Pmch<sup>m1Hubr</sup> (pro-melanin-concentrating hormone; ENU induced mutant1, Hubr) - Rat Genome Database

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Gene: Pmchm1Hubr (pro-melanin-concentrating hormone; ENU induced mutant1, Hubr) Rattus norvegicus
Symbol: Pmchm1Hubr
Name: pro-melanin-concentrating hormone; ENU induced mutant1, Hubr
RGD ID: 150429964
Description: The Pmch mutant allele was generated by target-selected ENU-driven mutagenesis, and high-throughput resequencing of genomic target sequences in progeny from mutagenized rats (Wistar/Crl background) revealed an ENU-induced premature stop codon in exon 1(K50X) of Pmch in a rat.
ASSOCIATED WITH decreased adipose tissue noradrenaline turnover; decreased body fat mass; decreased brown adipose tissue mass
Type: allele  of Pmch  
Previously known as: Pmch^[m1Hubr]
Is Marker For: Strains:   WI-Pmchm1Hubr  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Pmch expression during early development is critical for normal energy homeostasis. Mul JD, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E477-88. doi: 10.1152/ajpendo.00154.2009. Epub 2009 Nov 24.
2. Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive. Mul JD, etal., PLoS One. 2013;8(3):e60214. doi: 10.1371/journal.pone.0060214. Epub 2013 Mar 26.


Related Rat Strains
The following Strains have been annotated to Pmchm1Hubr



Nucleotide Sequences

Additional Information