Ighm<sup>em2Ang</sup> (immunoglobulin heavy constant mu; ZFN induced mutant2, Ang)

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Gene: Ighm^em2Ang (immunoglobulin heavy constant mu; ZFN induced mutant2, Ang) Rattus norvegicus

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Symbol:	Ighm^em2Ang
Name:	immunoglobulin heavy constant mu; ZFN induced mutant2, Ang
RGD ID:	150523758
Description:	Microinjection of Sprague-Dawley rat zygotes with ZFN mRNA speciﬁc for the JH locus resulted in the generation of a mutant animal with a 2465 bp DNA deletion, spanning the entire locus ASSOCIATED WITH decreased B cell number; decreased IgA level; decreased IgE level; ASSOCIATED WITH B cell deficiency
Type:	allele of Ighm
Is Marker For:	Strains: SD-Ighm^em2Ang
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

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Disease Annotations Click to see Annotation Detail View

B cell deficiency (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased B cell number (IMP)

decreased IgA level (IMP)

decreased IgE level (IMP)

decreased IgG level (IMP)

decreased IgM level (IMP)

increased length of allograft survival (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Characterization of immunoglobulin heavy chain knockout rats.	Ménoret S, etal., Eur J Immunol. 2010 Oct;40(10):2932-41. doi: 10.1002/eji.201040939.

Genomics

Related Rat Strains

The following Strains have been annotated to Ighm^em2Ang

SD-Ighm^em2Ang

Expression

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype