Krt10 (keratin 10) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Krt10 (keratin 10) Mus musculus
Analyze
Symbol: Krt10
Name: keratin 10
RGD ID: 1550484
MGI Page MGI
Description: Enables cytoskeletal protein binding activity. Involved in positive regulation of epidermis development. Acts upstream of or within several processes, including cellular response to calcium ion; intermediate filament organization; and keratinocyte development. Located in cytoplasm and keratin filament. Is active in cornified envelope. Is expressed in several structures, including alimentary system; lower urinary tract; penis; sensory organ; and skin. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis and epidermolytic hyperkeratosis 2. Orthologous to human KRT10 (keratin 10).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 56 kDa cytokeratin; CK-10; cytokeratin 10; cytokeratin-10; D130054E02Rik; epidermal keratin 10; intermediate filament protein; K10; K1C1; keratin complex 1, acidic, gene 10; keratin, type I cytoskeletal 10; keratin, type I cytoskeletal 59 kDa; keratin-10; Krt-1.1; Krt-1.10; Krt1-1; Krt1-10; suprabasal cytokeratin 10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,276,080 - 99,288,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,276,080 - 99,280,190 (-)EnsemblGRCm39 Ensembl
GRCm381199,385,254 - 99,397,449 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1199,385,254 - 99,389,364 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,246,568 - 99,250,678 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,201,517 - 99,205,443 (-)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1162.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dibromoethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-damascenone  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
chromium trinitrate  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cyclosporin A  (EXP,ISO)
DAPT  (ISO)
diallyl trisulfide  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenthion  (EXP)
fulvestrant  (ISO)
gentamycin  (ISO)
hyaluronic acid  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
microcystin RR  (ISO)
Mono-carboxy isooctyl phthalate  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (ISO)
naphthalene  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
orphenadrine  (ISO)
paracetamol  (EXP,ISO)
perfluorododecanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chromate  (EXP)
stattic  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
VX nerve agent  (ISO)
zearalenone  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse differentiation-specific keratins 1 and 10 require a preexisting keratin scaffold to form a filament network. Kartasova T, etal., J Cell Biol 1993 Mar;120(5):1251-61.
2. Relationship between the expression of differentiation-specific keratins 1 and 10 and cell proliferation in epidermal tumors. Kartasova T, etal., Mol Carcinog 1992;6(1):18-25.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Organization of a type I keratin gene. Evidence for evolution of intermediate filaments from a common ancestral gene. Krieg TM, etal., J Biol Chem 1985 May 25;260(10):5867-70.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Peng XD, etal., Genes Dev 2003 Jun 1;17(11):1352-65.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The genomic organization of type I keratin genes in mice. Sato H, etal., Genomics 1999 Mar 15;56(3):303-9.
15. Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity. Syder AJ, etal., J Clin Invest. 1994 Apr;93(4):1533-42.
Additional References at PubMed
PMID:1379726   PMID:1693084   PMID:1701153   PMID:1717610   PMID:2458356   PMID:2482246   PMID:6188955   PMID:6209405   PMID:7509717   PMID:7525178   PMID:7528240   PMID:8603923  
PMID:8707838   PMID:8991098   PMID:9090377   PMID:9378767   PMID:9434940   PMID:9620304   PMID:9665399   PMID:9786956   PMID:9822682   PMID:9847250   PMID:9873228   PMID:9882493  
PMID:9932492   PMID:10191051   PMID:10195895   PMID:10227293   PMID:10349636   PMID:10469329   PMID:10511477   PMID:10527845   PMID:10571739   PMID:10588870   PMID:10722328   PMID:10998148  
PMID:11042159   PMID:11062007   PMID:11076861   PMID:11157989   PMID:11321598   PMID:11371349   PMID:11408568   PMID:11747081   PMID:11889133   PMID:11973284   PMID:12077355   PMID:12119299  
PMID:12533516   PMID:12702649   PMID:12791272   PMID:12853470   PMID:12859204   PMID:12950086   PMID:14597196   PMID:14610273   PMID:14638864   PMID:14673151   PMID:14964469   PMID:15086023  
PMID:15102471   PMID:15388990   PMID:15454262   PMID:15482487   PMID:15528198   PMID:15679119   PMID:15753128   PMID:15944823   PMID:16054035   PMID:16085486   PMID:16141072   PMID:16141073  
PMID:16287854   PMID:16418220   PMID:16481354   PMID:16510873   PMID:16565508   PMID:16628254   PMID:16818453   PMID:16831889   PMID:16837463   PMID:16914743   PMID:16949565   PMID:17151017  
PMID:17276340   PMID:17631058   PMID:17631878   PMID:17960184   PMID:17991461   PMID:18039792   PMID:18043734   PMID:18166659   PMID:18311128   PMID:18356808   PMID:18369314   PMID:18410734  
PMID:18480165   PMID:18684741   PMID:18778700   PMID:18799693   PMID:18802465   PMID:18824566   PMID:18849982   PMID:19092943   PMID:19300453   PMID:19303854   PMID:19369394   PMID:19427292  
PMID:19470461   PMID:19494829   PMID:19571816   PMID:19749746   PMID:19762425   PMID:19892877   PMID:20106865   PMID:20335364   PMID:20930145   PMID:20962855   PMID:21067603   PMID:21081122  
PMID:21084308   PMID:21093383   PMID:21098114   PMID:21127502   PMID:21136383   PMID:21191420   PMID:21205794   PMID:21228373   PMID:21267068   PMID:21435444   PMID:21505443   PMID:21565611  
PMID:21615674   PMID:21677750   PMID:21703454   PMID:21768372   PMID:21780252   PMID:21873635   PMID:21938009   PMID:22094257   PMID:22135020   PMID:22241839   PMID:22274697   PMID:22366455  
PMID:22375063   PMID:22434869   PMID:22505032   PMID:22508511   PMID:22585574   PMID:22763785   PMID:22832491   PMID:22935613   PMID:22951731   PMID:23015591   PMID:23071748   PMID:23132931  
PMID:23151848   PMID:23178882   PMID:23237955   PMID:23271346   PMID:23300485   PMID:23775923   PMID:23831572   PMID:23906066   PMID:23911870   PMID:23945586   PMID:23954751   PMID:24055172  
PMID:24075906   PMID:24198274   PMID:24337118   PMID:24449888   PMID:24457600   PMID:24492243   PMID:24725274   PMID:24751727   PMID:24940650   PMID:25016959   PMID:25043184   PMID:25202828  
PMID:25209981   PMID:25299669   PMID:25316000   PMID:25329657   PMID:25340345   PMID:25377219   PMID:25422376   PMID:25430793   PMID:25468937   PMID:25503409   PMID:26162297   PMID:26268211  
PMID:26371508   PMID:26376988   PMID:26450968   PMID:26603179   PMID:26644517   PMID:26711500   PMID:26765568   PMID:26994968   PMID:27184845   PMID:27208706   PMID:27317810   PMID:27670610  
PMID:27807348   PMID:27931797   PMID:28017833   PMID:28205312   PMID:28369476   PMID:28507225   PMID:28589954   PMID:28688895   PMID:28964716   PMID:29044125   PMID:29078349   PMID:29198823  
PMID:29209830   PMID:29317263   PMID:29422532   PMID:29459677   PMID:29490983   PMID:29596938   PMID:29684311   PMID:30220568   PMID:30323305   PMID:30457570   PMID:30509557   PMID:30567998  
PMID:30701202   PMID:30923192   PMID:30952667   PMID:31092920   PMID:31216312   PMID:31220272   PMID:31356814   PMID:31519887   PMID:31578523   PMID:31597917   PMID:31693903   PMID:31833472  
PMID:32109382   PMID:32239614   PMID:32296175   PMID:32325033   PMID:32417257   PMID:32467224   PMID:32674056   PMID:32845239   PMID:33199643   PMID:33294854   PMID:33452256   PMID:33637728  
PMID:33779546   PMID:34050161   PMID:34078823   PMID:34107258   PMID:34474245   PMID:34905516   PMID:34997665   PMID:35247391   PMID:35585237   PMID:36049534   PMID:36077435   PMID:36630508  
PMID:36641754   PMID:36856110   PMID:37017303   PMID:37115925   PMID:37660780   PMID:38501211   PMID:38582368   PMID:38810653  


Genomics

Comparative Map Data
Krt10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,276,080 - 99,288,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,276,080 - 99,280,190 (-)EnsemblGRCm39 Ensembl
GRCm381199,385,254 - 99,397,449 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1199,385,254 - 99,389,364 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,246,568 - 99,250,678 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,201,517 - 99,205,443 (-)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1162.92NCBI
KRT10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,818,117 - 40,822,614 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,818,117 - 40,822,614 (-)EnsemblGRCh38hg38GRCh38
GRCh371738,974,369 - 38,978,866 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,227,895 - 36,232,373 (-)NCBINCBI36Build 36hg18NCBI36
Build 341736,227,895 - 36,232,373NCBI
Celera1735,635,920 - 35,640,414 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1734,768,729 - 34,773,223 (-)NCBIHuRef
CHM1_11739,209,679 - 39,214,200 (-)NCBICHM1_1
T2T-CHM13v2.01741,682,437 - 41,686,934 (-)NCBIT2T-CHM13v2.0
Krt10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,834,865 - 84,839,160 (-)NCBIGRCr8
mRatBN7.21084,338,695 - 84,343,279 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1084,338,706 - 84,343,701 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1089,282,528 - 89,286,524 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,780,663 - 88,784,659 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01084,172,644 - 84,176,640 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01087,296,445 - 87,301,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1087,296,451 - 87,300,736 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01087,091,976 - 87,100,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41088,288,620 - 88,292,615 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11088,302,989 - 88,306,985 (-)NCBI
Celera1083,077,920 - 83,081,916 (-)NCBICelera
Cytogenetic Map10q31NCBI
Krt10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545115,270,222 - 15,274,312 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545115,269,861 - 15,274,351 (-)NCBIChiLan1.0ChiLan1.0
KRT10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,129,997 - 24,134,515 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,020,443 - 26,024,955 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01716,461,624 - 16,466,136 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11716,686,898 - 16,691,221 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1716,686,898 - 16,690,415 (+)Ensemblpanpan1.1panPan2
KRT10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,863,715 - 21,868,587 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,863,767 - 21,868,587 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,336,709 - 21,341,572 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0922,656,504 - 22,661,353 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl922,656,547 - 22,661,353 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,431,293 - 21,436,162 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0921,690,028 - 21,694,877 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0921,814,216 - 21,819,078 (+)NCBIUU_Cfam_GSD_1.0
Krt10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,287,128 - 21,291,503 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,783,618 - 15,788,634 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,783,636 - 15,788,605 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,641,271 - 21,646,377 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11221,641,263 - 21,645,642 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,842,078 - 21,846,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,361,893 - 65,367,634 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1665,362,903 - 65,367,941 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,242,450 - 36,246,895 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247952,595,072 - 2,599,077 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247952,594,973 - 2,599,433 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Krt10
438 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:70
Interacting mature miRNAs:77
Transcripts:ENSMUST00000103131
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1301153Estq3_mestradiol regulated response QTL 3 (mouse)Not determined119689769399327028Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
Krt1-10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381199,388,738 - 99,389,334UniSTSGRCm38
MGSCv371199,250,052 - 99,250,648UniSTSGRCm37
Cytogenetic Map11DUniSTS
cM Map1157.95UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000103131   ⟹   ENSMUSP00000099420
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1199,276,080 - 99,280,190 (-)Ensembl
GRCm38.p6 Ensembl1199,385,254 - 99,389,364 (-)Ensembl
Ensembl Acc Id: ENSMUST00000211768   ⟹   ENSMUSP00000148044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1199,276,093 - 99,276,923 (-)Ensembl
GRCm38.p6 Ensembl1199,385,267 - 99,386,097 (-)Ensembl
RefSeq Acc Id: NM_010660   ⟹   NP_034790
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391199,276,080 - 99,280,190 (-)NCBI
GRCm381199,385,254 - 99,389,364 (-)NCBI
MGSCv371199,246,568 - 99,250,678 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011248768   ⟹   XP_011247070
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391199,276,080 - 99,288,631 (-)NCBI
GRCm381199,385,254 - 99,397,449 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034790   ⟸   NM_010660
- UniProtKB: A2A513 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011247070   ⟸   XM_011248768
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000148044   ⟸   ENSMUST00000211768
Ensembl Acc Id: ENSMUSP00000099420   ⟸   ENSMUST00000103131
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02535-F1-model_v2 AlphaFold P02535 1-570 view protein structure

Promoters
RGD ID:6848587
Promoter ID:MM_TRO:1749
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   MEF_B6
Transcripts:MTR075556.11.2448.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361199,247,116 - 99,247,627 (-)MPROMDB
RGD ID:6849486
Promoter ID:EP32005
Type:single initiation site
Name:MM_K1C1
Description:Keratin I 59K, KRT10 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 187; Mammalian cytokeratins group 1
Tissues & Cell Lines:epithelial cells
Experiment Methods:Nuclease protection; Sequencing of a full-length cDNA
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371199,250,669 - 99,250,729EPD
MGSCv361199,250,669 - 99,250,729EPD
RGD ID:8676568
Promoter ID:EPDNEW_M16314
Type:multiple initiation site
Name:Krt10_1
Description:Mus musculus keratin 10 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381199,389,361 - 99,389,421EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96685 AgrOrtholog
Ensembl Genes ENSMUSG00000019761 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000103131 ENTREZGENE
  ENSMUST00000103131.5 UniProtKB/TrEMBL
  ENSMUST00000211768.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16661 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96685 ENTREZGENE
NCBI Gene 16661 ENTREZGENE
PANTHER KERATIN, TYPE I CYTOSKELETAL 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Krt10 PhenoGen
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GSR7_MOUSE UniProtKB/TrEMBL
  A2A513 ENTREZGENE, UniProtKB/TrEMBL
  K1C10_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P08731 UniProtKB/Swiss-Prot
  Q8BUX3 UniProtKB/Swiss-Prot
  Q8BV09 UniProtKB/Swiss-Prot
  Q8BVU3 UniProtKB/Swiss-Prot
  Q9CXH6 UniProtKB/Swiss-Prot
  Q9JKB4 UniProtKB/Swiss-Prot