Smad5 (SMAD family member 5) - Rat Genome Database

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Gene: Smad5 (SMAD family member 5) Mus musculus
Analyze
Symbol: Smad5
Name: SMAD family member 5
RGD ID: 1550273
MGI Page MGI
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in SMAD protein signal transduction; negative regulation of transcription by RNA polymerase II; and ureteric bud development. Acts upstream of or within several processes, including osteoblast fate commitment; skeletal system development; and transforming growth factor beta receptor superfamily signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; egg cylinder; embryo mesenchyme; and genitourinary system. Orthologous to human SMAD5 (SMAD family member 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110051M15Rik; AI451355; dwarfin-C; Dwf-C; MAD homolog 5; Madh; Madh5; mothers against decapentaplegic homolog 5; mothers against DPP homolog 5; mSmad5; Mus; MusMLP; Smad 5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,850,804 - 56,890,191 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,850,823 - 56,890,190 (+)EnsemblGRCm39 Ensembl
GRCm381356,703,010 - 56,742,378 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,703,010 - 56,742,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371356,804,371 - 56,843,739 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,733,051 - 56,751,999 (+)NCBIMGSCv36mm8
Celera1357,765,382 - 57,797,308 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-methoxypsoralen  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
aucubin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dimethylselenide  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
gentamycin  (ISO)
glycerol 2-phosphate  (EXP)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
imperatorin  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phencyclidine  (EXP)
phenobarbital  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
Salidroside  (EXP)
simvastatin  (EXP)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal amnion morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal decidualization  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal digestive system development  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal embryo attachment  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo turning  (IAGP)
abnormal embryonic growth/weight/body size  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal germ cell morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal nervous system development  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal pregnancy  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal sclerotome morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal uterine receptivity  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal ventral body wall morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent forebrain  (IAGP)
absent primordial germ cells  (IAGP)
absent second pharyngeal arch  (IAGP)
absent third pharyngeal arch  (IAGP)
absent vitelline blood vessels  (IAGP)
decreased angiogenesis  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased embryo size  (IAGP)
decreased litter size  (IAGP)
decreased primordial germ cell number  (IAGP)
delayed chorioallantoic fusion  (IAGP)
delayed embryo implantation  (IAGP)
delayed heart development  (IAGP)
delayed neural tube closure  (IAGP)
dilated dorsal aorta  (IAGP)
dilated heart  (IAGP)
disorganized yolk sac vascular plexus  (IAGP)
early reproductive senescence  (IAGP)
edema  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
excessive folding of visceral yolk sac  (IAGP)
exencephaly  (IAGP)
failure of heart looping  (IAGP)
failure of initiation of embryo turning  (IAGP)
female infertility  (IAGP)
hemoperitoneum  (IAGP)
hemorrhage  (IAGP)
impaired embryo implantation  (IAGP)
impaired exercise endurance  (IAGP)
incomplete embryo turning  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased apoptosis  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased ovarian carcinoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased testis tumor incidence  (IAGP)
male infertility  (IAGP)
no abnormal phenotype detected  (IAGP)
pale yolk sac  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
suppressed circulating follicle stimulating hormone level  (IAGP)
vascular smooth muscle hypotrophy  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. Fukada T, etal., PLoS One. 2008;3(11):e3642. doi: 10.1371/journal.pone.0003642. Epub 2008 Nov 5.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Pangas SA, etal., Mol Cell Biol. 2008 Jan;28(1):248-57. Epub 2007 Oct 29.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Takahashi H, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.
12. Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60. Zavadil J, etal., Leukemia. 1997 Aug;11(8):1187-92.
Additional References at PubMed
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PMID:32467233   PMID:32541003   PMID:32616504   PMID:32662771   PMID:32664967   PMID:32698004   PMID:32720893   PMID:32734584   PMID:32747435   PMID:32866472   PMID:33046507   PMID:33060561  
PMID:33217406   PMID:33248111   PMID:33308444   PMID:33372189   PMID:33393086   PMID:33436499   PMID:33436697   PMID:33463047   PMID:33723039   PMID:33787491   PMID:33846290   PMID:34010654  
PMID:34052210   PMID:34062094   PMID:34099644   PMID:34107258   PMID:34129836   PMID:34157307   PMID:34184027   PMID:34184730   PMID:34292881   PMID:34321999   PMID:34557486   PMID:34677125  
PMID:34719843   PMID:34851738   PMID:34878095   PMID:34880220   PMID:35020897   PMID:35151207   PMID:35167946   PMID:35194044   PMID:35383354   PMID:35413235   PMID:35503090   PMID:35803228  
PMID:35858560   PMID:35877077   PMID:35894043   PMID:35951005   PMID:35998584   PMID:36067211   PMID:36115458   PMID:36116371   PMID:36257937   PMID:36314682   PMID:36445780   PMID:36566565  
PMID:36680774   PMID:36693323   PMID:36910145   PMID:36916392   PMID:36941249   PMID:37237002   PMID:37272529   PMID:37298583   PMID:37300483   PMID:37385754   PMID:37577930   PMID:37640003  
PMID:37680190   PMID:37702066   PMID:37869988   PMID:38057885   PMID:38171360   PMID:38175868   PMID:38246328   PMID:38300806   PMID:38404688   PMID:38466355   PMID:38752427   PMID:38794925  
PMID:38951500   PMID:39000154  


Genomics

Comparative Map Data
Smad5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,850,804 - 56,890,191 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,850,823 - 56,890,190 (+)EnsemblGRCm39 Ensembl
GRCm381356,703,010 - 56,742,378 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,703,010 - 56,742,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371356,804,371 - 56,843,739 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,733,051 - 56,751,999 (+)NCBIMGSCv36mm8
Celera1357,765,382 - 57,797,308 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.12NCBI
SMAD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385136,132,845 - 136,182,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5136,132,845 - 136,188,747 (+)EnsemblGRCh38hg38GRCh38
GRCh375135,468,534 - 135,518,421 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,496,435 - 135,546,321 (+)NCBINCBI36Build 36hg18NCBI36
Build 345135,496,434 - 135,546,321NCBI
Celera5131,593,276 - 131,643,157 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,657,006 - 130,706,874 (+)NCBIHuRef
CHM1_15134,901,165 - 134,951,034 (+)NCBICHM1_1
T2T-CHM13v2.05136,655,373 - 136,705,263 (+)NCBIT2T-CHM13v2.0
Smad5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,867,640 - 7,896,983 (-)NCBIGRCr8
mRatBN7.2177,862,332 - 7,891,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,864,720 - 7,891,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx177,885,190 - 7,895,389 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,416,674 - 9,426,832 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0177,881,573 - 7,891,768 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,307,448 - 8,336,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,311,796 - 8,331,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,484,309 - 10,513,839 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,814,164 - 13,824,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11713,814,163 - 13,824,358 (-)NCBI
Celera177,961,603 - 7,971,797 (-)NCBICelera
Cytogenetic Map17p14NCBI
Smad5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540831,183,659 - 31,229,384 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540831,183,727 - 31,228,355 (+)NCBIChiLan1.0ChiLan1.0
SMAD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24131,419,826 - 131,469,837 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15129,559,444 - 129,609,397 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05131,524,229 - 131,574,119 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15137,663,558 - 137,713,130 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5137,664,067 - 137,712,635 (+)Ensemblpanpan1.1panPan2
SMAD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11124,027,603 - 24,082,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1124,028,126 - 24,078,169 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,774,580 - 22,829,238 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,843,618 - 24,898,398 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,843,660 - 24,898,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11123,530,270 - 23,584,907 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,397,527 - 23,452,566 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01124,046,574 - 24,101,311 (+)NCBIUU_Cfam_GSD_1.0
Smad5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213124,200,433 - 124,242,080 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365973,225,374 - 3,264,604 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365973,225,374 - 3,264,604 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2138,287,710 - 138,344,762 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12138,287,635 - 138,344,092 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SMAD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,877,294 - 38,926,208 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2338,877,315 - 38,921,202 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603438,986,583 - 39,035,567 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473310,931,061 - 10,983,669 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473310,927,264 - 10,983,049 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smad5
1517 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3500
Count of miRNA genes:764
Interacting mature miRNAs:1008
Transcripts:ENSMUST00000069557, ENSMUST00000109874, ENSMUST00000109876, ENSMUST00000132302, ENSMUST00000136702, ENSMUST00000138677
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135647045676971314Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse

Markers in Region
BB283889  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381356,737,861 - 56,737,975UniSTSGRCm38
MGSCv371356,839,222 - 56,839,336UniSTSGRCm37
Celera1357,792,793 - 57,792,907UniSTS
Cytogenetic Map13B1UniSTS
cM Map1335.0UniSTS
Whitehead/MRC_RH13582.98UniSTS
AW742822  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381356,742,077 - 56,742,302UniSTSGRCm38
MGSCv371356,843,438 - 56,843,663UniSTSGRCm37
Celera1357,797,007 - 57,797,232UniSTS
Cytogenetic Map13B1UniSTS
cM Map1335.0UniSTS
Whitehead/MRC_RH13583.5UniSTS
D13Mit208  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381356,732,406 - 56,732,550UniSTSGRCm38
MGSCv371356,833,767 - 56,833,911UniSTSGRCm37
Celera1357,787,353 - 57,787,477UniSTS
Cytogenetic Map13B1UniSTS
cM Map1335.0UniSTS
Whitehead Genetic1321.9UniSTS
Whitehead_YAC13 UniSTS
AI451355  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381356,741,707 - 56,741,837UniSTSGRCm38
MGSCv371356,843,068 - 56,843,198UniSTSGRCm37
Celera1357,796,637 - 57,796,767UniSTS
Cytogenetic Map13B1UniSTS
cM Map1335.0UniSTS
Whitehead/MRC_RH13583.31UniSTS
UniSTS:237029  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381356,741,709 - 56,742,022UniSTSGRCm38
MGSCv371356,843,070 - 56,843,383UniSTSGRCm37
Celera1357,796,639 - 57,796,952UniSTS
Cytogenetic Map13B1UniSTS
cM Map1335.0UniSTS
UniSTS:237030  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381356,740,078 - 56,740,289UniSTSGRCm38
MGSCv371356,841,439 - 56,841,650UniSTSGRCm37
Celera1357,795,008 - 57,795,219UniSTS
Cytogenetic Map13B1UniSTS
cM Map1335.0UniSTS
Smad5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13B1UniSTS
Smad5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381356,727,473 - 56,727,623UniSTSGRCm38
MGSCv371356,828,834 - 56,828,984UniSTSGRCm37
Cytogenetic Map13B1UniSTS
Smad5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13B1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001164041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001164042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF063006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW556382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ087944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U58993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000069557   ⟹   ENSMUSP00000065798
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1356,850,823 - 56,890,190 (+)Ensembl
GRCm38.p6 Ensembl1356,703,010 - 56,742,377 (+)Ensembl
Ensembl Acc Id: ENSMUST00000109874   ⟹   ENSMUSP00000105500
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1356,851,481 - 56,888,117 (+)Ensembl
GRCm38.p6 Ensembl1356,703,668 - 56,740,304 (+)Ensembl
Ensembl Acc Id: ENSMUST00000109876   ⟹   ENSMUSP00000105502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1356,850,865 - 56,887,773 (+)Ensembl
GRCm38.p6 Ensembl1356,703,052 - 56,739,960 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132302
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1356,850,879 - 56,880,938 (+)Ensembl
GRCm38.p6 Ensembl1356,703,066 - 56,733,125 (+)Ensembl
Ensembl Acc Id: ENSMUST00000136702
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1356,880,830 - 56,886,806 (+)Ensembl
GRCm38.p6 Ensembl1356,733,017 - 56,738,993 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138677
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1356,850,852 - 56,881,027 (+)Ensembl
GRCm38.p6 Ensembl1356,703,039 - 56,733,214 (+)Ensembl
RefSeq Acc Id: NM_001164041   ⟹   NP_001157513
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391356,850,865 - 56,890,191 (+)NCBI
GRCm381356,703,052 - 56,742,378 (+)NCBI
MGSCv371356,804,371 - 56,843,739 (+)RGD
Celera1357,765,382 - 57,797,308 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001164042   ⟹   NP_001157514
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391356,851,481 - 56,890,191 (+)NCBI
GRCm381356,703,668 - 56,742,378 (+)NCBI
MGSCv371356,804,371 - 56,843,739 (+)RGD
Celera1357,765,382 - 57,797,308 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008541   ⟹   NP_032567
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391356,850,823 - 56,890,191 (+)NCBI
GRCm381356,703,010 - 56,742,378 (+)NCBI
MGSCv371356,804,371 - 56,843,739 (+)RGD
Celera1357,765,382 - 57,797,308 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006517117   ⟹   XP_006517180
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391356,851,185 - 56,890,186 (+)NCBI
GRCm381356,703,422 - 56,738,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006517118   ⟹   XP_006517181
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391356,850,993 - 56,890,186 (+)NCBI
GRCm381356,703,359 - 56,738,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247171   ⟹   XP_030103031
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391356,851,185 - 56,890,186 (+)NCBI
GRCm381356,703,394 - 56,738,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157882   ⟹   XP_036013775
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391356,850,804 - 56,890,186 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032567   ⟸   NM_008541
- UniProtKB: P70341 (UniProtKB/Swiss-Prot),   Q810K0 (UniProtKB/Swiss-Prot),   P97454 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001157513   ⟸   NM_001164041
- UniProtKB: P70341 (UniProtKB/Swiss-Prot),   Q810K0 (UniProtKB/Swiss-Prot),   P97454 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001157514   ⟸   NM_001164042
- UniProtKB: P70341 (UniProtKB/Swiss-Prot),   Q810K0 (UniProtKB/Swiss-Prot),   P97454 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006517181   ⟸   XM_006517118
- Peptide Label: isoform X1
- UniProtKB: P70341 (UniProtKB/Swiss-Prot),   Q810K0 (UniProtKB/Swiss-Prot),   P97454 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006517180   ⟸   XM_006517117
- Peptide Label: isoform X1
- UniProtKB: P70341 (UniProtKB/Swiss-Prot),   Q810K0 (UniProtKB/Swiss-Prot),   P97454 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030103031   ⟸   XM_030247171
- Peptide Label: isoform X1
- UniProtKB: P97454 (UniProtKB/Swiss-Prot),   P70341 (UniProtKB/Swiss-Prot),   Q810K0 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000105502   ⟸   ENSMUST00000109876
Ensembl Acc Id: ENSMUSP00000105500   ⟸   ENSMUST00000109874
Ensembl Acc Id: ENSMUSP00000065798   ⟸   ENSMUST00000069557
RefSeq Acc Id: XP_036013775   ⟸   XM_036157882
- Peptide Label: isoform X1
- UniProtKB: P97454 (UniProtKB/Swiss-Prot),   P70341 (UniProtKB/Swiss-Prot),   Q810K0 (UniProtKB/Swiss-Prot)
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97454-F1-model_v2 AlphaFold P97454 1-465 view protein structure

Promoters
RGD ID:8680510
Promoter ID:EPDNEW_M18286
Type:initiation region
Name:Smad5_1
Description:Mus musculus SMAD family member 5 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18287  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381356,703,013 - 56,703,073EPDNEW
RGD ID:8680512
Promoter ID:EPDNEW_M18287
Type:multiple initiation site
Name:Smad5_2
Description:Mus musculus SMAD family member 5 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18286  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381356,703,330 - 56,703,390EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1328787 AgrOrtholog
Ensembl Genes ENSMUSG00000021540 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000069557 ENTREZGENE
  ENSMUST00000069557.14 UniProtKB/Swiss-Prot
  ENSMUST00000109874 ENTREZGENE
  ENSMUST00000109874.2 UniProtKB/Swiss-Prot
  ENSMUST00000109876 ENTREZGENE
  ENSMUST00000109876.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17129 UniProtKB/Swiss-Prot
MGD MGI:1328787 ENTREZGENE
NCBI Gene 17129 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad5 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P70341 ENTREZGENE
  P97454 ENTREZGENE
  Q810K0 ENTREZGENE
  Q810W4_MOUSE UniProtKB/TrEMBL
  Q9CRR7_MOUSE UniProtKB/TrEMBL
  SMAD5_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P70341 UniProtKB/Swiss-Prot
  Q810K0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-10 Smad5  SMAD family member 5  Smad5  MAD homolog 5 (Drosophila)  Symbol and/or name change 5135510 APPROVED