Tspo<sup>em2Vpl</sup> (translocator protein; ZFN induced mutant2, Vpl) - Rat Genome Database

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Gene: Tspoem2Vpl (translocator protein; ZFN induced mutant2, Vpl) Rattus norvegicus
Symbol: Tspoem2Vpl
Name: translocator protein; ZFN induced mutant2, Vpl
RGD ID: 150429832
Description: Tspo-targeted genome editing in Sprague Dawley rats embryos by microinjecting with optimized and customized ZFNs designed for targeted gene KO. Locus-specific PCR was performed to identify Rat7 founders using the following primer pairs: COMPOZr-1kbF: 50-CCTGGATATGCTGTGTCCCC-30 and COMPOZr-1kbR: 50-TGATGGGTCATTTGTGCCCT-30.; Normal PCRs generated 818 bp for WT and 652 bp for the mutant (166 bp deletion).
ASSOCIATED WITH abnormal adrenal gland secretion; decreased circulating corticosterone level; decreased circulating testosterone level; ASSOCIATED WITH cholesterol ester storage disease
Type: allele  of Tspo  
Previously known as: Tspo^[em2Vpl]
Is Marker For: Strains:   SD-Tspoem2Vpl  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis. Owen DR, etal., Biochem J. 2017 Nov 21;474(23):3985-3999. doi: 10.1042/BCJ20170648.


Related Rat Strains
The following Strains have been annotated to Tspoem2Vpl



Nucleotide Sequences

Additional Information