Acvr2a (activin receptor IIA) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Acvr2a (activin receptor IIA) Mus musculus
Analyze
Symbol: Acvr2a
Name: activin receptor IIA
RGD ID: 1550139
MGI Page MGI
Description: Enables several functions, including PDZ domain binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in BMP signaling pathway. Acts upstream of or within several processes, including Sertoli cell proliferation; copulation; and regionalization. Located in cell surface. Is active in plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; gonad; gut; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome and colon cancer. Orthologous to human ACVR2A (activin A receptor type 2A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac; activin receptor type IIA; activin receptor type-2A; ACTR-IIA; ActrIIa; Acvr2; tAc; TactrII
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,704,121 - 48,793,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,704,121 - 48,793,281 (+)EnsemblGRCm39 Ensembl
GRCm38248,814,109 - 48,903,264 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,814,109 - 48,903,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv37248,669,629 - 48,758,784 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36248,636,166 - 48,724,172 (+)NCBIMGSCv36mm8
Celera250,486,791 - 50,575,736 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auchene hair morphology  (IAGP)
abnormal awl hair morphology  (IAGP)
abnormal behavior  (IEA)
abnormal coat/ hair morphology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IEA)
abnormal embryo size  (IEA)
abnormal embryonic tissue morphology  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hair cycle catagen phase  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle melanin granule morphology  (IAGP)
abnormal hair follicle outer root sheath morphology  (IAGP)
abnormal hair follicle regression  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair medulla  (IAGP)
abnormal hair medullary septa cells  (IAGP)
abnormal hair shaft melanin granule distribution  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal head morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal primitive streak elongation  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogonia morphology  (IAGP)
abnormal testis development  (IAGP)
abnormal vibrissa follicle morphology  (IAGP)
abnormal zigzag hair morphology  (IAGP)
absent allantois  (IAGP)
absent amnion  (IAGP)
absent corpus luteum  (IAGP)
absent hair club  (IAGP)
absent hair follicle bulb  (IAGP)
absent head fold  (IAGP)
absent heart tube  (IAGP)
absent incisors  (IAGP)
absent mesoderm  (IAGP)
absent vibrissae  (IAGP)
alopecia  (IAGP)
anophthalmia  (IEA)
azoospermia  (IAGP)
cleft palate  (IAGP)
cyclopia  (IAGP)
decreased eosinophil cell number  (IEA)
decreased forebrain size  (IAGP)
decreased male germ cell number  (IAGP)
decreased neutrophil cell number  (IEA)
decreased testis weight  (IAGP)
delayed male fertility  (IAGP)
diluted coat color  (IAGP)
early exit from anagen phase  (IAGP)
early exit from telogen phase  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic-extraembryonic boundary constriction  (IAGP)
eyelids open at birth  (IAGP)
failure to gastrulate  (IAGP)
female infertility  (IAGP)
increased atretic ovarian follicle number  (IAGP)
increased curvature of awl hairs  (IAGP)
increased curvature of guard hairs  (IAGP)
increased embryonic epiblast cell apoptosis  (IAGP)
increased hair follicle cell proliferation  (IAGP)
increased thigmotaxis  (IEA)
long nails  (IAGP)
lumbar vertebral transformation  (IAGP)
mandible hypoplasia  (IAGP)
microphthalmia  (IEA)
mosaic coat color  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
premature hair regrowth  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
reduced female fertility  (IAGP)
reduced hair shaft melanin granule number  (IAGP)
right pulmonary isomerism  (IAGP)
small melanosome  (IAGP)
small testis  (IAGP)
striated fur  (IAGP)
suppressed circulating follicle stimulating hormone level  (IAGP)
thick epidermis  (IAGP)
thin hair shaft  (IAGP)
thin uterus  (IAGP)
transposition of great arteries  (IAGP)
underdeveloped hair follicles  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
2. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
3. Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis. Gold EJ, etal., Mol Cell Endocrinol. 2003 Mar 28;201(1-2):143-53.
4. Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Jung B, etal., Gastroenterology. 2004 Mar;126(3):654-9.
5. Concomitant over-expression of activin/inhibin beta subunits and their receptors in human pancreatic cancer. Kleeff J, etal., Int J Cancer. 1998 Sep 11;77(6):860-8.
6. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells. Rossi MR, etal., Cancer Genet Cytogenet. 2005 Dec;163(2):123-9.
13. Osteoblasts express types I and II activin receptors during early intramembranous and endochondral bone formation. Shuto T, etal., J Bone Miner Res. 1997 Mar;12(3):403-11.
14. Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function. Szabó Z, etal., FASEB J. 2020 Aug;34(8):9911-9924. doi: 10.1096/fj.201903074RR. Epub 2020 May 19.
15. Downregulation of Activin A Receptor Type 2A Is Associated with Metastatic Potential and Poor Prognosis of Colon Cancer. Zhuo C, etal., J Cancer. 2018 Sep 8;9(19):3626-3633. doi: 10.7150/jca.26790. eCollection 2018.
Additional References at PubMed
PMID:1318045   PMID:1330789   PMID:1646080   PMID:7577669   PMID:7748787   PMID:7821227   PMID:7885474   PMID:7890768   PMID:8049070   PMID:8074643   PMID:8395525   PMID:8586443  
PMID:8612709   PMID:8732684   PMID:8875905   PMID:8959336   PMID:8995483   PMID:9482661   PMID:9610356   PMID:9825674   PMID:9886286   PMID:9986727   PMID:10231550   PMID:10349636  
PMID:10449041   PMID:10452853   PMID:10681527   PMID:10772805   PMID:10921901   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11416011   PMID:11459797   PMID:11459935  
PMID:11468775   PMID:11544199   PMID:11714685   PMID:12414726   PMID:12477932   PMID:12514121   PMID:12520002   PMID:12666204   PMID:12667445   PMID:12782414   PMID:14610273   PMID:14654247  
PMID:15277382   PMID:15342483   PMID:15451561   PMID:15883158   PMID:15913604   PMID:15963767   PMID:15963972   PMID:15970507   PMID:15976303   PMID:16093358   PMID:16141072   PMID:16141073  
PMID:16330774   PMID:16384867   PMID:16477644   PMID:16602821   PMID:16648306   PMID:16672363   PMID:16806156   PMID:16919269   PMID:16991118   PMID:17472960   PMID:17936261   PMID:18287559  
PMID:18621057   PMID:18799693   PMID:18927151   PMID:19148298   PMID:20011660   PMID:20801112   PMID:20801928   PMID:21538804   PMID:21784102   PMID:21873635   PMID:22056434   PMID:22485132  
PMID:22560297   PMID:22611050   PMID:23342175   PMID:23527555   PMID:23572558   PMID:24194600   PMID:24449835   PMID:24706813   PMID:24952961   PMID:25075125   PMID:25458897   PMID:26083127  
PMID:26321200   PMID:26774823   PMID:26962113   PMID:27030100   PMID:27462398   PMID:27626380   PMID:28659341   PMID:28843411   PMID:28844842   PMID:29031500   PMID:29620144   PMID:31311865  
PMID:32170006   PMID:32270195   PMID:32325033   PMID:33475143   PMID:34099644   PMID:34385332   PMID:35013323   PMID:36737727   PMID:37378449   PMID:38355793  


Genomics

Comparative Map Data
Acvr2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,704,121 - 48,793,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,704,121 - 48,793,281 (+)EnsemblGRCm39 Ensembl
GRCm38248,814,109 - 48,903,264 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,814,109 - 48,903,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv37248,669,629 - 48,758,784 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36248,636,166 - 48,724,172 (+)NCBIMGSCv36mm8
Celera250,486,791 - 50,575,736 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.38NCBI
ACVR2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382147,844,517 - 147,930,822 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2147,844,517 - 147,930,826 (+)EnsemblGRCh38hg38GRCh38
GRCh372148,602,086 - 148,688,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362148,319,040 - 148,404,863 (+)NCBINCBI36Build 36hg18NCBI36
Build 342148,436,303 - 148,519,242NCBI
Celera2142,316,710 - 142,402,536 (+)NCBICelera
Cytogenetic Map2q22.3-q23.1NCBI
HuRef2140,599,673 - 140,685,765 (+)NCBIHuRef
CHM1_12148,607,725 - 148,694,041 (+)NCBICHM1_1
T2T-CHM13v2.02148,294,972 - 148,381,274 (+)NCBIT2T-CHM13v2.0
Acvr2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,614,143 - 53,701,933 (+)NCBIGRCr8
mRatBN7.2333,204,961 - 33,292,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,205,523 - 33,289,968 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx336,594,864 - 36,673,345 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,179,586 - 45,258,078 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,001,947 - 43,080,473 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0332,947,901 - 33,034,598 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl332,947,378 - 33,034,282 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0338,113,728 - 38,197,531 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4329,779,827 - 29,808,881 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1329,676,198 - 29,705,253 (+)NCBI
Celera331,412,348 - 31,490,813 (+)NCBICelera
Cytogenetic Map3q12NCBI
Acvr2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544013,849,926 - 13,931,374 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544013,849,926 - 13,931,374 (+)NCBIChiLan1.0ChiLan1.0
ACVR2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21327,001,835 - 27,089,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B27,016,285 - 27,103,522 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,933,683 - 12,020,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B152,253,843 - 152,288,385 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B152,253,826 - 152,288,385 (+)Ensemblpanpan1.1panPan2
ACVR2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11949,642,429 - 49,726,720 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1949,641,219 - 49,723,420 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1949,765,961 - 49,850,433 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01951,114,507 - 51,199,229 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1951,113,374 - 51,198,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11949,760,723 - 49,845,201 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01949,894,649 - 49,979,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01951,291,788 - 51,376,557 (+)NCBIUU_Cfam_GSD_1.0
Acvr2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303112,344,483 - 112,422,388 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646929,194,908 - 29,273,196 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646929,195,329 - 29,273,237 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVR2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl154,173,805 - 4,259,706 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1154,177,333 - 4,259,056 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2153,828,828 - 3,910,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACVR2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11033,223,902 - 33,311,257 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1033,224,099 - 33,307,720 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040166,228,513 - 166,314,554 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acvr2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624866539,894 - 620,302 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624866539,967 - 619,575 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acvr2a
2372 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1726
Count of miRNA genes:655
Interacting mature miRNAs:870
Transcripts:ENSMUST00000063886, ENSMUST00000156681
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)23997166573971811Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24352061277520756Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24826974682269934Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24826974682269934Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24826974682269934Mouse
10449151Hdl8_mhigh density lipoprotein (HDL) level 8 (mouse)23812972567072607Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
10449150Pvldlc1_mplasma VLDL-cholesterol 1 (mouse)23812972567072607Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
10449145Lanq1_mlanosterol level QTL 1 (mouse)23812972567072607Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24352061277520756Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24419901778199017Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24813241282132495Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24352061277520756Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24352061277520756Mouse
13464253Ifvrq1_minfluenza virus resistance QTL 1 (mouse)23303449252034492Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4352061277520756Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174826974682269934Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
1300645Alcp1_malcohol preference locus 1 (mouse)Not determined24522812867838868Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24182071975820843Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse

Markers in Region
Acvr2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37248,670,195 - 48,670,336UniSTSGRCm37
Celera250,487,105 - 50,487,246UniSTS
Cytogenetic Map2C1.1UniSTS
10.MMHAP20FRD7.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38248,847,943 - 48,848,122UniSTSGRCm38
MGSCv37248,703,463 - 48,703,642UniSTSGRCm37
Celera250,520,374 - 50,520,553UniSTS
Cytogenetic Map2C1.1UniSTS
Whitehead_YAC2 UniSTS
D2Mit240  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38248,846,927 - 48,847,046UniSTSGRCm38
MGSCv37248,702,447 - 48,702,566UniSTSGRCm37
Celera250,519,358 - 50,519,477UniSTS
Cytogenetic Map2C1.1UniSTS
cM Map230.0UniSTS
Whitehead Genetic229.5UniSTS
Whitehead/MRC_RH2825.16UniSTS
Whitehead_YAC2 UniSTS
Acvr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38248,893,629 - 48,894,760UniSTSGRCm38
MGSCv37248,749,149 - 48,750,280UniSTSGRCm37
Celera250,566,101 - 50,567,232UniSTS
Cytogenetic Map2C1.1UniSTS
cM Map230.0UniSTS
MARC_31635-31636:1045776384:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38248,899,726 - 48,900,092UniSTSGRCm38
MGSCv37248,755,246 - 48,755,612UniSTSGRCm37
Celera250,572,198 - 50,572,564UniSTS
Cytogenetic Map2C1.1UniSTS
MARC_17905-17906:1025019334:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38248,898,544 - 48,899,839UniSTSGRCm38
MGSCv37248,754,064 - 48,755,359UniSTSGRCm37
Celera250,571,016 - 50,572,311UniSTS
Cytogenetic Map2C1.1UniSTS
Acvr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38248,812,179 - 48,812,389UniSTSGRCm38
MGSCv37248,667,699 - 48,667,909UniSTSGRCm37
Celera250,484,760 - 50,484,970UniSTS
Cytogenetic Map2C1.1UniSTS
cM Map230.0UniSTS
Acvr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C1.1UniSTS
cM Map230.0UniSTS
Acvr2b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
Cytogenetic Map2C1.1UniSTS
cM Map9 UniSTS
Acvr2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38248,814,675 - 48,814,816UniSTSGRCm38
MGSCv37248,670,195 - 48,670,336UniSTSGRCm37
Celera250,487,105 - 50,487,246UniSTS
Cytogenetic Map2C1.1UniSTS
Acvr2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C1.1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000063886   ⟹   ENSMUSP00000067305
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl248,704,121 - 48,793,281 (+)Ensembl
GRCm38.p6 Ensembl248,814,109 - 48,903,269 (+)Ensembl
Ensembl Acc Id: ENSMUST00000156681
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl248,780,401 - 48,790,260 (+)Ensembl
GRCm38.p6 Ensembl248,890,389 - 48,900,248 (+)Ensembl
RefSeq Acc Id: NM_007396   ⟹   NP_031422
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,704,121 - 48,793,276 (+)NCBI
GRCm38248,814,109 - 48,903,264 (+)ENTREZGENE
MGSCv37248,669,629 - 48,758,784 (+)RGD
Celera250,486,791 - 50,575,736 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006497623   ⟹   XP_006497686
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,704,560 - 48,792,761 (+)NCBI
GRCm38248,814,126 - 48,902,506 (+)NCBI
Sequence:
RefSeq Acc Id: NP_031422   ⟸   NM_007396
- Peptide Label: precursor
- UniProtKB: P27038 (UniProtKB/Swiss-Prot),   A2AI38 (UniProtKB/TrEMBL),   Q8BRV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497686   ⟸   XM_006497623
- Peptide Label: isoform X1
- UniProtKB: Q8BRV4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000067305   ⟸   ENSMUST00000063886
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27038-F1-model_v2 AlphaFold P27038 1-513 view protein structure

Promoters
RGD ID:6830720
Promoter ID:MM_KWN:29130
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000029496,   UC008JPO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36248,668,936 - 48,669,862 (+)MPROMDB
RGD ID:6830697
Promoter ID:MM_KWN:29131
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Kidney
Transcripts:OTTMUST00000029497
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36248,746,056 - 48,746,556 (+)MPROMDB
RGD ID:6877262
Promoter ID:EPDNEW_M2082
Type:initiation region
Name:Acvr2a_1
Description:Mus musculus activin receptor IIA , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38248,814,157 - 48,814,217EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102806 AgrOrtholog
Ensembl Genes ENSMUSG00000052155 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000063886 ENTREZGENE
  ENSMUST00000063886.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:102806 ENTREZGENE
NCBI Gene 11480 ENTREZGENE
PANTHER ACTIVIN RECEPTOR TYPE-2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acvr2a PhenoGen
PRINTS ACTIVIN2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AI38 ENTREZGENE, UniProtKB/TrEMBL
  AVR2A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BRV4 ENTREZGENE, UniProtKB/TrEMBL