Tspo<sup>em1Vpl</sup> (translocator protein; ZFN induced mutant1, Vpl)

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Gene: Tspo^em1Vpl (translocator protein; ZFN induced mutant1, Vpl) Rattus norvegicus

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Symbol:	Tspo^em1Vpl
Name:	translocator protein; ZFN induced mutant1, Vpl
RGD ID:	150429831
Description:	Tspo-targeted genome editing in Sprague Dawley rats embryos by microinjecting with optimized and customized ZFNs designed for targeted gene KO. Locus-specific PCR was performed to identify Rat5 founders using the following primer pairs: CKOZFN-F: 50-AGAGCATACTCTTGCCGTCG-30 and CKOZFN-R:50-ACTCCTAAAGGGGTTGCAGG-30; Normal PCRs generated 362 bp for the WT and 273 bp for the mutant,(89 bp deletion). ASSOCIATED WITH abnormal adrenal gland secretion; decreased circulating corticosterone level; decreased circulating testosterone level; ASSOCIATED WITH cholesterol ester storage disease
Type:	allele of Tspo
Is Marker For:	Strains: SD-Tspo^em1Vpl
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cholesterol ester storage disease (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal adrenal gland secretion (IMP)

decreased circulating corticosterone level (IMP)

decreased circulating testosterone level (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis.	Owen DR, etal., Biochem J. 2017 Nov 21;474(23):3985-3999. doi: 10.1042/BCJ20170648.

Genomics

Related Rat Strains

The following Strains have been annotated to Tspo^em1Vpl

SD-Tspo^em1Vpl

Expression

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype