Kras (Kirsten rat sarcoma viral oncogene homolog) - Rat Genome Database

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Gene: Kras (Kirsten rat sarcoma viral oncogene homolog) Mus musculus
Symbol: Kras
Name: Kirsten rat sarcoma viral oncogene homolog
RGD ID: 1550157
Description: Enables GTPase activity and protein-membrane adaptor activity. Involved in endocrine signaling. Acts upstream of or within several processes, including forebrain astrocyte development; modulation of chemical synaptic transmission; and positive regulation of Rac protein signal transduction. Located in membrane. Is expressed in several structures, including alimentary system; brain; early embryo; eye; and genitourinary system. Used to study several diseases, including Noonan syndrome 3; arteriovenous malformations of the brain; gastrointestinal system cancer (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and high grade glioma (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI929937; c-K-ras; c-Ki-ras; GTPase KRas; K-; K-ras; K-Ras 2; Ki; Ki-ras; Kirsten rat sarcoma oncogene 2, expressed; Kr; Kra; Kras-2; Kras2; MGC7141; p21 protein; p21B; ras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm396145,162,425 - 145,197,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6145,162,425 - 145,195,965 (-)EnsemblGRCm39 Ensembl
GRCm386145,216,699 - 145,250,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6145,216,699 - 145,250,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv376145,165,219 - 145,198,751 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366145,173,866 - 145,207,390 (-)NCBIMGSCv36mm8
Celera6148,290,985 - 148,324,546 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adenoma  (ISO)
anaplastic astrocytoma  (ISO)
anemia  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
arteriovenous malformations of the brain  (IAGP,ISO)
autoimmune lymphoproliferative syndrome type 4  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (IMP)
Capillary Malformation-Arteriovenous Malformation 1  (ISO)
Carcinogenesis  (ISO)
carcinoma  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiofaciocutaneous syndrome 1  (ISO)
cardiofaciocutaneous syndrome 2  (ISO)
cardiomyopathy  (IMP)
Cecal Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
chronic myeloid leukemia  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (IDA,ISO)
Costello syndrome  (ISO)
dilated cardiomyopathy  (IDA)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Encephalocraniocutaneous Lipomatosis  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (IAGP,ISO)
epidermal nevus  (ISO)
esophageal carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Sarcoma  (ISO)
fibrillary astrocytoma  (ISO)
gallbladder cancer  (ISO)
Gallbladder Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glioblastoma  (IMP,ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary diffuse gastric cancer  (ISO)
high grade glioma  (IMP,ISO)
Hodgkin's lymphoma  (ISO)
Hydrops Fetalis  (ISO)
hypertension  (IDA)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (IAGP,ISO)
juvenile myelomonocytic leukemia  (IAGP,ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Neoplasms  (ISO)
Klatskin's tumor  (ISO)
Leukocytosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (IAGP,ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (IMP,ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP)
lung sarcomatoid carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
Lynch syndrome  (ISO)
malignant astrocytoma  (IGI,ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
multiple myeloma  (ISO)
muscular atrophy  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (IMP)
myeloid sarcoma  (ISO)
Neoplasm Metastasis  (IEP,ISO)
Neoplastic Cell Transformation  (ISO)
neuroblastoma  (ISO)
Noonan syndrome  (IMP,ISO)
Noonan syndrome 3  (IAGP,ISO)
oculoectodermal syndrome  (ISO)
Ovarian Neoplasms  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (IAGP,ISO)
pancreatic ductal carcinoma  (ISO)
pancreatic mucinous cystadenoma  (ISO)
Paraproteinemias  (ISO)
Parasitic Liver Diseases  (ISO)
Penile Neoplasms  (ISO)
pilocytic astrocytoma  (ISO)
plasma cell neoplasm  (ISO)
prostate cancer  (IAGP)
Prostate Cancer, Hereditary, 1  (ISO)
prostate carcinoma in situ  (IAGP)
Prostatic Neoplasms  (IAGP,ISO)
RASopathy  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
seminoma  (ISO)
skin melanoma  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
T-cell acute lymphoblastic leukemia  (IMP)
teratoma  (ISO)
Thyroid Carcinoma, Nonmedullary 1  (ISO)
thyroid gland follicular carcinoma  (ISO)
thyroid gland medullary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Triple Negative Breast Neoplasms  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (ISO)
(trichloromethyl)benzene  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2-Bis(bromomethyl)propane-1,3-diol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-nitrophenol  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Methylchrysene  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
ARS-1620  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
Benz[j]aceanthrylene  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
ceruletide  (EXP)
CGP 52608  (ISO)
chloroethene  (EXP,ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chymostatin  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt atom  (EXP,ISO)
cobimetinib  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
cumene  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
Cyclopenta[cd]pyrene  (EXP)
dabrafenib  (ISO)
dextran sulfate  (EXP)
dibenzo[a,l]pyrene  (EXP)
dichlorine  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
farnesyl diphosphate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
guanosine  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
hydroxyurea  (EXP)
ionomycin  (ISO)
irbesartan  (EXP,ISO)
isoprenaline  (EXP)
isoprene  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
lovastatin  (EXP,ISO)
luzindole  (EXP)
manumycin A  (ISO)
MeIQx  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methohexital  (ISO)
methotrexate  (ISO)
monosodium L-glutamate  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nicotinic acid  (EXP)
ochratoxin A  (ISO)
oncrasin-1  (ISO)
oxirane  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
PD 0325901  (EXP,ISO)
pemetrexed  (ISO)
pentobarbital  (ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picrotoxin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
SB 431542  (ISO)
secobarbital  (ISO)
selumetinib  (ISO)
sevoflurane  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sotorasib  (ISO)
styrene  (EXP)
sulfur dioxide  (ISO)
sulindac  (ISO)
tacrolimus hydrate  (EXP)
Tanshinone I  (ISO)
Temsirolimus  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
Tetranitromethane  (EXP)
thiamylal  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
tiazofurine  (ISO)
tipifarnib  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trimetrexate  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinyl carbamate  (EXP)
zearalenone  (EXP)
zidovudine  (EXP)
zinc protoporphyrin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IGI)
cardiac muscle cell proliferation  (ISO)
cell population proliferation  (IGI)
cytokine-mediated signaling pathway  (ISO)
endocrine signaling  (IMP)
epithelial tube branching involved in lung morphogenesis  (IDA,IGI)
female pregnancy  (ISO)
forebrain astrocyte development  (IMP)
gene expression  (IMP)
glial cell proliferation  (IGI)
homeostasis of number of cells within a tissue  (IGI)
insulin-like growth factor receptor signaling pathway  (ISO)
liver development  (ISO)
myoblast proliferation  (ISO)
negative regulation of epithelial cell differentiation  (IDA)
negative regulation of neuron apoptotic process  (IGI)
neuron apoptotic process  (IGI)
positive regulation of cellular senescence  (ISO)
positive regulation of gene expression  (IMP,ISO)
positive regulation of glial cell proliferation  (IGI)
positive regulation of MAP kinase activity  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of Rac protein signal transduction  (IGI)
Rac protein signal transduction  (IGI)
Ras protein signal transduction  (IBA,IGI,IMP,TAS)
regulation of long-term neuronal synaptic plasticity  (IGI)
regulation of synaptic transmission, GABAergic  (IGI)
response to glucocorticoid  (ISO)
response to gravity  (ISO)
response to isolation stress  (ISO)
response to mineralocorticoid  (ISO)
signal transduction  (IEA)
skeletal muscle cell differentiation  (IGI)
striated muscle cell differentiation  (IGI)
type I pneumocyte differentiation  (IDA)
visual learning  (IGI)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal brain development  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal bronchiole morphology  (IAGP)
abnormal bronchoalveolar duct junction morphology  (IAGP)
abnormal bronchus epithelium morphology  (IAGP)
abnormal bronchus morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal centrosome morphology  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal colon goblet cell morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal common lymphocyte progenitor cell morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal cystic duct morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal DNA repair  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal ear position  (IAGP)
abnormal embryonic erythrocyte morphology  (IAGP)
abnormal embryonic erythropoiesis  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal extrahepatic bile duct morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal facial morphology  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal fibroblast proliferation  (IAGP)
abnormal gallbladder morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal hepatic portal vein morphology  (IAGP)
abnormal hepatic portal vein thrombosis  (IAGP)
abnormal hepatobiliary system morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lacrimal gland development  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung adenoma incidence  (IAGP)
abnormal lung development  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal metabolism  (IAGP)
abnormal metastatic potential  (IAGP)
abnormal mismatch repair  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic duct morphology  (IAGP)
abnormal peritoneum morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal prostate gland morphology  (IAGP)
abnormal prostate gland physiology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal rod electrophysiology  (IAGP)
abnormal skin sebaceous gland morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal survival  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal translation  (IAGP)
abnormal tumor incidence  (IAGP)
abnormal tumor morphology  (IAGP)
absent lacrimal glands  (IAGP)
absent Paneth cells  (IAGP)
absent visceral yolk sac blood islands  (IAGP)
absent vitelline blood vessels  (IAGP)
anemia  (IAGP)
anisopoikilocytosis  (IAGP)
arteriovenous malformation  (IAGP)
ascites  (IAGP)
bile duct hyperplasia  (IAGP)
bronchial epithelial hyperplasia  (IAGP)
bronchiolar epithelial hyperplasia  (IAGP)
cachexia  (IAGP)
cardiac fibrosis  (IAGP)
cellular necrosis  (IAGP)
cholestasis  (IAGP)
chromosomal instability  (IAGP)
chromosome breakage  (IAGP)
chylous ascites  (IAGP)
conotruncal ridge hyperplasia  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased B cell number  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating estradiol level  (IAGP)
decreased circulating progesterone level  (IAGP)
decreased circulating thyroid-stimulating hormone level  (IAGP)
decreased classified tumor incidence  (IAGP)
decreased cranium length  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased glutamic acid level  (IAGP)
decreased hematocrit  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased incidence of induced tumors  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased lung tumor incidence  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased lymphoma incidence  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased metastatic potential  (IAGP)
decreased ovarian tumor incidence  (IAGP)
decreased skin tumor incidence  (IAGP)
decreased survivor rate  (IAGP)
decreased T cell number  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor latency  (IAGP)
decreased tumor-free survival time  (IAGP)
dilated bile duct  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated gallbladder  (IAGP)
dilated heart  (IAGP)
dilated pancreatic duct  (IAGP)
dilated respiratory conducting tube  (IAGP)
disorganized pancreatic islets  (IAGP)
distended abdomen  (IAGP)
distended pericardium  (IAGP)
double outlet right ventricle  (IAGP)
early cellular replicative senescence  (IAGP)
edema  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged lung  (IAGP)
enlarged myocardial fiber  (IAGP)
enlarged pancreas  (IAGP)
enlarged pancreatic islets  (IAGP)
enlarged sebaceous gland  (IAGP)
enlarged spleen  (IAGP)
enlarged thyroid gland  (IAGP)
epidermal hyperplasia  (IAGP)
excessive folding of visceral yolk sac  (IAGP)
exocrine pancreas atrophy  (IAGP)
exocrine pancreatic insufficiency  (IAGP)
extramedullary hematopoiesis  (IAGP)
fetal growth retardation  (IAGP)
flattened snout  (IAGP)
Harderian gland hyperplasia  (IAGP)
heart hyperplasia  (IAGP)
hemoperitoneum  (IAGP)
hemorrhage  (IAGP)
hemorrhagic ascites  (IAGP)
hepatic necrosis  (IAGP)
hepatosplenomegaly  (IAGP)
hunched posture  (IAGP)
hydrops fetalis  (IAGP)
hyperpigmentation  (IAGP)
hypertension  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired branching involved in terminal bronchiole morphogenesis  (IAGP)
impaired granulosa cell differentiation  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased adenoma incidence  (IAGP)
increased apoptosis  (IAGP)
increased B cell number  (IAGP)
increased basophil cell number  (IAGP)
increased carcinoma incidence  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased cardiac output  (IAGP)
increased cell proliferation  (IAGP)
increased cellular sensitivity to oxidative stress  (IAGP)
increased cholangiocarcinoma incidence  (IAGP)
increased circulating erythropoietin level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased classified tumor incidence  (IAGP)
increased colon adenoma incidence  (IAGP)
increased cranium height  (IAGP)
increased cranium width  (IAGP)
increased cutaneous melanoma incidence  (IAGP)
increased dendritic cell number  (IAGP)
increased embryonic neuroepithelium apoptosis  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased endometrial carcinoma incidence  (IAGP)
increased eosinophil cell number  (IAGP)
increased esophageal papilloma incidence  (IAGP)
increased facial tumor incidence  (IAGP)
increased fibroblast proliferation  (IAGP)
increased fibrosarcoma incidence  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased granulocyte monocyte progenitor cell number  (IAGP)
increased granulocyte number  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased hair follicle cell proliferation  (IAGP)
increased hamartoma incidence  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inflammatory response  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased lip tumor incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung carcinoma incidence  (IAGP)
increased lung large cell carcinoma incidence  (IAGP)
increased lung non-small cell carcinoma incidence  (IAGP)
increased lung squamous cell carcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased lung weight  (IAGP)
increased lymphoblastic lymphoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased macrophage cell number  (IAGP)
increased malignant tumor incidence  (IAGP)
increased melanoma incidence  (IAGP)
increased mesothelioma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased monocyte cell number  (IAGP)
increased mouth tumor incidence  (IAGP)
increased myeloid cell number  (IAGP)
increased myeloid cell number in bone marrow  (IAGP)
increased myocardial fiber number  (IAGP)
increased neurofibroma incidence  (IAGP)
increased neurofibrosarcoma incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased neutrophil cell number  (IAGP)
increased oral papilloma incidence  (IAGP)
increased organ/body region tumor incidence  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreas adenoma incidence  (IAGP)
increased pancreas apoptosis  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased pancreas weight  (IAGP)
increased pancreatic acinar cell carcinoma incidence  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pancreatic intraepithelial neoplasia incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased prostate gland tumor incidence  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased regulatory T cell number  (IAGP)
increased sarcoma incidence  (IAGP)
increased skin papilloma incidence  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased spindle cell carcinoma incidence  (IAGP)
increased spleen red pulp amount  (IAGP)
increased splenocyte proliferation  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased stomach tumor incidence  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IAGP)
increased teratocarcinoma incidence  (IAGP)
increased testis tumor incidence  (IAGP)
increased thyroid carcinoma incidence  (IAGP)
increased thyroxine level  (IAGP)
increased trichoepithelioma incidence  (IAGP)
increased tumor growth/size  (IAGP)
increased tumor incidence  (IAGP)
increased tumor latency  (IAGP)
increased type II pneumocyte number  (IAGP)
increased urinary bladder carcinoma incidence  (IAGP)
intestinal obstruction  (IAGP)
intracranial hemorrhage  (IAGP)
jaundice  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, complete penetrance  (IAGP)
liver hypoplasia  (IAGP)
lung epithelium hyperplasia  (IAGP)
lung inflammation  (IAGP)
lymphatic vessel hypoplasia  (IAGP)
lymphedema  (IAGP)
lymphoid hyperplasia  (IAGP)
myeloid hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertelorism  (IAGP)
oxidative stress  (IAGP)
pale liver  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
pancreas cyst  (IAGP)
pancreas hyperplasia  (IAGP)
pancreas inflammation  (IAGP)
pancreatic acinar-to-ductal metaplasia  (IAGP)
paralysis  (IAGP)
pericardial edema  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polychromatophilia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
prostate gland hyperplasia  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
reticulocytosis  (IAGP)
ruffled hair  (IAGP)
sebaceous gland hyperplasia  (IAGP)
seminiferous tubule degeneration  (IAGP)
short tail  (IAGP)
skin lesions  (IAGP)
slow postnatal weight gain  (IAGP)
small heart  (IAGP)
small liver  (IAGP)
spleen vascular congestion  (IAGP)
squamous metaplasia of bulbourethral gland  (IAGP)
squamous metaplasia of urethral gland  (IAGP)
stomach mucosa hyperplasia  (IAGP)
submandibular gland hyperplasia  (IAGP)
tachypnea  (IAGP)
thick aortic valve  (IAGP)
thick epidermis  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thin myocardium  (IAGP)
thin ventricular wall  (IAGP)
thrombocytopenia  (IAGP)
thymus atrophy  (IAGP)
triangular face  (IAGP)
uterus adenomyosis  (IAGP)
ventricular septal defect  (IAGP)
weight loss  (IAGP)

References - curated
# Reference Title Reference Citation
1. GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma. Abel TW, etal., Mol Cancer Res. 2009 May;7(5):645-53. doi: 10.1158/1541-7786.MCR-08-0477. Epub 2009 May 12.
2. Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. Ahrendt SA, etal., Cancer. 2001 Sep 15;92(6):1525-30.
3. Association in the expression of Kirsten-ras oncogene and the major histocompatibility complex class I antigens in fibrosarcoma tumor cell variants exhibiting different metastatic capabilities. Alon Y, etal., Cancer Res. 1987 May 15;47(10):2553-7.
4. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
5. Biochemical characterization of a novel KRAS insertion mutation from a human leukemia. Bollag G, etal., J Biol Chem. 1996 Dec 20;271(51):32491-4.
6. Activation of RAS family genes in urothelial carcinoma. Boulalas I, etal., J Urol. 2009 May;181(5):2312-9. Epub 2009 Mar 19.
7. Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c-kit(+) cardiac progenitor cells by promoting miR-675. Cai B, etal., J Pineal Res. 2016 Aug;61(1):82-95. doi: 10.1111/jpi.12331. Epub 2016 Apr 29.
8. K-ras codon 12 and 61 point mutations in bromodeoxyuridine- and N-nitrosomethylurea-induced rat renal mesenchymal tumors. Calvert RJ, etal., Cancer Lett. 1996 Dec 3;109(1-2):1-7.
9. The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Calvisi DF, etal., Int J Cancer. 2009 Jun 16.
10. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
11. Mutant KRAS, chromosomal instability and prognosis in colorectal cancer. Castagnola P and Giaretti W, Biochim Biophys Acta. 2005 Nov 25;1756(2):115-25. Epub 2005 Jul 13.
12. Mutational analysis of KRAS, BRAF, and TP53 genes of ovarian serous carcinomas in Korean women. Cho YH, etal., Yonsei Med J. 2009 Apr 30;50(2):266-72.
13. Myocardial KRAS(G12D) expression does not cause cardiomyopathy in mice. Dalin MG, etal., Cardiovasc Res. 2014 Feb 1;101(2):229-35. doi: 10.1093/cvr/cvt260. Epub 2013 Nov 20.
14. Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance. Dietrich P, etal., Gut. 2018 Jul;67(7):1328-1341. doi: 10.1136/gutjnl-2017-315402. Epub 2017 Dec 23.
15. Mutations of the KRAS oncogene in endometrial hyperplasia and carcinoma. Dobrzycka B, etal., Folia Histochem Cytobiol. 2009;47(1):65-8.
16. Circulating free DNA, p53 antibody and mutations of KRAS gene in endometrial cancer. Dobrzycka B, etal., Int J Cancer. 2009 Dec 3.
17. MiR-193a-3p is an Important Tumour Suppressor in Lung Cancer and Directly Targets KRAS. Fan Q, etal., Cell Physiol Biochem. 2017;44(4):1311-1324. doi: 10.1159/000485491. Epub 2017 Nov 29.
18. Comprehensive analysis of genomic alterations of Chinese hilar cholangiocarcinoma patients. Feng F, etal., Int J Clin Oncol. 2021 Apr;26(4):717-727. doi: 10.1007/s10147-020-01846-z. Epub 2021 Jan 2.
19. Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM-LZ) and oncogenic KRAS in a mouse bone marrow transplantation model. Fu JF, etal., Int J Cancer. 2013 Oct 15;133(8):1792-802. doi: 10.1002/ijc.28195. Epub 2013 May 7.
20. Mucinous cystic neoplasms of the liver and pancreas: relationship between KRAS driver mutations and disease progression. Fujikura K, etal., Histopathology. 2017 Oct;71(4):591-600. doi: 10.1111/his.13271. Epub 2017 Aug 2.
21. Pathogenetic pathways in ovarian endometrioid adenocarcinoma: a molecular study of 29 cases. Geyer JT, etal., Am J Surg Pathol. 2009 Aug;33(8):1157-63.
22. TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study. Gormally E, etal., Cancer Res. 2006 Jul 1;66(13):6871-6.
23. Detection of a rare point mutation in Ki-ras of a human bladder cancer xenograft by polymerase chain reaction and direct sequencing. Grimmond SM, etal., Urol Res. 1992;20(2):121-6.
24. The inv(3)(q21q26)/t(3;3)(q21;q26) is frequently accompanied by alterations of the RUNX1, KRAS and NRAS and NF1 genes and mediates adverse prognosis both in MDS and in AML: a study in 39 cases of MDS or AML. Haferlach C, etal., Leukemia. 2011 May;25(5):874-7. doi: 10.1038/leu.2011.5. Epub 2011 Feb 1.
25. K-RasV14I recapitulates Noonan syndrome in mice. Hernandez-Porras I, etal., Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16395-400. doi: 10.1073/pnas.1418126111. Epub 2014 Oct 30.
26. Essential role for Ras signaling in glioblastoma maintenance. Holmen SL and Williams BO, Cancer Res. 2005 Sep 15;65(18):8250-5. doi: 10.1158/0008-5472.CAN-05-1173.
27. Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal. Hong HH, etal., Toxicol Pathol. 2015 Aug;43(6):872-82. doi: 10.1177/0192623315581192. Epub 2015 Jun 9.
28. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
29. Higher expression of K-ras is associated with parathyroid hormone-related protein-induced hypercalcaemia in renal cell carcinoma. Kamai T, etal., BJU Int. 2001 Dec;88(9):960-6.
30. Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation. Kong G, etal., J Biol Chem. 2013 Jun 21;288(25):18219-27. doi: 10.1074/jbc.M113.475376. Epub 2013 May 14.
31. The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231. Kozma SC, etal., Nucleic Acids Res. 1987 Aug 11;15(15):5963-71.
32. KRAS Status as an Independent Prognostic Factor for Survival after Yttrium-90 Radioembolization Therapy for Unresectable Colorectal Cancer Liver Metastases. Lahti SJ, etal., J Vasc Interv Radiol. 2015 Aug;26(8):1102-11. doi: 10.1016/j.jvir.2015.05.032.
33. Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases. Lee KH, etal., Cancer. 1995 Jun 15;75(12):2794-801.
34. Detection of KRAS mutations and their associations with clinicopathological features and survival in Chinese colorectal cancer patients. Li Z, etal., J Int Med Res. 2012;40(4):1589-98. doi: 10.1177/147323001204000439.
35. TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity. Liang MC, etal., Oncogene. 2010 Mar 18;29(11):1588-97. doi: 10.1038/onc.2009.452. Epub 2009 Dec 7.
36. Down-regulation of K-ras and H-ras in human brain gliomas. Lymbouridou R, etal., Eur J Cancer. 2009 May;45(7):1294-303. doi: 10.1016/j.ejca.2008.12.028. Epub 2009 Jan 27.
37. A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice. Lyubynska N, etal., Sci Transl Med. 2011 Mar 30;3(76):76ra27. doi: 10.1126/scitranslmed.3001069.
38. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
39. KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia. Malinowska-Ozdowy K, etal., Leukemia. 2015 Aug;29(8):1656-67. doi: 10.1038/leu.2015.107. Epub 2015 Apr 28.
40. Transcriptional activation of H- and N-ras oncogenes in human cervical cancer. Mammas IN, etal., Gynecol Oncol. 2004 Mar;92(3):941-8.
41. Activating KRAS mutation is prognostic only among patients who receive preoperative chemotherapy before resection of colorectal liver metastases. Margonis GA, etal., J Surg Oncol. 2016 Sep;114(3):361-7. doi: 10.1002/jso.24319. Epub 2016 Jun 6.
42. MGDs mouse GO annotations MGD data from the GO Consortium
44. Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner. Muñoz DM, etal., Glia. 2013 Nov;61(11):1862-72. doi: 10.1002/glia.22563. Epub 2013 Aug 30.
45. Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. Niihori T, etal., Nat Genet. 2006 Mar;38(3):294-6. Epub 2006 Feb 12.
46. K-ras point mutation in the nerve plexuses around the superior mesenteric artery in resectable adenocarcinoma of the pancreatic head: distribution pattern and related factors. Ohigashi H, etal., Arch Surg. 2000 Dec;135(12):1450-5.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. N-RAS and K-RAS gene mutations in Brazilian patients with multiple myeloma. Ortega MM, etal., Leuk Lymphoma. 2006 Feb;47(2):285-9.
49. The prevalence and prognostic significance of KRAS mutation in bladder cancer, chronic myeloid leukemia and colorectal cancer. Ouerhani S, etal., Mol Biol Rep. 2013 Jun;40(6):4109-14. doi: 10.1007/s11033-013-2512-8. Epub 2013 May 3.
50. Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. Paulsson K, etal., Genes Chromosomes Cancer. 2008 Jan;47(1):26-33.
51. K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Pearson HB, etal., Cancer Res. 2009 Jan 1;69(1):94-101.
52. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
53. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
54. Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. Potenza N, etal., EMBO Rep. 2005 May;6(5):432-7.
55. Primary mediastinal and testicular seminomas: a comparison of K-ras-2 gene sequence and p53 immunoperoxidase analysis of 26 cases. Przygodzki RM, etal., Hum Pathol. 1996 Sep;27(9):975-9.
56. Mouse MP Annotation Import Pipeline RGD automated import pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. The frequency of KRAS and BRAF mutations in intrahepatic cholangiocarcinomas and their correlation with clinical outcome. Robertson S, etal., Hum Pathol. 2013 Dec;44(12):2768-73. doi: 10.1016/j.humpath.2013.07.026. Epub 2013 Oct 15.
60. MEK1/2 dual-specificity protein kinases: Structure and regulation. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
61. Somatic mutations of signaling genes in non-small-cell lung cancer. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
62. Increases in Ki-ras and ornithine decarboxylase gene expression in rat pancreas after caerulein-induced pancreatitis. Sarfati P, etal., Digestion. 1996 Nov-Dec;57(6):453-63.
63. Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression. Saud SM, etal., Carcinogenesis. 2014 Dec;35(12):2778-86. doi: 10.1093/carcin/bgu209. Epub 2014 Oct 3.
64. Germline KRAS mutations cause Noonan syndrome. Schubbert S, etal., Nat Genet. 2006 Mar;38(3):331-6. Epub 2006 Feb 12.
65. The ALPPS Approach for Colorectal Liver Metastases: Impact of KRAS Mutation Status in Survival. Serenari M, etal., Dig Surg. 2018;35(4):303-310. doi: 10.1159/000471930. Epub 2017 Oct 14.
66. RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma. Sharma MK, etal., Neurology. 2005 Oct 25;65(8):1335-6.
67. Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis. Soman NR and Wogan GN, Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2045-9.
68. Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling. Stockand JD and Meszaros JG, Am J Physiol Heart Circ Physiol 2003 Jan;284(1):H176-84.
69. Assignment of three rat cellular RAS oncogenes to chromosomes 1, 4, and X. Szpirer J, etal., Somat Cell Mol Genet 1985 Jan;11(1):93-7.
70. K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat. Tanoguchi K, etal., Tohoku J Exp Med. 1999 Oct;189(2):87-93.
71. Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflight. Taylor WE, etal., J Gravit Physiol. 2002 Dec;9(2):61-70.
72. Monitoring of endometrial K-ras mutation in tamoxifen-treated patients with breast cancer. Tsujioka H, etal., Int J Gynecol Cancer. 2009 Aug;19(6):1052-6.
73. ACAT inhibition reverses LCAT deficiency and improves plasma HDL in chronic renal failure. Vaziri ND and Liang K, Am J Physiol Renal Physiol. 2004 Nov;287(5):F1038-43. Epub 2004 Jul 27.
74. Antisense knockdown of Kras inhibits fibrosis in a rat model of unilateral ureteric obstruction. Wang JH, etal., Am J Pathol. 2012 Jan;180(1):82-90. doi: 10.1016/j.ajpath.2011.09.036. Epub 2011 Nov 7.
75. MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2. Wang XF, etal., J Cancer Res Clin Oncol. 2012 Apr;138(4):573-84. doi: 10.1007/s00432-011-1114-x. Epub 2011 Dec 30.
76. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
77. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
78. Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer. Xia J, etal., Cancer Lett. 2016 Oct 10;381(1):31-40. doi: 10.1016/j.canlet.2016.07.014. Epub 2016 Jul 16.
79. Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. Zenker M, etal., J Med Genet. 2007 Feb;44(2):131-5. Epub 2006 Oct 20.
Additional References at PubMed
PMID:228288   PMID:1352876   PMID:1354597   PMID:1499088   PMID:1507224   PMID:1572642   PMID:1586998   PMID:1617215   PMID:1673105   PMID:1684952   PMID:1686731   PMID:1738193  
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