Add3<sup>em2Mcwi</sup> (adducin 3; ZFN induced mutant2, Mcwi) - Rat Genome Database

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Gene: Add3em2Mcwi (adducin 3; ZFN induced mutant2, Mcwi) Rattus norvegicus
Symbol: Add3em2Mcwi
Name: adducin 3; ZFN induced mutant2, Mcwi
RGD ID: 150429619
Description: ZFN system was used to Knock out the rat Add3 gene of FHH-Chr 1BN/Mcwi rat embryos.The ZFN mRNA was injected into the pronucleus of fertilized FHH-Chr 1BN/Mcwi embryos and transferred to the oviduct of pseudopregnant females. PCR genotyping of tail biopsies confirmed a 68-bp deletion using forward primer 5'-GCCCCCATGAGTCACTACAC-3' and reverse primer 5'-GCTACAGGAAGCATCTCCTGTG-3'.
ASSOCIATED WITH decreased tubuloglomerular feedback response; decreased vasoconstriction
Type: allele  of Add3  
Previously known as: Add3^[em2Mcwi]
Is Marker For: Strains:   FHH-Chr 1BN-Add3em2Mcwi /Roman  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease. Fan F, etal., J Am Soc Nephrol. 2020 Apr;31(4):687-700. doi: 10.1681/ASN.2019080784. Epub 2020 Feb 6.


Related Rat Strains
The following Strains have been annotated to Add3em2Mcwi



Nucleotide Sequences

Additional Information