Pmch<sup>m1Hubr</sup> (pro-melanin-concentrating hormone; ENU induced mutant1, Hubr) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pmchm1Hubr (pro-melanin-concentrating hormone; ENU induced mutant1, Hubr) Rattus norvegicus
Analyze
Symbol: Pmchm1Hubr
Name: pro-melanin-concentrating hormone; ENU induced mutant1, Hubr
RGD ID: 150429964
Description: The Pmch mutant allele was generated by target-selected ENU-driven mutagenesis, and high-throughput resequencing of genomic target sequences in progeny from mutagenized rats (Wistar/Crl background) revealed an ENU-induced premature stop codon in exon 1(K50X) of Pmch in a rat.
ASSOCIATED WITH decreased adipose tissue noradrenaline turnover; decreased body fat mass; decreased brown adipose tissue mass
Type: allele  of Pmch  
Previously known as: Pmch^[m1Hubr]
Is Marker For: Strains:   WI-Pmchm1Hubr  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Pmch expression during early development is critical for normal energy homeostasis. Mul JD, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E477-88. doi: 10.1152/ajpendo.00154.2009. Epub 2009 Nov 24.
2. Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive. Mul JD, etal., PLoS One. 2013;8(3):e60214. doi: 10.1371/journal.pone.0060214. Epub 2013 Mar 26.

Genomics


Related Rat Strains
The following Strains have been annotated to Pmchm1Hubr
WI-Pmchm1Hubr    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information