665799   PMID:22699974   PMID:22848540  
PMID:22872727   PMID:22991274   PMID:23049737   PMID:23063659   PMID:23092319   PMID:23151074   PMID:23211963   PMID:23285048   PMID:23350236   PMID:23424209   PMID:23523683   PMID:23565059  
PMID:23940579   PMID:24006456   PMID:24016759   PMID:24019535   PMID:24043815   PMID:24081879   PMID:24196349   PMID:24403060   PMID:24421076   PMID:24458641   PMID:24511140   PMID:24755984  
PMID:24764452   PMID:24781940   PMID:24802082   PMID:24952961   PMID:25030698   PMID:25043619   PMID:25091710   PMID:25180700   PMID:25200363   PMID:25202984   PMID:25264302   PMID:25572963  
PMID:25635707   PMID:25704811   PMID:25900369   PMID:26051942   PMID:26062989   PMID:26120030   PMID:26743170   PMID:27155222   PMID:27294705   PMID:27325674   PMID:27548529   PMID:27617438  
PMID:27922003   PMID:28179430   PMID:28276491   PMID:28355132   PMID:28453727   PMID:28508859   PMID:28684544   PMID:28835631   PMID:28920924   PMID:28924218   PMID:29106382   PMID:29237738  
PMID:29358379   PMID:29438518   PMID:29709479   PMID:30002415   PMID:30295643   PMID:31118232   PMID:31173626   PMID:31582413   PMID:32119672   PMID:32149735   PMID:32303578   PMID:32532986  
PMID:33060128   PMID:33227706   PMID:33375813   PMID:33550461   PMID:33557759   PMID:33571136   PMID:34407407   PMID:34963058   PMID:35194044   PMID:36055577   PMID:36172864   PMID:36190459  
PMID:36239412   PMID:37098137   PMID:37225978   PMID:37288572   PMID:37290124   PMID:37475697   PMID:38355793   PMID:38711167   PMID:38775153   PMID:38808888  


Genomics

Comparative Map Data
Angpt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39818,740,279 - 18,791,578 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl818,740,279 - 18,791,578 (-)EnsemblGRCm39 Ensembl
GRCm38818,690,263 - 18,741,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl818,690,263 - 18,741,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv37818,691,337 - 18,741,551 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36818,691,314 - 18,741,528 (-)NCBIMGSCv36mm8
Celera818,824,534 - 18,875,113 (-)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.3NCBI
ANGPT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3886,499,632 - 6,563,245 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl86,499,632 - 6,563,409 (-)EnsemblGRCh38hg38GRCh38
GRCh3786,357,153 - 6,420,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3686,347,601 - 6,408,170 (-)NCBINCBI36Build 36hg18NCBI36
Build 3486,347,600 - 6,408,172NCBI
Celera86,334,650 - 6,398,296 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef86,139,162 - 6,202,785 (-)NCBIHuRef
CHM1_186,445,906 - 6,509,954 (-)NCBICHM1_1
T2T-CHM13v2.086,254,102 - 6,317,682 (-)NCBIT2T-CHM13v2.0
Angpt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,790,760 - 77,841,241 (+)NCBIGRCr8
mRatBN7.21671,088,364 - 71,138,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1671,088,364 - 71,138,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1676,365,217 - 76,415,702 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,811,900 - 79,862,566 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01675,061,325 - 75,111,991 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,966,480 - 76,016,147 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,966,352 - 76,016,195 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,572,301 - 75,621,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,891,757 - 75,942,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11675,934,743 - 75,941,749 (+)NCBI
Celera1668,933,847 - 68,984,314 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Angpt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540354,139,823 - 54,195,032 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540354,139,823 - 54,193,740 (+)NCBIChiLan1.0ChiLan1.0
ANGPT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2721,294,413 - 21,380,483 (-)NCBINHGRI_mPanPan1-v2
Mhudiblu_PPA_v08718,367 - 782,534 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.186,506,012 - 6,566,915 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl86,506,014 - 6,566,915 (-)Ensemblpanpan1.1panPan2
ANGPT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11658,404,049 - 58,458,344 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1658,405,259 - 58,457,701 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1653,935,215 - 53,987,886 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01657,592,625 - 57,645,271 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1657,592,730 - 57,645,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11658,549,239 - 58,616,758 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01655,601,814 - 55,654,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01655,977,188 - 56,030,293 (+)NCBIUU_Cfam_GSD_1.0
Angpt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049434,473,275 - 4,524,605 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366154,472,247 - 4,524,556 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366154,472,261 - 4,524,537 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1537,544,707 - 37,599,041 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11537,544,177 - 37,600,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21542,687,923 - 42,787,653 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANGPT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.186,283,619 - 6,345,320 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl86,280,584 - 6,344,729 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605448,397,826 - 48,458,677 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angpt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248614,457,158 - 4,509,623 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248614,457,519 - 4,510,035 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Angpt2
1700 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:965
Count of miRNA genes:530
Interacting mature miRNAs:683
Transcripts:ENSMUST00000033846, ENSMUST00000170200
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse

Markers in Region
Angpt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37818,691,400 - 18,691,787UniSTSGRCm37
MGSCv37818,698,169 - 18,699,100UniSTSGRCm37
Celera818,831,376 - 18,832,305UniSTS
Celera818,824,597 - 18,824,984UniSTS
Cytogenetic Map8A1.3UniSTS
UniSTS:235845  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38818,724,531 - 18,724,952UniSTSGRCm38
MGSCv37818,724,531 - 18,724,952UniSTSGRCm37
Celera818,858,090 - 18,858,511UniSTS
Cytogenetic Map8A1.3UniSTS
Cytogenetic Map8A3UniSTS
D8Ertd51e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38818,725,478 - 18,725,680UniSTSGRCm38
MGSCv37818,725,478 - 18,725,680UniSTSGRCm37
Celera818,859,037 - 18,859,239UniSTS
Cytogenetic Map8A1.3UniSTS
Cytogenetic Map8A3UniSTS
cM Map87.0UniSTS
PMC314347P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38818,691,759 - 18,692,042UniSTSGRCm38
MGSCv37818,691,759 - 18,692,042UniSTSGRCm37
Celera818,824,956 - 18,825,239UniSTS
Cytogenetic Map8A1.3UniSTS
Cytogenetic Map8A3UniSTS
cM Map89.0UniSTS
Angpt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38818,691,400 - 18,691,787UniSTSGRCm38
MGSCv37818,691,400 - 18,691,787UniSTSGRCm37
Celera818,824,597 - 18,824,984UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map8A1.3UniSTS
Angpt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.3UniSTS
Angpt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.3UniSTS
Angpt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38818,698,169 - 18,699,100UniSTSGRCm38
MGSCv37818,698,169 - 18,699,100UniSTSGRCm37
Celera818,831,376 - 18,832,305UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map8A1.3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000033846   ⟹   ENSMUSP00000033846
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl818,740,279 - 18,791,578 (-)Ensembl
GRCm38.p6 Ensembl818,690,263 - 18,741,562 (-)Ensembl
Ensembl Acc Id: ENSMUST00000170200
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl818,742,103 - 18,749,563 (-)Ensembl
GRCm38.p6 Ensembl818,692,087 - 18,699,547 (-)Ensembl
RefSeq Acc Id: NM_007426   ⟹   NP_031452
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39818,740,279 - 18,791,578 (-)NCBI
GRCm38818,690,263 - 18,741,562 (-)NCBI
MGSCv37818,691,337 - 18,741,551 (-)RGD
Celera818,823,456 - 18,875,124 (-)NCBI
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031452   ⟸   NM_007426
- Peptide Label: precursor
- UniProtKB: Q3U1A1 (UniProtKB/Swiss-Prot),   Q9D2D2 (UniProtKB/Swiss-Prot),   O35608 (UniProtKB/Swiss-Prot),   B9EHQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000033846   ⟸   ENSMUST00000033846
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35608-F1-model_v2 AlphaFold O35608 1-496 view protein structure

Promoters
RGD ID:6848253
Promoter ID:MM_ACW:46980
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:ANGPT2.BSEP07,   ANGPT2.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36818,699,276 - 18,699,776 (-)MPROMDB
RGD ID:6842758
Promoter ID:MM_KWN:53776
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000033846
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36818,740,991 - 18,741,491 (-)MPROMDB
RGD ID:8666555
Promoter ID:EPDNEW_M11309
Type:initiation region
Name:Angpt2_1
Description:Mus musculus angiopoietin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38818,741,548 - 18,741,608EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1202890 AgrOrtholog
Ensembl Genes ENSMUSG00000031465 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033846 ENTREZGENE
  ENSMUST00000033846.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.215.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibrinogen-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_C-term_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11601 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1202890 ENTREZGENE
NCBI Gene 11601 ENTREZGENE
PANTHER FIBRINOGEN/TENASCIN/ANGIOPOEITIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19143:SF199 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Angpt2 PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ANGP2_MOUSE UniProtKB/Swiss-Prot
  B9EHQ4 ENTREZGENE, UniProtKB/TrEMBL
  O35608 ENTREZGENE
  Q3U1A1 ENTREZGENE
  Q9D2D2 ENTREZGENE
UniProt Secondary Q3U1A1 UniProtKB/Swiss-Prot
  Q9D2D2 UniProtKB/Swiss-Prot