Gnaq (guanine nucleotide binding protein, alpha q polypeptide) - Rat Genome Database

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Gene: Gnaq (guanine nucleotide binding protein, alpha q polypeptide) Mus musculus
Analyze
Symbol: Gnaq
Name: guanine nucleotide binding protein, alpha q polypeptide
RGD ID: 1550022
MGI Page MGI
Description: Enables G protein activity and enzyme regulator activity. Involved in several processes, including G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; maternal behavior; and neuron development. Located in cell body; dendrite; and membrane. Is active in plasma membrane and postsynaptic cytosol. Is expressed in several structures, including central nervous system; gonad; heart; intestine smooth muscle circular layer; and retina. Used to study congestive heart failure and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; congestive heart failure; and familial multiple nevi flammei. Orthologous to human GNAQ (G protein subunit alpha q).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110005L02Rik; 6230401I02Rik; AA408290; AW060788; Dsk; Dsk1; Dsk10; G alpha q; Gal; Galphaq; Gq; GqI; guanine nucleotide-binding protein alpha-q; guanine nucleotide-binding protein G(q) subunit alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391916,110,048 - 16,365,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1916,110,195 - 16,364,827 (+)EnsemblGRCm39 Ensembl
GRCm381916,132,684 - 16,388,520 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1916,132,831 - 16,387,463 (+)EnsemblGRCm38mm10GRCm38
MGSCv371916,207,321 - 16,461,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361916,199,850 - 16,454,472 (+)NCBIMGSCv36mm8
MGSCv361915,738,354 - 16,003,046 (+)NCBIMGSCv36mm8
Celera1916,873,630 - 17,041,492 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map1911.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-vinylcyclohexene dioxide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
bisphenol AF  (ISO)
bromochloroacetic acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (EXP)
cicaprost  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (EXP)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fingolimod hydrochloride  (ISO)
fluoxetine  (ISO)
folic acid  (EXP)
FR900359  (EXP)
fulvestrant  (ISO)
furfural  (ISO)
gadolinium atom  (EXP)
glucose  (EXP,ISO)
hexadecanoic acid  (EXP)
hexane  (ISO)
hydrogen cyanide  (EXP)
hydrogen sulfide  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methiothepin  (ISO)
methyl methanesulfonate  (ISO)
N-ethyl-5'-carboxamidoadenosine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
nickel dichloride  (ISO)
oleic acid  (ISO)
omipalisib  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
potassium chromate  (ISO)
serotonin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
sphingosine 1-phosphate  (ISO)
streptozocin  (ISO)
strontium atom  (EXP)
succimer  (EXP)
tamibarotene  (ISO)
Tanshinone I  (ISO)
theophylline  (ISO)
Thrombin  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
tungsten  (EXP)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
UTP  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IMP)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IDA)
cellular response to acidic pH  (ISO)
cranial skeletal system development  (IEA,IGI)
developmental pigmentation  (IEA,IMP)
embryonic digit morphogenesis  (IGI)
endothelin receptor signaling pathway  (IEA,IGI)
forebrain neuron development  (IMP)
G protein-coupled receptor signaling pathway  (IEA,IMP)
glutamate receptor signaling pathway  (IBA,IMP)
heart development  (IMP)
hormone-mediated signaling pathway  (ISO)
ligand-gated ion channel signaling pathway  (IEA,IGI,IMP)
maternal behavior  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of potassium ion transport  (ISO)
neuron remodeling  (IMP)
neuropeptide signaling pathway  (ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IEA,IGI)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  (IEA,IGI)
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA,IGI,IMP,ISO)
phospholipase C-activating serotonin receptor signaling pathway  (ISO)
positive regulation of insulin secretion  (IEA,IGI,IMP)
post-embryonic development  (IMP)
protein stabilization  (ISO)
regulation of blood pressure  (IEA,IGI)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of melanocyte differentiation  (IEA,IMP)
regulation of platelet activation  (IMP)
response to prostaglandin E  (ISO)
signal transduction  (IEA)
skeletal system development  (IMP)

Cellular Component
caveola  (ISO)
cell body  (IDA)
cytoplasm  (IBA)
dendrite  (IDA)
Golgi apparatus  (IEA)
heterotrimeric G-protein complex  (IBA,ISO,TAS)
membrane  (IDA,IEA)
nuclear membrane  (IEA)
nucleus  (IEA)
plasma membrane  (IDA,IEA,ISO,TAS)
postsynaptic cytosol  (IDA,ISO)
presynapse  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal afterhyperpolarization  (IAGP)
abnormal alisphenoid bone morphology  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal circulating calcium level  (IAGP)
abnormal dermal pigmentation  (IAGP)
abnormal epidermal pigmentation  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal glutamate-mediated receptor currents  (IAGP)
abnormal heart size  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal larynx morphology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal parathyroid gland morphology  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal pterygoid process morphology  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal thyroid follicular cell morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal thyroid gland physiology  (IAGP)
abnormal tympanic ring morphology  (IAGP)
abnormal urine calcium level  (IAGP)
abnormal vascular wound healing  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent long-term depression  (IAGP)
ataxia  (IAGP)
clonic seizures  (IAGP)
common ventricle  (IAGP)
darkened coat color  (IAGP)
decreased activity of thyroid gland  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased mean systemic arterial blood pressure  (IAGP)
decreased nitrate level  (IAGP)
decreased platelet aggregation  (IAGP)
decreased pulmonary respiratory rate  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased susceptibility to type I hypersensitivity reaction  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased vascular permeability  (IAGP)
decreased vasoconstriction  (IAGP)
decreased vasodilation  (IAGP)
delayed endochondral bone ossification  (IAGP)
domed cranium  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
gliosis  (IAGP)
heart hypoplasia  (IAGP)
hemopericardium  (IAGP)
hippocampal neuron degeneration  (IAGP)
hyperpigmentation  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
hypoxia  (IAGP)
impaired coordination  (IAGP)
increased bleeding time  (IAGP)
increased bone resorption  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased circulating thyroid-stimulating hormone level  (IAGP)
increased ear pigmentation  (IAGP)
increased foot pad pigmentation  (IAGP)
increased susceptibility to hypertension  (IAGP)
increased tail pigmentation  (IAGP)
increased urine calcium level  (IAGP)
incus hypoplasia  (IAGP)
lower jaw to upper jaw transformation  (IAGP)
malleus hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
proportional dwarf  (IAGP)
rachitic rosary  (IAGP)
seizures  (IAGP)
short mandible  (IAGP)
short snout  (IAGP)
small thyroid gland  (IAGP)
stapes hypoplasia  (IAGP)
tonic-clonic seizures  (IAGP)
trabecula carnea hypoplasia  (IAGP)
ventricular myocardium compact layer hypoplasia  (IAGP)
wide cranial sutures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Molecular properties of muscarinic acetylcholine receptors. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
2. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
3. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. Liggett SB, etal., Hum Mol Genet. 2007 Nov 15;16(22):2740-50. doi: 10.1093/hmg/ddm229. Epub 2007 Aug 24.
6. Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Mende U, etal., Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13893-8.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Discovery of new membrane-associated proteins overexpressed in small-cell lung cancer. Ocak S, etal., J Thorac Oncol. 2014 Mar;9(3):324-36. doi: 10.1097/JTO.0000000000000090.
10. Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. Offermanns S, etal., EMBO J 1998 Aug 3;17(15):4304-12.
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
19. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu Y, etal., J Pharmacol Sci. 2003 Jul;92(3):259-66.
Additional References at PubMed
PMID:1302014   PMID:2123549   PMID:7642703   PMID:8227063   PMID:8588930   PMID:8825633   PMID:8858601   PMID:8889548   PMID:8999798   PMID:9016340   PMID:9020153   PMID:9223268  
PMID:9223325   PMID:9296496   PMID:9391157   PMID:9554846   PMID:9607776   PMID:9640335   PMID:9765251   PMID:10037795   PMID:10349636   PMID:10433197   PMID:10481072   PMID:10629036  
PMID:10818132   PMID:10829070   PMID:10864945   PMID:10922068   PMID:10926822   PMID:11042159   PMID:11076861   PMID:11113135   PMID:11245652   PMID:11342430   PMID:11389023   PMID:11438569  
PMID:11685543   PMID:11689889   PMID:11826096   PMID:11891332   PMID:11907117   PMID:11985591   PMID:12077299   PMID:12183468   PMID:12351712   PMID:12397184   PMID:12411459   PMID:12477932  
PMID:12533510   PMID:12586747   PMID:12604601   PMID:12611815   PMID:12639992   PMID:12648486   PMID:12771155   PMID:12829380   PMID:12900409   PMID:12952937   PMID:12954641   PMID:14595844  
PMID:14630933   PMID:14742685   PMID:14755341   PMID:14976183   PMID:15175381   PMID:15304043   PMID:15322542   PMID:15326177   PMID:15340067   PMID:15367435   PMID:15466861   PMID:15489334  
PMID:15505105   PMID:15579147   PMID:15713647   PMID:15774906   PMID:15872115   PMID:15878957   PMID:15936338   PMID:16141072   PMID:16141073   PMID:16186103   PMID:16210321   PMID:16217033  
PMID:16223779   PMID:16251183   PMID:16339032   PMID:16354929   PMID:16380388   PMID:16504475   PMID:16602821   PMID:16754659   PMID:16847339   PMID:16988000   PMID:17023430   PMID:17088245  
PMID:17194762   PMID:17199045   PMID:17287521   PMID:17371949   PMID:17482476   PMID:17493641   PMID:17694176   PMID:17823129   PMID:17873012   PMID:17895403   PMID:17938235   PMID:18021799  
PMID:18084302   PMID:18199583   PMID:18213612   PMID:18219172   PMID:18237278   PMID:18353977   PMID:18473122   PMID:18487437   PMID:18552456   PMID:18667730   PMID:18674539   PMID:18801931  
PMID:18813283   PMID:18854320   PMID:18930063   PMID:18936096   PMID:18948082   PMID:18991294   PMID:19074439   PMID:19074441   PMID:19171764   PMID:19286657   PMID:19332487   PMID:19390533  
PMID:19478087   PMID:19889965   PMID:19940064   PMID:20200162   PMID:20372981   PMID:20440069   PMID:20508180   PMID:20579885   PMID:20624888   PMID:20715175   PMID:20886089   PMID:20966218  
PMID:21267068   PMID:21321132   PMID:21345793   PMID:21592972   PMID:21624053   PMID:21677750   PMID:21747049   PMID:21812758   PMID:21822282   PMID:21873635   PMID:22232556   PMID:22560942  
PMID:22562663   PMID:22577142   PMID:22595017   PMID:22640015   PMID:22672634   PMID:22723772   PMID:22750945   PMID:22794259   PMID:22885106   PMID:22972902   PMID:23022564   PMID:23066026  
PMID:23085334   PMID:23129751   PMID:23377541   PMID:23434405   PMID:23696743   PMID:23836924   PMID:24081657   PMID:24191038   PMID:24308950   PMID:24358341   PMID:24599464   PMID:24733892  
PMID:24870805   PMID:24958088   PMID:25090413   PMID:25495873   PMID:25560761   PMID:25595485   PMID:25605649   PMID:25732870   PMID:25832730   PMID:25844902   PMID:25857352   PMID:25963901  
PMID:25979088   PMID:26075576   PMID:26113083   PMID:26168216   PMID:26232433   PMID:26272756   PMID:26363170   PMID:26377475   PMID:26476043   PMID:26531127   PMID:26595811   PMID:26628681  
PMID:26763459   PMID:26843449   PMID:26930384   PMID:27016525   PMID:27115838   PMID:27276689   PMID:27330078   PMID:27348266   PMID:27364226   PMID:27387482   PMID:27589872   PMID:27716400  
PMID:27742837   PMID:27797339   PMID:27811142   PMID:27908836   PMID:28197018   PMID:28216651   PMID:28301547   PMID:28378742   PMID:28578927   PMID:28706196   PMID:28883467   PMID:29107092  
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PMID:34315875   PMID:34321999   PMID:34740971   PMID:34864945   PMID:35382561   PMID:37098137   PMID:37102682   PMID:37142655   PMID:37657560   PMID:37991948   PMID:38320000   PMID:38613153  
PMID:39108722   PMID:39225978  


Genomics

Comparative Map Data
Gnaq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391916,110,048 - 16,365,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1916,110,195 - 16,364,827 (+)EnsemblGRCm39 Ensembl
GRCm381916,132,684 - 16,388,520 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1916,132,831 - 16,387,463 (+)EnsemblGRCm38mm10GRCm38
MGSCv371916,207,321 - 16,461,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361916,199,850 - 16,454,472 (+)NCBIMGSCv36mm8
MGSCv361915,738,354 - 16,003,046 (+)NCBIMGSCv36mm8
Celera1916,873,630 - 17,041,492 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map1911.01NCBI
GNAQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38977,716,097 - 78,031,811 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl977,716,097 - 78,031,811 (-)EnsemblGRCh38hg38GRCh38
GRCh37980,331,013 - 80,646,727 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36979,525,009 - 79,836,012 (-)NCBINCBI36Build 36hg18NCBI36
Build 34977,564,746 - 77,875,746NCBI
Celera950,912,294 - 51,223,287 (-)NCBICelera
Cytogenetic Map9q21.2NCBI
HuRef950,167,421 - 50,477,535 (-)NCBIHuRef
CHM1_1980,482,435 - 80,793,672 (-)NCBICHM1_1
T2T-CHM13v2.0989,873,050 - 90,188,930 (-)NCBIT2T-CHM13v2.0
Gnaq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,852,453 - 223,098,754 (+)NCBIGRCr8
GRCr8 Ensembl1222,852,097 - 223,126,742 (+)EnsemblGRCr8 Ensembl
mRatBN7.21213,425,631 - 213,671,947 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1213,424,465 - 213,667,672 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1221,757,414 - 222,003,643 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,689,512 - 228,935,809 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,511,974 - 221,758,205 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01233,382,778 - 233,622,584 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1233,382,708 - 233,622,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01240,497,178 - 240,736,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,520,998 - 219,764,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1210,763,138 - 211,002,668 (+)NCBICelera
RGSC_v3.11219,685,020 - 219,928,420 (+)NCBI
Cytogenetic Map1q43NCBI
Gnaq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555121,381,159 - 1,658,409 (+)NCBIChiLan1.0ChiLan1.0
LOC100986730
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21176,877,498 - 77,190,897 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1976,883,323 - 77,196,700 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0946,816,409 - 47,129,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1976,570,773 - 76,773,847 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl976,575,815 - 76,773,849 (-)Ensemblpanpan1.1panPan2
GNAQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1180,733,530 - 80,928,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl180,715,366 - 80,928,065 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,197,285 - 81,391,732 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0181,038,541 - 81,345,574 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl181,038,966 - 81,343,028 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1180,931,602 - 81,126,112 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0180,652,980 - 80,847,487 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0181,383,410 - 81,578,003 (+)NCBIUU_Cfam_GSD_1.0
LOC101971998
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947127,896,936 - 128,074,513 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650313,099,558 - 13,276,152 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650313,098,517 - 13,276,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1230,605,265 - 230,907,674 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11230,607,469 - 230,906,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21257,372,859 - 257,378,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNAQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11288,666,375 - 88,988,989 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1288,670,424 - 88,871,154 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603876,997,006 - 77,320,682 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnaq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248115,163,793 - 5,486,140 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248115,158,665 - 5,485,812 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnaq
7765 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1836
Count of miRNA genes:770
Interacting mature miRNAs:1048
Transcripts:ENSMUST00000025541, ENSMUST00000167656, ENSMUST00000170229
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
38455997Cdtm2_mCD62L+ CD8 TM cells 2 (mouse)19997736419977364Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
12801464Rta2_mretinal aging 2 (mouse)141230287425302874Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
RH127065  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,371,180 - 16,371,396UniSTSGRCm38
MGSCv371916,445,670 - 16,445,886UniSTSGRCm37
Celera1917,025,229 - 17,025,445UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
Whitehead/MRC_RH19176.74UniSTS
RH136177  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,314,711 - 16,314,910UniSTSGRCm38
MGSCv371916,389,201 - 16,389,400UniSTSGRCm37
Celera1916,968,583 - 16,968,782UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
AW060788  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,385,140 - 16,385,260UniSTSGRCm38
MGSCv371916,459,630 - 16,459,750UniSTSGRCm37
Celera1917,039,179 - 17,039,299UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
Whitehead/MRC_RH19176.12UniSTS
Gnaq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371916,457,861 - 16,458,183UniSTSGRCm37
Celera1917,037,420 - 17,037,742UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
02.MMHAP85FRA8.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,220,016 - 16,220,177UniSTSGRCm38
MGSCv371916,294,506 - 16,294,667UniSTSGRCm37
Celera1916,874,090 - 16,874,251UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
Whitehead_YAC19 UniSTS
D19Mit52  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,146,324 - 16,146,460UniSTSGRCm38
MGSCv371916,220,814 - 16,220,950UniSTSGRCm37
Celera1916,798,688 - 16,798,824UniSTS
Cytogenetic Map19AUniSTS
cM Map198.0UniSTS
Whitehead Genetic199.8UniSTS
Whitehead/MRC_RH19174.41UniSTS
Whitehead_YAC19 UniSTS
RH124695  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,388,228 - 16,388,480UniSTSGRCm38
MGSCv371916,462,718 - 16,462,970UniSTSGRCm37
Celera1917,042,267 - 17,042,519UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
Gnaq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,383,371 - 16,383,693UniSTSGRCm38
MGSCv371916,457,861 - 16,458,183UniSTSGRCm37
Celera1917,037,420 - 17,037,742UniSTS
Cytogenetic Map19AUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025541   ⟹   ENSMUSP00000025541
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1916,110,195 - 16,364,827 (+)Ensembl
GRCm38.p6 Ensembl1916,132,831 - 16,387,463 (+)Ensembl
Ensembl Acc Id: ENSMUST00000167656
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1916,196,996 - 16,294,638 (+)Ensembl
GRCm38.p6 Ensembl1916,219,632 - 16,317,274 (+)Ensembl
Ensembl Acc Id: ENSMUST00000170229
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1916,110,660 - 16,293,891 (+)Ensembl
GRCm38.p6 Ensembl1916,133,296 - 16,316,527 (+)Ensembl
RefSeq Acc Id: NM_008139   ⟹   NP_032165
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391916,110,048 - 16,365,884 (+)NCBI
GRCm381916,132,684 - 16,388,520 (+)NCBI
MGSCv371916,207,321 - 16,461,943 (+)RGD
Celera1916,873,630 - 17,041,492 (+)RGD
cM Map19 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032165 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63306 (Get FASTA)   NCBI Sequence Viewer  
  AAH57583 (Get FASTA)   NCBI Sequence Viewer  
  BAE27882 (Get FASTA)   NCBI Sequence Viewer  
  EDL41539 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000025541
  ENSMUSP00000025541.6
GenBank Protein P21279 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032165   ⟸   NM_008139
- UniProtKB: Q6PFF5 (UniProtKB/Swiss-Prot),   P21279 (UniProtKB/Swiss-Prot),   Q3UHH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000025541   ⟸   ENSMUST00000025541
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21279-F1-model_v2 AlphaFold P21279 1-359 view protein structure

Promoters
RGD ID:13679048
Promoter ID:EPDNEW_M23673
Type:initiation region
Name:Gnaq_1
Description:Mus musculus guanine nucleotide binding protein, alpha q polypeptide, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381916,132,880 - 16,132,940EPDNEW
RGD ID:6830098
Promoter ID:MM_KWN:26578
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_008139
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361916,206,751 - 16,207,917 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95776 AgrOrtholog
Ensembl Genes ENSMUSG00000024639 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025541 ENTREZGENE
  ENSMUST00000025541.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro Gprotein_alpha_Q UniProtKB/Swiss-Prot
  Gprotein_alpha_su UniProtKB/Swiss-Prot
  GproteinA_insert UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:14682 UniProtKB/Swiss-Prot
MGD MGI:95776 ENTREZGENE
NCBI Gene 14682 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA UniProtKB/Swiss-Prot
  PTHR10218 UniProtKB/Swiss-Prot
Pfam G-alpha UniProtKB/Swiss-Prot
PhenoGen Gnaq PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot
  GPROTEINAQ UniProtKB/Swiss-Prot
PROSITE G_ALPHA UniProtKB/Swiss-Prot
SMART G_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt GNAQ_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UHH5 ENTREZGENE, UniProtKB/TrEMBL
  Q6PFF5 ENTREZGENE
UniProt Secondary Q6PFF5 UniProtKB/Swiss-Prot