Kras (Kirsten rat sarcoma viral oncogene homolog) - Rat Genome Database

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Gene: Kras (Kirsten rat sarcoma viral oncogene homolog) Mus musculus
Analyze
Symbol: Kras
Name: Kirsten rat sarcoma viral oncogene homolog
RGD ID: 1550157
MGI Page MGI
Description: Enables GTPase activity and protein-membrane adaptor activity. Involved in endocrine signaling. Acts upstream of or within several processes, including forebrain astrocyte development; modulation of chemical synaptic transmission; and positive regulation of Rac protein signal transduction. Located in membrane. Is expressed in several structures, including alimentary system; brain; early embryo; eye; and genitourinary system. Used to study several diseases, including Noonan syndrome 3; arteriovenous malformations of the brain; gastrointestinal system cancer (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and high grade glioma (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI929937; c-K-ras; c-Ki-ras; GTPase KRas; K-; K-ras; K-Ras 2; Ki; Ki-ras; Kirsten rat sarcoma oncogene 2, expressed; Kr; Kra; Kras-2; Kras2; MGC7141; p21 protein; p21B; ras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396145,162,425 - 145,197,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6145,162,425 - 145,195,965 (-)EnsemblGRCm39 Ensembl
GRCm386145,216,699 - 145,250,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6145,216,699 - 145,250,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv376145,165,219 - 145,198,751 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366145,173,866 - 145,207,390 (-)NCBIMGSCv36mm8
Celera6148,290,985 - 148,324,546 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adenoma  (ISO)
anaplastic astrocytoma  (ISO)
anemia  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
arteriovenous malformations of the brain  (IAGP,ISO)
autoimmune lymphoproliferative syndrome type 4  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (IMP)
Capillary Malformation-Arteriovenous Malformation 1  (ISO)
Carcinogenesis  (ISO)
carcinoma  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiofaciocutaneous syndrome 1  (ISO)
cardiofaciocutaneous syndrome 2  (ISO)
cardiomyopathy  (IMP)
Cecal Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
chronic myeloid leukemia  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (IDA,ISO)
Costello syndrome  (ISO)
dilated cardiomyopathy  (IDA)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Encephalocraniocutaneous Lipomatosis  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (IAGP,ISO)
epidermal nevus  (ISO)
esophageal carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Sarcoma  (ISO)
fibrillary astrocytoma  (ISO)
gallbladder cancer  (ISO)
Gallbladder Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glioblastoma  (IMP,ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary diffuse gastric cancer  (ISO)
high grade glioma  (IMP,ISO)
Hodgkin's lymphoma  (ISO)
Hydrops Fetalis  (ISO)
hypertension  (IDA)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (IAGP,ISO)
juvenile myelomonocytic leukemia  (IAGP,ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Neoplasms  (ISO)
Klatskin's tumor  (ISO)
Leukocytosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (IAGP,ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (IMP,ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP)
lung sarcomatoid carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
Lynch syndrome  (ISO)
malignant astrocytoma  (IGI,ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
multiple myeloma  (ISO)
muscular atrophy  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (IMP)
myeloid sarcoma  (ISO)
Neoplasm Metastasis  (IEP,ISO)
Neoplastic Cell Transformation  (ISO)
neuroblastoma  (ISO)
Noonan syndrome  (IMP,ISO)
Noonan syndrome 3  (IAGP,ISO)
oculoectodermal syndrome  (ISO)
Ovarian Neoplasms  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (IAGP,ISO)
pancreatic ductal carcinoma  (ISO)
pancreatic mucinous cystadenoma  (ISO)
Paraproteinemias  (ISO)
Parasitic Liver Diseases  (ISO)
Penile Neoplasms  (ISO)
pilocytic astrocytoma  (ISO)
plasma cell neoplasm  (ISO)
prostate cancer  (IAGP)
Prostate Cancer, Hereditary, 1  (ISO)
prostate carcinoma in situ  (IAGP)
Prostatic Neoplasms  (IAGP,ISO)
RASopathy  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
seminoma  (ISO)
skin melanoma  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
T-cell acute lymphoblastic leukemia  (IMP)
teratoma  (ISO)
Thyroid Carcinoma, Nonmedullary 1  (ISO)
thyroid gland follicular carcinoma  (ISO)
thyroid gland medullary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Triple Negative Breast Neoplasms  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (ISO)
(trichloromethyl)benzene  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2-Bis(bromomethyl)propane-1,3-diol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-nitrophenol  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Methylchrysene  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
ARS-1620  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
Benz[j]aceanthrylene  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
ceruletide  (EXP)
CGP 52608  (ISO)
chloroethene  (EXP,ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chymostatin  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt atom  (EXP,ISO)
cobimetinib  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
cumene  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
Cyclopenta[cd]pyrene  (EXP)
dabrafenib  (ISO)
dextran sulfate  (EXP)
dibenzo[a,l]pyrene  (EXP)
dichlorine  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
farnesyl diphosphate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
GDP  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
GTP  (ISO)
guanosine  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
hydroxyurea  (EXP)
ionomycin  (ISO)
irbesartan  (EXP,ISO)
isoprenaline  (EXP)
isoprene  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
lovastatin  (EXP,ISO)
luzindole  (EXP)
manumycin A  (ISO)
MeIQx  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methohexital  (ISO)
methotrexate  (ISO)
monosodium L-glutamate  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nicotinic acid  (EXP)
ochratoxin A  (ISO)
oncrasin-1  (ISO)
oxirane  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
PD 0325901  (EXP,ISO)
pemetrexed  (ISO)
pentobarbital  (ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picrotoxin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
SB 431542  (ISO)
secobarbital  (ISO)
selumetinib  (ISO)
sevoflurane  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sotorasib  (ISO)
styrene  (EXP)
sulfur dioxide  (ISO)
sulindac  (ISO)
tacrolimus hydrate  (EXP)
Tanshinone I  (ISO)
Temsirolimus  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
Tetranitromethane  (EXP)
thiamylal  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
tiazofurine  (ISO)
tipifarnib  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trimetrexate  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinyl carbamate  (EXP)
zearalenone  (EXP)
zidovudine  (EXP)
zinc protoporphyrin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IGI)
cardiac muscle cell proliferation  (ISO)
cell population proliferation  (IGI)
cytokine-mediated signaling pathway  (ISO)
endocrine signaling  (IMP)
epithelial tube branching involved in lung morphogenesis  (IDA,IGI)
female pregnancy  (ISO)
forebrain astrocyte development  (IMP)
gene expression  (IMP)
glial cell proliferation  (IGI)
homeostasis of number of cells within a tissue  (IGI)
insulin-like growth factor receptor signaling pathway  (ISO)
liver development  (ISO)
myoblast proliferation  (ISO)
negative regulation of epithelial cell differentiation  (IDA)
negative regulation of neuron apoptotic process  (IGI)
neuron apoptotic process  (IGI)
positive regulation of cellular senescence  (ISO)
positive regulation of gene expression  (IMP,ISO)
positive regulation of glial cell proliferation  (IGI)
positive regulation of MAP kinase activity  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of Rac protein signal transduction  (IGI)
Rac protein signal transduction  (IGI)
Ras protein signal transduction  (IBA,IGI,IMP,TAS)
regulation of long-term neuronal synaptic plasticity  (IGI)
regulation of synaptic transmission, GABAergic  (IGI)
response to glucocorticoid  (ISO)
response to gravity  (ISO)
response to isolation stress  (ISO)
response to mineralocorticoid  (ISO)
signal transduction  (IEA)
skeletal muscle cell differentiation  (IGI)
striated muscle cell differentiation  (IGI)
type I pneumocyte differentiation  (IDA)
visual learning  (IGI)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal brain development  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal bronchiole morphology  (IAGP)
abnormal bronchoalveolar duct junction morphology  (IAGP)
abnormal bronchus epithelium morphology  (IAGP)
abnormal bronchus morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal centrosome morphology  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal colon goblet cell morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal common lymphocyte progenitor cell morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal cystic duct morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal DNA repair  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal ear position  (IAGP)
abnormal embryonic erythrocyte morphology  (IAGP)
abnormal embryonic erythropoiesis  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal extrahepatic bile duct morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal facial morphology  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal fibroblast proliferation  (IAGP)
abnormal gallbladder morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal hepatic portal vein morphology  (IAGP)
abnormal hepatic portal vein thrombosis  (IAGP)
abnormal hepatobiliary system morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lacrimal gland development  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung adenoma incidence  (IAGP)
abnormal lung development  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal metabolism  (IAGP)
abnormal metastatic potential  (IAGP)
abnormal mismatch repair  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic duct morphology  (IAGP)
abnormal peritoneum morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal prostate gland morphology  (IAGP)
abnormal prostate gland physiology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal rod electrophysiology  (IAGP)
abnormal skin sebaceous gland morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal survival  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal translation  (IAGP)
abnormal tumor incidence  (IAGP)
abnormal tumor morphology  (IAGP)
absent lacrimal glands  (IAGP)
absent Paneth cells  (IAGP)
absent visceral yolk sac blood islands  (IAGP)
absent vitelline blood vessels  (IAGP)
anemia  (IAGP)
anisopoikilocytosis  (IAGP)
arteriovenous malformation  (IAGP)
ascites  (IAGP)
bile duct hyperplasia  (IAGP)
bronchial epithelial hyperplasia  (IAGP)
bronchiolar epithelial hyperplasia  (IAGP)
cachexia  (IAGP)
cardiac fibrosis  (IAGP)
cellular necrosis  (IAGP)
cholestasis  (IAGP)
chromosomal instability  (IAGP)
chromosome breakage  (IAGP)
chylous ascites  (IAGP)
conotruncal ridge hyperplasia  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased B cell number  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating estradiol level  (IAGP)
decreased circulating progesterone level  (IAGP)
decreased circulating thyroid-stimulating hormone level  (IAGP)
decreased classified tumor incidence  (IAGP)
decreased cranium length  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased glutamic acid level  (IAGP)
decreased hematocrit  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased incidence of induced tumors  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased lung tumor incidence  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased lymphoma incidence  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased metastatic potential  (IAGP)
decreased ovarian tumor incidence  (IAGP)
decreased skin tumor incidence  (IAGP)
decreased survivor rate  (IAGP)
decreased T cell number  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor latency  (IAGP)
decreased tumor-free survival time  (IAGP)
dilated bile duct  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated gallbladder  (IAGP)
dilated heart  (IAGP)
dilated pancreatic duct  (IAGP)
dilated respiratory conducting tube  (IAGP)
disorganized pancreatic islets  (IAGP)
distended abdomen  (IAGP)
distended pericardium  (IAGP)
double outlet right ventricle  (IAGP)
early cellular replicative senescence  (IAGP)
edema  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged lung  (IAGP)
enlarged myocardial fiber  (IAGP)
enlarged pancreas  (IAGP)
enlarged pancreatic islets  (IAGP)
enlarged sebaceous gland  (IAGP)
enlarged spleen  (IAGP)
enlarged thyroid gland  (IAGP)
epidermal hyperplasia  (IAGP)
excessive folding of visceral yolk sac  (IAGP)
exocrine pancreas atrophy  (IAGP)
exocrine pancreatic insufficiency  (IAGP)
extramedullary hematopoiesis  (IAGP)
fetal growth retardation  (IAGP)
flattened snout  (IAGP)
Harderian gland hyperplasia  (IAGP)
heart hyperplasia  (IAGP)
hemoperitoneum  (IAGP)
hemorrhage  (IAGP)
hemorrhagic ascites  (IAGP)
hepatic necrosis  (IAGP)
hepatosplenomegaly  (IAGP)
hunched posture  (IAGP)
hydrops fetalis  (IAGP)
hyperpigmentation  (IAGP)
hypertension  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired branching involved in terminal bronchiole morphogenesis  (IAGP)
impaired granulosa cell differentiation  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased adenoma incidence  (IAGP)
increased apoptosis  (IAGP)
increased B cell number  (IAGP)
increased basophil cell number  (IAGP)
increased carcinoma incidence  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased cardiac output  (IAGP)
increased cell proliferation  (IAGP)
increased cellular sensitivity to oxidative stress  (IAGP)
increased cholangiocarcinoma incidence  (IAGP)
increased circulating erythropoietin level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased classified tumor incidence  (IAGP)
increased colon adenoma incidence  (IAGP)
increased cranium height  (IAGP)
increased cranium width  (IAGP)
increased cutaneous melanoma incidence  (IAGP)
increased dendritic cell number  (IAGP)
increased embryonic neuroepithelium apoptosis  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased endometrial carcinoma incidence  (IAGP)
increased eosinophil cell number  (IAGP)
increased esophageal papilloma incidence  (IAGP)
increased facial tumor incidence  (IAGP)
increased fibroblast proliferation  (IAGP)
increased fibrosarcoma incidence  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased granulocyte monocyte progenitor cell number  (IAGP)
increased granulocyte number  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased hair follicle cell proliferation  (IAGP)
increased hamartoma incidence  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inflammatory response  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased lip tumor incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung carcinoma incidence  (IAGP)
increased lung large cell carcinoma incidence  (IAGP)
increased lung non-small cell carcinoma incidence  (IAGP)
increased lung squamous cell carcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased lung weight  (IAGP)
increased lymphoblastic lymphoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased macrophage cell number  (IAGP)
increased malignant tumor incidence  (IAGP)
increased melanoma incidence  (IAGP)
increased mesothelioma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased monocyte cell number  (IAGP)
increased mouth tumor incidence  (IAGP)
increased myeloid cell number  (IAGP)
increased myeloid cell number in bone marrow  (IAGP)
increased myocardial fiber number  (IAGP)
increased neurofibroma incidence  (IAGP)
increased neurofibrosarcoma incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased neutrophil cell number  (IAGP)
increased oral papilloma incidence  (IAGP)
increased organ/body region tumor incidence  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreas adenoma incidence  (IAGP)
increased pancreas apoptosis  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased pancreas weight  (IAGP)
increased pancreatic acinar cell carcinoma incidence  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pancreatic intraepithelial neoplasia incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased prostate gland tumor incidence  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased regulatory T cell number  (IAGP)
increased sarcoma incidence  (IAGP)
increased skin papilloma incidence  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased spindle cell carcinoma incidence  (IAGP)
increased spleen red pulp amount  (IAGP)
increased splenocyte proliferation  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased stomach tumor incidence  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IAGP)
increased teratocarcinoma incidence  (IAGP)
increased testis tumor incidence  (IAGP)
increased thyroid carcinoma incidence  (IAGP)
increased thyroxine level  (IAGP)
increased trichoepithelioma incidence  (IAGP)
increased tumor growth/size  (IAGP)
increased tumor incidence  (IAGP)
increased tumor latency  (IAGP)
increased type II pneumocyte number  (IAGP)
increased urinary bladder carcinoma incidence  (IAGP)
intestinal obstruction  (IAGP)
intracranial hemorrhage  (IAGP)
jaundice  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, complete penetrance  (IAGP)
liver hypoplasia  (IAGP)
lung epithelium hyperplasia  (IAGP)
lung inflammation  (IAGP)
lymphatic vessel hypoplasia  (IAGP)
lymphedema  (IAGP)
lymphoid hyperplasia  (IAGP)
myeloid hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertelorism  (IAGP)
oxidative stress  (IAGP)
pale liver  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
pancreas cyst  (IAGP)
pancreas hyperplasia  (IAGP)
pancreas inflammation  (IAGP)
pancreatic acinar-to-ductal metaplasia  (IAGP)
paralysis  (IAGP)
pericardial edema  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polychromatophilia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
prostate gland hyperplasia  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
reticulocytosis  (IAGP)
ruffled hair  (IAGP)
sebaceous gland hyperplasia  (IAGP)
seminiferous tubule degeneration  (IAGP)
short tail  (IAGP)
skin lesions  (IAGP)
slow postnatal weight gain  (IAGP)
small heart  (IAGP)
small liver  (IAGP)
spleen vascular congestion  (IAGP)
squamous metaplasia of bulbourethral gland  (IAGP)
squamous metaplasia of urethral gland  (IAGP)
stomach mucosa hyperplasia  (IAGP)
submandibular gland hyperplasia  (IAGP)
tachypnea  (IAGP)
thick aortic valve  (IAGP)
thick epidermis  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thin myocardium  (IAGP)
thin ventricular wall  (IAGP)
thrombocytopenia  (IAGP)
thymus atrophy  (IAGP)
triangular face  (IAGP)
uterus adenomyosis  (IAGP)
ventricular septal defect  (IAGP)
weight loss  (IAGP)
References

References - curated
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Additional References at PubMed
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