Gper1<sup>em1Bj</sup> (G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj) - Rat Genome Database

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Gene: Gper1em1Bj (G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj) Rattus norvegicus
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Symbol: Gper1em1Bj
Name: G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj
RGD ID: 151347865
Description: CRISPR/Cas 9 was utilized to delete rat Gper1 gene in the one-cell embryos of SS/Jr rats. RNA validation performed via deletion PCR using a sense primer at the 5' end and an antisense primer at the 3' end showed a deletion PCR product of 544 bps versus wild-type PCR product of 1484 bps.
ASSOCIATED WITH abnormal free fatty acids level; decreased mean systemic arterial blood pressure; decreased pulse pressure; ASSOCIATED WITH Dysbiosis
Type: allele  of Gper1  
Previously known as: Gper1em1Bj-/-; Gper1^[em1Bj]
Is Marker For: Strains:   SS-Gper1em1Bj-/-  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
Dysbiosis  (IMP)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1. Waghulde H, etal., Hypertension. 2018 Nov;72(5):1125-1132. doi: 10.1161/HYPERTENSIONAHA.118.11175.

Genomics


Related Rat Strains
The following Strains have been annotated to Gper1em1Bj
SS-Gper1em1Bj-/-    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-04 Gper1em1Bj  G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj  Gper1em1Bj-/-  G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj  Symbol changed 629549 APPROVED