Tshr<sup>em1Mlit</sup> (thyroid stimulating hormone receptor; CRISPR/Cas9 induced mutant 1, Mlit) - Rat Genome Database

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Gene: Tshrem1Mlit (thyroid stimulating hormone receptor; CRISPR/Cas9 induced mutant 1, Mlit) Rattus norvegicus
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Symbol: Tshrem1Mlit
Name: thyroid stimulating hormone receptor; CRISPR/Cas9 induced mutant 1, Mlit
RGD ID: 150521600
Description: CRISPR/Cas9 system targeting exon 10 of the rat Tshr gene was injected into Sprague Dawley embryos to create this mutant strain. The strain was homozygous with 5 bp deletion (CACGC) which introduces frameshift at residue 449 and a stop codon at 478 (P449fsX478).
ASSOCIATED WITH decreased circulating thyroxine level; decreased circulating triiodothyronine level; increased circulating thyroid-stimulating hormone level; ASSOCIATED WITH congenital hypothyroidism; Congenital Nongoitrous Hypothyroidism; Dwarfism
Type: allele  of Tshr  
Is Marker For: Strains:   SD-Tshrem1Mlit  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor. Yang J, etal., Sci Rep. 2018 Mar 5;8(1):4004. doi: 10.1038/s41598-018-22405-7.

Genomics


Related Rat Strains
The following Strains have been annotated to Tshrem1Mlit
SD-Tshrem1Mlit    


Expression


Sequence

Nucleotide Sequences


Additional Information