Myo15a<sup>ci2</sup> (myosin XVA; ci2 mutant)

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Gene: Myo15a^ci2 (myosin XVA; ci2 mutant) Rattus norvegicus

Analyze

Symbol:	Myo15a^ci2
Name:	myosin XVA; ci2 mutant
RGD ID:	150404269
Description:	This allele is a spontaneous mutation of Myo15a containing a base substitution (T->C) in exon 56 of Myo15, leading to an amino acid exchange from leucine (Leu) to proline (Pro) within the carboxy-terminal MyTH4 domain in the proteins' tail region. ASSOCIATED WITH abnormal a-wave implicit time; abnormal b-wave implicit time; abnormal vision; ASSOCIATED WITH blindness
Type:	allele of Myo15a
Is Marker For:	Strains: LEW-Myo15a^ci2/Ztm
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

blindness (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal a-wave implicit time (IAGP)

abnormal b-wave implicit time (IAGP)

abnormal vision (IAGP)

retina outer nuclear layer degeneration (IAGP)

retina photoreceptor degeneration (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	A mutation in Myo15 leads to Usher-like symptoms in LEW/Ztm-ci2 rats.	Held N, etal., PLoS One. 2011 Mar 29;6(3):e15669. doi: 10.1371/journal.pone.0015669.

Genomics

Related Rat Strains

The following Strains have been annotated to Myo15a^ci2

LEW-Myo15a^ci2/Ztm

Expression

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype