Slc9a6 <sup>em1Moro</sup> (solute carrier family 9 member A6;CRISPR/Cas9 induced mutant1, Moro) - Rat Genome Database

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Gene: Slc9a6 em1Moro (solute carrier family 9 member A6;CRISPR/Cas9 induced mutant1, Moro) Rattus norvegicus
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Symbol: Slc9a6 em1Moro
Name: solute carrier family 9 member A6;CRISPR/Cas9 induced mutant1, Moro
RGD ID: 151664749
Description: CRISPR/Cas9 system was used to generate this mutant. Guide RNA sequence is the following: 5'-CGGCTGTGTAACCCTGATGA-3'. Cas9-mediated cleavage at exon 7 in the Slc9a6 locus resulted in the insertion of 2 bp (TT) generating frameshift and a premature stop codon.
ASSOCIATED WITH abnormal lysosome physiology; astrocytosis; axon degeneration
Type: allele  of Slc9a6  
Previously known as: Slc9a6 ^[em1Moro]
Is Marker For: Strains:   SD-Slc9a6 em1Moro/Rrrc   SD-Slc9a6 em1Moro  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain. Lee Y, etal., Brain. 2021 Dec 20. pii: 6470622. doi: 10.1093/brain/awab467.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Slc9a6 em1Moro-var1 chrX 134443830 134443831 - TT insertion mRatBN7.2

Related Rat Strains
The following Strains have been annotated to Slc9a6 em1Moro


Expression


Sequence

Nucleotide Sequences


Additional Information