Add3<sup>em1Mcwi</sup> (adducin 3; ZFN induced mutant1, Mcwi) - Rat Genome Database

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Gene: Add3em1Mcwi (adducin 3; ZFN induced mutant1, Mcwi) Rattus norvegicus
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Symbol: Add3em1Mcwi
Name: adducin 3; ZFN induced mutant1, Mcwi
RGD ID: 150429617
Description: ZFN system was used to Knock out the rat Add3 gene of Crl:SD rat embryos.The ZFN mRNA was injected into the pronucleus of fertilized SpragueDawley embryos and transferred to the oviduct of pseudopregnant females. PCR genotyping of tail biopsies confirmed a 14-bp deletion using forward primer 5'-GCCCCCATGAGTCACTACAC-3' and reverse primer 5'-GCTACAGGAAGCATCTCCTGTG-3'.
ASSOCIATED WITH decreased tubuloglomerular feedback response; decreased vasoconstriction
Type: allele  of Add3  
Previously known as: Add3^[em1Mcwi]
Is Marker For: Strains:   SD-Add3em1Mcwi/ Roman  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease. Fan F, etal., J Am Soc Nephrol. 2020 Apr;31(4):687-700. doi: 10.1681/ASN.2019080784. Epub 2020 Feb 6.

Genomics


Related Rat Strains
The following Strains have been annotated to Add3em1Mcwi
SD-Add3em1Mcwi/ Roman    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information